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Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Wilson-Pérez HE, Sandoval DA, Kohli R, Bäckhed F and Seeley RJ.FXR is a molecular target for the effects of vertical sleeve gastrectomy.Nature, Mar 26th 2014 [Epub ahead of print]
Mehta M, Slaughter C, Xanthakos SA, Kohli R. High Prevalence of Hepatitis B Non-Immunity in Pediatric Non Alcoholic Fatty Liver Disease Patients. Digestive and Liver Disease, Apr 14th 2014 [Epub ahead of print]
Kohli R. There’s More under the Nonalcoholic Fatty Liver Disease Umbrella Than an Elevated Alanine Aminotransferase Level.J of Pediatr, 2014 Apr; 164(4):684-6.
Harley ITH, Stankiewicz TE, Softic S, Giles DA, Flick ML, Cappelletti M, Xanthakos SA, Steinbrecher KA, Sartor BR, Budelsky AL, Kohli R, Karp CL and Divanovic S.IL-17 signaling accelerates the progression of non-alcoholic fatty liver disease. Hepatology 2013 Oct 2. doi: 10.1002/hep.26746. [Epub ahead of print]Habegger KM, Al-Massadi O, Heppner KM, Myronovych A, Holland J, Berger J, Yi CX, Gao Y, Lehti M, Ottaway N, Amburgy S, Raver C, Müller TD, Pfluger PT, Kohli R, Perez-Tilve D, Seeley RJ, Tschöp M. Duodenal Nutrient Exclusion Improves Metabolic Syndrome and Stimulates Villus Hyperplasia.Gut 2013 Oct 9. doi: 10.1136/gutjnl-2013-304583. [Epub ahead of print]Ibrahim S, Gores GJ, Hirsova P, Kirby M, Miles L, Jaeschke A, Kohli R.MLK3-/- mice are protected against the development of high fat high carbohydrate diet-induced steatohepatitis. Liver Int, 2014 Mar; 34(3):427-37. Featured as cover art for journalMyronovych A, Kirby M, Ryan KK, Zhang W, Jha P, Setchell KDR, Dexheimer PJ, Aronow B, Seeley RJ, Kohli R. Vertical sleeve gastrectomy in obese mice increases serum bile acids while reducing liver steatosis in a weight-loss-independent manner.Obesity, 2014 Feb;22(2):390-400.Xanthakos SA, Podberesky DJ, Serai S, King E, Balistreri WF, Kohli R.Use of magnetic resonance elastography to non-invasively assess hepatic fibrosis in pediatric chronic liver disease. J of Pediatrics. 2014 Jan;164(1):186-8.Kohli R, Seeley RJ. The search for the mechanisms of bariatric surgery. Nature Reviews. 2013 Oct;9(10):572-4.
Foster M, Softic S, Caldwell J, Kohli R, de Kloet A, and Seeley RJ. Subcutaneous Adipose Tissue Transplantation in Diet-Induced Obese Mice Attenuates Metabolic Dysregulation While Removal Exacerbates It. Physiological Reports; 2013 Aug;1(2). pii: e00015.
Gadang V, Kohli R, Myronovych A, Hui D, Perez-Tilve D, Jaeschke A. MLK3 promotes the development of metabolic dysfunction induced by saturated fatty acid-enriched diet. Am J Physiol Endocrinol Metab. 2013 Aug;305(4):E549-56.Kohli R, Setchell KDR, Kirby M, Ryan KK, Berger J, Softic S, Zhang W, Toure M, Parks K, Smith K, Seeley RJ. A Novel Surgical Model in Obese Rats Uncovers Endoplasmic Reticulum Hepatoprotective Effects of Bile Acids Post-Bariatric Surgery. Endocrinology, 2013 Jul;154(7):2341-51. - Accompanying Editorial- Pournaras DJ, le Roux CW. Endocrinology. 2013 Jul;154(7):2255-6. - Are bile acids the new gut hormones? Lessons from weight loss surgery models. - Featured in Nature Reviews as a “Research Highlights” article: Wilson C. Nat Rev Endocrinol. 2013 May 7;9(7):379. Obesity: Bile acids and bariatric surgery.
DeVore S*, Kohli R*,
Lake K, Nicholas L, Dietrich K, Balistreri WF, Xanthakos SA. A Multidisciplinary Clinical Program is Effective in Stabilizing BMI and Reducing Transaminase Levels in Pediatric Patients with NAFLD. J
Pediatr Gastroenterol Nutr. [Epub
ahead of print]. March 19 2013.
Kohli R*, Bradley D*, Setchell KDR, Eagon C, Klein S. Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab.[Epub
ahead of print]. March 1 2013.
