David I. Bernstein, MD, MA
Director, Gamble Program and VTEU
conducts clinical vaccine trials, including trials involving infants and the elderly that are supported by the NIH through the Vaccine and Treatment Evaluation Unit which he directs at Cincinnati Children’s. His special interest is the pathogenesis and immunobiology of herpes viruses (herpes simplex and cytomegalovirus).
513-636-7625
david.bernstein@cchmc.org
David I. Bernstein, MD, MA
Director, Gamble Program and VTEU
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsRotavirus; herpes simplex virus; cytomegalovirus; preclinical and clinical evaluations of vaccine; immune response to herpes virus
Research InterestsEvaluation of vaccines and antivirals for herpes and rotovirus; development of improved adjuvants and delivery systems for vaccines; treatment and prevention of influenza, norovirus and parvovirus infections
Biography
Dr. Bernstein received his MA degree in microbiology and his MD degree from SUNY at Buffalo. His pediatric training was undertaken at USC and the New England Medical Center. This was followed by an ID fellowship at UCLA. During his fellowship he became interested in herpes viruses and vaccines. Upon arrival at Cincinnati Children’s Hospital Medical Center he began his work investigating the immunobiology of genital herpes infections. At this time he also became interested in rotavirus and along with his colleague Dr. Richard Ward he investigated the immune responses that provide protection. This work led to the development of a live attenuated human rotavirus vaccine initially named 89-12. The 89-12 vaccine was further modified and became the GlaxoSmithKline rotavirus vaccine, Rotarix, currently available in over 100 countries including the USA and EU. Dr. Bernstein is currently evaluating vaccines for CMV, HSV, influenza, avian influenza, RSV, norovirus and parvovirus. Dr. Bernstein has published over 200 manuscripts and book chapters on infectious diseases, vaccines and antivirals. Dr. Bernstein is currently the Albert Sabin Professor of pediatrics and director of the Division of Infectious Diseases at Cincinnati Children’s and directs one of eight NIH funded Vaccine Evaluation Units.
Education and Training
MA: Microbiology, State University of New York at Buffalo, Buffalo, NY, 1973.
MD: State University of New York at Buffalo School of Medicine, Buffalo, NY, 1977. Residency: Pediatrics, University of Southern California Medical Center, Los Angeles, CA; Tufts University School of Medicine, Boston, MA. Fellowship: Pediatric Infectious Disease, University of California, Los Angeles, CA. Certification: American Board of Medical Examiners, 1978; American Board of Pediatrics, 1981; Pediatrics, 1982.
Publications
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Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6. Widdice LE, Bernstein DI, Leonard AC, Marsolo KA, Kahn JA. Adherence to the HPV Vaccine Dosing Intervals and Factors Associated With Completion of 3 Doses. Pediatrics. 2010 Dec 13. Bernstein DI, Epstein T, Murphy-Berendts K, Liss GM. Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study. Ann Allergy Asthma Immunol. 2010 Jun;104(6):530-5.
Sublett JW, Bernstein DI. Occupational rhinitis. Curr Allergy Asthma Rep. 2010 Mar;10(2):99-104.
Bernstein DI. The changing epidemiology of rotavirus gastroenteritis. Introduction. Pediatr Infect Dis J. 2009 Mar;28(3 Suppl):S49.
Bernstein DI, Cardin RD, Bravo FJ, Strasser JE, Farley N, Chalk C, Lay M, Fairman J. Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines. Clin Vaccine Immunol. 2009 May;16(5):699-705.
Yee EL, Staat MA, Azimi P, Bernstein DI, Ward RL, Schubert C, Matson DO, Turcios-Ruiz RM, Parashar U, Widdowson MA, Glass RI. Burden of rotavirus disease among children visiting pediatric emergency departments in Cincinnati, Ohio, and Oakland, California, in 1999-2000. Pediatrics. 2008 Nov;122(5):971-7.
Bernstein DI, Edwards KM, Dekker CL, Belshe R, Talbot HK, Graham IL, Noah DL, He F, Hill H. Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. J Infect Dis. 2008 Mar 1;197(5):667-75. Bravo FJ, Cardin RD, Bernstein DI. A model of human cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 2007;76:104-110.
Kahn JA, Rosenthal SL, Tissot AM, Bernstein DI, Wetzel C, Zimet GD. Factors influencing pediatricians’ intention to recommend human papillomavirus vaccines. Ambul Pediatr. 2007;7:367-373.
Grants
The natural history of CMV-related hearing loss and the feasibility of CMV screening as adjunct to hearing in the newborn. Co-investigator / Principal Investigator (Cincinnati site). 2005 - 2012. #HHSN260200500008C. Vaccine and Treatment Evaluation Units (VTEUs): Evaluation of Control Measures Against Diseases Other Than AIDS. Principal Investigator. 2007 - 2014. #NO1-AI-80006.
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Steven Black, MD
Adjunct Professor, Center for Global Child Health
is focusing on the evaluation of vaccine safety, vaccine efficacy and the epidemiology of vaccine preventable diseases in the United States but especially in the developing world. He is interested in fostering collaborative efforts to improve vaccine safety and effectiveness assessment in low and middle income countries.
