• Research Faculty

  • A photo of Harinder Singh.

    Harinder Singh, PhD Director, Division of Immunobiology

    513-636-7641

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    Theresa Alenghat, VMD, PhD

    investigates central epigenomic pathways that regulate epithelial and immune cell homeostasis in the context of intestinal health and disease. The goal of her research is to provide insight into mechanisms underlying the host-commensal relationship and how this level of regulation affects the development of chronic diseases such as inflammatory bowel disease.

    513-803-7498

    A photo of Julio Aliberti.

    Julio Aliberti, MS, PhD

    is focused on defining the mechanisms underlying the induction and regulation of immune responses to intracellular pathogens, including Toxoplasma gondii and Mycobacterium tuberculosis, microbes that cause an immense burden of morbidity and mortality in the world at large. The ultimate goal of this research program is the development of novel preventive and therapeutic approaches to these pathogens.

    513-636-9041

    A photo of Claire Chougnet.

    Claire A. Chougnet, PhD

    aims to understand T cell function and dysfunction at a molecular level in human disease, with a focus on defining the molecular mechanisms that underlie T cell dysfunction in HIV/AIDS, defining the molecular mechanisms responsible for immune dysfunction in aging, and understanding the development of T cell responses in very early life.

    513-636-8847

    A photo of Senad Divanovic.

    Senad Divanovic, PhD

    investigates the molecular mechanisms underlying the regulation of innate immune signaling and inflammation in: (a) development and progression of obesity; (b) development and progression of non-alcoholic fatty liver disease; and (b) induction of preterm birth. These studies, range from reductive analysis of TLR ligand signaling and challenge to the role of IL-17 axis to diverse experimental models of obesity and infection.

    513-636-0286

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    Fred D. Finkelman, MD

    uses mouse models to study the roles of antibodies and cytokines in health and disease. Particular interests include allergic disorders, parasitic worm infections, and antibody-mediated disorders.

    513-636-6656

    A photo of Lee Grimes.

    H. Leighton (Lee) Grimes, PhD Director, Cancer Pathology Program, Division of Experimental Hematology & Division of Pathology

    focuses his research on the genetic development of cancerous cells and inherited blood diseases. His lab utilizes the Growth factor independent-1 transcription factor as a molecular probe to dissect hematopoiesis and leukemia. Dr. Grimes serves as the director of the Cancer Pathology Program of the Divisions of Experimental Hematology and Pathology.
    Visit the Grimes Lab

    513-636-6089

    A photo of Andrew Herr.

    Andrew B. Herr, PhD

    studies protein-protein interactions involved in immune receptor signaling and bacterial pathogenesis. His lab uses X-ray crystallography to solve the atomic structures of proteins along with techniques of biophysical chemistry to understand their interactions in solution. The goal is to understand the molecular basis for autoimmune responses and recurrent bacterial infections, and to develop new therapeutic applications.

    513-803-7490

    A photo of David Hildeman.

    David A. Hildeman, PhD Director, Immunology Graduate Program

    explores the molecular factors that control the decision between tolerance and immunity within T lymphocytes. Using genetic mouse models, viruses, and MHC tetrameric reagents, the lab is focused on the molecular regulation of antigen-specific T cell responses. Dr. Hildeman is also the current director of the Immunology Graduate Program.

    513-636-3923

    A photo of Kasper Hoebe.

    Kasper Hoebe, PhD

    focuses on mechanistic analysis of pathways of innate immune activation and the mechanisms underlying NK cell and CD8+ T cell development and cytolytic effector function, using forward genetic approaches. His discovery of an “endogenous adjuvant” pathway mediated by NK cell killing has led to research aimed at exploiting the knowledge obtained on NK cell-driven adaptive immune responses for the generation of new, safer vaccine approaches.

    513-803-1056

    A photo of Edith Janssen.

    Edith Janssen, PhD

    focuses on mechanistic analysis and translational exploitation of the processes in dendritic cells that balance pro- and anti-inflammatory immune responses to self after cell death. Dr. Janssen aims at harnessing dendritic cells to develop effective autologous cancer vaccines. Her recent discovery (with Dr. Jonathan Katz) that dysregulation of such cells suggests a potential role for therapeutic modulation of these cells in autoimmune disease.

    513-803-1055

    A photo of Michael Jordan.

    Michael B. Jordan, MD

    specializes in caring for children with histiocytic disorders, primary immune deficiencies, or who are undergoing bone marrow transplantation. His laboratory focuses on understanding effector T cell function, immune regulation, and the pathogenesis of hemophagocytic lymphohistiocytosis. He is also conducting preclinical scientific studies in addition to a translational clinical trial.

    513-636-7287

    A photo of Jonathan Katz.

    Jonathan D. Katz, PhD

    is working to understand the role that autoreactive T lymphocytes play in the Immunopathogenesis of type 1 diabetes, the most common pediatric autoimmune disease. Major focuses include defining: (a) the control of autoreactive T cells via central and peripheral tolerance; (b) the role NKT cells play in regulating autoreactive T cells; and (c) the role dendritic cells play in activating and regulating autoreactive T cells in type 1 diabetes.

    513-636-5306

    A photo of Ian Lewkowich.

    Ian P. Lewkowich, PhD

    investigates the factors that drive the development of severe allergic asthma, with a particular focus on the molecular mechanisms through which Th17 cytokines enhance IL-13 signaling, the regulation of the asthmatic response through the PD-1/PD-L axis and the mechanisms of the well-described maternal influence in inherited asthma risk.

    513-636-3999

    A photo of Yrina Rochman.

    Yrina Rochman, PhD

    is focused on elucidating molecular mechanisms of immunological responses. Particularly, on the role of cytokines in the adaptive immune response and T cell differentiation.