• Basic Science Research

    Biliary Atresia

    Gregory Tiao, MD

    Biliary atresia is a life-threatening disorder of the liver and bile ducts that occurs in infants. In most cases, it results in the need for liver transplantation. We are exploring the pathophysiology of biliary atresia and are focusing research efforts on the cholangiocyte (epithelial cells that line the bile ducts). We believe that an inflammatory process involving the cholangiocyte is responsible for the subsequent fibrosis and cirrhosis that results in end-stage liver disease.

    Liver Transplantation

    Frederick Ryckman, MDMaria Alonso-Peclet, MD, and John Bucuvalas, MD

    Research activities within the Liver Care Center include a number of basic science and clinical projects, including:

    • Participation in an ongoing multicenter study of acute fulminant liver failure
    • Functional-health and quality-of-life assessment in children following transplantation

    The center has played a lead role in the development of the SPLIT (Studies in Pediatric Liver Transplantation) data registry, which has developed a national database for pediatric liver transplantation to characterize and follow trends in:

    • Patient and graft survival
    • Rejection incidence
    • Growth parameters
    • Immunosuppressive therapy