513-803-0747
steven.black1@cchmc.org
Steven Black, MD
Adjunct Professor, Center for Global Child Health
Academic Information
UC Department of Pediatrics
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Specialties
Vaccine safety and the use of computerized data to evaluate vaccines in the developed and developing world; vaccine clinical trials
Biography
Education and Training
MD: University of California, San Diego, 1973 Residency: Pediatrics, Kaiser Hospital, San Fransisco CA; Infectious Disease, University of California, San Fransisco CA Certification: Pediatrics, 1980; Pediatric Infectious Diseases, 1995
Publications
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Black S, Ray P, Shinefield H, Saddier P, Nikas A. Lack of Association of Age of Vaccination and Risk of Breakthrough Varicella within Northern California Kaiser Permanente Medical Care Program. J Infect Dis. 2008 Mar1;197 Suppl 2:S139-42. Klein NP, Fireman B, Enright A, Ray P, Black S, Dekker C. A role for genetics in the immune response to varicella vaccine. Pediatr Infect Dis J. 2007April; 26(4):300-5. Bernstein HH, Eves K, Campbell K, Black SB, Twiggs JD et al. Comparison of the safety and immunogenicity of a refrigerator-stable versus frozen formulation of ProQuad (measles, mumps, rubella and varicella live) vaccine. Pediatrics 2007 Jun;119(6):e1299-305. Black S, France EK, Isaacman D, Bracken L, Lewis E, Hansen J, Fireman B, Austrian R et al. Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2007 Sept;26(9):771-7. Seigrist CA, Lewis EM, Eskola J, Black SB. Human Papilloma Virus Immunization in Adolescents: A Cohort Study to Illustrate What Events Might be Mistaken for Adverse Events. Pediat Infect Dis J. 2007 Nov; 2(11): 979-984.
Grants
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Rebecca C. Brady, MD
Director, Adult Clinical Services
is interested in adult vaccines and influenza. Dr. Brady is the PI for funded clinical trials of influenza vaccines in children and adults.
513-636-4578
rebecca.brady@cchmc.org
Rebecca C. Brady, MD
Director, Adult Clinical Services
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsAdult and pediatric infectious disease Research InterestsCytomegalovirus and other viral infections
Biography
Education and Training
MD: University of Kentucky, Lexington, KY, 1988. Residency: Internal Medicine/Pediatrics, University of Louisville, Louisville, KY. Fellowships: Pediatric Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio; Adult Infectious Diseases, University of Cincinnati, Cincinnati, OH. Certifications: Pediatrics, 1992, recertified 1999; Internal Medicine, 1993; Pediatric Infectious Diseases, 1997; Adult Infectious Diseases, 1997.
Publications
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Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine. 2010 Dec 6;28(52):8258-67.
Brady RC. Influenza. Adolesc Med State Art Rev. 2010 Aug;21(2):236-50, viii.
Subbramanian RA, Basha S, Brady RC, Hazenfeld S, Shata MT, Bernstein DI. Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutinin. Hum Immunol. 2010 Oct;71(10):957-63.
Brady RC, Treanor JJ, Atmar RL, Keitel WA, Edelman R, Chen WH, Winokur P, Belshe R, Graham IL, Noah DL, Guo K, Hill H. Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults. Vaccine. 2009 Aug 13;27(37):5091-5. de Bruyn G, Vargas-Cortez M, Warren T, Tyring SK, Fife KH, Lalezari J, Brady RC, Shahmanesh M, Kinghorn G, Beutner KR, Patel R, Drehobl MA, Horner P, Kurtz TO, McDermott S, Wald A, Corey L. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine.2006; 24:914-20. Treanor JJ, Schiff GM, Couch RB, Cate TR, Brady RC, Hay M, Wolff M, She D, Cox MMJ. Dose-related safety and immunogenicity of a trivalent baculovirus-expressed influenza-virus hemagglutinin vaccine in elderly adults. Journal of Infectious Diseases. 2006; 193:1223-8. Treanor JJ, Schiff GM, Hayden FG, Brady RC, Hay CM, Meyer AL, Holden-Wiltse J, Liang H, Gilbert A, Cox M. Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trial. Journal of the American Medical Association. 2007; 297:1577-82. Couch RC, Winokur P, Brady RC, Belshe R, Chen WH, Cate TR, Sigurdardottir B, Hoeper A, Graham IL, Edelman R, He F, Nino D, Capellan J, Ruben FL. Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects.Vaccine. 2007; 25:7656-63.
Grants
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Rhonda Cardin, PhD
studies the viral/host interactions that contribute to cytomegalovirus (CMV) pathogenesis and latency. Her lab recently identified the first CMV gene, M33, that plays a critical role in CMV latency. Her current studies aim to identify the mechanisms of M33 function in latency and may lead to therapies to control long-term latent CMV infection.
513-636-2420
rhonda.cardin@cchmc.org
Rhonda Cardin, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
The research focus of the Cardin lab is to understand the virus-host interactions that are important for CMV pathogenesis and immunological control of long term latent CMV infection. CMV encodes viral homologs to host proteins (such as IL-10, TNF, chemokine receptors) that interfere with the host immune response by immune evasion or by mimicry. Understanding the advantages provided by 'hijacking' of host proteins by CMV will lead to the development of effective vaccine strategies.
