Robbins Lab

  • Cardiomyocyte expression.

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    Cardiomyocyte expression.

    Cardiomyocyte-specific expression of directed genes. Shown is a summary of the alpha myosin heavy chain promoter sequences that can drive cardiomyocyte-specific expression of any gene product chosen by the laboratory. The top two panels show expression driven by the promoter during fetal development, specifically in the developing atria: this expression is restricted only to the atria before birth. After birth, this particular promoter drives expression throughout, but only in, the heart.

  • cMyBp-C.

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    Shown are the three filament systems that make up the contractile unit of the cardiac muscle cell: myosin (green), actin (orange) and titin (pink-white). The myosin binding protein C’s position in this apparatus is shown, as is its potential for signaling via reversible phosphorylation on distinct sites in the protein.