Maria H. Alonso, MD
Surgical Director, Kidney Transplant Program
Co-Surgical Director, Intestinal Transplant Surgery
Academic Information
Associate Professor, Division of Pediatric Surgery
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Specialties
Liver, kidney transplantation; hepatobiliary surgery; minimally invasive surgery; trauma
Biography
Education and Training
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 1982. Residency: Surgery, Eastern Virginia Graduate School of Medicine, Norfolk, VA. Fellowship: Trauma / Critical Care, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD; Trauma / Burn, Children's National Medical Center, Washington, D.C.; Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH. Certification: Surgery, 1999; Pediatric Surgery, 2001; Surgical Critical Care, 2001.
Grants
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Sean J. Barnett, MD, MS
Pediatric Surgeon
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Clinical InterestsMinimally invasive surgery; neonatal surgery; bariatric surgery; surgical oncology; medical innovation and instrument design Research InterestsMedical and surgical innovation; instrument design
Biography
Sean J. Barnett, MD, MS, is an Assistant Professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children’s Hospital Medical Center. He obtained his Bachelor of Science degree in Mechanical Engineering from Purdue University and his Master’s of Science in Human Anatomy from Wright State University. He completed his medical degree at The Boonshoft School of Medicine. His surgical internship and general surgery residency were completed at the University of Minnesota Hospitals and Clinics in Minneapolis, Minnesota. Additionally, he completed a two year fellowship in surgical infectious diseases while at the University of Minnesota. Most recently, he was a pediatric surgery fellow at Cincinnati Children’s Hospital Medical Center. Dr. Barnett has a special interest in minimally invasive surgery, neonatal surgery, bariatric surgery, and medical innovation.
Education and Training
BSME: Mechanical Engineering, Purdue University, West Lafayette, IN, 1993
MS: Human Anatomy, Wright State University, Dayton, OH, 1996
MD: Boonshoft School of Medicine, Dayton, OH, 2000
Residency: General Surgery, University of Minnesota School of Medicine, Minneapolis, MN
Fellowship: Pediatric Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Certification: General Surgery, 2008
Publications
View PubMed Publications
Dauplaise DJ, Barnett SJ, Frischer JS, Wong HR. Decompressive abdominal laparotomy for abdominal compartment syndrome in an unengrafted bone marrow recipient with septic shock. Crit Care Res Pract. 2010; pii: 102910.
Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8. Leslie DB, Kellogg TA, Boutelle KN, Barnett SJ, Schwarzenberg SJ, Harrison AR, Ikramuddin S. Preserved Vision Without Growth Retardation After Laparoscopic Roux-en-Y Gastric Bypass in a Morbidly Obese Child with Pseudotumor Cerebri: 36-month Follow-up . Journal of Pediatric Surgery. 2008;43(7):e27-30. Whitson BA, Huddleston SJ, Barnett SJ, Mohr WJ. Vacuum Induced Arm Compartment Syndrome and Pulmonary Embolism. Journal of Burn Care & Research. 2006;27(4): 552-4. Rivard AL, Simura KJ, Mohammad S, Magembe AJ, Pearson HM, Hallman MR, Barnett SJ, Gatlin D, Gallegos RP, Bianco RW. Rodent Intubation and Ventilation for Surgical Research. Journal of Investigative Surgery. 2006;19(4):267-274. Barnett SJ, Stanley C, Hanlon M, Acton RD, Saltzman DA, Ikramudin S, Buchwald H. Long Term Follow-Up and the Role of Surgery in Adolescents with Morbid Obesity. Surgery for Obesity and Related Disorders (SOARD). 2005;1(4): 394-398. Barnett SJ, Soto III LJ, Sorenson BS, Nelson BW, Leonard AS, Saltzman DA. Salmonella typhimurium Invades and Decreases Tumor Burden in Neuroblastoma. Journal of Pediatric Surgery. 2005;40(6): 993-998.
Grants
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Rebeccah L. Brown, MD
Associate Director, Trauma Services
Academic Information
Associate Professor, Division of Pediatric Surgery
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Specialties
Clinical InterestsGeneral pediatric surgery; trauma; injury prevention; Hirschsprung's disease; minimally invasive surgery; necrotizing enterocolitis Research InterestsPediatric trauma
Biography
Rebeccah L. Brown, MD, received a Bachelor of Science in Biology and Bachelor of Arts in Chemistry at New Mexico State University in Las Cruces, NM, in 1986. She graduated from University of New Mexico School of Medicine in Albuquerque, NM, with an MD in 1990. She completed her general surgery residency at University Hospital, in Cincinnati, Ohio, in 1997. During her general surgical training, she also performed two years of basic science and clinical research in burn injuries and wound healing at the Shriners Hospitals for Children -- Cincinnati. She also served as an extracorporeal membrane oxygenation (ECMO) fellow at Cincinnati Children's Hospital Medical Center. After completion of general surgery training, Dr. Brown completed a two-year fellowship in Pediatric Surgery at Children's Hospital of Buffalo in Buffalo, N.Y. She returned to Cincinnati Children's, Ohio, as assistant professor of Surgery and Pediatrics. Her main research interest is trauma and injury prevention, and she is currently the assistant director of Trauma Services. Dr. Brown's clinical interests besides trauma and injury prevention include general pediatric surgery, minimally invasive surgery, inflammatory bowel disease, and Hirschsprung's disease. Dr. Brown is a member of multiple professional organizations including the American College of Surgeons, American Medical Association, American Medical Women's Association, American College of Surgeons -- Ohio Chapter, Cincinnati Pediatric Society, and Mont Reid Surgical Society.
Education and Training
MD: University of New Mexico School of Medicine, Albuquerque, N.M., 1990. Residency: General Surgery, University of Cincinnati Hospital, Cincinnati, Ohio, 1997. Fellowship: Shriners Burns Institute, Cincinnati, Ohio, 1992-1994; ECMO, Children's Hospital Medical Center, Cincinnati, Ohio, 1993-1994; Pediatric Surgery Fellow, Children's Hospital of Buffalo, Buffalo, N.Y., 1997-1999. Certification: Board-certified General Surgery, 1998; board-certified, Pediatric Surgery.