Biography
Education and Training
BA: Biology and Psychology, Washington University, St. Louis, Missouri, 1983.
PhD: Microbiology, Louisiana State University, Baton Rouge, Louisiana, 1989.
Publications
View PubMed Publications
Bravo FJ, Bernstein DI, Beadle JR, Hostetler KY, Cardin RD. Oral Hexadecyloxypropyl-Cidofovir (HDP-CDV) Therapy of Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection. Antimicrob Agents Chemother. 2010 Nov 15. [Epub ahead of print]
Farley N, Bernstein DI, Bravo FJ, Earwood J, Sawtell N, Cardin RD. Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. Antiviral Res. 2010 May;86(2):188-95. Epub 2010 Feb 16.
Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A. Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Virol J. 2009 Dec 2;6:214.
Cardin RD, Schaefer GC, Allen JR, Davis-Poynter NJ, Farrell HE. The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency. J Virol. 2009 Aug;83(15):7590-601. Epub 2009 May 13.
Bernstein DI, Cardin RD, Bravo FJ, Strasser JE, Farley N, Chalk C, Lay M, Fairman J. Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines. Clin Vaccine Immunol. 2009 May;16(5):699-705. Epub 2009 Mar 11.
Bravo FJ, Cardin RD, Bernstein DI. A model of human cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 2007 Nov;76(2):104-10. Epub 2007 Jul 10.
Bravo FJ, Cardin RD, Bernstein DI. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006 Feb 15;193(4):591-7. Epub 2006 Jan 13.
Grants
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Beverly L. Connelly, MD
Director, Infection Control Program
is interested in the epidemiology of vaccine-preventable diseases with a particular focus on influenza and pertussis. She is also interested in the epidemiology and prevention of healthcare-associated infections with a focus on device-related infections. In addition, she is interested in healthcare quality improvement initiatives.
513-636-8492
beverly.connelly@cchmc.org
Beverly L. Connelly, MD
Director, Infection Control Program
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsHospital infection control; post-graduate medical education programs; vaccine preventable disease; antibiotic resistance Research InterestsVaccine preventable pediatric infections; neural persistence of herpes viruses
Biography
Education and Training
MD: Medical College of Georgia, Augusta, Ga., 1979. Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1979-1982. Fellowship: Pediatric Infectious Disease, Children's Hospital Medical Center, Cincinnati, Ohio, 1983-1986. Certification: Pediatrics, 1984; Pediatric Infectious Diseases, 1994, recertified, 2000.
Grants
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Tibor Farkas, DVM, PhD
is interested in the development of animal and tissue culture models for calicivirus gastroenteritis by utilizing unique tissue culture adaptable primate-enteric caliciviruses. He hopes to address fundamental questions of pathobiology, immunity, host susceptibility, virus replication and virus-host interactions.
513-636-0131
tibor.farkas@cchmc.org
Tibor Farkas, DVM, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Viral gastroenteritis; enteric caliciviruses of humans and animals
Biography
Education and Training
DVM: University of Veterinary Medical Sciences, Budapest, Hungary, 1988.
PhD: United Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi, Japan, 1998.
Publications
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Farkas T, Cross RW, Hargitt E 3rd, Lerche NW, Morrow AL, Sestak K. Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses. J Virol. 2010 Sep;84(17):8617-25.
Farkas T, Dufour J, Jiang X, Sestak K. Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaques. J Gen Virol. 2010 Mar;91(Pt 3):734-8.
Wei C, Farkas T, Sestak K, Jiang X. Recovery of infectious virus by transfection of in vitro-generated RNA from tulane calicivirus cDNA. J Virol. 2008 Nov;82(22):11429-36.
Tan M, Xia M, Cao S, Huang P, Farkas T, Meller J, Hegde RS, Li X, Rao Z, Jiang X. Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study. Virology. 2008 Sep 30;379(2):324-34.
Farkas T, Sestak K, Wei C, Jiang X. Characterization of a rhesus monkey calicivirus representing a new genus of Caliciviridae.J Virol. 2008 Jun;82(11):5408-16.
Xia M, Farkas T, Jiang X. Norovirus capsid protein expressed in yeast forms virus-like particles and stimulates systemic and mucosal immunity in mice following an oral administration of raw yeast extracts. J Med Virol. 2007 Jan;79(1):74-83.
Farkas T, Deng X, Ruiz-Palacios G, Morrow A, Jiang X. Development of an enzyme immunoassay for detection of sapovirus-specific antibodies and its application in a study of seroprevalence in children. J Clin Microbiol. 2006 Oct;44(10):3674-9.
Huang P, Farkas T, Zhong W, Tan M, Thornton S, Morrow AL, Jiang X. Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns.J Virol. 2005 Jun;79(11):6714-22.
Thornton SA, Sherman SS, Farkas T, Zhong W, Torres P, Jiang X. Gastroenteritis in US Marines during Operation Iraqi Freedom. Clin Infect Dis. 2005 Feb 15;40(4):519-25.
