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Richard G. Azizkhan, MD Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery
does clinical trials and studies in patients with complex vascular anomalies and Epidermolysis Bullosa.
Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery
Professor, UC Department of Surgery
Complex mediastinal airway disorders; surgical oncology; neonatal anomalies; chest wall deformities; vascular malformations; esophageal disorders; pediatric trauma; epidermolysis bullosa
Trauma systems; injury prevention; fetal lung development; vascular malformations; solid tumors in childhood
Richard G. Azizkhan, MD, PhD (Hon), is the surgeon-in-chief at Cincinnati Children’s Hospital Medical Center. He is the first occupant of the Lester W. Martin Chair of pediatric surgery and is a professor of surgery and pediatrics at the University of Cincinnati, College of Medicine.
Dr. Azizkhan has published extensively and is author of more than 200 papers and chapters, and four books. Dr. Azizkhan’s experience and innovations in the management of complex mediastinal airway disorders, surgical oncology, neonatal anomalies, chest wall deformities, vascular malformations, epidermolysis bullosa, esophageal disorders and pediatric trauma have led to international recognition and numerous awards.
Dr. Azizkhan has served in leadership roles in numerous national and international surgical organizations including the American Academy of Pediatrics’ Surgical Section, American Pediatric Surgical Association and the American College of Surgeons. He is currently President of the World Federation of Associations of Pediatric Surgeons (WOFAPS). He has been active in establishing international medical education exchange programs and medical humanitarian activities in Central Europe, the Middle East, Latin America, Asia and Africa. One of his most significant opportunities was to be one of the 8 USAID supported coordinators of the medical reconstruction of the health care system in central Bosnia Herzegovina after the war ended in 1995. His work and relationship with academic health centers, national and regional health ministries throughout the Balkans is maintained actively today through the Cincinnati Children’s /Tuzla University and Zagreb Children’s Hospital affiliations which he coordinates. He was awarded an Honorary PhD from Tuzla University in 2001 and honorary citizenship of Tuzla in 2006 for his continuing contributions to improving the health system in Bosnia and all of the former Yugoslavian republics. He received the R. K. Ghandi Gold medal in 2005 from the Indian Association of Pediatric Surgeons for his impact globally.
MD: Doctor of Medicine, Milton S. Hershey Center of Pennsylvania State University College of Medicine Hershey, PA, 1972 to 1975.
Residency: Pediatric Surgery, Johns Hopkins Hospital, Baltimore, MD; Surgery, University of Virginia Medical Center, Charlottesville, VA.
Fellowship: Department of Surgery, Children's Hospital Medical Center, Harvard Medical School, Boston, MA.
Certification: General Surgery, 1984, recertified 1992; Pediatric Surgery, 1986, recertified 1993; Surgical Critical Care, 1989.
Daniel von Allmen, MD Director, Division of General and Thoracic Surgery
Director, Division of General and Thoracic Surgery
Pediatric surgical oncology; pediatric inflammatory bowel disease; surgical innovation; surgical robotics
Oncology; innovation; surgical workforce
Daniel von Allmen, MD, comes to Cincinnati from Chapel Hill, NC where he was the Surgeon-in-Chief and Division Chief at the North Carolina Children’s Hospital.
Dr. von Allmen completed his general surgery training at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center. He is currently the Program Committee chair of the American Pediatric Surgical Association. He also serves on the Program Committee for the American Academy of Pediatrics Surgical Section and is a member of the Steering Committee for the Surgical Section of the Children’s Oncology Group.
Dr. von Allmen's special clinical interests include pediatric surgical oncology, pediatric inflammatory bowel disease, surgical innovation, and surgical robotics.
Mayer ML, Beil HA, von Allmen D. Distance to care and relative supply among pediatric surgical subspecialties. J Pediatr Surg. 2009;44:483-495.
Maria H. Alonso-Peclet, MD Surgical Director, Kidney Transplant Program
Surgical Director, Kidney Transplant Program
Co-Surgical Director, Intestinal Transplant Surgery
Associate Professor, UC Department of Surgery
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 1982.
Residency: Surgery, Eastern Virginia Graduate School of Medicine, Norfolk, VA.
Fellowship: Trauma / Critical Care, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD; Trauma / Burn, Children's National Medical Center, Washington, D.C.; Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH.
Certification: Surgery, 1999; Pediatric Surgery, 2001; Surgical Critical Care, 2001.
Rebeccah L. Brown, MD Associate Director, Trauma Services
Associate Director, Trauma Services
General pediatric surgery; trauma; injury prevention; minimally invasive surgery; necrotizing enterocolitis; neonatal surgery; minimally invasive surgery; congenital hemolytic anemias; chest wall deformities
Pediatric trauma; injury prevention
Rebeccah L. Brown, MD, received a Bachelor of Science in Biology and Bachelor of Arts in Chemistry at New Mexico State University in Las Cruces, NM, in 1986. She graduated from University of New Mexico School of Medicine in Albuquerque, NM, with an MD in 1990. She completed her general surgery residency at University of Cincinnati Medical Center, in Cincinnati, Ohio, in 1997.
