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Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute
Co-Director, Perinatal Institute
Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Professor, UC Department of Pediatrics
Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy
Visit the Whitsett Lab.
Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.
Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.
Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.
Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.
Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.
Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.
MD: Columbia University, New York, NY, 1973.
Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.
Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6.
Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development.2010 Dec;137(23):3953-63.
Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304.
Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010 Nov 15;347(2):301-14.
Perl AK, Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir Crit Care Med. 2010 Sep 24.
Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2010 Sep 20.
Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13.
Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451.
Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61.
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.
James M. Greenberg, MD Co-Director, Perinatal Institute
investigates the developmental biology of pulmonary vascular development, including how vascular endothelial growth factor (VEGF) mediates pulmonary vascular, lymphatic and airway development. He studies how VEGF mediates organization of pulmonary vasculature during late fetal life as well as how certain proteins implicated in axonal guidance during central nervous system development also direct developmental processes in the lung.
Director, Division of Neonatology
Neonatal chronic lung disease; late preterm infant
MD: University of Illinois College of Medicine, Chicago, IL, 1977-1981.
Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, MN, 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1984.
Fellowship: Immunology/Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.
Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal/Perinatal Medicine, 1989.
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.
Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.
Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.
Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.
Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.
Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.
Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.
Louis J. Muglia, MD, PhD Co-Director, Perinatal Institute
Director, Center for Prevention of Preterm Birth
Visit the Muglia Lab.
Dr. Muglia has pioneered the in vivo analyses of regulation of the endocrine stress response and the molecular pathways leading to birth using novel genetically altered mutant mice. These studies have elucidated the importance of corticotropin-releasing hormone, glucocorticoids, and prostaglandins in neuroendocrine modulation, behavior, and perinatal adaptation. These studies have evolved over the last decade to specifically focus on the mechanisms controlling the timing for birth in humans using genetics and comparative genomics. The composition of the biological clock metering the duration of human gestation remains a central question in reproductive biology. The goal of the Muglia Laboratory is to understand the molecular timing machinery comprising this biological clock to prevent or better treat human preterm labor and delivery.
Among Dr. Muglia’s achievements are more than 180 publications and many awards, including a Burroughs Wellcome Fund Career Development Award in the biomedical sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation and Association of American Physicians. In 2010, Dr. Muglia was elected to fellow in the American Association for the Advancement of Science. He is an active member of the Society for Pediatric Research, Society for Neuroscience, and the Lawson Wilkins Pediatric Endocrine Society. Dr. Muglia currently serves as chair of the Board of Scientific Counselors for the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. In 2013, Dr. Muglia was elected to membership in the Institute of Medicine of the National Academies.
BS: University of Michigan, Ann Arbor, MI, 1981.
PhD: University of Chicago, Chicago, IL, 1986.
MD: University of Chicago, Chicago, IL, 1988.
Plunkett J, Doniger S, Orabona G, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Victoria Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, McGregor TL, McElroy JJ, Oetjens MT, Teramo K, Boreck I, Fay J, Muglia L. An evolutionary genomic approach to identify genes involved in human birth timing. PLoS Genetics. 2011; 7: e1001365.
Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010; 362: 529-535.
Kolber BJ, Boyle MP, Wieczorek L, Kelley CL, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK, Muglia LJ. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci. 2010; 30: 2571-2581.
Plunkett J, Feitosa MF, Trusgnich M, Wangler MF, Palomar L, Kistka ZA-F, DeFranco EA, Shen TT, Stormo EAD, Puttonen H, Hallman M, Haataja R, Luukkonen A, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Teramo K, Borecki I, Muglia LJ. Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity. 2009; 68: 209-219.
Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS, Muglia LJ. Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci USA. 2008; 105: 12004 - 12009.
Roizen J, Asada M, Tong M, Tai H-H, Muglia LJ. Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol. 2008; 22: 105-112.
Kistka Z A-F, Palomar P, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007; 196: 131.e1-131.e6.
Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol. 2003; 17: 1454-1469.
Gross G, Imamura T, Luedke C, Vogt SK, Olson LM, Nelson DM, Sadovsky Y, Muglia LJ. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Proc. Natl. Acad. Sci. USA. 1998; 95: 11871-11875.
Muglia LJ, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995; 373:427-432.
Maternal Temperament, Stress, Inflammation and Preterm Birth. Multi-PI. NIH/NICHD. Sep 2013-Aug 2017.
March of Dimes Prematurity Research Center Ohio Collaborative. Coordinating PI. March of Dimes. Jul 2013-Jun 2018.
Shawn K. Ahlfeld, MD
investigates the effects of neonatal lung injury on alveolar repair and development. Using developmentally-relevant genetic and physiologic approaches, he is identifying the role of interstitial fibroblasts in mechanisms behind alveolar simplification characteristic of bronchopulmonary dysplasia, with the long-term goal of developing novel therapies that promote normal alveolar lung development and function.
Assistant Professor, UC Department of Pediatrics
Neonatal-perinatal medicine; bronchopulmonary dysplasia
As a neonatal fellow and junior faculty, Dr. Ahlfeld has evaluated the role of matricellular proteins in saccular and early alveolar lung development. He and his team has determined that hyperoxia exposure resulted in the mis-expression of the Transforming Growth Factor Beta (TGFβ)-responsive extracellular matrix protein, periostin, during critical periods of saccular-alveolar lung development. Periostin proved to be a novel marker for both normal myofibroblastic activity during alveolarization and abnormal myofibroblastic persistence during late fibrotic stages of lung injury.