Grants
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A. Roshni Dasgupta, MD
Pediatric Surgeon
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Clinical InterestsSurgical oncology and vascular malformations; minimally invasive surgery; general pediatric surgery Research Interestsoncology and vascular malformations
Biography
Education and Training
MD: University of Toronto, Toronto Canada, 1996 Residency: Massachusetts General Hospital, Harvard Medical School 1996-2003 Research Fellowship: University of Oxford, Oxford England Fellowship: Hospital for Sick Children, Toronto, Canada
Publications
View PubMed Publications
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33. Dasgupta R, Adams D, Elluru R, Wentzel MS, Azizkhan RG. Noninterventional treatment of selected head and neck lymphatic malformations. J Pediatr Surg. 2008 May;43(5):869-73. Dasgupta R, Langer JC. Evaluation and management of persistent problems after surgery for Hirschsprung disease in a child. J Pediatr Gastroenterol Nutr. 2008 Jan;46(1):13-9. Review. Dasgupta R, Roberts E, Superina RA, Kim PC. Effectiveness of Rex shunt in the treatment of portal hypertension. J Pediatr Surg. 2006 Jan;41(1):108-12; discussion 108-12.
Gasparini FF, Navarro OM, Dasgupta R, Gerstle JT, Thorner PS, Manson DE. Ileocolic intussusception mimicking the imaging appearance of midgut volvulus as a result of extrinsic duodenal obstruction. Pediatr Radiol. 2005 Dec;35(12):1246-9.
Dasgupta R, Kim PC.Relationship between surgical volume and clinical outcome: should pediatric surgeons be doing pancreaticoduodenectomies? J Pediatr Surg. 2005 May;40(5):793-6.
Dasgupta R, Langer JC. Trans-anal pullthrough for Hirschsprung Disease. Semin Pediatr Surg. 2005 Feb;14(1):64-71.
Dasgupta R, Langer JC. Hirschsprung Disease. Curr Probl Surg. 2004 Dec;41(12):942-88.
Dasgupta R, Schnitzer JJ, Hendren WH, Donahoe PK. Congenital adrenal hyperplasia: surgical considerations required to repair a 46 XX patient raised as a boy. J Pediatr Surg. 2003 Aug;38(8):1269-73. Book ChaptersDasgupta R and Ryan D. Pediatric Trauma.In The Trauma Handbook of the Massachusetts General Hospital. Lippincott, Williams & Wilkins, 2004. Dasgupta R and Langer JC. Complications of Colon Surgery. In Complications of Pediatric Surgery. Informa Healthcare, 2007.
Grants
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Belinda Hsi Dickie, MD, PhD
Colorectal Center
is a pediatric surgeon who has a basic science lab in vascular biology. Her lab is focusing on the pathways of lypmphangiogesis and the genetics involved in the development of vascular malformations.
513-636 3240
belinda.dickie@cchmc.org
Belinda Hsi Dickie, MD, PhD
Colorectal Center
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Colorectal surgery; vascular malformations; minimally invasive surgery; general pediatric surgery
Biography
Belinda Hsi Dickie, MD, PhD, is an assistant professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center. She obtained her medical degree at the University of Toronto, Ontario Canada and subsequently did her general surgery residency, and completed her PhD, at the University of Alberta, Alberta, Canada. Dr. Dickie continued her training at the University of Alberta, with a fellowship in advanced minimally invasive surgery. She then relocated to the United States where she continued her training and completed fellowships in pediatric vascular malformations and pediatric colorectal surgery at Cincinnati Children’s Hospital Medical Center. She has recently completed her training in pediatric surgery at the University of Florida. She was recruited back to Cincinnati Children’s Hospital in 2011. Dr. Dickie has a special interest in the medical and surgical treatment of vascular malformations, pediatric colorectal surgery (including Hirschsprung’s Disease, inflammatory bowel disease, anorectal malformations) and minimally invasive surgery. She also has a lab in vascular biology looking at the genetics and molecular pathways involved with lymphangiogensis, and the development of vascular malformations
Education and Training
MD: University of Toronto, Toronto,Ontario, Canada 1998.
Residency: General Surgery, University of Alberta, Edmonton, Alberta, Canada.
Fellowship: Advanced Minimally Invasive Surgery, University of Alberta, Edmonton, Alberta, Canada; Vascular anomalies, Cincinnati Children's, Cincinnati, OH; Pediatric Colorectal Surgery, Cincinnati Children's, Cincinnati, OH; Pediatric Surgery, University of Florida Gainesville, Florida,
Certification: General Surgery, 2006; Pediatric Surgery, 2011.
Publications
View PubMed Publications
Levitt MA, Dickie B, Peña A. Evaluation and treatment of the patient with Hirschsprung disease who is not doing well after a pull-through procedure. Semin Pediatr Surg. 2010 May;19(2):146-53.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
Kneteman NM, Weiner AJ, O'Connell J, Collett M, Gao T, Aukerman L, Kovelsky R, Ni ZJ, Zhu Q, Hashash A, Kline J, Hsi B, Schiller D, Douglas D, Tyrrell DL, Mercer DF. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology. 2006 Jun;43(6):1346-53.
Hao C, Song JH, Hsi B, Lewis J, Song DK, Petruk KC, Tyrrell DL, Kneteman NM. TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res. 2004 Dec 1;64(23):8502-6.
Hsu EC, Hsi B, Hirota-Tsuchihara M, Ruland J, Iorio C, Sarangi F, Diao J, Migliaccio G, Tyrrell DL, Kneteman N, Richardson CD. Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. Nat Biotechnol. 2003 May;21(5):519-25.
Grants
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Richard A. Falcone Jr., MD, MPH
Director, Trauma Services
Academic Information
Associate Professor, Division of Pediatric Surgery
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Specialties
Clinical InterestsPediatric injury prevention and outcomes; trauma education; management of colorectal disorders; inflammatory bowel disease; minimally invasive surgery; surgical oncology; extracorporeal life support (ECLS) Research InterestsInjury prevention; health disparities; pediatric colorectal disorders; use of simulation to improve teamwork and safety
Biography
Education and Training
MPH: Harvard School of Public Health, Boston, MA, 2007.
MD: New York University School of Medicine, 1995.
General Surgery Residency: University of Cincinnati, 1995-2002.
Pediatric Surgery Fellowship: Cincinnati Children's Hospital Medical Center, 2002-2004.
Certification: Surgery 2004; Pediatric Surgery 2006.