During her general surgical training, she also performed two years of basic science and clinical research in burn injuries and wound healing at the Shriners Hospitals for Children -- Cincinnati. She also served as an extracorporeal membrane oxygenation (ECMO) fellow at Cincinnati Children's Hospital Medical Center.
After completion of general surgery training, Dr. Brown completed a two-year fellowship in Pediatric Surgery at Children's Hospital of Buffalo in Buffalo, N.Y. She returned to Cincinnati Children's, Ohio, as assistant professor of Surgery and Pediatrics. Her main research interest is trauma and injury prevention, and she is currently the assistant director of Trauma Services, the fellowship director for the Pediatric Trauma Fellowship, and the director and cofounder of the Buckle Up for Life or Abrochate a la Vida program funded by Toyota.
Dr. Brown's clinical interests besides trauma and injury prevention include general pediatric surgery, minimally invasive surgery, inflammatory bowel disease, and Hirschsprung's disease.
Dr. Brown is a member of multiple professional organizations including the American College of Surgeons, American Medical Association, American Medical Women's Association, American College of Surgeons -- Ohio Chapter, Cincinnati Pediatric Society, Mont Reid Surgical Society, American Pediatric Surgical Association, American Academy of Pediatrics - Surgical Section and Injury Prevention Section, Eastern Association for the Surgery and Trauma, and Pediatric Trauma Society.
MD: University of New Mexico School of Medicine, Albuquerque, N.M., 1990.
Residency: General Surgery, University of Cincinnati Hospital, Cincinnati, Ohio, 1997.
Fellowship: Shriners Burns Institute, Cincinnati, Ohio, 1992-1994; ECMO, Children's Hospital Medical Center, Cincinnati, Ohio, 1993-1994; Pediatric Surgery Fellow, Children's Hospital of Buffalo, Buffalo, N.Y., 1997-1999.
Certification: Board-certified General Surgery, 1998, 2007; board-certified, Pediatric Surgery, 2000, 2009.
A. Roshni Dasgupta, MD, MPH Pediatric Surgeon
Surgical oncology and vascular malformations; minimally invasive surgery; general pediatric surgery
oncology and vascular malformations
MD: University of Toronto, Toronto Canada, 1996
Residency: Massachusetts General Hospital, Harvard Medical School 1996-2003
Research Fellowship: University of Oxford, Oxford England
Fellowship: Hospital for Sick Children, Toronto, Canada
MPH: Harvard School of Public Health, Boston, MA, 2009.
Murrell Z, Dasgupta R. What predicts the risk of recurrent lung metastases? J Pediatr Surg. 2013 May;48(5):1020-4.
Burke ME, Lyden ER, MezaJL, Ladas EJ, Dasgupta R, Wiegner EA, Arndt CA. Does Body Mass Index at Diagnosis or Weight Change during Therapy Predict Toxicity or Survival in Intermediate Risk Rhabdomyosarcoma? A Report from The Children’s Oncology Group Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2013 May;60(5):748-53.
Chen W, Gupta A, Adams D, Patel M, Dasgupta R. Generalized lymphatic malformation with chylothorax: long-term management of a highly morbid condition in a pediatric patient. J Pediatr Surg. 2013 Mar;48(3):e9-e12.
Gupta AA, Anderson JR, Pappo AS, Spunt SL, Dasgupta R, Indelicato DJ, Hawkins DS. Patterns of Chemotherapy-Induced Toxicities in Younger Children and Adolescents with Rhabdomyosarcoma: A Report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Cancer. 2012 Feb 15;118(4):1130-7.
Dasgupta R, Rodeberg DA. Update on Rhabdomyosarcoma. Semin Pediatr Surg. 2012 Feb;21(1):68-78.
Rymeski B, Burns K, Nagarajan R, Correll J, Kent D, O'Brien M, Perentesis JP, Dasgupta R. Long-term complications after staging laparotomy for Hodgkin lymphoma. J Clin Oncol. 2012.
Hammill A, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan R, Adams D. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 2011 Dec 1;57(6):1018-24.
Chen W, Wagner L, Boyd T, Nagarajan R, Dasgupta R. Extra-lobar pulmonary sequestration presenting with torsion: a case report and review of literature. J Pediatr Surg. 2011 Oct;46(10):2025-8.
Weiss BD, Dasgupta R, Gelfand MJ, Laor T, Yin H, Breneman JC, Lavigne R, Elluru RG, Wagner LM. Use of sentinel lymph node biopsy for staging para-meningeal rhabdomyosarcoma. Pediatr Blood Cancer. 2011 Sep;57(3):520-3.
Murrell Z, Dickie B, Dasgupta R. Lung Nodules in Pediatric Oncology Patients: A Prediction Rule for When to Biopsy. J Pediatri Surg. 2011 May;46(5):833-7.
Richard A. Falcone Jr., MD, MPH Director, Trauma Services
Director, Trauma Services
Pediatric injury prevention and outcomes; trauma education; management of colorectal disorders; inflammatory bowel disease; minimally invasive surgery; surgical oncology; extracorporeal life support (ECLS)
Injury prevention; health disparities; pediatric colorectal disorders; use of simulation to improve teamwork and safety
Cook R, Gillespie GL, Kronk, R, Daugherty M, Moody SM, Allen LJ, Shebesta KB, Falcone RA. Effect of an Educational Intervention on Nursing Staff Knowledge, Confidence, and Practice in the Care of Children with Mild Traumatic Brain Injury. Neuro Nurse. 2013 Apr;45(2):108-18.