Under a scholar grant through the Prematurity and Respiratory Outcomes Program (PROP), they have demonstrated, for the first time, that plasma periostin levels in extremely premature infants during the first weeks of age correlate with the development and severity of BPD. Their investigations into TGFβ superfamily signaling during saccular and alveolar lung development, as well as its role in BPD pathogenesis, are ongoing.
Contrary to the prevailing notion of up-regulation, TGFβ extracellular signaling ligands, intracellular signaling messengers, and down-stream signaling targets are all down-regulated during early hyperoxic lung injury. They have determined that TGFβ down-regulation coincides with a period of saccular-alveolar lung development that is critical for development of distal lung complexity and function. The down-regulation of TGFβ signaling during this critical window of lung development occurs well before the up-regulation of TGFβ signaling associated with chronic hyperoxic lung injury that they and others have described.
Additionally, his team has identified that a second matricellular protein, TGFβ-induced protein (TGFBI), is a novel extracellular matrix protein mis-expressed by neonatal hyperoxia and vital for normal alveolar development.
Their findings have provided new mechanistic targets in BPD pathogenesis and have challenged the paradigm related to the role of TGFβ up-regulation in neonatal lung injury.
MD: Indiana University School of Medicine, Indianapolis, IN, 2005.
Residency: Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
Fellowship: Neonatal-Perinatal Medicine, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
Certification: General Pediatrics, 2008; Neonatal and Perinatal Medicine, 2012.
Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ. Initial suppression of transforming growth factor-β signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia. Am J Pathol. 2016.
Goss KN, Tepper RS, Lahm T, Ahlfeld SK. Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia. Am J Respir Cell Mol Biol. 2015;53(6):902-6.
Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, *Ahlfeld SK, *Lahm T. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L797-806. (* co-senior authorship).
Assaf SJ, Chang DV, Tiller CJ, Kisling JA, Case J, Mund JA, Slaven JE, Yu Z, Ahlfeld SK, Poindexter B, Haneline LS, Ingram DA, Tepper RS. Lung Parenchymal Development in Premature Infants without Bronchopulmonary Dysplasia. Pediatr Pulmonol. 2015;50(12):1313-9.
Beam K, Aliaga S, Ahlfeld S, Cohen-Wolkowiez M, Smith P, Laughon M. A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants. J Perinatol. 2014;34(9):705-10.
Ahlfeld SK, Gao Y, Conway SJ, Tepper RS. Relationship of Structural to Functional Impairment during Alveolar-Capillary Membrane Development. Am J Pathol. 2015;185(4):913-9.
Ahlfeld SK, Conway SJ. Assessment of Inhibited Alveolar-Capillary Membrane Structural Development and Function in Bronchopulmonary Dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100(3):168-79.
Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW, Conway SJ. Periostin down-regulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol. 2013;97(6):373-85.
Ahlfeld SK, Conway SJ. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2012;94(1):3-15.
Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011;186(8):4959-66.
Henry T. Akinbi, MD Attending Neonatologist, Neonatology and Pulmonary Biology
studies host defense proteins in innate defense of the lungs using gene-targeted mice. The role of lysozyme in: 1) lung infection; 2) inflammation and 3) anti-oxidant defense is a major focus of his research program.
Attending Neonatologist, Neonatology and Pulmonary Biology
Neonatal infections; blood transfusions
MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.
Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.
Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.
Certification: General Pediatrics, 1991; Recertification, 1998; Newborn Medicine, 1995; Recertification, 2002.
McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14.
Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52. Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83. Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26 Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.
Tanya E. Cahill, MD Director, High-Risk Clinic
is interested in high risk infant follow-up and neonatal abstinence syndrome.
Director, High-Risk Clinic
High risk infant follow up; neonatal abstinence syndrome
MD: University of Cincinnati, Cincinnati, OH, 2000.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2003.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2006.
Certification: Pediatrics, 2003; Neonatology, 2008.
Michael W. Crossman, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology
focuses on intestinal function and host-microbial interactions, bioethics and neonatal palliative care.
Intestinal function and host-microbial interactions; bioethics and neonatal palliative care
PhD: Biochemistry, St. Louis University, St. Louis, MO, 1985.
MD: St. Louis University, St. Louis, MO, 1986.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.
Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.
Certification: Neonatal - Perinatal Medicine, 1995, 2003.
Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.
Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12.
Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.
Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.
Hitesh Deshmukh, MD, PhD
and his laboratory focuses on the role of intestinal commensal bacteria in development of appropriate innate immune responses to pathogens in neonates. The ultimate goal of this research is to develop novel therapeutic approaches to decrease mortality in premature babies, one of the most vulnerable groups.
MB; BS: University of Mumbai, Mumbai, India, 2001.
PhD: University of Cincinnati, Cincinnati, OH, 2006.
Residency: Pediatrics, State University of New York at Buffalo, Buffalo, NY, 2011.