Publications
View PubMed Publications
Makley AT, Falcone RA Jr. Posttraumatic stress disorder in the pediatric trauma patient.Semin Pediatr Surg. 2010 Nov;19(4):292-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Rangel EL, Burd RS, Falcone RA Jr; Multicenter Child Abuse Disparity Group. Socioeconomic disparities in infant mortality after nonaccidental trauma: a multicenter study.J Trauma. 2010 Jul;69(1):20-5.
Chatoorgoon K, Huezo K, Rangel E, François N, Schweer L, Daugherty M, Koehn M, Ricketts C, Brown RL, Garcia VF, Falcone RA Jr. Unnecessary imaging, not hospital distance, or transportation mode impacts delays in the transfer of injured children.Pediatr Emerg Care. 2010 Jul;26(7):481-6.
Martin CA, Care M, Rangel EL, Brown RL, Garcia VF, Falcone RA Jr. Severity of head computed tomography scan findings fail to explain racial differences in mortality following child abuse.Am J Surg. 2010 Feb;199(2):210-5.
Levitt MA, Martin CA, Falcone RA Jr, Peña A. Transanal rectosigmoid resection for severe intractable idiopathic constipation. J Pediatr Surg. 2009 Jun;44(6):1285-90; discussion 1290-1.
Rangel EL, Cook BS, Bennett BL, Shebesta K, Ying J, Falcone RA. Eliminating disparity in evaluation for abuse in infants with head injury: use of a screening guideline. J Pediatr Surg. 2009 Jun;44(6):1229-34; discussion 1234-5.
Falcone RA Jr, Martin C, Brown RL, Garcia VF. Despite overall low pediatric head injury mortality, disparities exist between races.J Pediatr Surg. 2008 Oct;43(10):1858-64.
Falcone RA Jr, Daugherty M, Schweer L, Patterson M, Brown RL, Garcia VF. Multidisciplinary pediatric trauma team training using high-fidelity trauma simulation.J Pediatr Surg. 2008 Jun;43(6):1065-71.
Martin C, Falcone RA Jr. Pediatric traumatic brain injury: an update of research to understand and improve outcomes. Curr Opin Pediatr. 2008 Jun;20(3):294-9. Review.
Grants
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Jason S. Frischer, MD
Director, Extracorporeal Membrane Oxygenation Program
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Clinical InterestsColorectal surgery including inflammatory bowel disease (Crohn's disease and ulcerative colitis); surgical oncology (Wilms tumor and neuroblastoma); minimally invasive surgery; ECMO; congenital diaphragmatic hernia (CDH); neonatal surgery Research InterestsAngiogenesis in pediatric solid tumors (Neuroblastoma, Wilm’s tumor, and Ewing’s Sarcoma) and in inflammatory bowel disease (Crohn’s disease and ulcerative colitis)
Biography
Jason S. Frischer, MD, is an Assistant Professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center. He earned his medical degree at SUNY Downstate Medical Center. His surgical internship and general surgery residency were completed at the Mount Sinai School of Medicine in New York. Additionally, he spent two years as an ECMO fellow and a postdoctoral research fellow in tumor biology at the Children’s Hospital of New York, Columbia University. He went on to complete his pediatric surgery training at the Children’s Hospital of New York, Columbia University. Dr. Frischer has a special interest in colorectal surgery including inflammatory bowel disease (Crohn's disease and ulcerative colitis), surgical oncology (Wilms tumor and neuroblastoma), minimally invasive surgery, ECMO, congenital diaphragmatic hernia (CDH) and neonatal surgery.
Education and Training
BS: Cornell University, Ithaca, NY, 1995.
MD: Suny Downstate Medical Center, Brooklyn, NY, 1999.
Surgical Internship: Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, NY, 1999-2000.
Residency: Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, NY, 2000-2001.
Fellowship: Children's Hospital of New York - Presbyterian, New York, NY, 2001-2003.
Residency: Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, NY, 2003-2005.
Chief Resident: Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, NY, 2005-2006.
Residency: Children's Hospital of New York – Presbyterian, New York, NY, 2006-2007.
Chief Resident: Children's Hospital of New York – Presbyterian, New York, NY, 2007-2008.
Certification: American Board of Surgery - General Surgery, 2007. American Board of Surgery - Pediatric Surgery, 2010
Publications
Keswani SG, Le LD, Morris LM, Lim FY, Katz AB, Ghobril N, Habli M, Frischer JS, Crombleholme TM. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.J Pediatr Surg. 2011 Jan;46(1):33-8. Dauplaise DJ, Barnett SJ, Frischer JS, Wong HR. Decompressive abdominal laparotomy for abdominal compartment syndrome in an unengrafted bone marrow recipient with septic shock.Crit Care Res Pract. 2010;2010. pii: 102910 Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5. Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient.Pediatr Surg Int. 2010 Nov;26(11):1125-8. Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia.J Pediatr Surg. 2010 Apr;45(4):703-8.
Ruiz-Elizalde R, Frischer JS, Crowles RA. Button-Loop Feeding Jejunostomy.J Gastrointest Surg. 2008.
Kadenhe-Chiweshe A, Papa J, McCrudden KW, Frischer J, Bae JO, Huang J, Fisher J, Lefkowitch JH, Feirt N, Rudge J, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res. 2008 Jan:6(1):1-9.
Grants
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Victor F. Garcia, MD
Founding Director, Trauma Services
Academic Information
Professor, Division of Pediatric Surgery
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Specialties
Pediatric injury research and control; chest-wall deformities; minimally invasive surgery (use of the laparoscope and thoracoscope to diagnose and treat surgical diseases); surgical weight loss; minority health care
Biography
Pediatric Surgeon Victor Garcia, MD, is the founding director of Trauma Services at Cincinnati Children's Hospital Medical Center and a professor for the Division of Pediatric Surgery. He is the co-chair for the CoreChange Initiative.
Education and Training
MD: University of Pennsylvania, School of Medicine, Philadelphia, PA, 1974.
Residency: Walter Reed Army Medical Center, Washington, DC, 1978.
Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA.
Certification: Surgery, 1979; Pediatric Surgery, 1982; Surgical Critical Care, 1991.