Farkas T, Nakajima S, Sugieda M, Deng X, Zhong W, Jiang X. Seroprevalence of noroviruses in swine.J Clin Microbiol. 2005 Feb;43(2):657-61.
Grants
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Robert W. Frenck, Jr., MD
Director, Clinical Medicine
has been working on the clinical testing of the 13-valent conjugate pneumococcal vaccine. Current trials include use of the vaccine in children who have undergone bone marrow transplant. He also developed evaluation of a model for norovirus infection, and will be leading a series of clinical trials to test a new candidate vaccine to prevent infections by Shigella.
513-803-3164
robert.frenck@cchmc.org
Robert W. Frenck, Jr., MD
Director, Clinical Medicine
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Vaccine research; enteric diseases; travel medicine
Biography
Robert W. Frenck, Jr, MD, received his undergraduate degree from the University of California at San Diego in 1977 followed by his doctor of medicine degree from the University of Texas Health Science Center at Houston in 1981. He trained at the National Naval Medical Center in Bethesda, Maryland completing his pediatric residency in 1984. After 3 years as a general pediatrician at the US Naval Hospital, Japan, he entered pediatric infectious disease fellowship training at the University of Texas Health Science Center at Houston which he completed in 1990. Dr. Frenck is board-certified in both pediatrics and infectious diseases. Dr. Frenck's research interests include therapeutic and vaccine clinical trials with special interest in enteric diseases. After completing a 25 year career in the Navy, Dr. Frenck joined the UCLA Center for Vaccine Research in 2004 and served until 2006 as Director of the Center and a Professor of Pediatrics at UCLA School of Medicine. Dr. Frenck has been active in the American Academy of Pediatrics and currently serves on the Red Book Committee. He is an acknowledged authority in infectious diseases and has authored over 60 articles and book chapters on various aspects of this subject.
Education and Training
BA: University of California at San Diego, San Diego, CA, 1977.
MD: University of Texas Medical School at Houston, Houston, TX, 1981.
Internship and Residency: US Naval Hospital, Bethesda, MD, 1981 - 1984.
Fellowship: Pediatric Infectious Diseases, University of Texas Medical School at Houston, Houston, TX, 1987 - 1990.
Publications
View PubMed Publications
Riddle MS, Rockabrand DM, Schlett C, Monteville MR, Frenck RW, Romine M, Ahmed SF, Sanders JW. A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the multinational force and observers, sinai, egypt.Am J Trop Med Hyg. 2011 Jan;84(1):59-64. Schlaudecker EP, Frenck RW Jr. Adolescent pneumonia.Adolesc Med State Art Rev. 2010 Aug;21(2):202-19, vii-viii. Review. Braverman PK, Frenck RW Jr, Holland-Hall C. Infectious diseases and immunizations. Preface. Adolesc Med State Art Rev. 2010 Aug;21(2):xii. No abstract available. Matson DO, Abdel-Messih IA, Schlett CD, Bok K, Wienkopff T, Wierzba TF, Sanders JW, Frenck RW Jr. Rotavirus genotypes among hospitalized children in Egypt, 2000-2002. J Infect Dis. 2010 Sep 1;202 Suppl:S263-5. Frenck RW Jr, Seward JF. Varicella vaccine safety and immunogenicity in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids. Arthritis Care Res (Hoboken). 2010 Jul;62(7):903-6. No abstract available. Mansour AM, Nakhla II, Sultan YA, Frenck RW Jr. Brucella meningitis: first reported case in Egypt. East Mediterr Health J. 2009 Jul-Aug;15(4):1040-4. No abstract available. Porter CK, Riddle MS, Tribble DR, Putnam SD, Rockabrand DM, Frenck RW, Rozmajzl P, Kilbane E, Fox A, Ruck R, Lim M, Johnston J, Murphy E, Sanders JW. The epidemiology of travelers' diarrhea in Incirlik, Turkey: a region with a predominance of heat-stabile toxin producing enterotoxigenic Escherichia coli.Diagn Microbiol Infect Dis. 2010 Mar;66(3):241-7. Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 Jan;105(1):148-54. Frenck RW, Fathy H, Sherif M, Mohran Z, El Mohammedy, Francis HW, Rockabrand D, Mounir BI, Rozmajzl P, Frierson H. Sensitivity and Specificity of Various Tests for the Diagnosis of H. pylori in Egyptian Children. Pediatrics; 2006;118:e1195-1202. Monteville MR, Riddle MS, Baht U, Putnam SD, Frenck RW, Brooks K, Moustafa M, Bland J, Sanders JW. Incidence, Etiology and Impact of Diarrhea Among Deployed US Military Personnel in Support of Operation Iraqi Freedom and Operation Enduring Freedom. Am Soc Trop Med Hyg; 2006;75:762-7.
Grants
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Xi Jason Jiang, PhD
focuses on enteric viruses causing acute gastroenteritis, mainly the human noroviruses and rotaviruses. His major approaches include molecular virology, recombinant technology, epidemiology, immunology and bioinformatics. He is also interested in development of vaccine and antivirals against these important pathogens.
