• Research Faculty

  • A photo of Russell Ware.

    Russell E. Ware, MD, PhD Director, Division of Hematology

    is a recognized expert in sickle cell disease. He is the national PI for several NHLBI-funded sickle cell clinical trials and has recently begun an international program to improve the diagnosis, treatment, and research for sickle cell disease in developing countries. His laboratory focuses on genetic modifiers of sickle cell disease, as well as the pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea therapy.
    Visit the Ware Lab.


    A photo of Ralph A. Gruppo.

    Ralph A. Gruppo, MD Director, Comprehensive Hemophilia and Thrombosis Center

    research involves numerous clinical trials of promising therapies for hemophilia, von Willebrand Disease, and hemolytic uremic syndrome. His research also includes the study of thrombosis in children, including the use of site-directed thrombolytic therapy in the prevention of long-term complications of thrombosis.


    A photo of Theodosia A. Kalfa.

    Theodosia A. Kalfa, MD, PhD

    focuses on the study of intracellular signals in erythropoiesis and mature red blood cells, specifically the signals conducted by Rho GTPases regulating terminal erythroid maturation and enucleation. Her lab also studies the role of Rac GTPases in generation of reactive oxygen species (ROS) within red blood cells from patients and animal models with sickle-cell disease along with the signaling mechanisms and consequences of increased ROS in sickle cells.
    Visit the Kalfa Lab.


    A photo of Karen Kalinyak.

    Karen A. Kalinyak, MD Medical Director, Sickle Cell Clinic

    conducts research to understand the clinical course of sickle-cell disease and determine how to prevent or minimize complications. She served as local PI in numerous multi-institutional clinical trials, including Prophylactic Penicillin Study (PROPS II), Stroke with Transfusions Changing to Hydroxyurea (SWiTCH) Trial, Silent Infarct Transfusion Trial (SIT) and two SCD Clinical Research Network studies (PROACTIVE and IMPROVE).


    A photo of Patrick McGann.

    Patrick T. McGann, MD, MS

    focuses his research efforts on improving the diagnosis, care, and outcomes for children with sickle cell anemia across the world, particularly in sub-Saharan Africa. Current projects include the investigation of hydroxyurea in Africa (REACH), the development and testing of inexpensive point-of-care diagnostics in hematology, and  analysis of serotype distribution of invasive pneumococcal disease in Angola.


    A photo of Eric Mullins.

    Eric Mullins, MD

    has a research interest in the interplay between the hemostatic system and the immune system in the setting of inflammatory diseases and infection. 


    A photo of Joseph Palumbo.

    Joseph S. Palumbo, MD

    focuses on interactions between the hemostatic system and innate immunity effecting tumor progression and Langerhans' cell histiocytosis.


    A photo of Charles Quinn.

    Charles T. Quinn, MD, MS Director, Hematology Clinical and Translational Research

    investigates causes and ways to predict, prevent and treat brain injury in sickle cell disease, such as stroke and cognitive dysfunction, both locally in Cincinnati and as a member of national and international study teams. Other areas of research include developing a method to directly measure of red blood cell turnover rate in sickle cell disease, identification and treatment of cardiomyopathy and nephropathy in sickle cell disease, and new agents to treat and prevent pain (VOC) in sickle cell disease.


    A photo of Susan Rose.

    Susan R. Rose, MD Member, Division of Endocrinology

    investigates hypothalamic pituitary function and disorders of growth, puberty or thyroid hormone. She has special interest in the effects of neural injury on hypothalamic-pituitary function, such as after traumatic brain injury, cranial radiation, anoxia, iron overload.


    A photo of Cristina Tarango.

    Cristina Tarango, MD Medical Director, Hemophilia Treatment Center

    focuses on pediatric thrombosis and hemostasis. She also has an interest in medical education.