Robbins Lab

McLendon PM, Robbins J. Desmin-related cardiomyopathy: an unfolding story. AJP: Heart and Circulatory Physiology June, 2011. 

Li J, Horak KM, Su H, Sanbe A, Robbins J, Wang XJ. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. J. Clinical Invest. July, 2011. 

Robbins J. Twenty years of gene targeting: what we don’t know. Circ. Res. Sept. 2011. 

Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avrikin A, Lasko V, Lorenz JN, Maille, M, Martin JM, Heller-Brown J, Bers DM, Molkentin JD, James J, Robbins J. A critical function for ser-282 in cardiac myosin binding protein-c phosphorylation and cardiac function.Circ. Res. 109: 145-150. 2011. 

Li X, Chan TO, MyersV,Zhang X-Q, Song J, Zhang J, Funakoshi H, Robbins J, Koch WJ, Cheung JY, Feldman AM. Controlled and cardiac-restricted overexpression of the arginine vasopressin v1a receptor causes reversible left ventricular dysfunction through Ga_q-mediated cell signaling. Circulation. 124: 572-581.2011. 

James J, Robbins J. Treating heart failure by altering muscle motor function. Circ. Res. 109: 5-7. 2011. 

Pattison JS,  Robbins J. Autophagy and proteotoxicity in cardiomyocytes. Autophagy 7: 1-2. 2011. 

Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryAB^R120G cardiomyocytes. Circ. Res. 109: 151-160. 2011. 

Mun JY, Gulick J, Robbins J, Woodhead J, Lehman W, Craig R. Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C).  J. Mol. Biol. 410: 214-225. 2011. 

Stanley BA, Graham DR, James J, Mitsak M, Tarwater PM, Robbins J, Van Eyck JE. Altered myofilament stoichiometry in response to heart failure in a cardioprotective a-myosin heavy chain transgenic rabbit model Proteomics 5: 147-158. 2011. 

James J, Robbins J. Signaling and myosin binding protein-C.  J. Biol. Chem. 286: 9913-9919. 2011.

Maloyan A, Sayegh J, Osinska H, Chua BHL, Robbins J. Manipulation of death pathways in desmin-related cardiomyopathy. Circ. Res. May, 2010.

Maloyan A, Robbins J. Autophagy in desmin-related cardiomyopathy: Thoughts at the halfway point. Autophagy. Jul, 2010.

James J, Hor K, Moga MA, Martin L, Robbins J. Effects of myosin heavy chain manipulation in experimental heart failure. J. Mol. Cell. Cardiology. May, 2010.

Heineke J, Wollert KC, Osinska H, Sargent M, York AJ, Robbins J, Molkentin J. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. J. Mol. Cell. Cardiology. 48: 1080-1087. 2010.

Maillet M, Davis J, Auger-Messier M, York A, Osinska H, Piquereau J, Lorenz JN, Robbins J, Ventura-Clapier R, Molkentin JD. Heart-specific deletion of CNB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. J. Biol. Chem. 2865: 6716-6724. 2010.

Terrell D, Robbins J. Protein conformation-based disease: getting to the heart of the matter. Annual Review Physiol. 72: 1-3. 2010.

Bardswell SC, Cuello F, Rowland A, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkirin M. Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca²⁺sensitivity and cross-bridge cycling. J. Biol. Chem. 285: 5674-5682. 2010.

Nakamura T, Gulick J, Colbert MC, Robbins J. Protein tyrosine phosphatase activity in neural crest is essential for normal heart and skull development. Proc. Natl. Acad. Sci., U S A. 106:11270-11275. 2009.

Nakamura T, Gulick J, Pratt R, Robbins J. Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations. Proc. Natl. Acad. Sci., U S A. 106: 15436-15441. 2009.

Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass D, Lorenz JN, Robbins J. Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy. Circ. Res. 104: 1021-1028. 2009.

Xiang FL, Hammoud L, Robbins J, Feng Q. Cardiomyocyte-specific overexpression of human stem cell factor improves cardiac function and survival post myocardial infarction in mice. Circulation. 120: 1065-1074. 2009.

Itoh H, MacGillivray C,Kwon HS, Lammerding J, Robbins J, Lee R, So P. Three-dimensional cardiac architecture determined by two-photon microtomy. J. Biomedical Optics. Jul-Aug, 2009.

Nakayama H, Bodi I, Chen X, Lorenz JN, Houser SR, Robbins J, Schwartz A, Molkentin JD. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J Clin Invest. 119: 3787-3796. 2009.

Nicolaou P, Rodriguez P, Zhou X, Ren X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar R, Jones K, Kranias EG. Inducible expression of active protein phospphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemic/reperfusion injury. Circ Res. 104: 1012-1020. 2009.

Suzuki T, Palmer BM, James J, Yuan Wang Y, Chen Z, VanBuren P, Maughan DW, Robbins J, LeWinter MM. Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbits. Circulation, Heart Failure. Jul, 2009.

Sadayappan S, Klevitsky R, Lorenz JN, Sargent M, Gulick J, Molkentin JD, Robbins J. Cardiac myosin binding protein-C phosphorylation in a beta-myosin heavy chain background. Circulation. 119: 1253-1262. 2009.

Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe P, Geenen DL, Buttrick PM, Solaro RJ. Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem. 285: 5097-5106. 2009.