Daugherty MC, Mehlman CT, Moody S, LeMaster T, Falcone RA Jr. Significant Rate Of Misuse Of The Hare Traction Splint For Children With Femoral Shaft Fractures. J Emerg Nurs. 2013 Jan;39(1):97-103.
Chatoorgoon K, Brown RL, Garcia VF, Falcone RA. Role of Computed Tomography and Clinical Findings in Pediatric Blunt Intestinal Injury: A Multi-Center Study. Pediatric Emergency Care. 2012 Dec;28(12):1338-42.
Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA Jr. Assessment of factors associated with the delayed transfer of pediatric trauma patients: an emergency physician survey. Pediatr Emerg Care. 2012 Aug;28(8):758-63.
Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R. A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. J Trauma Acute Care Surg. 2012 Aug;73(2):377-84; discussion 384.
Burton KS, Pendergrass TL, Byczkowski TL, Taylor RG, Moyer MR, Falcone RA, Geis GL. Impact of Simulation-Based Extracorporeal Membrane Oxygenation Training in the Simulation Laboratory and Clinical Environment. Simul Healthc. 2011 Oct;6(5):284-91.
Goldberg, J, McClaine RJ, Cook B, Garcia VF, Brown RL, Crone K, Falcone RA. Use of a mild traumatic brain injury guidelines to reduce inpatient hospital imaging and charges. J Pediatr Surg. 2011 Sep;46(9):1777-83.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Jason S. Frischer, MD Director, Extracorporeal Membrane Oxygenation Program, Division of Pediatric General and Thoracic Surgery
is a pediatric surgeon who has matched his clinical interest in Inflammatory Bowel Disease (IBD) with his basic and translational research programs. He is investigating angiogenesis, or the development of blood vessels in IBD (Crohn’s disease and Ulcerative Colitis), and how it relates to inflammation and healing. He also has interests in ECMO, CDH and anticoagulation outcomes research.
Director, Extracorporeal Membrane Oxygenation Program, Division of Pediatric General and Thoracic Surgery
Assistant Professor, UC Department of Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Victor F. Garcia, MD Founding Director, Trauma Services
Founding Director, Trauma Services
Garcia V. Comment on: Laparoscopic Roux-en-Y gastric bypass versus laparoscopic adjustable gastric banding: five years of follow-up. Surg Obes Relat Dis. 2010 Sep-Oct;6(5):475-6.
Chatoorgoon K, Huezo K, Rangel E, François N, Schweer L, Daugherty M, Koehn M, Ricketts C, Brown RL, Garcia VF, Falcone RA Jr. Unnecessary imaging, not hospital distance, or transportation mode impacts delays in the transfer of injured children. Pediatr Emerg Care. 2010 Jul;26(7):481-6.
Martin CA, Care M, Rangel EL, Brown RL, Garcia VF, Falcone RA Jr. Severity of head computed tomography scan findings fail to explain racial differences in mortality following child abuse. Am J Surg. 2010 Feb;199(2):210-5.
Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass. J Pediatr. 2010 Jan;156(1):103-108.e1.
Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22.
Falcone RA Jr, Martin C, Brown RL, Garcia VF. Despite overall low pediatric head injury mortality, disparities exist between races. J Pediatr Surg. 2008 Oct;43(10):1858-64.
Falcone RA Jr, Daugherty M, Schweer L, Patterson M, Brown RL, Garcia VF. Multidisciplinary pediatric trauma team training using high-fidelity trauma simulation. J Pediatr Surg. 2008 Jun;43(6):1065-71.
Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol. 2008 Apr 8; \51(14):1342-8.
Rangel SJ, Martin CA, Brown RL, Garcia VF, Falcone RA Jr. Alarming trends in the improper use of motor vehicle restraints in children: implications for public policy and the development of race-based strategies for improving compliance. J Pediatr Surg. 2008 Jan;43(1):200-7.
Falcone RA Jr, Brown RL, Garcia VF. Disparities in child abuse mortality are not explained by injury severity. J Pediatr Surg. 2007 Jun;42(6):1031-6; discussion 1036-7.
Mounira A. Habli, MD Maternal Fetal Medicine Specialist, Fetal Care Center of Cincinnati
Maternal Fetal Medicine Specialist, Fetal Care Center of Cincinnati
Assistant Director of Clinical Research, Good Samaritan Hospital
Obstetrics and Gynecology, Good Samaritan Hospital
Modification of the Wigglesworth model of Intrauterine growth restriction in mice as the animal model; invitro assessment of Insulin like growth factors and adenoviral associated gene expression of insulin like growth factor-I in a rat trophoblast cell line (RCHO-1)
Pizarro D, Habli M, Grier M, Bombrys A, Sibai B, Livingston J. Higher maternal doses of methadone does not increase neonatal abstinence syndrome. J Subst Abuse Treat. 2011 Jan 19.
Keswani SG, Le LD, Morris LM, Lim FY, Katz AB, Ghobril N, Habli M, Frischer JS, Crombleholme TM. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy. J Pediatr Surg. 2011 Jan;46(1):33-8.
Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9.
Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7.
Habli M, Bombrys A, Lewis D, Lim FY, Polzin W, Maxwell R, Crombleholme T. Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience. Am J Obstet Gynecol. 2009 Oct;201(4):417.e1-7.
Habli M, Eftekhari N, Wiebracht E, Bombrys A, Khabbaz M, How H, Sibai B. Long-term maternal and subsequent pregnancy outcomes 5 years after hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. Am J Obstet Gynecol. 2009 Oct;201(4):385.e1-5.
Katz AB, Keswani SG, Habli M, Lim FY, Zoltick PW, Midrio P, Kozin ED, Herlyn M, Crombleholme TM. Placental gene transfer: transgene screening in mice for trophic effects on the placenta. Am J Obstet Gynecol. 2009 Nov;201(5):499.e1-8
Habli M, Lim FY, Crombleholme T. Twin-to-twin transfusion syndrome: a comprehensive update. Clin Perinatol. 2009 Jun;36(2):391-416, x. Review.
Bombrys AE, Barton JR, Habli M, Sibai BM. Expectant management of severe preeclampsia at 27(0/7) to 33(6/7) weeks' gestation: maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management. Am J Perinatol. 2009 Jun;26(6):441-6.
Lubow JM, How HY, Habli M, Maxwell R, Sibai BM. Indications for delivery and short-term neonatal outcomes in late preterm as compared with term births. Am J Obstet Gynecol. 2009 May;200(5):e30-3.
Michael A. Helmrath, MD, MS Surgical Director, Intestinal Rehabilitation Program
Surgical Director, Intestinal Rehabilitation Program
Director of Surgical Research
As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s Hospital, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.
BA: Miami University, Oxford, OH, 1987.
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.
Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.
Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW. Adaptation after small bowel resection is attenuated by sialoadenectomy: The role for endogenous epidermal growth factor. Surgery. 1998;124 (5):848-854.
Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr., Stern LE, Warner BW. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol Gastrointest Liver Physiol. 1999;277:G533-G540.
Helmrath MA, Fong JJ, Dekaney CM, Henning SJ. Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;292(1): G215-222.
Shroyer NF, Helmrath MA, Wang YYC, Antalffy B, Henning SJ, Zoghbi HY. Intestine specific ablation of Math 1 in mice reveals a role in cellular homeostasis. Gastroenterology. 2007;132(7):2478-2488.
Dekaney CM, Fong JJ, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;293(5): G1013-22.
Dekaney CM, von Allmen DC, Garrison AP, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileocecal resection. Surgery. 2008;144(2):174-81.
Garrison AP, Dekaney CM, von Allmen DC, Lund PK, Henning SJ, Helmrath MA. Early but not late administration of glucagons-like peptide-2 following ileocecal resection augments putative intestinal stem cell expansion. Am J Physiol Liver Physiol. 2009;296(3): G643-50.
Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA, Lund PK. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora. Gut. 2009;58(8);1104-12.
Garrison AP, Helmrath MA, Dekaney CM. Intestinal Stem Cells. J Pediatr Gastroenterol Nutr. 2009;49(1):2-7.
Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Research. 2011;168(1):62-69.
Mechanisms of intestinal stem cell expansion following resection. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Disease. Jul 2009 - June 2014. #R01DK083325.Collaborative approach to the study of intestinal epithelial stem cells. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2009 - Aug 2014. #1U01DK085547.
Neointestine from live donors & pluripotent stem cells. Co-investigator. CCST University of Cincinnati. 07/01/11 – 06/30/11.
Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 11/01/11 – 10/31/16. U01 DK072493.
Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 04/01/12 – 03/31/17. R01 DK092456.
Belinda Hsi Dickie, MD, PhD Colorectal Center
is a pediatric surgeon who has a basic science lab in vascular biology. Her lab is focusing on the pathways of lymphangiogenesis and the genetics involved in the development of vascular malformations.
513-636 3240 firstname.lastname@example.org
Assistant Professor, UC Department of Pediatrics
Phone: 513-636 3240
Colorectal surgery; vascular malformations; minimally invasive surgery; general pediatric surgery
Belinda Hsi Dickie, MD, PhD, is an assistant professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center. She obtained her medical degree at the University of Toronto, Ontario Canada and subsequently did her general surgery residency, and completed her PhD, at the University of Alberta, Alberta, Canada. Dr. Dickie continued her training at the University of Alberta, with a fellowship in advanced minimally invasive surgery. She then relocated to the United States where she continued her training and completed fellowships in pediatric vascular malformations and pediatric colorectal surgery at Cincinnati Children’s Hospital Medical Center. She has recently completed her training in pediatric surgery at the University of Florida. She was recruited back to Cincinnati Children’s Hospital in 2011.
