Infectious Diseases

Significant Accomplishments

Top-funded Research Division

Our division became the top-funded research division at Cincinnati Children’s this year. Our total external funding reached $10.5 million, from diverse sources that include the NIH, CDC, Burroughs Wellcome, Bill and Melinda Gates Foundation, NASA, and industry. We also had the highest increase in grant funding among all Cincinnati Children’s research divisions - at 25 percent. Our projects include studies of the pathogenesis of cytomegalovirus, herpes simplex virus, norovirus/calicivirus, and Candida infections; vaccine response; macrophage biology; normal and aberrant immune responses in pregnancy; and surveillance for community-acquired infections.

Transplant Infectious Disease Program Launched

We launched the Transplant Infectious Disease program this year under the direction of Lara Danziger-Isakov, MD, who was recruited from the Cleveland Clinic. Danziger-Isakov collaborates with clinicians and investigators in solid organ transplant and the bone marrow transplant unit. Overall, our clinicians provided consultative expertise to 691 inpatients and 1,695 outpatient visits in 2012. Billings hit $1.49 million. These numbers represent a three-fold rise in clinical activity since 2010.

Inventions That Improve Child Health

Jason Jiang, PhD, and Ming Tan, PhD, have licensed the technology for a norovirus vaccine to LigoCyte. The Center for Technology Commercialization also patented an antibody from the Hostetter laboratory that prevents Candida albicans biofilm formation.