Fellowship: Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 2014.
Certification: American Board of Pediatrics, 2012.
Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, et al. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nature Medicine. 2014 Apr 20.
Yan QS, Sharma-Kuinkel BK, Deshmukh HS, Tsalik EL, Cr DD, Lucas JA et al. Dusp3 and Psme3 Are Associated with Murine Susceptibility to Staphylococcus aureus Infection and Human Sepsis. Plos Pathogens. 2014 Jun 5;10(6).
Deshmukh HS, Lioy J. The use of early lung biopsy in detection of fatal pulmonary disease in the neonate. The Journal of Pediatrics. 2014 Apr;164(4):934-6.
Deshmukh HS, Caty MG, Ryan RM, Lakshminrusimha S. Intermittent 'bulge' in the umbilical cord. Journal of Perinatology. 2010 Jul;30(7):500-2.
Ahn SH, Deshmukh HS8, Johnson N, Cowell LG, Rude TH, Scott WK, et al. Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS Pathogens. 2010;6(9):e1001088. *co-first author.
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, et al. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. American Journal of Respiratory and Critical Care Medicine. 2009 Nov 1;180(9):834-45.
Deshmukh HS, Hamburger JB, Ahn SH, McCafferty DG, Yang SR, Fowler VG, Jr. Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infection and immunity. 2009 Apr;77(4):1376-82.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, et al. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. American Journal of Respiratory Cell and Molecular Biology. 2008 Apr;38(4):446-54.
Campbell SJ, Deshmukh HS*, Nelson CL, Bae IG, Stryjewski ME, Federspiel JJ, et al. Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections. Journal of Clinical Microbiology. 2008 Feb;46(2):678-84. *co-first author.
Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. American Journal of Respiratory and Critical Care Medicine. 2005 Feb 15;171(4):305-14.
Neera K. Goyal, MD, MSc Attending Physician, Division of Hospital Medicine
studies the role of hospital and community-based interventions to improve outcomes among preterm and other high risk newborns. Approaches to preterm birth prevention through social determinants of health is also an ongoing interest.
Attending Physician, Division of Hospital Medicine
Hospital medicine; level 1 and level 2 nursery care
As a Robert Wood Johnson Foundation Clinical Scholar at the University of Pennsylvania (2009-2011), Dr. Goyal studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, as well as the impact of discharge timing on readmission risk. She also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development.
She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of Hospital Medicine. In 2012 she received the BIRCWH K12 Award to evaluate the role of community-based home visiting to improve pregnancy and infant health outcomes. Currently, Dr. Goyal is studying programmatic effects on health care utilization in ED and primary care settings for full term and preterm infants.
BA: Emory University, Atlanta, GA, 2001.
MD: University of Texas Southwestern Medical Center in Dallas, Dallas, TX, 2005.
MSc: Health Policy Research, University of Pennsylvania, Philadelphia, PA, 2011.
Residency: Children's Hospital of Philadelphia, Philadelphia, PA, 2008.
Moyer LB, Goyal NK, Meinzen-Derr JK, Ward LP, Rust CL, Wexelblatt SL, Greenberg JM. Factors Associated with Readmission in Late-Preterm Infants: A Matched Case Control Study. Hosp Pediatr. 2014 Sep;4(5):298-304.
Simpson E, Goyal NK, Dhepyasuwan N, Flaherman V, Chung EK, Von Kohorn I, Burgos A, Taylor J. Prioritizing a Research Agenda: A Delphi Study of the Better Outcomes through Research for Newborns (BORN) Network. Hosp Pediatr. 2014 Jul;4(4):195-202.
Goyal NK, Hall ES, Ammerman RT, Meinzen-Derr JK, Jones DE, Short JA, Van Ginkel JB. Association of maternal and community factors with enrollment in home visiting among at-risk, first time mothers. Am J Public Health. 2014 Feb;104 Suppl 1:S144-51.
Hall ES, Goyal NK*, Ammerman RT, Miller MM, Jones DE, Short JA, Van Ginkel JB. Development of a linked perinatal data resource from state administrative and community-based program data. Matern Child Health J. 2014 Jan;18(1):316-25.
Goyal NK, Hall ES, Meinzen-Derr JK, Kahn RS, Short JA, Van Ginkel JB, Ammerman RT. Dosage effect of prenatal home visiting on pregnancy outcomes in at-risk, first-time mothers. Pediatrics. 2013 Nov;132 Suppl 2:S118-25.
Goyal NK, Teeters A, Ammerman RT. Home Visiting and Outcomes of Preterm Infants: A Systematic Review. Pediatrics. 2013 Sep;132(3):502-16.
Goyal N, Zubizarreta JR, Small DS, Lorch SA. Length of stay and readmission among late preterm infants: an instrumental variable approach. Hosp Pediatr. 2013 Jan;3(1):7-15.
Goyal NK, Fiks AG, Lorch SA. Persistence of underweight status among late preterm infants. Arch Pediatr Adolesc Med. 2012 May;166(5):424-30.
Goyal NK, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.
Goyal NK, Fiks AG, Lorch SA. Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics. 2011 Oct;128(4):e830-8.