Publications
View PubMed Publications
Garcia V. Comment on: Laparoscopic Roux-en-Y gastric bypass versus laparoscopic adjustable gastric banding: five years of follow-up. Surg Obes Relat Dis. 2010 Sep-Oct;6(5):475-6. Chatoorgoon K, Huezo K, Rangel E, François N, Schweer L, Daugherty M, Koehn M, Ricketts C, Brown RL, Garcia VF, Falcone RA Jr. Unnecessary imaging, not hospital distance, or transportation mode impacts delays in the transfer of injured children. Pediatr Emerg Care. 2010 Jul;26(7):481-6. Martin CA, Care M, Rangel EL, Brown RL, Garcia VF, Falcone RA Jr. Severity of head computed tomography scan findings fail to explain racial differences in mortality following child abuse. Am J Surg. 2010 Feb;199(2):210-5. Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass. J Pediatr. 2010 Jan;156(1):103-108.e1. Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22. Falcone RA Jr, Martin C, Brown RL, Garcia VF. Despite overall low pediatric head injury mortality, disparities exist between races. J Pediatr Surg. 2008 Oct;43(10):1858-64. Falcone RA Jr, Daugherty M, Schweer L, Patterson M, Brown RL, Garcia VF. Multidisciplinary pediatric trauma team training using high-fidelity trauma simulation. J Pediatr Surg. 2008 Jun;43(6):1065-71. Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol. 2008 Apr 8; \51(14):1342-8. Rangel SJ, Martin CA, Brown RL, Garcia VF, Falcone RA Jr. Alarming trends in the improper use of motor vehicle restraints in children: implications for public policy and the development of race-based strategies for improving compliance. J Pediatr Surg. 2008 Jan;43(1):200-7. Falcone RA Jr, Brown RL, Garcia VF. Disparities in child abuse mortality are not explained by injury severity. J Pediatr Surg. 2007 Jun;42(6):1031-6; discussion 1036-7.
Grants
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Mounira A. Habli, MD
Maternal Fetal Medicine Specialist, Fetal Care Center of Cincinnati
Assistant Director of Clinical Research, Good Samaritan Hospital
Obstetrics and Gynecology, Good Samaritan Hospital
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Modification of the Wigglesworth model of Intrauterine growth restriction in mice as the animal model; invitro assessment of Insulin like growth factors and adenoviral associated gene expression of insulin like growth factor-I in a rat tophoblast cell line (RCHO-1)
Biography
Education and Training
BS: Biology, American University of Beirut, Beirut Lebanon.
MS: Masters Clinical Epidemiology and Biostatistics, Translational Research, University of Cincinnati, Cincinnati, Ohio, 2010.
MD: American University of Beirut, Beirut, Lebanon, 1998.
MFM: University of Cincinnati Maternal Fetal Medicine, 2009.
Publications
View PubMed Publications
Pizarro D, Habli M, Grier M, Bombrys A, Sibai B, Livingston J. Higher maternal doses of methadone does not increase neonatal abstinence syndrome.J Subst Abuse Treat. 2011 Jan 19. Keswani SG, Le LD, Morris LM, Lim FY, Katz AB, Ghobril N, Habli M, Frischer JS, Crombleholme TM. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.J Pediatr Surg. 2011 Jan;46(1):33-8. Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation.Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9. Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM.The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome.Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7. Habli M, Bombrys A, Lewis D, Lim FY, Polzin W, Maxwell R, Crombleholme T. Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience.Am J Obstet Gynecol. 2009 Oct;201(4):417.e1-7. Habli M, Eftekhari N, Wiebracht E, Bombrys A, Khabbaz M, How H, Sibai B. Long-term maternal and subsequent pregnancy outcomes 5 years after hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome.Am J Obstet Gynecol. 2009 Oct;201(4):385.e1-5. Katz AB, Keswani SG, Habli M, Lim FY, Zoltick PW, Midrio P, Kozin ED, Herlyn M, Crombleholme TM. Placental gene transfer: transgene screening in mice for trophic effects on the placenta.Am J Obstet Gynecol. 2009 Nov;201(5):499.e1-8 Habli M, Lim FY, Crombleholme T. Twin-to-twin transfusion syndrome: a comprehensive update.Clin Perinatol. 2009 Jun;36(2):391-416, x. Review. Bombrys AE, Barton JR, Habli M, Sibai BM. Expectant management of severe preeclampsia at 27(0/7) to 33(6/7) weeks' gestation: maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management.Am J Perinatol. 2009 Jun;26(6):441-6. Lubow JM, How HY, Habli M, Maxwell R, Sibai BM. Indications for delivery and short-term neonatal outcomes in late preterm as compared with term births.Am J Obstet Gynecol. 2009 May;200(5):e30-3.
Grants
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Michael A. Helmrath, MD, MS
Surgical Director, Intestinal Rehabilitation Center
Academic Information
Professor, Division of Pediatric Surgery
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Biography
Education and Training
BA: Miami University, 1987. MD: University of Cincinnati College of Medicine, 1993.
MS: University of Cincinnati College of Medicine, 1989.
Publications
View PubMed Publications
Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22. Inge T, Helmrath M, Vierra M, Ikramuddin S. Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen. J Laparoendosc Adv Surg Tech A. 2008 Feb;18(1):157-69. Inge TH, Krebs NF, Garcia VF, Skelton JA, Guice KS, Strauss RS, Albanese CT, Brandt ML, Hammer LD, Harmon CM, Kane TD, Klish WJ, Oldham KT, Rudolph CD, Helmrath MA, Donovan E, Daniels SR. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics. 2004 Jul;114(1):217-23. Review. Fridriksson JH, Helmrath MA, Wessel JJ, Warner BW. Hypercalcemia associated with extracorporeal life support in neonates. J Pediatr Surg. 2001 Mar;36(3):493-7. Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr, Stern LE, Warner BW. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol. 1999 Sep;277(3 Pt 1):G533-40. Helmrath MA, Erwin CR, Shin CE, Warner BW. Enterocyte apoptosis is increased following small bowel resection. J Gastrointest Surg. 1998 Jan-Feb;2(1):44-9. Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW. Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. Surgery. 1998 Nov;124(5):848-54. Shin CE, Helmrath MA, Falcone RA Jr, Fox JW, Duane KR, Erwin CR, Warner BW. Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration. J Surg Res. 1998 Jun;77(1):11-6. Helmrath MA, Shin CE, Erwin CR, Warner BW. The EGF\EGF-receptor axis modulates enterocyte apoptosis during intestinal adaptation. J Surg Res. 1998 Jun;77(1):17-22. Helmrath MA, Shin CE, Erwin CR, Warner BW. Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression. J Pediatr Surg. 1998 Jul;33(7):980-4; discussion 984-5.