513-636-0119
jason.jiang@cchmc.org
Xi Jason Jiang, PhD
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Infectious diseases; viral gastroenteritis
Biography
Education and Training
BS: Public Health, Shanghai Medical University, 1978.
PhD: Baylor College of Medicine, Houston, Texas, 1988.
Post-doctoral fellow: Baylor College of Medicine, Houston, Texas, 1993.
Publications
View PubMed Publications
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants.J Pediatr. 2011 Jan 20. Tan M, Fang PA, Xia M, Chachiyo T, Jiang W, Jiang X. Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles.Virology. 2011 Feb 20;410(2):345-52. Tan M, Huang P, Xia M, Fang PA, Zhong W, McNeal M, Wei C, Jiang W, Jiang X. Norovirus P particle, a novel platform for vaccine development and antibody production.J Virol. 2011 Jan;85(2):753-64. Tan M, Jiang X. Norovirus gastroenteritis, carbohydrate receptors, and animal models. PLoS Pathog. 2010 Aug 26;6(8). pii: e1000983. Review. Farkas T, Dufour J, Jiang X, Sestak K. Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaques.J Gen Virol. 2010 Mar;91(Pt 3):734-8. Tan M, Xia M, Chen Y, Bu W, Hegde RS, Meller J, Li X, Jiang X. Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution.PLoS One. 2009;4(4):e5058. Huang P, Morrow AL, Jiang X. The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognition.Glycoconj J. 2009 Nov;26(8):1085-96. Tan M, Fang P, Chachiyo T, Xia M, Huang P, Fang Z, Jiang W, Jiang X. Noroviral P particle: structure, function and applications in virus-host interaction.Virology. 2008 Dec 5;382(1):115-23. Wei C, Farkas T, Sestak K, Jiang X. Recovery of infectious virus by transfection of in vitro-generated RNA from tulane calicivirus cDNA.J Virol. 2008 Nov;82(22):11429-36. Tan M, Xia M, Cao S, Huang P, Farkas T, Meller J, Hegde RS, Li X, Rao Z, Jiang X. Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study.Virology. 2008 Sep 30;379(2):324-34.
Grants
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Monica Malone McNeal, MS
Associate Director, Laboratory of Specialized Clinical Studies
directs the Laboratory for Specialized Clinical Studies, which develops and performs state-of-the-art assays for assessment of viruses and human immune responses.
513-636-7648
monica.mcneal@cchmc.org
Monica Malone McNeal, MS
Associate Director, Laboratory of Specialized Clinical Studies
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
Clinical InterestsVaccine development; rotavirus; influenza and CMV Research InterestsImmunology of rotavirus infection
Biography
Monica Malone McNeal, MS, is a virologist in the Division of Infectious Diseases at Cincinnati Children’s Hospital Medical Center. She has more than 23 years of experience in rotavirus research. She has established an adult mouse model that has been used extensively in this facility and labs around the world. Her major expertise is in immunology and vaccine development. Currently she is the Associate Director of the Laboratory for Specialized Clinical Studies. This lab provides support for clinical studies involved in vaccine development. They perform work for several major pharmaceutical companies in addition to supporting other clinical researchers at Cincinnati Children’s.
Education and Training
MS: University of Cincinnati, Cincinnati, OH, 1981.
Publications
View PubMed Publications
Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods.Pediatr Infect Dis J. 2010 Dec;29(12):1083-6. Tan M, Huang P, Xia M, Fang PA, Zhong W, McNeal M, Wei C, Jiang W, Jiang X. Norovirus P particle, a novel platform for vaccine development and antibody production.J Virol. 2011 Jan;85(2):753-64. Ward RL, McNeal MM. VP6: A candidate rotavirus vaccine.J Infect Dis. 2010 Sep 1;202 Suppl:S101-7. Review. Bernstein DI, Farley N, Bravo FJ, Earwood J, McNeal M, Fairman J, Cardin R. The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs.Vaccine. 2010 May 7;28(21):3748-53. Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams.J Pediatr Surg. 2009 Aug;44(8):1479-90. Ward RL, McNeal MM, Steele AD. Why does the world need another rotavirus vaccine?Ther Clin Risk Manag. 2008 Feb;4(1):49-63. Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia.Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G16-G26. McNeal MM, Stone SC, Basu M, Clements JD, Choi AH, Ward RL. IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein.Viral Immunol. 2007 Dec;20(4):571-84. Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication.Surgery. 2007 Aug;142(2):192-201. Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.
Grants
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Nancy M. Sawtell, PhD
leads studies of herpes simplex virus and has identified VP16, the first gene essential for triggering the virus’s emergence from its latent state in the human nervous system. Reactivation of the virus in the brains of older mice carrying the human APOE 4 gene to leads to lesions that resemble Alzheimer’s. Visit the Sawtell Lab.
513-636-7880
nancy.sawtell@cchmc.org
Nancy M. Sawtell, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Molecular mechanisms of herpes virus latency and reactivation; viral persistence; pathogenesis; animal models of disease Visit the Sawtell Lab.
Biography
Education and Training
BA: Chemistry, Case Western Reserve University, 1975. PhD: Pathology and Immunology, University of Cincinnati Medical College, Cincinnati, OH, 1986.
