• Basic Science Research

    Going to the Source of Heart Disease

    The Heart Institute has the nation’s only basic science division focused solely on problems related to pediatric heart disease. Basic research is carried out within the institute’s Division of Molecular Cardiovascular Biology. The division’s faculty of PhDs, MDs and MD / PhDs focus on understanding the molecular mechanisms that drive normal and abnormal heart and muscle development.

  • Our basic research is known internationally with faculty members serving on many national advisory and review boards. Research funding includes four major program grants and 14 individual grants from the National Institutes of Health. Additionally, our work is funded by many other national and international sources, including substantial grants from:

    Faculty members are actively involved in training future clinical and basic researchers. Our laboratories offer MD and PhD fellows a rich research experience that is often translated directly into the clinic. Our fellows’ and students’ efforts have been recognized nationally; they have successfully applied for and been awarded 17 individual grants to support their basic and translational research efforts.

    Our wide-ranging basic research is directed toward critical problems in pediatric cardiology:

    • Normal and abnormal heart development and function
    • Cell signaling
    • Human cardiovascular genetics
    • Heart failure
    • Cardiomyopathy
    • Congenital heart disease
    • Adult congenital heart disease
    • Valve disease
    • Metabolic syndrome
  • Faculty Conducting Basic Science Research in the Heart Institute

    FacultyFocus of Research
    Burns Blaxall, PhDDeveloping novel heart failure therapeutics
    James Gulick, MSContractile protein structure function
    Zaza Khuchua, PhDCardiac lipid and phospholipid metabolism
    Marjorie Maillet, PhDCardiac hypertrophy and heart failure
    Douglas Millay, PhDMuscle development; cell fusion; muscular dystrophy
    Jeff Molkentin, PhDCardiac signaling and transcriptional mechanisms in disease
    Jeffrey Robbins, PhDThe laboratory uses genetically engineered models of human heart disease to establish cause and effect relationships
    Joshua Waxman, PhDGenetic mechanisms of normal and abnormal heart development
    Katherine Yutzey, PhDMolecular regulation of heart development and disease
  • Scientists conducting basic science research in the Heart Institute.