Grants
Mechanisms of intestinal stem cell expansion following resection. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Disease. Jul 2009 - June 2014. #R01DK083325.
Collaborative approach to the study of intestinal epithelial stem cells. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2009 - Aug 2014. #1U01DK085547.
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Thomas H. Inge, MD, PhD, FACS, FAAP
Surgical Director, Surgical Weight Loss Program for Teens
Director, Center for Bariatric Research and Innovation
Attending Surgeon, Cincinnati Children’s Hospital Medical Center
Academic Information
Professor, Division of Pediatric Surgery
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Specialties
Obesity surgery and research; neonatal surgery; gastroesophageal reflux disease; minimally invasive surgery; thoracic surgery
Biography
Thomas H. Inge, MD, PhD, is a Virginia native who grew up in a rural, farming community in Dinwiddie County. He received his BS in Biology at the College of William and Mary in Williamsburg, VA, in 1987. Dr. Inge entered the Medical College of Virginia in Richmond, VA, in the Medical Scientist Training Program, and pursued degrees in Microbiology / Immunology and Medicine. He graduated with MD and PhD degrees in 1993. Dr. Inge received his surgical training at Stanford University Hospital in Palo Alto, CA, where he developed an interest in pediatric surgery. At the completion of his chief resident year in 1998, he moved to Birmingham, AL, for specialty training in pediatric surgery at the Children's Hospital of Alabama, with an emphasis on pediatric minimally invasive surgery. Dr. Inge became a full-time member of the surgical staff at Cincinnati Children's Hospital Medical Center and faculty member of the University of Cincinnati College of Medicine, Department of Surgery, Division of Pediatric Surgery, in July 2000. In addition to general pediatric surgical practice, Dr. Inge's clinical research focus is related to bariatric surgery in adolescents. He is the surgical director of the Surgical Weight Loss Program for Teens, offering surgery for overweight adolescents with complications from their excess weight. He has served as a consultant to the Food and Drug Administration for projects related to device treatment of pediatric obesity. He is also the Principal Investigator of two research projects funded by National Institutes of Health (NIH) and co-investigator of another NIH funded project examining the role of surgery for management of adolescent obesity. He currently serves as Study Chairman of Teen-LABS, a multicenter research consortium examining outcomes of adolescent bariatric surgery. Dr. Inge has given over 50 invited lectures nationally and internationally over the past four years, has mentored more than a dozen fellows and students, and has authored more than 70 published chapters and manuscripts.
Education and Training
BS: College of William and Mary, Williamsburg, VA, 1987.
MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 1993.
PhD: Virginia Commonwealth University, Richmond, VA, 1993.
Residency: Stanford University Hospital, Stanford, CA, 1998. Fellowship: Children's Hospital of Alabama, Birmingham, AL, 2000. Board Certification: Diplomate of the American Board of Surgery, December 1999; Certification in Pediatric Surgery, American Board of Surgery, March 2002.
Publications
View PubMed Publications
Zeller MH, Guilfoyle SM, Reiter-Purtill J, Ratcliff MB, Inge TH, Long JD. Adolescent bariatric surgery: caregiver and family functioning across the first postoperative year.Surg Obes Relat Dis. 2010 Jul 29. Ratcliff MB, Reiter-Purtill J, Inge TH, Zeller MH. Changes in depressive symptoms among adolescent bariatric candidates from preoperative psychological evaluation to immediately before surgery. Surg Obes Relat Dis. 2011 Jan-Feb;7(1):50-4. Inge TH, Xanthakos S. Sleeve gastrectomy for childhood morbid obesity: why not?Obes Surg. 2010 Jan;20(1):118-20. Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass.J Pediatr. 2010 Jan;156(1):103-108.e1. Miyano G, Kalra M, Inge TH. Adolescent paraplegia, morbid obesity, and pickwickian syndrome: outcome of gastric bypass surgery.J Pediatr Surg. 2009 Mar;44(3):e41-4. Zeller MH, Modi AC, Noll JG, Long JD, Inge TH. Psychosocial functioning improves following adolescent bariatric surgery.Obesity (Silver Spring). 2009 May;17(5):985-90. Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22. Modi AC, Loux TJ, Bell SK, Harmon CM, Inge TH, Zeller MH. Weight-specific health-related quality of life in adolescents with extreme obesity. Obesity (Silver Spring). 2008 Oct;16(10):2266-71. Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of cardiac abnormalities in morbidly obese adolescents.J Am Coll Cardiol. 2008 Apr 8;51(14):1342-8. Inge TH. Childhood obesity--a problem of surgical proportions? Nat Clin Pract Gastroenterol Hepatol. 2008 Apr;5(4):180-1.
Grants
Adolescent Bariatrics-- Assessing Health Benefits & Risks (Administrative Supplement to fund additional research on risk taking behaviors). Co-Investigator. National Institutes of Health, National Institute of Drug Abuse: Administrative Supplement for Drug Abuse Research. Jul 2009 - Mar 2011. #1U01DK072493-01.
Administrative Supplement for Drug Abuse Research; Adolescent Bariatrics-- Assessing Health Benefits & Risks (Administrative Supplement to fund additional research on Obstructive Sleep Apnea). Principal Investigator. National Institute of Drug Abuse. Sept 2009 - Sept 2011. #1U01DK072493-01.
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Helen N. Jones, PhD
is a placental physiologist who has research interests in placental function in pathological pregnancies and the development of non-viral mediated gene therapies in fetal growth restriction. Her lab studies the underlying mechanisms of placental insufficiency and potential therapies leading to increased placental function and fetal growth.
513-636-7861
helen.jones@cchmc.org
Helen N. Jones, PhD
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Regulation of placental growth and function; regulation of mechanisms of placental nutrient transfer and consequences for fetal growth
Biography
Education and Training
PhD: Rowett Research Institute, University of Aberdeen, Scotland, 2005.
BS: University of St. Andrews, Scotland, 2000.