Publications
View PubMed Publications
Farley N, Bernstein DI, Bravo FJ, Earwood J, Sawtell N, Cardin RD. Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. Antiviral Res. 2010 May;86(2):188-95.
Thompson RL, Preston CM, Sawtell NM. De novo synthesis of VP16 coordinates the exit from HSV latency in vivo. PLoS Pathog. 2009 Mar;5(3):e1000352.
Currier MA, Gillespie RA, Sawtell NM, Mahller YY, Stroup G, Collins MH, Kambara H, Chiocca EA, Cripe TP. Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide. Mol Ther. 2008 May;16(5):879-85.
Thompson RL, Sawtell NM. Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo. J Virol. 2006 Nov;80(22):10919-30. Sawtell NM, Thompson RL, Haas RL. Herpes simplex virus DNA synthesis is not a decisive regulatory event in the initiation of lytic viral protein expression in neurons in vivo during primary infection or reactivation from latency. J Virol. 2006 Jan;80(1):38-50.
Sawtell NM. Detection and quantification of the rare latently infected cell undergoing herpes simplex virus transcriptional activation in the nervous system in vivo. Methods Mol Biol. 2005;292:57-72. Sawtell NM, Thompson RL. Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences. J Virol. 2004 Jul;78(14):7784-94. Thompson RL, Shieh MT, Sawtell NM. Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo. J Virol. 2003 Nov;77(22):12319-30.
Sawtell NM. Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation. J Virol. 2003 Apr;77(7):4127-38. Sawtell NM, Thompson RL, Stanberry LR, Bernstein DI. Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo. J Infect Dis. 2001 Oct 15;184(8):964-71.
Grants
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Elizabeth P. Schlaudecker, MD, MPH
uses epidemiology and clinical studies to explore the interplay between maternal and child immunologic responses to immunization. Past studies on respiratory viruses in Honduras have led to her current focus on immunologic responses to influenza. Her primary research goal is to improve the prevention of pediatric infectious diseases worldwide.
513-803-5187
elizabeth.schlaudecker@cchmc.org
Elizabeth P. Schlaudecker, MD, MPH
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Global Health; influenza; prevention of infant infection with maternal immunization
Biography
Elizabeth P. Schlaudecker, MD, MPH, is a faculty member in the Division of Infectious Diseases and the Global Health Center. Dr. Schlaudecker received her medical degree and master's in public health from The University of Cincinnati and completed a pediatrics residency and chief residency at Cincinnati Children's. Dr. Schlaudecker was awarded a Fogarty International Clinical Research Fellowship from the National Institutes of Health in 2009, and she investigated the etiology and seasonality of viral respiratory disease in Honduran children under the age of five. She was awarded the Pediatric Infectious Diseases Society Blue Ribbon Research award in 2011 for similar work in Bangladesh. After joining the faculty of Cincinnati Children's in 2011, she continued her influenza research with a Procter Scholars award. Dr. Schlaudecker has traveled to Honduras, the Dominican Republic, Costa Rica, Ecuador, Kenya, South Africa, and Cameroon as part of her clinical and research training.
Education and Training
MD: University of Cincinnati, Cincinnati, OH, 2003. Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006. Chief Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007. Fellowship: Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011. MPH: Public Health, University of Cincinnati, Cincinnati, OH, 2011. Certification: Pediatrics, 2006.
Publications
View PubMed Publications
Schlaudecker EP, Steinhoff MC, Moore SR. Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries. Curr Opin Infect Dis. 2011 Jul 2. Epub ahead of print.
Schlaudecker EP and Steinhoff MC. Helping mothers prevent influenza illness in their infants. Pediatrics. 2010;126(5):1008-1011.
Schlaudecker EP and Frenck RW. Adolescent pneumonia. Adolesc Med State Art Rev. 2010;21:202-219.
Grants
Comparison of Immunological Responses to Influenza Infection and Immunization in Pregnant and Non-Pregnant Women. Principal Investigator. Cincinnati Children’s Hospital Medical Center. 2011 - 2013.
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Mary Allen Staat, MD, MPH
Director, International Adoption Center
is interested in population-based epidemiological surveillance studies in order to understand what viral and bacterial diseases are circulating at any given time, as well as to evaluate the efficacy of vaccines for these agents. She has also been a leader in the medical and psychological evaluation of internationally adopted children.
513-636-2877
mary.staat@cchmc.org
Mary Allen Staat, MD, MPH
Director, International Adoption Center
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsHelicobacter pylori, rotavirus epidemiology, travel medicine and infectious diseases of international adoptees Research InterestsEpidemiology of enteric infections and surveillance of infectious diseases
Biography
Mary Allen Staat, MD, MPH, is director of the International Adoption Center and a member of the Infectious Disease Division at Cincinnati Children's Hospital Medical Center. Dr. Staat is a board-certified pediatrician and is also board-certified in Infectious Disease and Preventive Medicine. She is an associate professor of Pediatrics at the University of Cincinnati and a faculty member of the Cincinnati Children's Hospital Research Foundation.
