• CACN Projects

    Working Together to Change Outcomes

    The Center for Acute Care Nephrology is committed to developing optimal care – and realizing the optimal outcomes – for children with or at risk for acute kidney injury. Through its collaborations, the CACN will conduct projects that explore earlier identification, treatment and prevention of acute kidney injury and acute renal failure.

    • The CACN will conduct one of the first prospective studies to use urinary acute kidney injury (AKI) biomarkers to direct care to prevent or mitigate AKI in infants after cardiac bypass surgery.
    • An ongoing collaborative study with Texas Children’s Hospital is the first to study the effects of dialysis on subclinical kidney injury in infants recovering from cardiac bypass surgery.
    • A first-of-its-kind study will compare peritoneal dialysis and IV furosemide as fluid balance control therapies for infants recovering from cardiac bypass surgery.
    • A combined pediatric and adult study will be the first of its kind to use urinary AKI biomarkers to direct fluid removal therapy using an extracorporeal device.
    • Normal saline (NS) is the standard for fluid resuscitation therapy in the pediatric emergency center setting. But NS can compound acidosis, prolong patient vomiting and lead to extended times in the emergency center. This study will compare NS with an approved but underutilized fluid for fluid resuscitation, which should reverse the acidosis seen in acute gastroenteritis.
    • We will assess new criteria for identifying patients at risk for developing AKI in the PICU. If these criteria are validated, they will serve as the basis for evaluating patients for future diagnostic, therapeutic and interventional trials.
    • Critically ill children with AKI receiving continuous renal replacement therapy (CRRT) are treated with numerous life-saving medications.  The pharmacokinetics of these medications are most likely altered in patients with AKI and receiving CRRT, yet we have few data to guide clinicians in optimal dosing. This study will develop and validate reliable dosing profiles for multiple medications in the AKI/CRRT scenario.
    • We will conduct one of the first prospective studies to utilize newly validated urinary AKI biomarkers to evaluate critically ill children with multiorgan dysfunction syndrome. The biomarkers will allow us to direct early interventions to prevent or mitigate worsening AKI in the patients.
    • The ppCRRT is a collaborative research consortium of 12 US pediatric centers with the aim to study all aspects of pediatric AKI and CRRT.  Currently, 370 patients have been enrolled in the ppCRRT, with 10 publications resulting from this work.  The ppCRRT is in the planning stages of numerous prospective trials to evaluate medications, devices and outcomes in children who develop AKI and require CRRT.
  • The Pediatric Acute Care Nephrology and Dialysis Fellowship

    The Pediatric Acute Care Nephrology and Dialysis Fellowship is designed provide a protected research experience in this critical area of care and foster collaboration among nephrologists, intensive care cardiologists and critical care medicine specialists.

    Learn more about the fellowship.