Bramlage K, Bansal V, Xanthakos SA, Kohli R. Nonalcoholic Fatty Liver Disease in Children- what should one do? Ind J Pediatr, 80 (Suppl 1):S109–S114. Mar 2013.
Stefater M, Kohli R, Inge TH. Advances in the Surgical Treatment
of Morbid Obesity. Mol Aspects Med; 34(1):84-94. Feb 2013.
Squires J, Sisk RA, Balistreri WF, Kohli R. Isolated Unilateral Cytomegalovirus Retinitis: Rare Long-Term Complication after Pediatric Liver Transplantation. Pediatr Trans;17(1):E16-9. Feb 2013.
Ryan KK, Kohli R,
Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ. Fibroblast growthfactor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in rats. Endocrinology; 154(1):9-15. Jan 2013.
Minar P, Alonso MH, Smith MT, Kohli R. An adolescent girl with belly pain… one gall bladder too many? J Pediatr Gastroenterol Nutr; 55(6):e142. Dec 2012.
Gaitonde S, Kohli
R, Seeley RJ. The role of the gut hormone GLP-1 in the metabolic improvements caused by Ileal Transposition.J of Surg Res;
178(33-39). Nov 2012.
Xanthakos SA, Kohli R. Treating Pediatric NAFLD with Cysteamine – is Adiponectin the Key? J of Pediatr, 161(4):579-81. Oct 2012.
SA,Kohli R. Pediatric Non-alcoholic Fatty Liver Disease:Prevalence, Diagnosis, Risk factors, and Management. Clinical
Liver Dis; 1(4): doi: 10.1002/cld.75 Aug 2012.
Softic S, Kirby M, Berger N, Shroyer N, Woods
SC, Kohli R. Insulin Concentration Modulates Hepatic Lipid Accumulation in Mice in part via Transcriptional Regulation of Fatty Acid Transport Proteins. PLOS One; 7(6):e38952. 2012.
Bedel A, Hemmelgarn T, Kohli R. Comparison of Valganciclovir versus Ganciclovir for CMV prophylaxis in Pediatric Liver Transplant Recipients- A Single Center Study. Liv Transpl;18(3):347-54. Mar 2012.
Foster MT, Shi H, Softic S, Kohli R, Seeley RJ and Woods SC. Visceral Adipose Transplantation-Induced Improvements in Glucose Tolerance in Mice: Alterations in Liver Fat Metabolism. 2011 Nov;54(11):2890-9 Bansal V, Kohli R. Peutz Jeghers Syndrome. Review for www.emedicine.comhttp://emedicine.medscape.com/article/1664349Kohli R, Feldstein AE. Animal Models of NASH: Are we there yet? J of Hepatology 2011, Oct;55(4):941-3 Kohli R, Stefater M, Inge TH. Molecular Insights from Bariatric Surgery. Reviews in Endo Metab Disord 2011 Sep;12(3):211-7. Ibrahim SH, Kohli R, Gores GJ. Mechanisms of Lipotoxicity in NAFLD and Clinical Implications. J Pediatr Gastroenterol Nutr 2011 Aug;53(2):131-40. Brunt EM et al for NASH Clinical Research Network. NAFLD activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011 Mar;53(3):810-20. Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. The Relationships of Steatosis Type, Grade, and Zonality with Histological Features in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr 2011 Feb;52(2):190-197.
Kohli R. Indian Childhood Cirrhosis- Revisited. J of Pediatr 2010 Nov; 157, 766. Kohli R, Kirby M, Setchell KDR, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D’Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity related co-morbidities. Am J Physio 2010 Sep; 299: G652 - G660. Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-Fructose-Diet Induces Hepatic Fibrosis and Elevates Plasma Oxidized Coenzyme Q9 in a Novel Murine Model of Obesity and NASH. Hepatology 2010 Sep; 52(3):934-44. Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Progression of Nonalcoholic Steatohepatitis in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr; 50(4):453-6.
Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 2009 Oct; 50(4):1113-20. Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the PI 3-kinase cell survival pathway. J Biol Chem 2007 282: 21327-21336. Kohli R, Alonso EM, Whitington PF. Liver Transplantation: The Recipient: Long-term Outcome: Pediatric Recipient. Living Donor Organ Transplantation, Eds Gruessner RWG, Benedetti E. McGraw Hill New York: 2008:656-61. Wainwright MS, Kohli R, Whitington PF, Chase D. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry following hypoxia-ischemia in newborn rats. Stroke 2006; 37; 524-530. Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline deficient medium. Am J Physio 2006; 291: G55–G62. Kohli R, Harris DC and Whitington PF. Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophy. J Pediatr Gastroenterol Nutr 2005; 41:121–124 Kohli R, Melin-Aldana H and Sentongo TA. Mesalamine-induced pneumonitis during therapy for chronic inflammatory bowel disease – a pediatric case report. J Pediatr Gastroenterol Nutr 2005 Oct; 41(4): 479-482. Kohli R, Li B U.K. Differential diagnosis of recurrent abdominal pain Pediatric Annals 2004 Feb; 33(2): 113-22. Kohli R, Li B U.K. Diarrhea and Malabsorption Syndromes Just the facts in Pediatrics, Eds Green T, Franklin W, Tanz R. McGraw-Hill Professional; New York 2004; 301-304 Kohli R, Abdel-Azim H and Inamdar S. Gastrointestinal perforation in childhood lupus: A case report and discussion. Pediatr Rheum Online Journal 2004; 2(6) Arora NK, Ganguly S, Agadi SN, Irshad M, Kohli R et al. Hepatitis B immunization in low birth weight infants: do they need an additional dose? Acta Paediatrica 2002; 91(9): 995-1001 Arora NK, Kohli R et al. Hepatic technetium-99m-mebrofenin iminodiacetate scans and serum gamma-glutamyl transpeptidase levels interpreted in series to differentiate between extrahepatic biliary atresia and neonatal hepatitis. Acta Paediatrica 2001; 90(9): 975-81 Arora NK, Kohli R. Diagnostic Approach for Neonatal Cholestasis. Textbook of Neonatal Surgery, Ed Gupta DK. Modern Publishers, New Delhi 2000; Edn 1:276-279 Arora NK, Kohli R. Work up of an infant with neonatal cholestasis in an Indian setup Journal of the Indian Association of Pediatric Surgeons 1999; 4:73-80
Invited Speaker- Annual NASPGHAN Scientific Meeting, Atlanta, GA. Treatment of NASH in Children.Invited Speaker- Department of Pediatrics Grand Rounds, University of Florida, Gainesville, FL. Liver Disease as a Complication of Obesity.Diseases Week, Chicago, IL: Invited Speaker-The Biology of Bariatric Surgery: Translational Symposium- AGA; Bile Acids & the Regulation of Energy Balance.Invited Speaker-4th Annual Cincinnati Diabetes & Obesity Center Symposium, Cincinnati, OH. Mechanisms of metabolic improvements after bariatric surgery.Invited Speaker-14th Annual Levine Diabetes & Obesity Symposium Digestive, City of Hope, Pasadena, CA. Perspectives on the metabolic improvements of bariatric surgery.Invited Speaker- Department of Pediatrics Grand Rounds, Wayne State University, Detroit, MI. Liver Disease as a Complication of ObesityMedical Student Lecturer- 3rd Year Medical Students, University of Cincinnati College of Medicine, Cincinnati, OH. Treating Obesity with Bariatric Surgery- what does bile have to do with it?
Invited Speaker- Bone Marrow Transplant and Immune Deficiency Seminar Series, CCHMC. Nonalcoholic fatty liver disease: should we be screening after cancer treatment?
Invited Speaker- Annual NASPGHAN Scientific Meeting, Salt Lake City, UT Nonalcoholic Fatty Liver Disease in Children.Invited Speaker-Annual Clinic Days, Wayne State University, Detroit, MI. Nonalcoholic Fatty Liver Disease in Children.Invited Speaker-Paediatric Liver GI Nutrition Center, King’s College Hospital, London, UK. Nonalcoholic Fatty Liver Disease and Bariatric Surgery in Children.Digestive Diseases Week, San Diego, CA:Invited Speaker- Mechanisms of Bariatric Surgery: Research Symposium, American Gastroenterology Association; Invited Speaker- Department of Pediatrics Grand Rounds, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Liver Disease as a Complication of Obesity
Invited Speaker- Mechanisms of Bariatric Surgery: Research Symposium, American Gastroenterology Association. Digestive Diseases Week, San Diego, CA-2012 Invited Speaker- Department of Pediatrics Grand Rounds, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Liver Disease as a Complication of Obesity-2012 Abstract Presentation- Keystone Obesity and Type 2 Diabetes Meeting, Santa Fe, NM. Role of IL-17 in the development and progression of non-alcoholic fatty liver disease-2012