Publications
View PubMed Publications
Wang K, Dong HQ, Zhao ZL, Li YY, Li C, Jones HN, Shi DL,Zhang XZ. Novel Vesicles Self-Assembled from Amphiphilic Star-Armed PEG-Polypeptide Hybrid Copolymers for Drug Delivery.Macromolecular Bioscience 11:65-71, 2011. Jones HN, Powell TL, Jansson T. Differential regulation of placental amino acid transport mechanisms by Adiponectin. Diabetes 59(5):1161-70, 2010. Jones HN, Powell TL, Jansson T. IL-6 stimulates System A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2.Am J Physiol Cell Physiol. 297(5):C1228-35, 2009. Jones HN,Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.FASEB J. 23(1):271-8, 2009. McArdle HJ, Andersen HS, Jones H, Gambling L. Copper and iron transport across the placenta: regulation and interactions.J Neuroendocrinol. 20(4):427-31., 2008. Jones HN, Powell TL, Jansson T. Regulation of Placental Nutrient Transport – A Review, Placenta 28l; 763- 774, 2007. Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M. Epigenetics and imprinting of the trophoblast -- a workshop report. Placenta. Suppl A:S122-6, 2006. McArdle HJ, Andersen HS, Jones H, Gambling L. Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats – A Review.Placenta 27:56-60, 2006. Jones HN, Ashworth CJ, Page KR, McArdle HJ. Cortisol stimulates System A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).Am. J. Physiol Endocrinology and Metabolism. 291(3):E596-603, 2006. Jones HN, Ashworth CJ, Page KR, McArdle HJ. Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction.Reproduction. 131:951-60, 2006.
Grants
Development of non-viral DNA delivery systems for placental gene therapy. Principal Investigator. University Research Council, University of Cincinnati July 2011 - June 2012.
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Sundeep G. Keswani, MD
Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Fetal Surgeon, Fetal Care Center of Cincinnati
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment
Biography
Education and Training
BA: University of Colorado, Boulder, CO, 1994.
MD: Ross University School of Medicine, 2000.
Residency: Louisiana State University Health Sciences Center, New Orleans, LA, 2000-2007.
Fellowship: The Children's Institute for Surgical Science, The Children's Hospital of Philadelphia & The Hospital of the University of Pennsylvania, Philadelphia, PA, 2002-2004.
Fellowship: Postdoctoral Research Fellow, The Center for Molecular Fetal Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2004.
Fellowship: Pediatric Surgery Fellowship, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, 2007-2009.
Licensure: American Board of Surgery Certified; Louisiana State Medical Licensure, active ; Missouri State Medical Licensure, active; Ohio State Medical Licensure, active; Indiana State Medical Licensure, active
Publications
View PubMed Publications
Keswani SG, Le LD, Morris LM, Lim FY, Katz AB, Ghobril N, Habli M, Frischer JS, Crombleholme TM. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.J Pediatr Surg. 2011 Jan;46(1):33-8. Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient.Pediatr Surg Int. 2010 Nov;26(11):1125-8. Morris LM, Klanke CA, Lang SA, Pokall S, Maldonado AR, Vuletin JF, Alaee D, Keswani SG, Lim FY, Crombleholme TM. Characterization of endothelial progenitor cells mobilization following cutaneous wounding.Wound Repair Regen. 2010 Jul-Aug;18(4):383-90. Katz AB, Keswani SG, Habli M, Lim FY, Zoltick PW, Midrio P, Kozin ED, Herlyn M, Crombleholme TM. Placental gene transfer: transgene screening in mice for trophic effects on the placenta.Am J Obstet Gynecol. 2009 Nov;201(5):499.e1-8 Vachharajani AJ, Rao R, Keswani S, Mathur AM. Outcomes of exomphalos: an institutional experience. Pediatr Surg Int. 2009 Feb;25(2):139-44. Khan AR, Morris LM, Keswani SG, Khan IR, Le L, Lee WC, Hunt JP. Tuberculous peritonitis: a surgical dilemma. South Med J. 2009 Jan;102(1):94-5. Bucher BT, Seigel J, Rosenblum E, Nesslein C, Keswani SG, Foglia R, Dillon P, Warner BW and Keller MS. A pediatric ambulatory wound service (PAWS): A novel approach in wound management. J Ped Surg 2009. Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation.Wound Repair Regen. 2008 Jan-Feb;16(1):70-9. Parvadia JK, Keswani SG, Vaikunth S, Maldonado AR, Marwan A, Stehr W, Erwin C, Uzvolgyi E, Warner BW, Yamano S, Taichman N, Crombleholme TM. Role of VEGF in small bowel adaptation after resection: the adaptive response is angiogenesis dependent.Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G591-8. Keswani SG, Javazon EH, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.
Grants
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Marc A. Levitt, MD
Director, Colorectal Center
Academic Information
Associate Professor, Division of Pediatric Surgery
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Specialties
Colorectal surgery, minimally invasive surgery
Biography
Marc A. Levitt, MD, is director of the Colorectal Center, joined the staff of Cincinnati Children's Hospital Medical Center on June 1, 2005. Dr. Levitt was recruited from Schneider Children's Hospital of the North Shore – Long Island Jewish Health System in New Hyde Park, New York. Dr. Levitt received his undergraduate degree from the University of Pennsylvania, and his medical degree from the Albert Einstein College of Medicine, where he was elected to the Alpha Omega Alpha Society. Dr. Levitt completed his general surgery residency at the Mount Sinai Medical Center in New York and also served as a clinical and research fellow in pediatric colorectal surgery with Dr. Alberto Peña, at Schneider Children's Hospital. Dr. Levitt completed his pediatric surgery fellowship at the Children's Hospital of Buffalo, and was a pediatric surgical attending there, serving as the clinical director of their Pediatric Miniature Access Surgery Center. Dr. Levitt's interests include pediatric colorectal surgery and pediatric minimally invasive surgery.
Education and Training
MD: Albert Einstein College of Medicine.
Residency: Mount Sinai Medical Center, New York.
Fellowhip: Children's Hospital of Buffalo.
Certification: General Surgery, 2000; Pediatric Surgery, 2002.
Publications
View PubMed Publications
Rangel SJ, Lawal TA, Bischoff A, Chatoorgoon K, Louden E, Peña A, Levitt MA. The appendix as a conduit for antegrade continence enemas in patients with anorectal malformations: Lessons learned from 163 cases treated over 18 years. J Pediatr Surg. 2011 Jun;46(6):1236-42.
Chatoorgoon K, Peña A, Lawal T, Hamrick M, Louden E, Levitt MA. Neoappendicostomy in the management of pediatric fecal incontinence. J Pediatr Surg. 2011 Jun;46(6):1243-9,.
