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Mark C. Steinhoff, MD Director, Global Health Center
is interested in the broad effects of immunization in prevention of illness both in US and low-resource regions. The Mother’s Gift project of antenatal maternal immunization with influenza vaccine showed protection of mothers and their unvaccinated infants, as well as increased birth weights of the newborns. His team is currently evaluating antenatal influenza vaccine in 3,600 pregnant women in S. Asia to assess the broader effects of prevention of influenza. In Cincinnati, they are evaluating the safety and immunogenicity of influenza vaccines provided to mothers after delivery. They are also carrying out a prospective antepartum influenza vaccine study to assess the differences in immune response between healthy pregnant and nonpregnant women.
Director, Global Health Center
Professor, UC Department of Pediatrics
MD: University of Chicago, Chicago, Illinois, 1973.
Residency and Chief Residency: Pediatrics, University of Rochester Medical Center, Rochester, New York.
Fellowship, Infectious Diseases: University of Rochester Medical Center, Rochester, New York.
Certification: New York State Medical License, 1976; Pediatrics, 1978; Tamil Nadu Medical Council (India), 1980; Michigan Medical License, 1985; Maryland Medical License, 1986; Ohio Medical License, 2010; Pediatric Infectious Diseases Society, 1988.
Steinhoff MC, MacDonald N, Pfeifer D, Muglia LJ. Influenza vaccine in pregnancy: policy and research strategies. Lancet. 2014;383:1611-3.
Schlaudecker EP, Steinhoff MC, Omer SB, et al. IgA and neutralizing antibodies to influenza a virus in human milk: a randomized trial of antenatal influenza immunization. PLoS one. 2013;8:e70867.
Henkle E, Steinhoff MC, Omer SB, et al. The effect of exclusive breast-feeding on respiratory illness in young infants in a maternal immunization trial in Bangladesh. Pediatr Infect Dis J. 2013;32:431-5.
Zhang T, Zhu Q, Zhang X, et al. The clinical characteristics and direct medical cost of influenza in hospitalized children: a five-year retrospective study in Suzhou, China. PLoS one. 2012;7:e44391.
Steinhoff MC, Omer SB, Roy E, et al. Neonatal outcomes after influenza immunization during pregnancy: a randomized controlled trial. CMAJ. 2012;184:645-53.
Schlaudecker EP, McNeal MM, Dodd CN, Ranz JB, Steinhoff MC. Pregnancy modifies the antibody response to trivalent influenza immunization. J Infect Dis. 2012;206:1670-3.
Omer SB, Goodman D, Steinhoff MC, et al. Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study. PLoS Med. 2011;8:e1000441.
Steinhoff MC, Omer SB, Roy E, et al. Influenza immunization in pregnancy--antibody responses in mothers and infants. N Engl J Med. 2010;362:1644-6.
Verghese VP, Friberg IK, Cherian T, et al. Community effect of Haemophilus influenzae type b vaccination in India. Pediatr Infect Dis J. 2009;28:738-40.
Zaman K, Roy E, Arifeen SE, et al. Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med. 2008;359:1555-64.
Steven Black, MD
is focusing on the evaluation of vaccine safety, vaccine efficacy and the epidemiology of vaccine preventable diseases in the United States but especially in the developing world. He is interested in fostering collaborative efforts to improve vaccine safety and effectiveness assessment in low and middle income countries.
Adjunct Professor, UC Department of Pediatrics
Vaccine safety and the use of computerized data to evaluate vaccines in the developed and developing world; vaccine clinical trials
MD: University of California, San Diego, 1973.
Residency: Pediatrics, Kaiser Hospital, San Francisco CA; Infectious Disease, University of California, San Francisco, CA.
Certification: Pediatrics, 1980; Pediatric Infectious Diseases, 1995.
Black S, Ray P, Shinefield H, Saddier P, Nikas A. Lack of Association of Age of Vaccination and Risk of Breakthrough Varicella within Northern California Kaiser Permanente Medical Care Program. J Infect Dis. 2008 Mar1;197 Suppl 2:S139-42.