Wu X, Blair NS, Sargent M, York AJ, Robbins J, Shull G, Molkentin JD. Plasma membrane Ca²⁺-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition. J Clin Invest. 119: 976-985. 2009.

Waggoner J, Ginsburg K, Bersohn M, Mitton B, Haghighi K, Robbins J, Bers D, Kranias E. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. Am J Physiol. 296: H698-703. 2009.

Gulick J, Robbins J. Cell-type-specific transgenesis in the mouse. Methods in Molecular Biology. 561: 91-106. 2009.

Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, Robbins J. Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci, U S A. 105: 18930-18936. 2008.

Pattison JS, Robbins J. Protein misfolding and cardiac disease: Establishing cause and effect.Autophagy. 4(6). 2008.

Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, Ingwall JS. Calcineurin-induced energy wasting in a transgenic mouse model of heart failure. Am J Physiol Heart Circ Physiol. 294: H1459-1466. 2008.

Molkentin J, Robbins J. With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. JMCC. 46: 130-136. 2008.

Moga MA, Nakamura T, Robbins J. Genetic approaches for changing the heart. JMCC. 45: 148-155. 2008.

Pattison JS, Sanbe A, Maloyan A, Martin L, Osinska H, Klevitsky R, Robbins J. Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation. 117: 2743-2751. 2008.

Jaleel N, Nakayama H, Chen X, Kubo H, MacDonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, Houser SR. Ca²⁺ influx through T- and L-type Ca²⁺ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circ Res. 103: 1109-1119. 2008.

Yano N, Tseng A, Zhao TC, Robbins J, Padbury J, Tseng YT. Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility--a new transgenic model. Am J Physiol Heart Circ Physiol. 295: 1690-1694. 2008.

Lowey S, Lesko LM, Rovner AS, Hodges AR, White SL, Low RB, Gulick J, Robbins J. Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone. J. Biol. Chem. 283: 20579-2089. 2008.

Sadayappan S, Finley N, Howarth JW, Osinska H, Klevitsky R, Lorenz JN, Rosevear PR, Robbins J. Role of the acidic N’ region of cardiac troponin I in regulating myocardial function. FASEB Journal. 22: 1246-1257. 2008.

Sadayappan S, Robbins J. The death of transcriptional chauvinism in the control and regulation of cardiac contractility. NY Acad Sci. 1123: 1-9. 2008.

Pattison JS, Waggoner JR, James J, Martin L, Gulick J, Osinska H, Klevitsky R, Kranias EG, Robbins J. Phospholamban overexpression in transgenic rabbits. Transgenic Res. 17: 157-170. 2008.

Millay DP, Sargent MA, Osinska H, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature Med. 14: 442-447. 2008.

Wolf CM, Arad M, Ahmad F, Bernstein SA, Toka O, Morley G, Robbins J, Seidman JG, Seidman CE, Berul CI. Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 117: 144-154. 2008.

Pinz I, Robbins J, Benjamin IJ, Ingwall J. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 22: 84-92. 2008.

Krenz M, Sadayappan S, Osinska HE, Henry JA, Beck S, Warshaw DM, Robbins J. Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. J. Biol. Chem. 282: 24057-24064. 2007.

Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD. Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. Am. J. Physiol. Heart Circ. Physiol. 293: H3768-H3771. 2007.

Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholm TM, Molkentin JD. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J. Clin. Invest. 117: 3198-3210. 2007.

Nagyama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA. Control of in vivo left ventricular contraction/relaxation kinetics by myosin binding protein C. Circulation. 116: 2399-2408. 2007.

Diwan A, Krenz M, Sayed FM, Wanasapura J, Ren X, Matkovich SJ, Koesters AG, Li H, Kirshenbaum LA, Robbins J, Jones WK, Dorn GW. Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of bnip3 restrains postinfarction remodeling in mice. J. Clin. Invest. 117: 2825-2833. 2007.

Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW 2nd, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ. Res. 101: 313-321. 2007.

Maloyan A, Gulick J, Glabe CG, Kayed R, Robbins J. Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc. Natl. Acad. Sci. U S A. 104: 5995-6000. 2007.

Nakamura T, Colbert M, Krenz M, Molkentin JD, Hahn HS, Dorn GW 2nd, Robbins J. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest. 117: 2123-2132. 2007.

Hsieh PCH, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Med. 13, 970-974. 2007.

Yasuda S-I, Coutu P, Sadayappan S, Robbins J, Metzger JM. Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circ Res. 101: 377-386. 2007.

Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang L, Zhang H, Jaleel N, Chua BHL, Hewett TE, Robbins J, Houser SR, Molkentin JD. Ca²⁺- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin. Invest. 117, 2123-2132. 2007.

Purcell NH, Wilkins BJ, York A, Robbins J, Molkentin J. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.Proc. Natl. Acad. Sci. U S A. 104, 14074-14079. 2007.

Galvez AS,Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J,Lynch RA, Marreez Y, Dorn GW. Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Circ. Res. 100, 1071-1078. 2007.

Nishizawa T, Shen YT, Rossi F, Hong C, Robbins J, Ishikawa J, Sadoshima J, Vatner D, Vatner S. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsa. Am. J. Physiol. 292, H971-975. 2007.

Hoyer K, Krenz M, Robbins J, Ingwall JS. Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency. J. Mol. Cell. Cardiol. 42, 214-221. 2007.

Yutzey KE, Robbins J. Principles of genetic murine models for cardiac disease. Circulation 115: 792-799. 2007.