Kohli Lab

DeVore S*, Kohli R*, Lake K, Nicholas L, Dietrich K, Balistreri WF, Xanthakos SA. A Multidisciplinary Clinical Program isEffective in Stabilizing BMI and Reducing Transaminase Levels in PediatricPatients with NAFLD.J Pediatr Gastroenterol Nutr. [Epub ahead of print]. March 19 2013.

Kohli R*, Bradley D*, Setchell KDR, Eagon C, Klein S. Weight loss induced byRoux-en-Y gastric bypass but not laparoscopic adjustable gastric bandingincreases circulating bile acids. J Clin Endocrinol Metab.[Epub ahead of print]. March 1 2013.

Bramlage K, Bansal V, Xanthakos SA, Kohli R. Nonalcoholic Fatty Liver Disease in Children- what should one do? Ind J Pediatr, 80 (Suppl 1):S109–S114. Mar 2013.

Stefater M, Kohli R, Inge TH. Advances in the Surgical Treatment of Morbid Obesity. Mol Aspects Med; 34(1):84-94. Feb 2013.

Squires J, Sisk RA, Balistreri WF, Kohli R. Isolated Unilateral Cytomegalovirus Retinitis: RareLong-Term Complication after Pediatric Liver Transplantation. Pediatr Trans;17(1):E16-9. Feb 2013.

Ryan KK, Kohli R, Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ. Fibroblast growthfactor-19 action in the brain reduces food intake andbody weight and improves glucose tolerance in rats.Endocrinology; 154(1):9-15. Jan 2013.

Minar P, Alonso MH, Smith MT, Kohli R. An adolescent girl withbelly pain… one gall bladder too many? J Pediatr Gastroenterol Nutr; 55(6):e142. Dec 2012.

Gaitonde S, Kohli R, Seeley RJ. The role of the gut hormone GLP-1 in the metabolicimprovements caused by Ileal Transposition.J of Surg Res; 178(33-39). Nov 2012.

Xanthakos SA, Kohli R. Treating Pediatric NAFLD with Cysteamine – isAdiponectin the Key?J of Pediatr, 161(4):579-81. Oct 2012.

Xanthakos SA,Kohli R. Pediatric Non-alcoholic Fatty Liver Disease:Prevalence, Diagnosis, Risk factors, and Management. Clinical Liver Dis; 1(4): doi: 10.1002/cld.75 Aug 2012.

Softic S, Kirby M, Berger N, Shroyer N, Woods SC, Kohli R. Insulin Concentration ModulatesHepatic Lipid Accumulation in Mice in part via Transcriptional Regulation ofFatty Acid Transport Proteins. PLOS One; 7(6):e38952. 2012.

Bedel A, Hemmelgarn T, Kohli R. Comparison of Valganciclovir versus Ganciclovir forCMV prophylaxis in Pediatric Liver Transplant Recipients- A Single CenterStudy.Liv Transpl;18(3):347-54. Mar 2012.

Foster MT, Shi H, Softic S, Kohli R, Seeley RJ and Woods SC. Visceral Adipose Transplantation-Induced Improvements in Glucose Tolerance in Mice: Alterations in Liver Fat Metabolism. 2011 Nov;54(11):2890-9 

Bansal V, Kohli R. Peutz Jeghers Syndrome. Review for www.emedicine.comhttp://emedicine.medscape.com/article/1664349

Kohli R, Feldstein AE. Animal Models of NASH: Are we there yet? J of Hepatology 2011, Oct;55(4):941-3 

Kohli R, Stefater M, Inge TH. Molecular Insights from Bariatric Surgery. Reviews in Endo Metab Disord 2011 Sep;12(3):211-7.

Ibrahim SH, Kohli R, Gores GJ. Mechanisms of Lipotoxicity in NAFLD and Clinical Implications. J Pediatr Gastroenterol Nutr 2011 Aug;53(2):131-40.

Brunt EM et al for NASH Clinical Research Network. NAFLD activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011 Mar;53(3):810-20.

Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. The Relationships of Steatosis Type, Grade, and Zonality with Histological Features in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr 2011 Feb;52(2):190-197.

Kohli R. Indian Childhood Cirrhosis- Revisited. J of Pediatr 2010 Nov; 157, 766.

Kohli R, Kirby M, Setchell KDR, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D’Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity related co-morbidities. Am J Physio 2010 Sep; 299: G652 - G660.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-Fructose-Diet Induces Hepatic Fibrosis and Elevates Plasma Oxidized Coenzyme Q9 in a Novel Murine Model of Obesity and NASH. Hepatology 2010 Sep; 52(3):934-44.

Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Progression of Nonalcoholic Steatohepatitis in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr; 50(4):453-6.

Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 2009 Oct; 50(4):1113-20.

Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the PI 3-kinase cell survival pathway. J Biol Chem 2007 282: 21327-21336.

Kohli R, Alonso EM, Whitington PF. Liver Transplantation: The Recipient: Long-term Outcome: Pediatric Recipient. Living Donor Organ Transplantation, Eds Gruessner RWG, Benedetti E. McGraw Hill New York: 2008:656-61.

Wainwright MS, Kohli R, Whitington PF, Chase D. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry following hypoxia-ischemia in newborn rats. Stroke 2006; 37; 524-530.

Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline deficient medium. Am J Physio 2006; 291: G55–G62.

Kohli R, Harris DC and Whitington PF. Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophy. J Pediatr Gastroenterol Nutr 2005; 41:121–124

Kohli R, Melin-Aldana H and Sentongo TA. Mesalamine-induced pneumonitis during therapy for chronic inflammatory bowel disease – a pediatric case report. J Pediatr Gastroenterol Nutr 2005 Oct; 41(4): 479-482.

Kohli R, Li B U.K. Differential diagnosis of recurrent abdominal pain Pediatric Annals 2004 Feb; 33(2): 113-22.

Kohli R, Li B U.K. Diarrhea and Malabsorption Syndromes Just the facts in Pediatrics, Eds Green T, Franklin W, Tanz R. McGraw-Hill Professional; New York 2004; 301-304

Kohli R, Abdel-Azim H and Inamdar S. Gastrointestinal perforation in childhood lupus: A case report and discussion. Pediatr Rheum Online Journal 2004; 2(6)

Arora NK, Ganguly S, Agadi SN, Irshad M, Kohli R et al. Hepatitis B immunization in low birth weight infants: do they need an additional dose? Acta Paediatrica 2002; 91(9): 995-1001

Arora NK, Kohli R et al. Hepatic technetium-99m-mebrofenin iminodiacetate scans and serum gamma-glutamyl transpeptidase levels interpreted in series to differentiate between extrahepatic biliary atresia and neonatal hepatitis. Acta Paediatrica 2001; 90(9): 975-81

Arora NK, Kohli R. Diagnostic Approach for Neonatal Cholestasis. Textbook of
Neonatal Surgery, Ed Gupta DK. Modern Publishers, New Delhi 2000; Edn 1:276-279 

Arora NK, Kohli R. Work up of an infant with neonatal cholestasis in an Indian setup Journal of the Indian Association of Pediatric Surgeons 1999; 4:73-80

Role of Ileum in Reducing Obesity Related Comorbidities. Principal Investigator. National Institutes of Health. Sep 2009 - Aug 2013. #1K08DK084310.

Ethicon Enhanced Assay Development. Co-investigator. University of Cincinnati. Jan 2009 - Jan 2014.

Clinical Research Network in Non-Alcoholic Steatohepatitis (NASH CRN). Co-investigator. National Institutes of Health. Aug 2009 - Apr 2014. #U01DK061732.

 Invited Speaker- Mechanisms of Bariatric Surgery: Research Symposium, American Gastroenterology Association. Digestive Diseases Week, San Diego, CA-2012

Invited Speaker- Department of Pediatrics Grand Rounds, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Liver Disease as a Complication of Obesity-2012

Abstract Presentation- Keystone Obesity and Type 2 Diabetes Meeting, Santa Fe, NM. Role of IL-17 in the development and progression of non-alcoholic fatty liver disease-2012

Abstract Presentations- AASLD- 2011 San Francisco, CA:
• Oral Presentation- NASH Parallel Session: Choledocho-Jejunal Bile Diversion in Obese Rats Increases Serum Tauro-urso-deoxy-cholic acid (TUDCA) Levels & Concomitantly Reduces Hepatic Steatosis;
• Poster Presentation- NASH Poster Session: The Nox4-GSH Pathway Mediates Fibrosis in a Murine Model of Fibrotic Nonalcoholic Steatohepatitis (NASH);
• Poster Presentation- NASH Poster Session: Serum oxidized Coenzyme Q levels are associated with severity of ballooning in biopsy confirmed pediatric nonalcoholic fatty liver disease
• Poster Presentation- Pediatric Liver Disease Session: Retrospective review of the incidence of cytomegalovirus infection and disease post liver transplantation in pediatric patients: Comparison of prophylactic oral ganciclovir versus oral valganciclovir.