Beth E. Haberman, MD Senior Medical Director, Neonatal Services
has special interests in the care of infants with congenital diaphragmatic hernia and follow-up care of premature and term infants with complex medical needs.
Senior Medical Director, Neonatal Services
Medical Director, Newborn Intensive Care Unit (NICU)
Medical Director, Neonatal Transport Program
Associate Director, High-Risk Infant Follow-Up Program
Associate Professor, UC Department of Pediatrics
CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.
MD: University of Louisville, Louisville, KY, 1993.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.
Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.
Steven B. Hoath, MD
has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.
Emeritus, UC Department of Pediatrics
Human skin development; multiple roles of the skin in neonatal care; new perspectives on the skin as a sensory interface; role of the skin as an accessible environmental interface which complements ‘internal’ medicine; evidence-based organizational change in healthcare delivery to newborns; interface between medicine and nursing; focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.
Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.
He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of seven international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.
He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on five patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.
Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.
Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.
Residency: University of California, Los Angeles, 1977-79.
Internship: Harbor-UCLA Medical Center, 1976-1977.
MD: University of California, Los Angeles, CA, 1976.
Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.
Baccalaureate: Stanford University, Biology & German Studies, 1972.
Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.
Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.
Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.
Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.
Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.
Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.
Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.
Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology
has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.
Director, Division of Perinatal Biology
Clinical trials in neonatology; bronchopulmonary dysplasia
MD: University of California, San Diego, CA, 1973.
PhD: University of California, San Diego, CA, 1973.
Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.
Fellowship: University of California, San Diego, CA, 1975 to 1977.
Board Certified: Pediatrics and Neonatal-Perinatal Medicine.
Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.
Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.
Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.
Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.
Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.
Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.
Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.
Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.
Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.
Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.
Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology
has a research focus in perinatal cardiology, premature infants with congenital heart disease, fetal diagnosis, and simulation.
Cardiac intensive care; neonatology; premature infants with congenital heart disease; mechanical assist devices; fetal diagnosis; ethics
MD: University of Illinois.
Residency: University of Texas Health Science Center at San Antonio.
Fellowships: Neonatal / Perinatal, Children’s Hospital of Wisconsin; Pediatric Cardiology, Children’s Hospital of Wisconsin; Pediatric Critical Care, Children’s Hospital of Philadelphia.
MA: Bioethics, Medical College of Wisconsin.
Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education
Director, Neonatology Continuing Medical Education
Global Health Center
Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity
MBBS: University of Bombay, India, 1984.
DCH: College of Physicians and Surgeons, Bombay, India, 1986.
MD, Pediatrics: University of Bombay, India, 1986.
Residency: University of Bombay, India, 1984-87.
Residency: Children's Hospital of Michigan, Detroit, MI, 1988-90.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1990-1993.
Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010 Sep;68(3):210-5.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis. Pediatr Res. 2010 May 28.
Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5.
Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124.
Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5.
Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7.
Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.
Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology
does clinical/translational research in preterm birth, fetal maturity and timing of delivery using biomarkers in amniotic fluid transcriptome. She is jointly appointed in Global Health. She is the associate editor for the 2nd Edition of Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation. She serves on the American Academy of Pediatrics Helping Babies Survive Planning Group. She is collaborating on several research studies of HBB around the world.
Perinatal epidemiology and public health; global health
Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal maturity, and biomarker discovery in amniotic fluid, with the hopes of developing less invasive tests of fetal maturity. She has received a BIRCWH K12 OMICS K12, and Perinatal Institute Pilot and Feasibility awards to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.
Dr. Kamath-Rayne is jointly appointed in Global Health and serves on the American Academy of Pediatrics Helping Babies Survive Planning Group. She is the associate editor for the 2nd Edition of Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and contributing editor to Essential Care for Small Babies. She is collaborating on several research studies of HBB around the world. With Dr. Alan Jobe, she has served as a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide. Finally, she does research on educational outcomes of teaching neonatal resuscitation to pediatric residents.
MD: Georgetown University, Washington, DC, 2000.
Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2003.
Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, CO, 2008.
MPH: Colorado School of Public Health, Aurora, CO, 2008.
Kamath-Rayne BD, Du Y, Hughes M, Wagner E, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y. Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity. BMC Med Genomics. 2015;8(1):67.
Seto TL, Tabangin ME, Josyula S, Taylor KK, Vasquez JC, Kamath-Rayne BD. Educational outcomes of Helping Babies Breathe training at a community hospital in Honduras. Perspect Med Educ. 2015;4(5):225-32.
Kamath-Rayne BD, Griffin JB, Moran K, Jones B, Downs A, McClure EM, Goldenberg RL, Rouse D, Jobe AH. Resuscitation and obstetrical care to reduce intrapartum-related neonatal death: A MANDATE study. Matern Child Health J. 2015;12(Suppl 2):S13.
Kamath-Rayne BD, Habli M, Rodriguez Z, Wu M, Gresh J, DeFranco EA.Antenatal exposure to sulindac and risk of necrotizing enterocolitis. Am J Obstet Gynecol. 2015 Jan;212(1):96.e1-7.
Hall ES, Folger AT, Kelly E, Kamath-Rayne BD. Impact of gestational age estimate method on the calculation of preterm birth rates. Matern Child Health J. 2014;18(3):755-62.
Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: An evaluation of neonatal outcomes. Obstet Gynecol. 2012;119(5):909-916.
Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.
Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.
Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010.
Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.
Prediction of Fetal Maturity Using Novel Biomarkers from Cell Free Amniotic Fluid Transcriptome. Principal Investigator. National Institutes of Health OMICS K12. Nov 2014-Oct 2016.
Retention of neonatal resuscitation skills in pediatric residents. Principal Investigator. Perinatal Institute Pilot and Feasibility Grant. Jul 2015-Jun 2017.
Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology
focuses on understanding variations in evidence-based care practices across hospitals and identifying strategies for increasing the implementation of evidence and other innovations into practice. She recently began a line of investigation aimed at building the evidence base for quality improvement so that QI can be used more effectively as a strategy for improving quality and patient outcomes.
Understanding variations in evidence-based care practices across hospitals; examining strategies for increasing the implementation of evidence into practice in perinatal care; using a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.
Heather C. Kaplan, MD, MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and has formed collaborative relationships with obstetrical and neonatal care providers across the state.
Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.
BA: Washington University, St. Louis, MO.
MD: Northwestern University, Chicago, IL.
Residency: Children's National Medical Center, Washington, DC.
Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA.
MSCE: University of Pennsylvania, Philadelphia, PA.
Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.
Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.
Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.
Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
Alan P. Kenny, MD, PhD
studies the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development, including the role of a pool of foregut progenitor cells in the ventral endoderm which are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme.
Instructor, UC Department of Pediatrics
Neonatal care; neonatal lung disease; neonatal malformations and anomalies
Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?
These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.
MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.
Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.
Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.
Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.
Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.
Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Kenny A. Vitamin A for prevention of bronchopulmonary dysplasia. Preemie Press. Local news brief for Good Samaritan Hospital. 2007.
Angerer LM, Kenny AP, Newman LA, Angerer RC. Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Signal Transduction Wiley Interscience, New York. 2007 7(2), 174-178.
Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center
investigates the role of the innate immune system in neonatal infection. Specific projects currently focus on the role of surfactant protein D in neonatal sepsis and acute respiratory distress syndrome and on neutrophil function in cystic fibrosis patients.
Neonatal Director, Cincinnati Fetal Center
Neonatology; congenital diaphragmatic hernia; neonatal infection
BS: Calvin College, MI, 1992.
MD: Vanderbilt University, TN, 2000.
PhD: Vanderbilt University, TN, 2000.
Residency: Cincinnati Children's Hospital Medical Center, 2003.
Fellowship: Cincinnati Children's Hospital Medical Center, 2005.
Thomas R. Korfhagen, MD, PhD Attending Pediatrician, Neonatology and Pulmonary Biology
studies the roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF receptor signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Attending Pediatrician, Neonatology and Pulmonary Biology
Care of high-risk infants; pediatric patients with complex, long term medical problems
BA: University of Cincinnati, Cincinnati, OH, 1972.
PhD: University of Cincinnati, Cincinnati, OH, 1976.
MD: University of Cincinnati, Cincinnati, OH, 1981.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director).
Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.
Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.
Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.
Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.
Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.
Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship
is interested in early craniofacial development and focuses on the tissue interactions that direct the formation, migration and differentiation of neural crest cells. The Melton Lab focuses on understanding the influence of the endothelium and the cranial mesoderm on neural crest development.
Associate Program Director, Neonatal-Perinatal Medicine Fellowship
Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.
Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.
Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital Medical Center. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.
BA: Washington University, St. Louis, MO, 1991.
MD: University of Nebraska, Omaha, NE, 1995.
Residency: Children's Mercy Hospital, Kansas City, MO, 1998.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.
Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.
Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.
Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.
Stephanie L. Merhar, MD, MS Attending Neonatologist, Neonatology and Pulmonary Biology
is interested in optimizing neuroimaging in preterm and term infants at risk for brain injury, neonatal seizure treatment and neurodevelopmental outcomes of infants in the NICU.
MD: University of Pennsylvania, Philadelphia, PA, 2005.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2005-2008.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, 2008-2011.
Certification: Pediatrics, 2008.
Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7.
Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154. Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6.
Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30.
Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.
Nagendra K. Monangi, MD Attending Neonatologist, Neonatology and Pulmonary Biology
Maternal / infant nutrition; vitamin D
MBBS: Andhra Medical College, Visakhapatnam, India, 2001.
Post Graduate Diploma: Pediatrics, Osmania Medical College, Hyderabad, India, 2005.
Residency: Pediatrics, University of South Alabama, Mobile, AL, 2009.
Fellwoship: Neonatal-Perinatal Medicine, Cincinnati Children’s Hospital Medical Center / University of Cincinnati, Cincinnati, OH, 2012.
Certification: Pediatrics, 2009; Neonatology, Board Eligible.
Ardythe L. Morrow, PhD Director, Center for Interdisciplinary Research in Human Milk and Lactation
Director, Center for Interdisciplinary Research in Human Milk and Lactation
Human milk; child health and nutrition
Dr. Morrow received her MSc in nutrition from the University of the West Indies, Kingston, Jamaica (1980) and PhD in epidemiology from the University of Texas at Houston (1991). Since 1987 she has worked with colleagues in Mexico, Boston, and Houston on an NIH-funded program project on human milk immune protection against infectious disease.