Klein NP, Fireman B, Enright A, Ray P, Black S, Dekker C. A role for genetics in the immune response to varicella vaccine. Pediatr Infect Dis J. 2007April; 26(4):300-5.
Bernstein HH, Eves K, Campbell K, Black SB, Twiggs JD et al. Comparison of the safety and immunogenicity of a refrigerator-stable versus frozen formulation of ProQuad (measles, mumps, rubella and varicella live) vaccine. Pediatrics 2007 Jun;119(6):e1299-305.
Black S, France EK, Isaacman D, Bracken L, Lewis E, Hansen J, Fireman B, Austrian R et al. Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2007 Sept;26(9):771-7.
Seigrist CA, Lewis EM, Eskola J, Black SB. Human Papilloma Virus Immunization in Adolescents: A Cohort Study to Illustrate What Events Might be Mistaken for Adverse Events. Pediat Infect Dis J. 2007 Nov; 2(11): 979-984.
Adekunle H. Dawodu, MBBS, FRCPCH Director, International Patient Care and Education
is focusing on perinatal and pediatric vitamin D nutrition. His current research focuses on the study of the efficacy and safety of high dose vitamin D supplementation to prevent vitamin D deficiency in pregnant Arab mothers and their newborn infants.
Director, International Patient Care and Education
International child health; neonatology; perinatal epidemiology; perinatal and pediatric vitamin D and calcium metabolism
MBBS: University of Ibadan Medical School, Ibadan, Nigeria, 1968.
DTCH: University of Liverpool, Liverpool, England, 1973.
Fellowship: Neonatology, University of Cincinnati, Cincinnati, OH, 1977.
Dawodu A, Akinbi H. Vitamin D nutrition in pregnancy: current opinion. Int J Women’s Health. 2013 Jun24;5:333-43.
Dawodu A, Saadi HF, Bekdache G, Javed Y, Altaye M, Hollis BW. Randomized Controlled Trial (RCT) of Vitamin D Supplementation in Pregnancy in a Population with Endemic Vitamin D Deficiency. J Clin Endocrinol Metab. 2013 June;98:2337-46.
Dawodu A, Zalla L, Woo JG, Herbers PM, Davidson BS, Heubi JE, Morrow AL. Heightened attention to supplementation is needed to improve the vitamin D status of breastfeeding mothers and infants when sunshine exposure is restricted. Matern Child Nutr. 2014 Jul;10(3):383-97.
Dawodu A, Tsang RC. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Adv Nutr. 2012 May 1;3:353-61.
Dawodu A, Wagner CL. Prevention of vitamin D deficiency in mothers and infants worldwide - a paradigm shift. Paediatr Int Child Health. 2012 Feb;32(1):3-13.
Dawodu A, Kochiyil J and Altaye N. Pilot study of sunlight exposure and vitamin D status in Arab women of child bearing age. East Mediterr Health J. 2011 Jul;17(7):570-74.
Dawodu A, Nath R. High prevalence of moderately severe vitamin D deficiency in pre-term infants. Pediatr Int. 2011 Apr;53(2):207-10.
Saadi HF, Dawodu A, Afandi B, Zayed R, Benedict S, Nagelkerke N, Hollis, BW. Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants. Matern Child Nutri. 2009 Jan;5(1):25-32.
Dawodu A, Wagner CL. Mother-child vitamin D deficiency: an international perspective. Arch Dis Child. 2007 Sep;92(9):737-740.
Saadi HF, Dawodu A, Afandi BO, Zayed R, Benedict S, Nagelkerke N. Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women. Am J Clin Nutr. 2007 Jun;85(6):1565-71.