Education and Training
MD: University of Kentucky, Lexington, Ky., 1986. MPH: Johns Hopkins University, Baltimore, Md., 1991. Residency: Pediatrics, Baylor College of Medicine, Houston, Texas, 1986-1989; Preventive Medicine, Johns Hopkins University, Baltimore, Md., 1990-1994. Fellowship: Infectious Diseases, Baylor College of Medicine, Houston, Texas, 1989-1990; Epidemiology, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Md., 1990-1993. Certification: Pediatrics, 1989; Preventive Medicine, 1996; Pediatric Infectious Diseases, 1999.
Publications
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Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6. Abdulla RY, Rice MA, Donauer S, Hicks KR, Poore D, Staat MA. Hepatitis A in internationally adopted children: screening for acute and previous infections. Pediatrics. 2010 Nov;126(5):e1039-44. Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010 Nov 23;28(50):7947-55. Fairbrother G, Cassedy A, Ortega-Sanchez IR, Szilagyi PG, Edwards KM, Molinari NA, Donauer S, Henderson D, Ambrose S, Kent D, Poehling K, Weinberg GA, Griffin MR, Hall CB, Finelli L, Bridges C, Staat MA; New Vaccine Surveillance Network (NVSN). High costs of influenza: Direct medical costs of influenza disease in young children. Vaccine. 2010 Jul 12;28(31):4913-9. Mast TC, Walter EB, Bulotsky M, Khawaja SS, DiStefano DJ, Sandquist MK, Straus WL, Staat MA. Burden of childhood rotavirus disease on health systems in the United States. Pediatr Infect Dis J. 2010 Feb;29(2):e19-25.
Payne DC, Szilagyi PG, Staat MA, Edwards KM, Gentsch JR, Weinberg GA, Hall CB, Curns AT, Clayton H, Griffin MR, Fairbrother G, Parashar UD. Secular variation in United States rotavirus disease rates and serotypes: implications for assessing the rotavirus vaccination program. Pediatr Infect Dis J. 2009 Nov;28(11):948-53.
Dickey M, Jamison L, Michaud L, Care M, Bernstein DI, Staat MA. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis J. 2009 Apr;28(4):318-21. Linam WM, Margolis PA, Staat MA, Britto MT, Hornung R, Cassedy A, Connelly BL. Risk factors associated with surgical site infection after pediatric posterior spinal fusion procedure. Infect Control Hosp Epidemiol. 2009 Feb;30(2):109-16.
Stadler LP, Mezoff AG, Staat MA. Hepatitis B virus screening for internationally adopted children. Pediatrics. 2008 Dec;122(6):1223-8. Yee EL, Staat MA, Azimi P, Bernstein DI, Ward RL, Schubert C, Matson DO, Turcios-Ruiz RM, Parashar U, Widdowson MA, Glass RI. Burden of rotavirus disease among children visiting pediatric emergency departments in Cincinnati, Ohio, and Oakland, California, in 1999-2000. Pediatrics. 2008 Nov;122(5):971-7.
Grants
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Mark C. Steinhoff, MD
Director, Global Health Center
is interested in the broad effects of immunization in prevention of illness both in US and low-resource regions. The Mother’s Gift project of antenatal maternal immunization with influenza vaccine showed protection of mothers and their unvaccinated infants, as well as increased birth weights of the newborns. His team is currently evaluating antenatal influenza vaccine in 3,600 pregnant women in S. Asia to assess the broader effects of prevention of influenza. In Cincinnati, they are evaluating the safety and immunogenicity of influenza vaccines provided to mothers after delivery. They are also carrying out a prospective antepartum influenza vaccine study to assess the differences in immune response between healthy pregnant and nonpregnant women.
513-636-1376
mark.steinhoff@cchmc.org
Mark C. Steinhoff, MD
Director, Global Health Center
Academic Information
Professor, UC Department of Pediatrics
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Biography
Education and Training
MD: University of Chicago, Chicago, Illinois, 1973. Residency and Chief Residency: Pediatrics, University of Rochester Medical Center, Rochester, New York. Fellowship, Infectious Diseases: University of Rochester Medical Center, Rochester, New York. Certification: New York State Medical License, 1976; Pediatrics, 1978; Tamil Nadu Medical Council (India), 1980; Michigan Medical License, 1985; Maryland Medical License, 1986; Ohio Medical License, 2010; Pediatric Infectious Diseases Society, 1988.
Publications
View PubMed Publications
Omer SB, Goodman D, Steinhoff MC, et al. Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study. PLoS Med. 2011;8:e1000441. McNeil SA, Dodds LA, Fell DB, et al. Effect of respiratory hospitalization during pregnancy on infant outcomes. Am J Obstet Gynecol. 2011;204:S54-7. Steinhoff MC. Influenza in young children: burden, immunisation, and policy. Lancet Infect Dis. 2011 Jan;11(1):2-3. Schlaudecker EP, Steinhoff MC. Helping mothers prevent influenza illness in their infants. Pediatrics. 2010 Nov;126(5):1008-11.
