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General and Thoracic Surgery

Significant Accomplishments

Intestinal Rehabilitation 

Michael Helmrath, MD, has expertise in intestinal rehabilitation.  His basic science research continues to focus on intestinal failure and intestinal stem cells.  He is studying the mechanisms of intestinal stem cell expansion following resection.  His research is funded by the National Institutes of Health as an R01. Also, he has submitted a second R01 that is pending.  His research will help better understand how the cells (intestinal stem cells) that renew the lining of the intestine every day increase in number to help compensate following intestinal loss. 

Bariatric Surgery   

Thomas Inge, MD, PhD, directs the Center for Bariatric Research and Innovation, which partners with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to lead the national effort to prospectively gather data and publish evidence-based recommendations for use of weight loss surgery in adolescents.  The Teen LABS study continues to be funded by the NIDDK, the largest multicenter study to document outcomes of adolescents undergoing weight loss surgery.  He has submitted a competitive renewal to continue this important research.    

Wound Healing 

Sundeep Keswani, MD, is focusing on the molecular mechanisms underlying the fetal regenerative wound healing phenotype. If goals are realized, his work may yield a wide range of therapeutics for diseases characterized by excessive fibroplasia.  His basic science interests in fetal wound healing are closely paired with his clinical practice in fetal surgery and he is leading an initiative to create a clinical center of excellence in pediatric wound care.  He has submitted his first K08 application to the National Institutes of Health.   

Biliary Atresia  

Gregory Tiao, MD, continues to develop his research in biliary atresia. Tiao received funding on his R01 submission during the past year.