Levitt MA, Mathis KL, Pemberton JH. Surgical treatment for constipation in children and adults. Best Practice & Research Clinical Gastroenterology. 2011 Jun;25:167-179.
Levitt MA, Bischoff A, Peña A. Pitfalls and challenges of cloaca repair: How to reduce the need for reoperations. J Pediatr Surg. 2011 Jun;46(6):1250-1255.
Lawal TA, Chatoorgoon K, Bischoff A, Peña A, Levitt MA. Management of h-type rectovestibular and rectovaginal fistulas. J Pediatr Surg. 2011 Jun;46(6):1226-30.
Lawal TA, Rangel SJ, Bischoff A, Peña A, Levitt MA. Laparoscopic assisted Malone Appendicostomy in the Management of Fecal Incontinence in Children. J Laparoendosc Adv Surg Tech. 2011 Jun;21(5):455-9. Alam S, Lawal TA, Peña A, Sheldon C, Levitt MA. Acquired posterior urethral diverticulum following surgery for anorectal malformations. J Pediatr Surg. 2011 Jun;46(6):1231-5.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Podberesky DJ, Weaver NC, Anton CG, Lawal T, Hamrick MC, Alam S, Peña A, Levitt MA. MRI of acquired posterior urethral diverticulum following surgery for anorectal malformations. Pediatr Radiol. 2011 Apr 16. Calvo-Garcia MA, Kline-Fath BM, Levitt MA, Lim FY, Linam LE, Patel MN, Kraus S, Crombleholme TM, Peña A. Fetal MRI clues to diagnose cloacal malformations. Pediatr Radiol. 2011 Mar 16.
Grants
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Foong-Yen Lim, MD
Surgical Director, Fetal Care Center of Cincinnati
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Open fetal surgery and fetoscopic surgery; ex-utero intrapartum treatment (EXIT); congenital high airway obstruction syndrome (CHAOS); congenital diaphragmatic hernia (CDH); fetal gene therapy; neonatal surgery; thoracic surgery; minimally invasive surgery
Biography
Education and Training
Pediatric Surgery Fellowship: The Children's Hospital of Philadelphia, 2004 – 2006.
General Surgery Residency: Penn State Milton S. Hershey Medical Center, 2002-2004.
Pediatric Surgery Research Fellowship and Fetal Surgery Fellowship: The Children's Hospital of Philadelphia, 2000-2002.
General Surgery Residency: Penn State Milton S. Hershey Medical Center, 1997-2000.
MD: Medical University of South Carolina, Charleston, SC, 1993 – 1997.
BS: Graceland College, Lamoni, Iowa, 1989 – 1993.
Publications
View PubMed Publications
Keswani SG, Le LD, Morris LM, Lim FY, Katz AB, Ghobril N, Habli M, Frischer JS, Crombleholme TM. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy. J Pediatr Surg. 2011 Jan;46(1):33-8.
Guimaraes CV, Kline-Fath BM, Linam LE, Calvo Garcia MA, Rubio EI, Lim FY. MRI findings in multifetal pregnancies complicated by twin reversed arterial perfusion sequence (TRAP). Pediatr Radiol. 2010 Dec 22.
Bischoff A, Levitt MA, Lim FY, Guimarães C, Peña A. Prenatal diagnosis of cloacal malformations. Pediatr Surg Int. 2010 Nov;26(11):1071-5.
Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9.
Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7.
Morris LM, Klanke CA, Lang SA, Pokall S, Maldonado AR, Vuletin JF, Alaee D, Keswani SG, Lim FY, Crombleholme TM. Characterization of endothelial progenitor cells mobilization following cutaneous wounding. Wound Repair Regen. 2010 Jul-Aug;18(4):383-90.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Morris LM, Klanke CA, Lang SA, Lim FY, Crombleholme TM. TdTomato and EGFP identification in histological sections: insight and alternatives. Biotech Histochem. 2010 Dec;85(6):379-87.
Vaikunth SS, Morris LM, Polzin W, Gottliebson W, Lim FY, Kline-Faith B, Crombleholme TM. Congenital high airway obstruction syndrome due to complete tracheal agenesis: an accident of nature with clues for tracheal development and lessons in management. Fetal Diagn Ther. 2009;26(2):93-7.
Habli M, Bombrys A, Lewis D, Lim FY, Polzin W, Maxwell R, Crombleholme T. Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience. Am J Obstet Gynecol. 2009 Oct;201(4):417.e1-7.
Grants
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Jaimie D. Nathan, MD
Pediatric Surgeon
Academic Information
Assistant Professor, Division of Pediatric Surgery
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Specialties
Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; neonatal surgery; minimally invasive surgery
Biography
Education and Training
MD: Yale University, New Haven, Connecticut, 1998.
Residency: Intern, General Surgery, Duke University Medical Center, Durham, North Carolina, 1998 - 1999; Junior Assistant Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 1999 - 2000; Senior Assistant Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 2002 - 2004; Chief Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 2004 - 2005. Fellowships: Surgical Research Fellowship, Duke University Medical Center, Durham, North Carolina, 2000 - 2002; Pediatric Surgery Fellowship, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2005 - 2007; Transplant Surgery Fellowship, University of Cincinnati, Cincinnati, Ohio, 2007 - 2009. Certification: American Board of Surgery, 2007; American Board of Surgery, Certification in Pediatric Surgery, 2008.
Publications
View PubMed Publications
Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30. Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200. Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease.J Pediatr Surg. 2007 Jan;42(1):143-7. Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235. Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727. Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Cell Physiol Biochem. 2005 15:51-58. Book ChaptersNathan JD, Campbell KM, Tiao GM, Alonso MH, Ryckman FC. Portal hypertension. In: Mattei P, ed. Fundamentals of Pediatric Surgery (2nd edition). Ryckman FC, Alonso MH, Nathan JD, Tiao G. Solid organ and intestinal transplantation. In: Holcomb WH, Murphy JP, eds. Pediatric Surgery (5th edition). Nathan JD, Ryckman FC. Biliary atresia. In: Chung DH, ed. Atlas of Pediatric Surgical Techniques: A Volume in the Surgical Techniques Atlas Series (1st edition).