Dr. Hsi Dickie has a special interest in the medical and surgical treatment of vascular malformations, pediatric colorectal surgery (including Hirschsprung’s Disease, inflammatory bowel disease, anorectal malformations) and minimally invasive surgery. She also has a lab in vascular biology looking at the genetics and molecular pathways involved with lymphangiogenesis, and the development of vascular malformations
Thomas H. Inge, MD, PhD, FACS, FAAP Surgical Director, Surgical Weight Loss Program for Teens
Surgical Director, Surgical Weight Loss Program for Teens
Director, Center for Bariatric Research and Innovation
Attending Surgeon, Cincinnati Children’s Hospital Medical Center
Obesity surgery and research; neonatal surgery; gastroesophageal reflux disease; minimally invasive surgery; thoracic surgery
Thomas H. Inge, MD, PhD, is a Virginia native who grew up in a rural, farming community in Dinwiddie County. He received his BS in Biology at the College of William and Mary in Williamsburg, VA, in 1987. Dr. Inge entered the Medical College of Virginia in Richmond, VA, in the Medical Scientist Training Program, and pursued degrees in Microbiology / Immunology and Medicine. He graduated with MD and PhD degrees in 1993.
Dr. Inge received his surgical training at Stanford University Hospital in Palo Alto, CA, where he developed an interest in pediatric surgery. At the completion of his chief resident year in 1998, he moved to Birmingham, AL, for specialty training in pediatric surgery at the Children's Hospital of Alabama, with an emphasis on pediatric minimally invasive surgery. Dr. Inge became a full-time member of the surgical staff at Cincinnati Children's Hospital Medical Center and faculty member of the University of Cincinnati College of Medicine, Department of Surgery, Division of Pediatric Surgery, in July 2000.
In addition to general pediatric surgical practice, Dr. Inge's clinical research focus is related to bariatric surgery in adolescents. He is the surgical director of the Surgical Weight Loss Program for Teens, offering surgery for overweight adolescents with complications from their excess weight. He has served as a consultant to the Food and Drug Administration for projects related to device treatment of pediatric obesity. He is also the Principal Investigator of two research projects funded by National Institutes of Health (NIH) and co-investigator of another NIH funded project examining the role of surgery for management of adolescent obesity. He currently serves as Study Chairman of Teen-LABS, a multicenter research consortium examining outcomes of adolescent bariatric surgery.
Dr. Inge has given over 50 invited lectures nationally and internationally over the past four years, has mentored more than a dozen fellows and students, and has authored more than 70 published chapters and manuscripts.
BS: College of William and Mary, Williamsburg, VA, 1987.MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 1993.PhD: Virginia Commonwealth University, Richmond, VA, 1993.Residency: Stanford University Hospital, Stanford, CA, 1998.
Fellowship: Children's Hospital of Alabama, Birmingham, AL, 2000.
Board Certification: Diplomate of the American Board of Surgery, December 1999; Certification in Pediatric Surgery, American Board of Surgery, March 2002.
Zeller MH, Guilfoyle SM, Reiter-Purtill J, Ratcliff MB, Inge TH, Long JD. Adolescent bariatric surgery: caregiver and family functioning across the first postoperative year. Surg Obes Relat Dis. 2010 Jul 29.
Ratcliff MB, Reiter-Purtill J, Inge TH, Zeller MH. Changes in depressive symptoms among adolescent bariatric candidates from preoperative psychological evaluation to immediately before surgery. Surg Obes Relat Dis. 2011 Jan-Feb;7(1):50-4.
Inge TH, Xanthakos S. Sleeve gastrectomy for childhood morbid obesity: why not? Obes Surg. 2010 Jan;20(1):118-20.
Miyano G, Kalra M, Inge TH. Adolescent paraplegia, morbid obesity, and pickwickian syndrome: outcome of gastric bypass surgery. J Pediatr Surg. 2009 Mar;44(3):e41-4.
Zeller MH, Modi AC, Noll JG, Long JD, Inge TH. Psychosocial functioning improves following adolescent bariatric surgery. Obesity (Silver Spring). 2009 May;17(5):985-90.
Modi AC, Loux TJ, Bell SK, Harmon CM, Inge TH, Zeller MH. Weight-specific health-related quality of life in adolescents with extreme obesity. Obesity (Silver Spring). 2008 Oct;16(10):2266-71.
Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol. 2008 Apr 8;51(14):1342-8.
Inge TH. Childhood obesity--a problem of surgical proportions? Nat Clin Pract Gastroenterol Hepatol. 2008 Apr;5(4):180-1.
Helen N. Jones, PhD
is a placental physiologist who has research interests in placental function in pathological pregnancies and the development of non-viral mediated gene therapies in fetal growth restriction. Her lab studies the underlying mechanisms of placental insufficiency and potential therapies leading to increased placental function and fetal growth.
Regulation of placental growth and function; regulation of mechanisms of placental nutrient transfer and consequences for fetal growth
Wang K, Dong HQ, Zhao ZL, Li YY, Li C, Jones HN, Shi DL,Zhang XZ. Novel Vesicles Self-Assembled from Amphiphilic Star-Armed PEG-Polypeptide Hybrid Copolymers for Drug Delivery. Macromolecular Bioscience 11:65-71, 2011.
Jones HN, Powell TL, Jansson T. Differential regulation of placental amino acid transport mechanisms by Adiponectin. Diabetes 59(5):1161-70, 2010.
Jones HN, Powell TL, Jansson T. IL-6 stimulates System A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol. 297(5):C1228-35, 2009.
Jones HN,Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 23(1):271-8, 2009.