Tamma PD, Steinhoff MC, Omer SB. Influenza infection and vaccination in pregnant women. Expert Rev Respir Med. 2010 Jun;4(3):321-8. Steinhoff MC, Omer SB, Roy E, Arifeen SE, Raqib R, Altaye M, Breiman RF, M B B S KZ. Influenza immunization in pregnancy--antibody responses in mothers and infants. N Engl J Med. 2010 Apr 29;362(17):1644-6.
Tamma PD, Ault KA, del Rio C, Steinhoff MC, Halsey NA, Omer SB. Safety of influenza vaccination during pregnancy. Am J Obstet Gynecol. 2009 Dec;201(6):547-52. Verghese VP, Friberg IK, Cherian T, Raghupathy P, Balaji V, Lalitha MK, Thomas K, John TJ, Steinhoff MC. Community effect of Haemophilus influenzae type b vaccination in India. Pediatr Infect Dis J. 2009 Aug;28(8):738-40.
Minz S, Balraj V, Lalitha MK, Murali N, Cherian T, Manoharan G, Kadirvan S, Joseph A, Steinhoff MC. Incidence of Haemophilus influenzae type b meningitis in India. Indian J Med Res. 2008 Jul;128(1):57-64. Zaman K, Roy E, Arifeen SE, Rahman M, Raqib R, Wilson E, Omer SB, Shahid NS, Breiman RF, Steinhoff MC. Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med. 2008 Oct 9;359(15):1555-64.
Grants
Infant effects of maternal influenza immunization: a randomized double blind controlled field trial in Guatemala. Co-Investigator. National Institutes of Health. 2010-2012. A randomized, double-blind trial, comparing the safety in mothers and their infants and immunogenicity in mothers of live attenuated influenza vaccine (LAIV) to inactivated trivalent influenza vaccine (TIV) when administered to breast feeding women. Principal Investigator. National Institutes of Health. 2010-2013. Epidemiology and burden of influenza in children, Suzhou, Jiangsu Province, People’s Republic of China. Co-Investigator. Centers for Disease Control and Prevention. 2010-2013.
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Ming Tan, PhD
is interested in understanding the initial steps of human norovirus infection and in developing strategies to prevent the infection. His research focuses on the structure-function relationship of norovirus capsid to understand how norovirus interacts with host cells through the viral receptors that have recently been identified as human histo-blood group antigens.
513-636-0510
ming.tan@cchmc.org
Ming Tan, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Noroviruses; human caliciviruses; viral gastroenteritis
Biography
Education and Training
PhD University of Münster, Münster, Germany, 1997.
Publications
View PubMed Publications
Chen YT, Tan M, Xia M, Hao N, Zhang XJ, Huang PW, Jiang X, Li XM, Rao ZH. Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity selected by human histo-blood group antigen receptors. PLoS Pathogens. 2011. Tan M, Jiang X. Norovirus-host interaction: multi-selections by the human HBGAs. Trends in Microbiology. 2011.
Tan M, Fang PA, Xia M, Chachiyo T, Jiang W, Jiang X. Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles. Virology. 2011 Feb 20;410(2):345-52. Tan M, Huang P, Xia M, Fang PA, Zhong W, McNeal M, Wei C, Jiang W, Jiang X. Norovirus P particle, a novel platform for vaccine development and antibody production. J Virol. 2011 Jan;85(2):753-64. Yang Y, Xia M, Tan M, Huang PW, Zhong WM, Pang XL, Lee BE, Meller J, Wang T, and Jiang X. Genetic and phenotypic characterization of GII-4 noroviruses isolated in 1987-2008. Journal of Virology. 2010 Sep; 84(18): 9595-607.
Tan M, and Jiang X. Norovirus gastroenteritis, carbohydrate receptors and animal models. PLoS Pathogen. 2010 Aug 26;6(8).
Tan M, Xia M, Chen Y, Bu W, Hegde RS, Meller J, Li X and Jiang X. Conservation of Receptor Binding Interfaces, Evidence of Human HBGA selection in Norovirus Evolution . PLoS One. 2009; 4(4): e5058.
Tan M, Fang P, Chachiyo T, Xia M, Huang P, Fang Z, Jiang W and Jiang X. Noroviral P Particle: Structure, Function and Applications in Virus-Host Interaction . Virology. 2008; 382 (1):115-123.
Jin M, Xie HP, Duan ZJ, Liu N, Zhang Q, Wu BS, Li HY, Cheng WX, Yang SH, Yu JM, Xu ZQ, Cui SX, Zhu L, Tan M, Jiang X and Fang ZY. Emergence of the GII4/2006b Variant and Recombinant Noroviruses in China . Journal of Medical Virology. 2008; 80(11):1997-2004.
Tan M, Xia M, Cao S, Huang P, Farkas T, Meller J, Hegde RS, Li X, Rao Z and Jiang X. Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study . Virology. 2008; 379(2):324-334.
Grants
Noroviral P particle, a multifunctional platform for vaccine development. Principal Investigator. National Institutes of Health. June 2011 - May 2013. Norwalk-like viruses and their receptors. Co-Investigator. National Institutes of Health. Sep 2010 - Apr 2015.
Novel vaccine against norovirus. Co-Principal Investigator. National Institutes of Health. May 2010 - Apr 2015.
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