Russell E. Ware, MD, PhD Marjory J. Johnson Chair of Hematology Translational Research
Marjory J. Johnson Chair of Hematology Translational Research
Director, Division of Hematology
Co-Executive Director, Cancer and Blood Diseases Institute
Associate Director, Global Health Center
Russell Ware, MD, PhD, has been involved with a wide variety of clinical and translational hematology research projects for over 25 years, but his primary interests have focused on sickle cell disease. Dr. Ware has substantial personal experience with directing patient-oriented research, and he currently runs an NIH-funded laboratory effort that investigates genetic modifiers of sickle cell disease. The main focus of his lab research is to understand the phenotypic variability that occurs with hydroxyurea treatment, through the study of hydroxyurea pharmacokinetics, pharmacodynamics, pharmacogenetics, and pharmacogenomics. Dr. Ware is also the national principal investigator for several NIH-funded multicenter sickle cell clinical trials, including the recently completed Stroke With Transfusions Changing to Hydroxyurea (SWiTCH), and the current TCD With Transfusions Changing to Hydroxyurea (TWiTCH) and Sparing Conversion to Abnormal TCD Elevations (SCATE) studies that include non-US clinical sites. Most recently, Dr. Ware has moved his research efforts into the international arena, starting SCD pilot screening programs in Angola, and now conducting clinical trials to determine the safety and efficacy of hydroxyurea in developing countries.
MD: Duke University School of Medicine, Durham, NC, 1979-83.
Residency: Baylor College of Medicine, Houston, TX, 1983-86.
Fellowship: Duke Medical Center, Durham, NC, 1986-89.
PhD: Duke University School of Medicine, Durham, NC, 1987-91.
Certification: Pediatric Hematology/Oncology.
Ndeezi G, Kiyaga C, Hernandez AG, Munube D, Howard TA, Ssewanyana I, Nsungwa J, Kiguli S, Ndugwa CM, Ware RE, Aceng JR. Burden of sickle cell trait and disease in the Uganda Sickle Surveillance Study (US3): a cross-sectional study. Lancet Glob Health. 2016 Mar;4(3):e195-e200.
Aygun B, Mortier NA, Kesler K, Schultz WH, Alvarez O, Rogers Z, Kwiatkowski J, Miller S, Sylvestre P, Cohen A, Ware RE. Therapeutic phlebotomy is safe in children with sickle cell anemia and can be effective treatment for transfusional iron overload. Br J Haematol. 2015;169(2):262-266.
Ware RE, Davis BR, Schultz WH, Brown, Aygun B, Sarnaik S, Odame I, Fuh B, George A, Owen W, Luchtman-Jones L, Rogers ZR, Hilliard L, Gauger C, Piccone C, Lee MT, Kwiatkowski JL, Jackson S, Miller ST, Roberts C, Heeney MM, Kalfa TA, Nelson S, Imran H, Nottage K, Alvarez O, Rhodes M, Thompson AA, Rothman JA, Helton KJ, Roberts D, Coleman J, Bonner MJ, Kutlar A, Patel N, Wood J, Piller L, Wei P, Luden J, Mortier NA, Stuber SE, Luban NL, Cohen AR, Pressel, Adams RJ. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet. 2015 Feb;387(10019):661-670.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014 Sep 10;312(10):1033-48.
Ware RE. Is sickle cell anemia a neglected tropical disease? PLoS Negl Trop Dis. 2013 May 30;7(5):e2120.
Ware RE and Helms RW for the SWiTCH Investigators. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Blood. 2012;119(17):3925-3932.
Ware RE, Despotovic JM, Mortier NA, Flanagan JM, He J, Smeltzer M, Kimble AC, Aygun B, Wu S, Howard T, Sparreboom A. Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. Blood. 2011;118(18):4985-4991.
Wang WC, Ware RE, Miller ST, Iyer RV, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicenter, randomized, controlled trial (BABY HUG). Lancet. 2011;377(9778):1663-1672.
Ware RE, Zimmerman SA, Sylvestre PB, Mortier NA, Davis JS, Treem WR, Schultz WH. Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy. J Pediatr. 2004;145:346-352.
Zimmerman SA, Schultz WH, Davis JS, Pickens CV, Mortier NA, Howard TA, Ware RE. Sustained long-term hematological efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease. Blood. 2004;103:2039-2045.
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