(All fields required)
Please enter a valid email.
Please enter your name.
What is : (So we know you are human.)
Please supply the correct answer.
Our projects focus on different aspects of herpes simplex virus (HSV) disease from a molecular perspective. We are exploring how VP16, the viral transactivator of lytic gene expression, is turned on from the latent viral genome. Also, we are investigating the role of Trim19 (PML) nuclear body formation in silencing the HSV genome in sensory neurons. Our work also includes the identification of host genes conferring susceptibility and resistance to HSV disease using a forward genetic approach.
Our lab also studies the role of IL10 in modulating the accrual of central nervous system (CNS) lesions during long-term HSV latency / reactivation cycles. IL10 plays a pivotal role in curtailing the inflammatory responses and thus balances resolution and pathogenic outcome.
To date, the importance of IL10 during long-term repeated reactivation cycles within the CNS has not been reported. Utilizing mice deficient in IL10, we tested the hypothesis that IL10 plays a critical role in limiting reactive damage within the nervous system during latent infection.
Our findings suggest HSV latency in the CNS has the potential, in a susceptible host background, to mediate a silent progressive development of CNS pathology. This has significant implications for neurological disorders in an aging population.
click to enlarge
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY: 1-513-636-4900
New to Cincinnati Children’s or live outside of the Tristate area? 1-877-881-8479
© 1999-2015 Cincinnati Children's Hospital Medical Center