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Our lab focuses on understanding the molecular mechanisms underlying herpes simplex virus (HSV) latency and reactivation. These processes are central to the human disease caused by this virus. Our research efforts encompass many approaches, from in vitro biochemical and molecular studies to the development and utilization of refined in vivo model systems.
Recently, we have made an observation that shifts the HSV reactivation paradigm, identifying an essential role for the viral tegument protein VP16 in the earliest stages of HSV reactivation in neurons in vivo.
Several ongoing projects stem from this observation:
Our additional areas of investigation include:
Read more about the Sawtell Lab’s herpes simplex research.
Nancy Sawtell, PhD
Mailing Address:Division of Infectious Diseases3333 Burnet Ave.MLC 7017Cincinnati, OH 45229-3039
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900
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