• Research Faculty

  • A photo of Jeffrey Robbins.

    Jeffrey Robbins, PhD Director and Endowed Chair, Molecular Cardiovascular Biology

    established the means to direct the heart to synthesize normal and mutant proteins. They can turn these on and off at will and this allows them to establish cause-and-effect relationships between mutant proteins and the development of cardiac disease. The lab is particularly interested in how protein aggregation can cause cardiac disease but also studies the contractile protein mutations that cause hypertrophic cardiomyopathy and heart failure.
    Visit the Robbins Lab.


    A photo of Burns Blaxall.

    Burns C. Blaxall, PhD, FAHA Director of Translational Science, Heart Institute

    is interested in understanding the molecular mechanisms associated with the development and progression of heart failure. We are particularly interested in developing novel heart failure therapeutics targeting myocardial function and fibrosis. To this end, we also seek to understand the pathologic role of cardiac myocyte and non-myocyte (i.e.. fibroblast) intercellular communication.


    A photo of James D. Gulick.

    James D. Gulick, MS

    is a member of the Robbins lab, studying cardiac structure and function. His interest lies primarily in understanding how certain mutations in contractile protein genes are able to alter the function of the heart.
    Visit the Robbins Lab web site.


    A photo of Jeanne M. James.

    Jeanne M. James, MD

    is a pediatric cardiologist, interested in exploring the pathological processes that lead to abnormal heart function as well as the compensatory phenomena intrinsic to the myocardium that may assist in recovery of function. 
    Visit the James Lab web site.


    A photo of Zaza Khuchua.

    Zaza Khuchua, PhD

    research Interests are mitochondrial structure, function, biogenesis and recycling in normal and pathological heart muscle. More specifically we are interested in defects in cardiac lipid and phospholipid metabolism. We employ genetically engineered mice to model human genetic disorders.


    A photo of Marjorie Maillet.

    Marjorie Maillet, PhD

    is interested in understanding the signaling pathways that lead to cardiac hypertrophy and heart disease. Her current projects aim at defining new signaling pathways that regulate calcineurin and NFAT in the heart as well as characterizing MAP kinases targets associated with cardiac hypertrophy and heart failure.
    Visit the Molkentin lab.


    A photo of Douglas Millay.

    Douglas Millay, PhD

    is interested in understanding how precursor cells fuse to form multi-nucleated skeletal muscle. We recently discovered a necessary component (named myomaker) of the muscle fusion machinery. Our goal is to delineate the mechanisms by which this multi-pass membrane protein directs cell-cell fusion and manipulate muscle cell fusion as a strategy for in vivo cell therapy.
    Visit the Millay Lab website.


    A photo of Jeffery Molkentin.

    Jeffery D. Molkentin, PhD Professor | Howard Hughes Medical Institute Investigator

    is interested in understanding the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation.
    Visit the Molkentin Lab.


    A photo of Enkhsaikhan Purevjav.

    Enkhsaikhan Purevjav, MD, PhD

    focuses on identifying and screening the potential genes responsible for inherited and acquired cardiac diseases, creating in vitro and in vivo cardiomyopathy models and performing functional studies of mutations identified. Additionally, she studies the effects of factors such as viral infections, drugs (ACE inhibitors and beta-blockers) and mechanical stress (cyclic mechanical stretch, acute and chronic exercise) on cardiac function.


    A photo of Joshua Waxman.

    Joshua S. Waxman, PhD Assistant Professor

    uses genetic, molecular and cellular biological techniques to understand the underlying mechanisms of congenital heart defects and cardiomyocyte formation during development.
    Visit the Waxman Lab.


    A photo of Katherine Yutzey.

    Katherine Yutzey, PhD

    is focused on the molecular mechanisms of heart development and disease. Particular emphasis is on signaling pathways and transcription factors that control heart valve development as well as contribute to pediatric and adult valve disease. Additional projects address the development of coronary vasculature, cardiac fibrosis and maturation of cardiac muscle after birth.

    Visit the Yutzey Lab.