Abstract Presentations- AASLD - 2011 San Francisco, CA: • Oral Presentation- NASH Parallel Session: Choledocho-Jejunal Bile Diversion in Obese Rats Increases Serum Tauro-urso-deoxy-cholic acid (TUDCA) Levels & Concomitantly Reduces Hepatic Steatosis; • Poster Presentation- NASH Poster Session: The Nox4-GSH Pathway Mediates Fibrosis in a Murine Model of Fibrotic Nonalcoholic Steatohepatitis (NASH); • Poster Presentation- NASH Poster Session: Serum oxidized Coenzyme Q levels are associated with severity of ballooning in biopsy confirmed pediatric nonalcoholic fatty liver disease • Poster Presentation- Pediatric Liver Disease Session: Retrospective review of the incidence of cytomegalovirus infection and disease post liver transplantation in pediatric patients: Comparison of prophylactic oral ganciclovir versus oral valganciclovir. Invited Speaker- Department of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT The Role of Bile Acids in Bariatric Surgery. -2011 Invited Speaker- Ethicon Endo-Surgery Sponsored Symposium at American Society of Metabolic and Bariatric Surgery Annual Meeting, Orlando, FL. Ileal Interposition to new Procedure Developement-2011 Invited Speaker and Session Moderator – Ethicon Endo Surgery’s Metabolic Applied Research Strategy Annual Meeting, Massachusetts General Hospital, Boston, MA- 2011 Invited Speaker – Neuroendocrinology of Obesity and Stress Seminar Series, Metabolic Disease Institute, University of Cincinnati. Role of bile acids in bariatric surgical procedures- 2011 Invited Speaker – Cincinnati Diabetes and Obesity Center Research Retreat, Insulin Signaling and Fat Transport in the Liver- 2011 Abstract Presentations- Digestive Diseases Week- 2011, Chicago, IL: • AASLD Plenary Session: The Hepatic Inflammasome Has an Increased NK-T and CD8+ T- Cell Signature in a Murine Model of Fibrotic Nonalcoholic Steatohepatitis (NASH); • AGA Poster Presentation: Choledocho-Jejunal Bile Diversion Protects Against Obesity Related Co-Morbidities by Increasing Serum Bile Acid and GLP-1 Levels Invited Speaker – Fluxes and Barriers Research Seminar Series, Department of Physiology, University of Cincinnati College of Medicine- 2011 Abstract Presentation – Keystone Obesity and Type 2 Diabetes Meeting, Keystone, CO. Short-Circuiting of the Bile Acid Entero-Hepatic Circulation via a Choledocho-Jejunal Bile Diversion Reduces Obesity Related Co-morbidities - 2011
Invited Speaker - Type-2 Diabetes Meeting, Johnson & Johnson- New Delhi, India. Increased frequency of bile acid cycling causes T2DM remission and excess weight loss - 2010 Oral Presentation- Global Obesity Summit (Travel Award to Post-Doctoral Fellow), University of Mississippi Medical Center, Jackson, Mississippi- 2010 Abstract Presentation - Annual AASLD Scientific Meeting, Boston. Insulin Signaling Mediates Hepatic Steatosis through Fatty Acid Transport Proteins (FATPs) in a U-Shaped Dose Dependent Manner-2010 Oral Presentation - Annual NASPGHAN Scientific Meeting, New Orleans. Hepatic Steatosis in Type 2 and Type 1 Diabetes Mellitus is Mediated by Insulin Signaling via Fatty Acid Transport Proteins-2010 Invited Speaker - Digestive Health Center Seminar Series, University of Cincinnati. CoEnzyme Q in the Pathogenesis of NAFLD – 2010 Invited Speaker - 20th Annual Pediatric Gastroenterology, Hepatology, and Nutrition Conference, Post Graduate Institute of Medical Education & Research, Chandigarh, India- 2010 Invited Speaker – Department of Gastroenterology Research Seminar Series, University of Cincinnati. Nonalcoholic Fatty Liver Disease – 2010 Invited Speaker - Chacha Nehru Bal Chikitsalaya, New Delhi, India. Complications of Chronic Liver Disease in Children - 2010
Invited Speaker - Institute for Liver and Biliary Sciences, New Delhi, India. Nonalcoholic Fatty Liver Disease - 2009 Oral Presentation - 5th International Pediatric Transplant Congress, Istanbul, Turkey. Hyponatremia Increases Mortality in Pediatric Patients listed for Liver Transplantation - 2009 Invited Speaker - Digestive Health Center Seminar Series, University of Cincinnati. Ileal Transposition: Studying the Mechanistic Role of the Hind Gut in Weight Loss Surgery - 2009 Invited Speaker - Neuroendocrinology of Obesity and Stress Seminar Series, University of Cincinnati. Intestinal adaptation and metabolic changes after ileal transposition surgery in rats - 2009 Invited Speaker - CDHNF-NASPGHAN 10th Anniversary Conference, San Diego. Ileal Transposition reduces obesity related co-morbidities - 2008 Invited Speaker - World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Iguassu Falls, Brazil Diagnostic paradigms in steatohepatitis - 2008
Biomarkers and Methods for Determining Disease Progression in Nonalcoholic Steatohepatitis (NASH) (USPTO Application #: #20110212468 - Class: 435 721)
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