McArdle HJ, Andersen HS, Jones H, Gambling L. Copper and iron transport across the placenta: regulation and interactions. J Neuroendocrinol. 20(4):427-31., 2008.
Jones HN, Powell TL, Jansson T. Regulation of Placental Nutrient Transport – A Review, Placenta 28l; 763- 774, 2007.
Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M. Epigenetics and imprinting of the trophoblast -- a workshop report. Placenta. Suppl A:S122-6, 2006.
McArdle HJ, Andersen HS, Jones H, Gambling L. Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats – A Review. Placenta 27:56-60, 2006.
Jones HN, Ashworth CJ, Page KR, McArdle HJ. Cortisol stimulates System A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). Am. J. Physiol Endocrinology and Metabolism. 291(3):E596-603, 2006.
Jones HN, Ashworth CJ, Page KR, McArdle HJ. Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction. Reproduction. 131:951-60, 2006.
Sundeep G. Keswani, MD Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Fetal Surgeon, Fetal Care Center of Cincinnati
Director, Pediatric Advanced Wound Care and Skin Services
Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment
Dr. Sundeep G. Keswani is a pediatric and fetal surgeon. He is also the director of the Pediatric Advanced Wound Care and Skin Service (PAWS), which is a state-of-the-art wound care center devoted to the care of children. Dr. Keswani is the lead principal investigator in the Cincinnati Children’s Wound Healing Research Group, which is an NIH-funded laboratory that focuses on understanding the molecular mechanisms which underlie the fetus’ ability to regeneratively heal wounds with the goal of developing novel therapeutics to achieve regenerative wound healing in postnatal tissue.
Alice King MD, Swathi Balaji PhD, Louis D. Le MD, Emily Marsh, Timothy M. Crombleholme MD, Sundeep G. Keswani MD. Interleukin-10 Regulates Fetal Extracellular Matrix Hyaluronan Production. Journal of Pediatric Surgery. (In press).
Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs. Pediatrics. 2013 Jun;131(6):e1950-60.
Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 2013 Jun 11.
King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism. J Surg Res. 2013 Apr 24.
Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications. J Surg Res. 2013 Apr 3.
Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One. 2012;7(8):e43633.
Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound Repair Regen. 2012 Jul-Aug;20(4):592-600.
Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 2008 Jan-Feb;16(1):70-9.
Javazon EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.
Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004 Sep-Oct;12(5):497-504.
Marc A. Levitt, MD Director, Colorectal Center
Director, Colorectal Center
Pediatric colorectal surgery; pediatric minimally invasive surgery
Dr. Levitt is the director of the Colorectal Center for Children at Cincinnati Children's Hospital Medical Center. He joined the full-time staff at Cincinnati Children's Hospital Medical Center in June 2005 when he and Dr. Peña were recruited to create the world’s first and only multidisciplinary and comprehensive Colorectal Center for Children.
Dr. Levitt received his undergraduate degree from the University of Pennsylvania, and his medical degree from the Albert Einstein College of Medicine, where he was elected to the Alpha Omega Alpha Society and worked with Dr. Peña as a medical student in 1992. Dr. Levitt completed his general surgery residency at the Mount Sinai Medical Center in New York and also served as a clinical and research fellow in pediatric colorectal surgery with Dr. Peña at Schneider Children's Hospital. He completed his pediatric surgery fellowship at the Children's Hospital of Buffalo, and was a pediatric surgical attending there, serving as the clinical director of their Pediatric Miniature Access Surgery Center, from 1999 to 2002. He was faculty at the Albert Einstein College of Medicine and Pediatric Surgeon at Schneider Children’s Hospital, North Shore Long Island Jewish Health System from 2002 to 2005.
Bischoff A, Calvo-Garcia MA, Baregamian N, Levitt MA, Lim FY, Hall J, Peña A. Prenatal Counseling for Cloaca and Cloacal Exstrophy – Challenges faced by Pediatric Surgeons. Pediatr Surg Intl. 2012.
Livingston JC, Elicevik M, Breech L, Crombleholme TM, Peña A, Levitt MA. Persistent Cloaca: A 10-Year Review of Prenatal Diagnosis. Journal of Ultrasound in Medicine. 2012.
Hamrick M, Eradi B, Bischoff A, Louden E, Peña A, Levitt MA. Rectal Atresia and Stenosis; Unique Anorectal Malformations. J Pediatr Surg. 2012;47(6): 1280-4.
Chatoorgoon K, Peña A, Lawal TA, Louden E, Levitt MA. The Problematic Duhamel Pouch in Hirschsprung’s Disease: Manifestations and Treatment. European Journal of Pediatric Surgery. 2011;21: 366-9.
Bischoff A, Levitt MA, Peña A. Total Colonic Aganglionosis – A Surgical Challenge: How to Avoid Complications. Pediatr Surg Int. 2011 Oct;27(10): 1047-52.
Podberesky DJ, Weaver NC, Anton CG, Lawal T, Hamrick MC, Alam S, Peña A, Levitt MA. MRI of Acquired Posterior Urethral Diverticulum Following Surgery for Anorectal Malformations. Pediatr Radiol. 2011 Sept;41(9): 1139-1145.