Invited Speaker- Department of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT The Role of Bile Acids in Bariatric Surgery. -2011

Invited Speaker- Ethicon Endo-Surgery Sponsored Symposium at American Society of Metabolic and Bariatric Surgery Annual Meeting, Orlando, FL. Ileal Interposition to new Procedure Developement-2011
Invited Speaker and Session Moderator–Ethicon Endo Surgery’s Metabolic Applied Research Strategy Annual Meeting, Massachusetts General Hospital, Boston, MA- 2011

Invited Speaker – Neuroendocrinology of Obesity and Stress Seminar Series, Metabolic Disease Institute, University of Cincinnati. Role of bile acids in bariatric surgical procedures- 2011

Invited Speaker – Cincinnati Diabetes and Obesity Center Research Retreat, Insulin Signaling and Fat Transport in the Liver- 2011

Abstract Presentations- Digestive Diseases Week- 2011, Chicago, IL:
• AASLD Plenary Session: The Hepatic Inflammsome Has an Increased NK-T and CD8+ T- Cell Signature in a Murine Model of Fibrotic Nonalcoholic Steatohepatitis (NASH);
• AGA Poster Presentation: Choledocho-Jejunal Bile Diversion Protects Against Obesity Related Co-Morbidities by Increasing Serum Bile Acid and GLP-1 Levels

Invited Speaker – Fluxes and Barriers Research Seminar Series, Department of Physiology, University of Cincinnati College of Medicine- 2011

Abstract Presentation – Keystone Obesity and Type 2 Diabetes Meeting, Keystone, CO. Short-Circuiting of the Bile Acid Entero-Hepatic Circulation via a Choledocho-Jejunal Bile Diversion Reduces Obesity Related Co-morbidities- 2011

 Invited Speaker - Type-2 Diabetes Meeting, Johnson & Johnson- New Delhi, India. Increased frequency of bile acid cycling causes T2DM remission and excess weight loss - 2010

Oral Presentation- Global Obesity Summit (Travel Award to Post-Doctoral Fellow), University of Mississippi Medical Center, Jackson, Mississippi- 2010

Abstract Presentation - Annual AASLD Scientific Meeting, Boston. Insulin Signaling Mediates Hepatic Steatosis through Fatty Acid Transport Proteins (FATPs) in a U-Shaped Dose Dependent Manner-2010

Oral Presentation - Annual NASPGHAN Scientific Meeting, New Orleans. Hepatic Steatosis in Type 2 and Type 1 Diabetes Mellitus is Mediated by Insulin Signaling via Fatty Acid Transport Proteins-2010

Invited Speaker - Digestive Health Center Seminar Series, University of Cincinnati. CoEnzyme Q in the Pathogenesis of NAFLD – 2010

Invited Speaker - 20th Annual Pediatric Gastroenterology, Hepatology, and Nutrition Conference, Post Graduate Institute of Medical Education & Research, Chandigarh, India- 2010

Invited Speaker – Department of Gastroenterology Research Seminar Series, University of Cincinnati. Nonalcoholic Fatty Liver Disease – 2010

Invited Speaker - Chacha Nehru Bal Chikitsalya, New Delhi, India. Complications of Chronic Liver Disease in Children- 2010

 Invited Speaker - Institute for Liver and Biliary Sciences, New Delhi, India. Nonalcoholic Fatty Liver Disease - 2009

Oral Presentation - 5th International Pediatric Transplant Congress, Istanbul, Turkey. Hyponatremia Increases Mortality in Pediatric Patients listed for Liver Transplantation - 2009

Invited Speaker - Digestive Health Center Seminar Series, University of Cincinnati. Ileal Transposition: Studying the Mechanistic Role of the Hind Gut in Weight Loss Surgery - 2009

Invited Speaker - Neuroendocrinology of Obesity and Stress Seminar Series, University of Cincinnati. Intestinal adaptation and metabolic changes after ileal transposition surgery in rats - 2009

Invited Speaker - CDHNF-NASPGHAN 10th Anniversary Conference, San Diego. Ileal Transposition reduces obesity related co-morbidities - 2008

Invited Speaker - World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Iguassu Falls, Brazil Diagnostic paradigms in steatohepatitis - 2008

 Biomarkers and Methods for Determining Disease Progression in Nonalcoholic Steatohepatitis (NASH) (USPTO Application #: #20110212468 - Class: 435 721)