She is currently professor of pediatrics at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine. She founded and directs the Center for Epidemiology and Biostatistics that has 35 faculty and staff and a multi-disciplinary Human Milk Research Program that includes clinical and basic science investigators in eight divisions.
She has published extensively on breastfeeding promotion and human milk protection against infectious diseases. Her primary focus is on protection by human milk glycans and protection against infectious disease, but she has expanded her research to understanding the relationship between breastfeeding and chronic diseases. She has been an ad hoc reviewer for NIH on breastfeeding research and a technical advisor for international breastfeeding policy and programs for Gates Foundation, UNICEF, and WHO, is on the editorial board of the Journal of Human Lactation and the journal of the Academy of Breastfeeding Medicine. She is an elected member of the American Pediatric Society. She has over 100 publications, and is the primary author of the WHO monograph, Community-based Strategies for Breastfeeding Promotion and Support in Developing Countries (2004).
She has served as chair of the Milk Club of the (American) Society for Pediatric Research for the past four years. In 1997, she received a Young Investigator award from ISRHML for her randomized trial of breastfeeding support (Lancet, 1999). She was co-organizer of the 2002 ISRHML international meeting in Mexico and is co-editor of the book "Protecting Infants through Human Milk: Advancing the Scientific Evidence."
BA: Rice University, Houston, TX.
MSc: University of the West Indies, Kingston, Jamaica.
PhD: The University of Texas School of Public Health, Houston, TX, 1991.
South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Farkas T, Cross RW, Hargitt E 3rd, Lerche NW, Morrow AL, Sestak K. Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses. J Virol. 2010 Sep;84(17):8617-25.
Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9.
Huang P, Morrow AL, Jiang X. The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognition. Glycoconj J. 2009 Nov;26(8):1085-96.
Meinzen-Derr J, Morrow AL, Hornung RW, Donovan EF, Dietrich KN, Succop PA. Epidemiology of necrotizing enterocolitis temporal clustering in two neonatology practices. J Pediatr. 2009 May;154(5):656-61.
Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. Reporting individual test results of environmental chemicals in breast milk: potential for premature weaning. Breastfeed Med. 2008 Dec;3(4):207-13.
Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.
Meinzen-Derr J, Poindexter B, Wrage L, Morrow AL, Stoll B, Donovan EF. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J Perinatol. 2009 Jan;29(1):57-62.
Woo JG, Dolan LM, Morrow AL, Geraghty SR, Goodman E. Breastfeeding helps explain racial and socioeconomic status disparities in adolescent adiposity. Pediatrics. 2008 Mar;121(3):e458-65.
Laurel B. Moyer, MD Medical Director, TriHealth Nurseries
has research interests that include quality improvement, late preterm infants, and international health.
Medical Director, TriHealth Nurseries
Chair, Neonatal Pediatrics
Quality improvement; global health
MD: University of Vermont College of Medicine, Burlington, VT, 1999-2003.
Residency: University of Massachusetts, Department of Pediatrics, Worcester, MA, 2003-2006.
Fellowship: University of North Carolina, Division of Neonatal-Perinatal Medicine, Chapel Hill, NC, 2006-2009.
Certification: American Board of Pediatrics, 2006.
Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU
is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.
Medical Director, University of Cincinnati Medical Center NICU
Medical Director, Cincinnati Perinatal Outreach Project
Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital
Non-invasive ventilation of the preterm infant; business case for quality improvements
MBBS: Bangalore Medical College, Bangalore, India, 1985.
MD/DNB: JN Medical College, Belgaum, India, 1990.
Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.
Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1996, 1998-2000.
Credentials: Pediatrics, 1998; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Feb 14.
Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep;25(9):608-11.
Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol. 2005 Jul;25(7):440-6. Review.
Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec;191(6):2090-6.
Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9.
Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review.
Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.
Amy T. Nathan, MD Medical Director, Neonatology and Pulmonary Biology
focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
Medical Director, Neonatology and Pulmonary Biology
Necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care
Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
MD: Yale University School of Medicine, New Haven, CT, 1998.
Residency: University of North Carolina, Chapel Hill, NC, 1998-2002.
Fellowship: University of North Carolina, Chapel Hill, NC, 2002-2005.
Certification: Pediatrics 2001; Neonatology, 2008.
Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.
Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.
Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.
Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.
Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.
Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.
Laurie A. Nommsen-Rivers, PhD, RD, IBCLC
has research interests that include human milk and lactation, clinical management of the breastfeeding dyad and perinatal epidemiology.
Dr. Nommsen-Rivers's broad research objective is to provide evidence-based strategies for supporting the mother-baby dyad in successfully establishing breastfeeding. Her current area of research examines the causes and consequences of early breastfeeding difficulties, with particular emphasis on delayed onset of lactogenesis.
BS: University of California, Davis, CA, 1985.
MS: University of California, Davis, CA, 1989.
PhD: University of California, Davis, CA, 2007.
Registered Dietitian: Registration # 706227, continuously since 1991.
International Board Certified Lactation Consultant: Continuously since 1993.