Rangel SJ, Lawal TA, Bischoff A, Chatoorgoon K, Louden E, Peña A, Levitt MA. The Appendix as a Conduit for Antegrade Continence Enemas in Patients with Anorectal Malformations: Lessons Learned from 163 Cases treated over 18 years. J Pediatr Surg. 2011 Jun;46(6): 1236-42.
Alam S, Lawal TA, Peña A, Sheldon C, Levitt MA. Acquired Posterior Urethral Diverticulum Following Surgery for Anorectal Malformations. 2010 Jun;J Pediatr Surg. 46(6): 1231-5.
Chatoorgoon K, Peña A, Lawal TA, Hamrick M, Louden E, Levitt MA. Neoappendicostomy in the Management of Pediatric Fecal Incontinence. J Pediatr Surg. 2011 Jun;46(6): 1243-49.
Bischoff A, Levitt MA, Peña A. Laparoscopy and its use in the Repair of Anorectal Malformations. J Pediatr Surg. 2011;46(8): 1609-17.
Foong-Yen Lim, MD Surgical Director, Fetal Care Center of Cincinnati
Surgical Director, Fetal Care Center of Cincinnati
Jaimie D. Nathan, MD Surgical Director, Intestinal Transplant Program
is a pediatric general, thoracic and transplant surgeon, who has a basic science research program in the role of the gut microbiome in the modulation of liver injury and cholangiopathies. His lab studies the gut-liver axis as it relates to the pathogenesis of a number of liver diseases which can progress to end-stage liver disease requiring transplantation.
Surgical Director, Intestinal Transplant Program
Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery
BS: Yale University, New Haven, CT, 1993.
MD: Yale University, New Haven, CT, 1998.
Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.
Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.
Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.
Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.
Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.
Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.
Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011 Sep;46(9):1732-1738.
Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.
Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.
Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.
Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.
Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.
Alberto Peña, MD Founding Director, Colorectal Center
Founding Director, Colorectal Center
Clinical research regarding colorectal problems in children
Alberto Peña, MD, director of the Colorectal Center, at Cincinnati Children's, received his medical degree at the Military Medical School in Mexico City, in 1962.
Dr. Peña trained in general surgery and medical pediatrics at the Central Military Hospital, finishing in 1968. From 1969 until December 1971, he trained at Boston Children's Hospital.
Dr. Peña moved back to Mexico City as the surgeon-in-chief of the National Institute of Pediatrics from January 1972 until June 1985.
Dr. Peña joined the full-time staff at Schneider Children's Hospital in July 1985 and was the chief of Pediatric Surgery and professor of Surgery at the Albert Einstein College of Surgeons.
In 1982, Dr. Peña described a new approach for the management of anorectal malformations: Posterior Sagittal Anoplasty / PSARP, also known as the Pull-Through Procedure.
Since 1982 until the present, Dr. Peña has been traveling all over the world, lecturing and operating on children affected by this particular malformation.
At the present time, Dr. Peña dedicates 80 percent of his time to the treatment of anorectal problems in children.
Seventy percent of the patients operated on by Dr. Peña at Cincinnati Children's come from other states and from all over the world.
Lawal TA, Rangel SJ, Bischoff A, Peña A, Levitt MA. Laparoscopic-Assisted Malone Appendicostomy in the Management of Fecal Incontinence in Children. J Laparoendosc Adv Surg Tech A. 2011 Mar 2.
Lawal TA, Chatoorgoon K, Collins MH, Coe A, Peña A, Levitt MA. Redo pull-through in Hirschsprung's disease for obstructive symptoms due to residual aganglionosis and transition zone bowel. J Pediatr Surg. 2011 Feb;46(2):342-7.
Bischoff A, Levitt MA, Lim FY, Guimarães C, Peña A. Prenatal diagnosis of cloacal malformations. Pediatr Surg Int. 2010 Nov;26(11):1071-5.
Bischoff A, Levitt MA, Lawal TA, Peña A. Colostomy closure: how to avoid complications. Pediatr Surg Int. 2010 Nov;26(11):1087-92.
Bischoff A, Levitt MA, Breech L, Louden E, Peña A. Hydrocolpos in cloacal malformations. J Pediatr Surg. 2010 Jun;45(6):1241-5.
Peña A, Bischoff A, Breech L, Louden E, Levitt MA. Posterior cloaca--further experience and guidelines for the treatment of an unusual anorectal malformation. J Pediatr Surg. 2010 Jun;45(6):1234-40.
Levitt MA, Kant A, Peña A. The morbidity of constipation in patients with anorectal malformations. J Pediatr Surg. 2010 Jun;45(6):1228-33.
Levitt MA, Peña A. Minimally invasive treatment of fecal incontinence and constipation in children. Minerva Chir. 2010 Apr;65(2):223-34. Review.
Levitt MA, Dickie B, Peña A. Evaluation and treatment of the patient with Hirschsprung disease who is not doing well after a pull-through procedure. Semin Pediatr Surg. 2010 May;19(2):146-53.
Levitt MA, Peña A. Cloacal malformations: lessons learned from 490 cases. Semin Pediatr Surg. 2010 May;19(2):128-38.
Frederick C. Ryckman, MD Professor of Surgery / Transplantation
Professor of Surgery / Transplantation
Sr. Vice President, Medical Operations
Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities
Frederick C. Ryckman, MD, is clinical director of the Pediatric General and Thoracic Surgery Division.