Grants
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Alberto Peña, MD
Founding Director, Colorectal Center
Academic Information
Professor, Division of Pediatric Surgery
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Specialties
Clinical research regarding colorectal problems in children
Biography
Alberto Peña, MD, director of the Colorectal Center, at Cincinnati Children's, received his medical degree at the Military Medical School in Mexico City, in 1962. Dr. Peña trained in general surgery and medical pediatrics at the Central Military Hospital, finishing in 1968. From 1969 until December 1971, he trained at Boston Children's Hospital. Dr. Peña moved back to Mexico City as the surgeon-in-chief of the National Institute of Pediatrics from January 1972 until June 1985. Dr. Peña joined the full-time staff at Schneider Children's Hospital in July 1985 and was the chief of Pediatric Surgery and professor of Surgery at the Albert Einstein College of Surgeons. In 1982, Dr. Peña described a new approach for the management of anorectal malformations: Posterior Sagittal Anoplasty / PSARP, also known as the Pull-Through Procedure. Since 1982 until the present, Dr. Peña has been traveling all over the world, lecturing and operating on children affected by this particular malformation. At the present time, Dr. Peña dedicates 80 percent of his time to the treatment of anorectal problems in children. Seventy percent of the patients operated on by Dr. Peña at Cincinnati Children's come from other states and from all over the world.
Education and Training
MD: Military Medical School, Mexico City, Mexico, 1962.
esidency: Central Military Hospital, Mexico City, Mexico, 1966; Children's Hospital Medical Center, Boston, MA, 1969-1971.
Publications
View PubMed Publications
Lawal TA, Rangel SJ, Bischoff A, Peña A, Levitt MA. Laparoscopic-Assisted Malone Appendicostomy in the Management of Fecal Incontinence in Children. J Laparoendosc Adv Surg Tech A. 2011 Mar 2. Lawal TA, Chatoorgoon K, Collins MH, Coe A, Peña A, Levitt MA. Redo pull-through in Hirschprung's disease for obstructive symptoms due to residual aganglionosis and transition zone bowel.J Pediatr Surg. 2011 Feb;46(2):342-7. Bischoff A, Levitt MA, Lim FY, Guimarães C, Peña A. Prenatal diagnosis of cloacal malformations.Pediatr Surg Int. 2010 Nov;26(11):1071-5. Bischoff A, Levitt MA, Lawal TA, Peña A. Colostomy closure: how to avoid complications.Pediatr Surg Int. 2010 Nov;26(11):1087-92. Bischoff A, Levitt MA, Breech L, Louden E, Peña A. Hydrocolpos in cloacal malformations. J Pediatr Surg. 2010 Jun;45(6):1241-5. Peña A, Bischoff A, Breech L, Louden E, Levitt MA. Posterior cloaca--further experience and guidelines for the treatment of an unusual anorectal malformation. J Pediatr Surg. 2010 Jun;45(6):1234-40. Levitt MA, Kant A, Peña A. The morbidity of constipation in patients with anorectal malformations.J Pediatr Surg. 2010 Jun;45(6):1228-33. Levitt MA, Peña A. Minimally invasive treatment of fecal incontinence and constipation in children.Minerva Chir. 2010 Apr;65(2):223-34. Review. Levitt MA, Dickie B, Peña A. Evaluation and treatment of the patient with Hirschsprung disease who is not doing well after a pull-through procedure.Semin Pediatr Surg. 2010 May;19(2):146-53. Levitt MA, Peña A. Cloacal malformations: lessons learned from 490 cases.Semin Pediatr Surg. 2010 May;19(2):128-38.
Grants
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Frederick C. Ryckman, MD
Vice President, System Capacity & Perioperative Operations
Director, Pediatric Surgery Training Program
Academic Information
Professor, Division of Pediatric Surgery
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Specialties
Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities
Biography
Education and Training
BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.
MD: University of Michigan Medical School, Ann Arbor, MI, 1977.
Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.
Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.
Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.
Publications
View PubMed Publications
Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21. Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42. Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43. Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72. Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7. Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8. Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33. Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30. Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25. Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Grants
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Greg M. Tiao, MD
Surgical Director, Liver Transplantation
is a pediatric and transplant surgeon with research interests and experience in pathogenic mechanisms of induced biliary asteria. His most current projects concentrate on the molecular determinants and intracellular signaling pathways and virus of induced biliary asteria.
513-636-4371
greg.tiao@cchmc.org
Greg M. Tiao, MD
Surgical Director, Liver Transplantation
Director, Small Bowel Program
Associate Director, Pediatric Surgery Training Program
Pediatric Surgeon
Academic Information
Associate Professor, Division of Pediatric Surgery
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Specialties
Liver, kidney and small bowel transplantation; hepatobiliary disease; Neonatal surgery; biliary atresia; minimally invasive surgery
Biography
As a pediatric surgeon and a transplant surgeon, I am involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant when necessary. I see the many challenges a child and their family experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is my career goal. Our short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver. Our overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction.Our focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, how infected cholangiocytes modify the microenvironment activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, I have defined an area of independence from Dr Jorge Bezerra, my primary research mentor.
Education and Training
BS: Northwestern University, Evanston, IL, 1986. MD: University of Illinois, Chicago, IL, 1990. Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998. Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.
Publications
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G Ross ME. Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation. Peditr Blood Cancer 2011;56(3):498-500. Bondoc A, Jafri M, Donnelly B, Mohanty S, McNeal M, Ward R, Tiao G. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J of Pediatric Surgery. 2009;44(8):1479-90. PMCID: PMC2748872 Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J of Pediatric Surgery. 2009;44(3):500-507. PMCID: PMC2730110 Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2008;295(1):G16-G26. PMCID: PMC2494723 Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM. Effect of rotavirus strain on the murine model of biliary atresia. J Virol. 2007;81(4):1671-9. Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery. 2007;142(2):192-201. Tiao GM, Alonso MH, Ryckman FC. Pediatric liver transplantation. Semin Pediatr Surg. 2006;15(3):218-227. Tiao G, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. Liver transplantation in children under one year of age-the cincinnati experience. J Pediatr Surg. 2005;40(1):268-273. Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Schneider GL, Aronow B, Bezerra JA. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology. 2004;39(4):954-962. Shivakumar P, Cambell KM, Sabla GE, Mietke A, Tiao G, McNeal NM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004;114(3):322-329.
Grants
The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011-Marh 2016. Intracellular Signaling Pathways and Virus Induced Biliary Asteria. Principal Investigator. May 2010-Apr 2012.
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