Onyango AW, Nommsen-Rivers L, Siyam A, Borghi E, de Onis M, Garza C, Lartey A, Baerug A, Bhandari N, Dewey KG, Araújo CL, Mohamed AJ, Van den Broeck J; for the WHO Multicentre Growth Reference Study Group. Post-partum weight change patterns in the WHO Multicentre Growth Reference Study. Matern Child Nutr. 2011 Feb 22. doi: 10.1111/j.1740-8709.2010.00295.x.
Nommsen-Rivers LA, Cohen RJ, Chantry CJ, Dewey KG. The Infant Feeding Intentions scale demonstrates construct validity and comparability in quantifying maternal breastfeeding intentions across multiple ethnic groups. Matern Child Nutr. 2010 Jul 1;6(3):220-7.
Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr. 2010 Sep;92(3):574-84.
Nommsen-Rivers LA, Chantry CJ, Cohen RJ, Dewey KG. Comfort with the idea of formula feeding helps explain ethnic disparity in breastfeeding intentions among expectant first-time mothers. Breastfeed Med. 2010 Feb;5(1):25-33.
Marshall AM, Nommsen-Rivers LA, Hernandez LL, Dewey KG, Chantry CJ, Gregerson KA, Horseman ND. Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution. J Clin Endocrinol Metab. 2010 Feb;95(2):837-46.
Nommsen-Rivers LA, Dewey KG. Growth of breastfed infants. Breastfeed Med. 2009 Oct;4 Suppl 1:S45-9.
Nommsen-Rivers LA, Mastergeorge AM, Hansen RL, Cullum AS, Dewey KG. Doula care, early breastfeeding outcomes, and breastfeeding status at 6 weeks postpartum among low-income primiparae. J Obstet Gynecol Neonatal Nurs. 2009 Mar-Apr;38(2):157-73.
Nommsen-Rivers LA, Dewey KG. Development and validation of the Infant Feeding Intentions Scale. Matern Child Health J. 2009;13(3):334-42.
Nommsen-Rivers LA, Heinig MJ, Cohen RJ, Dewey KG. Newborn wet and soiled diaper counts and timing of onset of lactation as indicators of breastfeeding inadequacy. J Hum Lact. 2008;24(1):27-33.
Mihaela Pavlicev, PhD
PhD: University of Vienna, Austria, 2003.
Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).
Pavličev M, Wagner GP. A model of developmental evolution: selection, pleiotropy, compensation. TrEE. 2012;27: 316-322.
Pavličev M, Hansen TF. Genotype-phenotype maps maximizing evolvability: modularity revisited. Evolutionary Biology. 2011;38: 371-389.
Pavličev M, Norgard EA, Fawcett GL, Cheverud JM. Evolution of pleiotropy: Epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. J. Experimental Zoology B. 2011;316B: 371-385.
Pavličev M, Wagner GP, Cheverud JM. Evolution of adaptive phenotypic variation patterns by direct selection on evolvability. Proc. Roy. Soc. 2011;278: 1903-1912.
Pavličev M, Le Rouzic AP, Wagner GP, Cheverud JM, Hansen TF. Directionality of epistasis in a murine intercross population. Genetics. 2010;185:1489-1505.
Pavličev M, Cheverud JM, Wagner GP. Measuring morphological integration using eigenvalue variance. Evolutionary Biology. 2009;36:157-170.
Wagner GP, Kenney-Hunt JP, Pavličev M, Peck JR, Waxman D, and Cheverud JM. Pleiotropic scaling of gene effects and the "Cost of complexity". Nature. 2008;452: 470-472.
Pavličev M, Kenney-Hunt JP, Norgard AE, Roseman CC, Wolf J, and Cheverud JM. Genetic variation in pleiotropy: Differential epistasis as a source of variation in the allometric relationships between bone lengths and body weight. Evolution. 2008;62 (1): 199-213.
Wagner GP, Pavličev M, Cheverud JM. The road to modularity. Nature Reviews Genetics. 2007;8: 921- 931.
Brenda Poindexter, MD, MS Director of Clinical and Translational Research, Perinatal Institute
Director of Clinical and Translational Research, Perinatal Institute
MD: Medical College of Ohio, Toledo, OH, 1990.
MS: Indiana University, Indianapolis, IN, 2004.
Residency: Cincinnati Children's Medical Hospital Center, Cincinnati, OH, 1993.
Fellowship: Indiana University School of Medicine, Indianapolis, IN, 1997.
Certification: General Pediatrics 1993; Neonatal and Perinatal Medicine, 1997.
John H. Reuter, MD, PhD Attending Neonatologist, Neonatology and Pulmonary Biology
is active in the administration of a 4000 delivery/year community level II service. His academic interests include breast milk and nutrition in the preterm infant.
Chair, Department of Pediatrics at Bethesda North Hospital Nurseries
Adjunct Associate Professor, UC Department of Pediatrics
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1976.
PhD: Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, 1973.
Residency: Pediatrics, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, OH, 1978.
Fellowship: Moffitt Hospital, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA, 1980.
Certifications: Pediatrics, 1982 Neonatal; Perinatal Medicine, 1983.
Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center
studies the molecular and cellular mechanisms that regulate processing of surfactant protein C, a protein that is critical for lung function.
Medical Director, Newborn Services, St. Elizabeth Medical Center
Director, Neonatology Fellowship Training Program
Hypotension in ELBW infants; EMR
Ward R. Rice, MD, PhD, is the director of the Neonatology Fellowship Training Program and director of Newborn Services, St. Elizabeth Medical Center.
Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.
His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of surfactant protein C.
PhD: University of Chicago, Chicago, Illinois, 1972-76.
PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane."
MD: University of Chicago, Chicago, Illinois, 1972-78.
Internship: Duke University Medical Center, Durham, North Carolina, 1978-79.
Residency: Duke University Medical Center, Durham, North Carolina, 1979-81.
Fellowship Neonatology: University of Cincinnati College of Medicine, Children's Hospital Medical Center, 1981-83.
Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.
Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.
Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.
Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.
Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.
Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.
Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.
Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.
Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.
Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.
Kurt R. Schibler, MD Director, Neonatology Clinical Research Program
is the principal investigator for the NICHD Neonatal Research Network at Cincinnati Children’s and is also involved in thematic collaborative research investigating the immune mechanisms underlying morbidity and mortality associated with preterm birth. He aims to identify infants at high risk for developing necrotizing enterocolitis and late onset infection and to devise strategies to prevent and to treat these complications.
Director, Neonatology Clinical Research Program
Clinical trials; neonatal immune development
MD: University of Cincinnati, Cincinnati, Ohio, 1984.
Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.
Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.
Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 Jan 20.
Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.
Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.
Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8.
Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16.
Schibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.
Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.
Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.
Debora I. Sinner, PhD
is interested in understanding the molecular mechanisms underlying foregut formation. Specifically, her lab focuses on the molecular mechanism underlying lung and upper airway development and the paracrine interactions between epithelium and mesenchyme. Ultimately, her goal is to use the embryo as a paradigm to understand diseases affecting upper airway and lung. To this end her lab utilizes knockout mouse models and the frog embryo combined with molecular and cellular approaches using in vitro systems.
Developmental biology; pulmonary biology
Visit the Sinner Lab.
Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease.
After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's within the UC Department of Pediatrics. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.
MS: University of Buenos Aires, Argentina, 1999.
PhD: University of Buenos Aires, Argentina, 2003.
Post doctoral training: Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2009.
Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010 Jan;239(1):56-68.
Sinner D, Kordich JJ, Opoka R Rankin SA,. Lin S-J, Jonatan D, Zorn AM, Wells JM. Beta-catenin/Tcf activity is repressed by Sox17 and enhanced by Sox4 in colon carcinoma cells. Mol Cell Biol. 2007;27:7802-7815.
Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development. 2006 May;133(10):1955-66.
Sinner D, Rankin S, Lee M, Zorn AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development. 2004 Jul;131(13):3069-80.
Sinner D, Caviglia JM, Jawerbaum A, Igal RA, Gonzalez E. Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2. Reprod Fertil Dev. 2003;15(1-2):75-80.
Kristen Suhrie, MD Neonatologist, Perinatal Institute
is working on a translational research project to develop a prenatal genetic screening test to identify fetuses affected by genetic disorders using cell free fetal DNA obtained from a maternal blood sample as early as the first trimester of pregnancy. The goal of her research is to identify fetuses affected by genetic disease early in pregnancy to allow for improved prenatal and neonatal care for these patients.
Neonatologist, Perinatal Institute
Neonatology; genetic disorders presenting in the neonatal period
MD: University of Tennessee, Memphis, TN, 2003.
Residency: Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
Fellowship: Neonatology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
Certification: Pediatrics, 2008; Neonatology, 2012.
Laura Placke Ward, MD
focuses on strategies to prevent significant hyperbilirubinemia in term and late preterm infants.
Multidisciplinary quality improvement; family centered care; evidence-based practice
Dr. Ward has been a neonatologist in the division since 2002, and attends at The University Hospital.
MD: St. Louis University School of Medicine, St. Louis, MO, 1994.
Residency: Children’s National Medical Center, Washington DC, 1994-1997.
Fellowship: Children’s National Medical Center, Washington DC, 1997-2000.
Certifications: Pediatrics, 1997; Neonatology, 2003.
Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
focuses on neonatal follow-up, including the follow-up of graduates from the NICU and drug exposed neonates with neonatal abstinence syndrome. Her future research plans involve neuroimaging and therapy based on the neurological findings.
Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
Neonatologist, Good Samaritan Hospital
Medical Director, Mercy Hospital Fairfield Nurseries
Neonatal high risk infant follow-up and developmental follow-up
MD: University of Cincinnati Medical School, Cincinnati, OH, 1978.
Residency: Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, 1978-1981.
Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, 1983.
Certifications: Pediatrics, 1983; Neonatology, 1983.
Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008 Jan;152(1):140, 140.e1.
Wedig KE, Kogan J, Schorry EK, Whitsett JA. Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4.
Scott L. Wexelblatt, MD Medical Director, Regional Newborn Services
has interests in the late preterm infant and regional newborn care.
Medical Director, Regional Newborn Services
MD: University of Vermont, Burlington, VT, 1996.
Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Certification: Pediatrics, 1999.
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