Dr. Ryckman is also vice president of System Capacity & Perioperative Operations.
Dr. Ryckman is also a pediatric surgeon at the Fetal Care Center of Cincinnati.
Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.
Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.
Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.
Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.
Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.
Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Aimen F. Shaaban, MD Director, Center for Fetal Cellular and Molecular Therapy
is a pediatric surgeon who leads a research program studying in utero transplantation. His laboratory seeks to better understand the manner in which immunologic tolerance develops in the fetus following transplantation in order to design less toxic and more effective therapies for the treatment of numerous diseases such as sickle cell disease, thalassemia, immunodeficiency, spinal muscular atrophy and inherited metabolic disorders.
Director, Center for Fetal Cellular and Molecular Therapy
Surgical treatment of fetal and newborn diseases including: open and minimally invasive fetal surgery; congenital lung and airway disease; congenital esophageal disease; sacrococcygeal teratoma; conjoined twins; neonatal surgery.
Examination of the mechanisms of long-term immunologic tolerance to prenatally transplanted stem cells; developmental hematology, pluripotent stem cell biology; fetal gene therapy
Dr. Shaaban served as an associate professor of surgery with tenure and as director of the Laboratory for Fetal Cellular Therapy at the University of Iowa Carver College of Medicine from 2008-2012. Prior to that he served as director of the Laboratory for Fetal Cellular Therapy at University of Wisconsin College of Medicine from 2002-2008.
MD: University of Illinois College of Medicine, Chicago, IL, 1991.
General Surgery Residency: University of Iowa Hospital and Clinics, Iowa City, Iowa, Jul 1991-Jun1996.
Pediatric Surgical Residency: The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, Jul 2000-Jun 2001.
Post-doctoral Fellowship in Fetal Surgery Research: Children's Institute for Surgical Science, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, Jul 1996-Jun 1999.
Certification: Diplomate of the National Board of Medical Examiners, 1991; diplomate of the American Board of Surgery, 1997, 2011; diplomate of the American Board of Pediatric Surgery, 2006.
Al-Hajjat A, Durkin ET, Shaaban AF: Regulation of the earliest immune response to in utero hematopoietic cellular transplantation. Chimerism 2011; 1(2): 1-3.
Delgado D, Webster DE, DeSantes KB, Durkin ET, Shaaban AF: KIR receptor-ligand incompatibility predicts killing of osteosarcoma cells by allogeneic NK cells. Pediatric Blood and Cancer, 2010, 55(7):1300-5.
Durkin ET, Shaaban AF: Commonly encountered surgical problems in the fetus and neonate. Pediatric Clinics of North America, 2009, Jun;56(3):647-69.
Durkin ET, Jones KA, Elnaggar D, Rajesh D, Shaaban AF: Early chimerism threshold predicts sustained engraftment in prenatal allogeneic chimeras. Blood, 2008, Dec 15;112(13):5245-53.
Durkin ET, Shaaban AF. Recent advances and controversies in pediatric laparoscopic surgery. Surgical Clinics of North America 2008 Oct;88(5):1101-19, viii.
Durkin ET, Lund, DP, Shaaban AF, Schurr, MJ, Weber SW: Age-Related Differences in the Diagnosis and Morbidity of Intestinal Malrotation. Journal of the American College of Surgeons 2008 Apr;206(4):658-63.
Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin II, Thomson JA, Shaaban AF: Differential Requirements for Hematopoietic Commitment between Human and Rhesus Embryonic Stem Cells. Stem Cells 2007; 25: 490-499.
Shaaban AF, Kim HB, Liechty KW, Flake AW: Prenatal transplantation of cytokine-stimulated marrow improves early chimerism and prolongs allograft survival in chimerism resistant strain combination but results in poor long-term engraftment. Exp Hematol. 2006 Sep;34(9):1278-87.
Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW: Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Medicine 2000; 6(11): 1282-6.
Shaaban AF, Kim HB, Milner R, Fichter C, Flake AW: A kinetic analysis of the homing of prenatally transplanted murine allogeneic and congenic marrow. Blood 1999;94(9): 3251-7.
Greg M. Tiao, MD Richard and Geralyn Azizkhan Chair in Pediatric Surgery
is a pediatric surgeon and a pediatric transplant surgeon who has his basic research in the care of children afflicted with biliary atresia.
Richard and Geralyn Azizkhan Chair in Pediatric Surgery
Surgical Director, Liver Transplantation
Associate Director, Pediatric Surgery Fellowship
Associate Professor, UC Department of Pediatrics
As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.
Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr Jorge Bezerra, his primary research mentor.
BS: Northwestern University, Evanston, IL, 1986.
MD: University of Illinois, Chicago, IL, 1990.
Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.
Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.
Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.
Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. Journal of Surgical Research. Epub ahead of print. 2012.
Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Frontiers in Bioscience. 2012 Jan;E4:1293-1302.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011;46:1732-1738.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.
Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.
Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.
Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Jun.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Pediatr Blood Cancer. 2010;DOI 10.1002/pbc.22768.
Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.
Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.
The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011 - Mar 2016.
Nycomed Liver Trial. Principal Investigator. 2012 - present. TC-2402-040-SP.
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