• Current Projects

    Quantification of PAO Accumulation in Human Cardiomyopathy Specimens
    In this project we are studying hearts explanted from adults with end stage heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy. Using an antibody that recognizes a PAO conformer, we are able to quantify the amount of myocardium occupied by PAO. Correlations of PAO accumulation with markers of altered intracellular homeostasis, patient age, clinical cardiac status and comorbidities are also focuses of this project.

    Funding: RO1 HL087862-01A1
    Principle Investigator:  Jeffrey Robbins NIH / NHLBI

    Echocardiography of Murine Species
    The Mouse Echocardiography Core is currently supporting a variety of mouse and rat cardiac projects in molecular cardiovascular biology including studies of hypertrophic and dilated cardiomyopathies, congenital cardiac malformations and cardiac valve dysfunction. In addition to adult and juvenile mouse echocardiography, detailed anatomic and functional studies are also performed in fetal rats and mice.

    Cine loop of a mouse with normal left ventricular size and systolic function.

    Cine loop of a mouse with left ventricular dilation and depressed systolic function.

    Cine loop of a mouse with left ventricular hypertrophy and depressed systolic function.

    Cine loop of fetal mouse at embryonic day 18.5.

  • Confocal imaging of preamyloid oligomer (PAO) staining.

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  • Representative images of mouse echocardiography with a 30MHz transducer.

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