Molecular Cardiovascular Biology

E-mail this page

(All fields required)

Please enter a valid email.

Please enter your name.

Please enter a valid email.

Molecular Cardiovascular Biology

 

Division Publications

  1. Accornero F, van Berlo JH, Benard MJ, Lorenz JN, Carmeliet P, Molkentin JD. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circulation research. 2011; 109:272-80.
  2. Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA, Stevens MV, Camenisch TD, Conway SJ, Doetschman T. Transforming growth factor Beta2 is required for valve remodeling during heart development. Developmental dynamics : an official publication of the American Association of Anatomists. 2011; 240:2127-41.
  3. Bedard JE, Haaning AM, Ware SM. Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease. PloS one. 2011; 6:e23755.
  4. Cast AE, Gao C, Amack JD, Ware SM. An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis. Developmental biology. 2012; 364:22-31.
  5. Chakraborty S, Yutzey KE. Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Developmental biology. 2012; 363:234-46.
  6. Cheek JD, Wirrig EE, Alfieri CM, James JF, Yutzey KE. Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease. Journal of molecular and cellular cardiology. 2012; 52:689-700.
  7. Czosek RJ, Goldenberg P, Miller EM, Spicer R, Towbin JA, Ware SM. Cardiac electrical system involvement in Alstrom syndrome: uncommon causes of dilated cardiomyopathies. Cardiogenetics. 2012; 2:e2.
  8. Dohn TE, Waxman JS. Distinct phases of Wnt/beta-catenin signaling direct cardiomyocyte formation in zebrafish. Developmental biology. 2012; 361:364-76.
  9. Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD. Decreased cardiac L-type Ca(2) channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation. 2012; 122:280-90.
  10. Goonasekera SA, Molkentin JD. Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte. J Mol Cell Cardiol. 2012; 52:317-22.
  11. Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers DM, Kranias EG. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology. 2012; 52:773-82.
  12. Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA, Jr.. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental cell. 2011; 21:469-78.
  13. Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ. Animal Models of Heart Failure: A Scientific Statement From the American Heart Association. Circ Res. 2012; 111:131-150.
  14. James J, Kinnett K, Wang Y, Ittenbach RF, Benson DW, Cripe L. Electrocardiographic abnormalities in very young Duchenne muscular dystrophy patients precede the onset of cardiac dysfunction. Neuromuscular disorders : NMD. 2011; 21:462-7.
  15. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012; 483:96-9.
  16. Kindel SJ, Miller EM, Gupta R, Cripe LH, Hinton RB, Spicer RL, Towbin JA, Ware SM. Pediatric cardiomyopathy: importance of genetic and metabolic evaluation. J Card Fail. 2012; 18:396-403.
  17. Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCalpha/beta With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury. Circulation research. 2011; 109:1396-400.
  18. Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:493-504.
  19. Lee MP, Yutzey KE. Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. PloS one. 2011; 6:e29758.
  20. Li J, Horak KM, Su H, Sanbe A, Robbins J, Wang X. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. The Journal of clinical investigation. 2011; 121:3689-700.
  21. Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Galphaq-mediated cell signaling. Circulation. 2011; 124:572-81.
  22. Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell metabolism. 2012; 15:545-53.
  23. Liu Q, Chen Y, Auger-Messier M, Molkentin JD. Interaction Between NFkappaB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling. Circulation research. 2012; 110:1077-86.
  24. Liu Q, Molkentin JD. Protein kinase Calpha as a heart failure therapeutic target. J Mol Cell Cardiol. 2011; 51:474-8.
  25. Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A Thrombospondin-Dependent Pathway for a Protective ER Stress Response. Cell. 2012; 149:1257-68.
  26. Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR. A caveolae-targeted L-type Ca(2) channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circulation research. 2012; 110:669-74.
  27. McBride KL, Ware SM. Modifying Mendel: approaches for identification of susceptibility alleles for human cardiovascular malformations. Circ Cardiovasc Genet. 2012; 5:274-6.
  28. McLendon PM, Robbins J. Desmin-related cardiomyopathy: an unfolding story. American journal of physiology. Heart and circulatory physiology. 2011; 301:H1220-8.
  29. Mead TJ, Yutzey KE. Notch signaling and the developing skeleton. Advances in experimental medicine and biology. 2012; 727:114-30.
  30. Mead TJ, Yutzey KE. Notch pathway regulation of neural crest cell development in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:376-89.
  31. Miller EM, Hopkin R, Bao L, Ware SM. Implications for genotype-phenotype predictions in Townes-Brocks syndrome: case report of a novel SALL1 deletion and review of the literature. American journal of medical genetics. Part A. 2012; 158A:533-40.
  32. Muili KA, Ahmad M, Orabi AI, Mahmood SM, Shah AU, Molkentin JD, Husain SZ. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury. American journal of physiology. Gastrointestinal and liver physiology. 2012; 302:G898-905.
  33. Mun JY, Gulick J, Robbins J, Woodhead J, Lehman W, Craig R. Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). Journal of molecular biology. 2011; 410:214-25.
  34. Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW. Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical journal. 2011; 101:1661-9.
  35. Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circulation research. 2011; 109:151-60.
  36. Pattison JS, Robbins J. Autophagy and proteotoxicity in cardiomyocytes. Autophagy. 2011; 7:1259-60.
  37. Quinn ME, Haaning A, Ware SM. Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice. Human molecular genetics. 2012; 21:1888-96.
  38. Robbins J. Twenty years of gene targeting: what we don't know. Circulation research. 2011; 109:722-3.
  39. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research. 2011; 109:141-50.
  40. Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012; 125:1134-46.
  41. Sengupta A, Chakraborty S, Paik J, Yutzey KE, Evans-Anderson HJ. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:803-13.
  42. Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Liu C, Ware S, Stanek J. Ductus arteriosus aneurysm with massive thrombosis of pulmonary artery and fetal hydrops. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2012; 15:79-85.
  43. Sorrell MR, Waxman JS. Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation. Developmental biology. 2011; 358:44-55.
  44. Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM. SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing. Genome Biol. 2011; 12:R91.
  45. Tariq M, Le TT, Putnam P, Kindel SJ, Keddache M, Ware SM. Targeted capture and massively parallel sequencing in pediatric cardiomyopathy: development of novel diagnostics. Cardiogenetics. 2012; 2:e7.
  46. Tranter M, Liu Y, He S, Gulick J, Ren X, Robbins J, Jones WK, Reineke TM. In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20:601-8.
  47. van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:12331-6.
  48. Ware SM, Aygun MG, Hildebrandt F. Spectrum of clinical diseases caused by disorders of primary cilia. Proceedings of the American Thoracic Society. 2011; 8:444-50.
  49. Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. Journal of molecular and cellular cardiology. 2012; 52:219-27.
  50. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, 2nd, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of clinical investigation. 2011; 121:3269-76.
Please give to Cincinnati Children's.
US-News-Honor-Roll-FooterBest Places to Work Logo

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900

New to Cincinnati Children’s or live outside of the tri-state area? 1-877-881-8479

© 1999-2013 Cincinnati Children's Hospital Medical Center