Henry T. Akinbi, MD
studies host defense proteins in innate defense of the lungs using gene-targeted mice. The role of lysozyme in: 1) lung infection; 2) inflammation and 3) anti-oxidant defense is a major focus of his research program.
513-636-8915
henry.akinbi@cchmc.org
Henry T. Akinbi, MD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Neonatal infections; blood transfusions; role of Lysozyme in airway host defense
Education and Training
MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.
Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.
Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.
Certification: General Pediatrics, 1991. Recertification, 1998. Newborn Medicine, 1995, Recertification, 2002.
Publications
View PubMed Publications
McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14. Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35. Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9.
Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6. Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52.
Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83.
Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.
Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81. Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26
Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.
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Laurel B. Bookman, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Quality improvement; global health
Education and Training
MD: University of Vermont College of Medicine, Burlington, VT, 1999-2003.
Residency: University of Massachusetts, Department of Pediatrics, Worcester, MA, 2003-2006.
Fellowship: University of North Carolina, Division of Neonatal-Perinatal Medicine, Chapel Hill, NC, 2006-2009.
Certification: American Board of Pediatrics, 2006.
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Tanya E. Cahill, MD
Director, High-Risk Clinic
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
High risk infant follow up; neonatal abstinence syndrome
Education and Training
MD: University of Cincinnati, Cincinnati, OH 2000.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2000-2003.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2003-2006.
Certification: Pediatrics, 2003; Neonatology, 2008.
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Michael W. Crossman, MD, PhD
Attending Neonatologist
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Intestinal function and host-microbial interactions; bioethics and neonatal palliative care
Education and Training
PhD: Biochemistry, St. Louis University, St. Louis Mo., 1985. MD: St. Louis University, St. Louis, Mo., 1986. Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990. Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.
Certification: Neonatal - Perinatal Medicine, 1995, 2003.
Publications
View PubMed Publications
Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5. Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12.
Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087. Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.
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Edward F. Donovan, MD
Director, Child Policy Research Center
Academic Information
Emeritus, UC Department of Pediatrics
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Specialties
Population health; quality improvement research; perinatal epidemiology
Education and Training
MD: University of California at Los Angeles School of Medicine, Los Angeles, CA, 1967 to 1971.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1971 to 1973.
Fellowship: Newborn Physiology, University of Cincinnati College of Medicine, 1975 to 1977; Respiratory Muscle Physiology, McGill University, Montreal, Quebec, 1978 to 1979.
Certification: Neonatal-Perinatal Medicine
Publications
View PubMed Publications
Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35. Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics. 2010 Aug;126(2):e367-73. Donovan EF, Besl J, Paulson J, Rose B, Iams J; Ohio Perinatal Quality Collaborative. Infant death among Ohio resident infants born at 32 to 41 weeks of gestation. Am J Obstet Gynecol. 2010 Jul;203(1):58.e1-5. SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network, Finer NN, Carlo WA, Walsh MC, Rich W, Gantz MG, Laptook AR, Yoder BA, Faix RG, Das A, Poole WK, Donovan EF, Newman NS, Ambalavanan N, Frantz ID 3rd, Buchter S, Sánchez PJ, Kennedy KA, Laroia N, Poindexter BB, Cotten CM, Van Meurs KP, Duara S, Narendran V, Sood BG, O'Shea TM, Bell EF, Bhandari V, Watterberg KL, Higgins RD. Early CPAP versus surfactant in extremely preterm infants. N Engl J Med. 2010 May 27;362(21):1970-9. Donovan EF, Lannon C, Bailit J, Rose B, Iams JD, Byczkowski T; Ohio Perinatal Quality Collaborative Writing Committee. A statewide initiative to reduce inappropriate scheduled births at 36.0 - 38.0 weeks' gestation. Am J Obstet Gynecol. 2010 Mar;202(3):243.e1-8. Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD; NICHD Neonatal Research Network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30;359(18):1885-96.
Donovan EF, Ammerman RT, Besl J, Atherton H, Khoury JC, Altaye M, Putnam FW, Van Ginkel JB. Intensive home visiting is associated with decreased risk of infant death. Pediatrics. 2007 Jun;119(6):1145-51. Gerhardt WE, Schoettker PJ, Donovan EF, Kotagal UR, Muething SE. Putting evidence-based clinical practice guidelines into practice: an academic pediatric center's experience. Jt Comm J Qual Patient Saf. 2007 Apr;33(4):226-35. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.el-8. Clark E, Donovan E, Schoettker P. From outdated to updated, keeping clinical guidelines valid. Int J Qual Health Care. 2006 Jun;18(3):165-6.
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Neera K. Goyal, MD, MSHP
Assistant Professor, Department of Pediatrics
studies quality of care for preterm and term neonates. She is currently pursuing research that evaluates discharge management of late preterm neonates (born 34-36 weeks gestation) and its impact on readmission risk. She has also conducted research on the impact of late preterm birth on early childhood morbidity and health care utilization.
513-803-7836
Neera K. Goyal, MD, MSHP
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Quality of care during birth hospitalization for late preterm and other high risk newborns; neonatal readmission; prevention of preterm birth
Biography
Neera Goyal, MD MSHP, is a general pediatrician and a child health researcher. Her research interests are in perinatal care – in particular, how Level 1 and Level 2 birth hospitals manage higher risk term and late preterm newborns. She has studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, and she is currently researching the impact of discharge timing on risk of readmission for late preterm newborns. She has also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development. Dr. Goyal’s work has been published in peer-reviewed literature, and in 2011 she received the Pediatric Academic Societies Travel Award for Young Investigators.
Originally from Dallas, TX, Dr. Goyal received her bachelor’s degree in Atlanta, Georgia at Emory University, majoring in Philosophy. She earned her M.D. from University of Texas Southwestern Medical Center in Dallas. She completed a pediatrics residency at Children’s Hospital of Philadelphia in 2008 and worked as a neonatology hospitalist from 2008-2009. She then pursued further training in health services research as a Robert Wood Johnson Foundation Clinical Scholar at University of Pennsylvania in Philadelphia. She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of General and Community Pediatrics, Section of Hospital Medicine.
Education and Training
MD: Univ. of Texas Southwestern Medical Center at Dallas, 2005. Residency: Pediatrics, Children’s Hospital of Philadelphia, 2008. Fellowship: The Robert Wood Johnson Foundation Clinical Scholars, University of Pennsylvania, 2011 Certification: Pediatrics, 2008.
Publications
Goyal N, Fiks A, Lorch SA. The association of late preterm birth with asthma in young children: A practice-based study. Pediatrics. 2011. Goyal N, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.
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Beth E. Haberman, MD
Medical Director, Newborn Intensive Care Unit (NICU)
has special interests in the care of infants with congenital diaphragmatic hernia and follow-up care of premature and term infants with complex medical needs.
513-636-5465
beth.haberman@cchmc.org
Beth E. Haberman, MD
Medical Director, Newborn Intensive Care Unit (NICU)
Medical Director, Neonatal Transport Program
Associate Director, High-Risk Infant Follow-Up Program
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs
Education and Training
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.
MD: University of Louisville, Louisville, KY, 1993.
Publications
View PubMed Publications
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.
Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.
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Eric S. Hall, PhD
participates in a number of interdisciplinary teams investigating prematurity and neonatal disease. Along with coordinating data collection and exchange efforts, his work involves the application of knowledge discovery techniques to clinical data sets, as well as the development of software tools to assist in the summarization of clinical data and the modeling of clinical processes.
513-803-2083
eric.hall@cchmc.org
Eric S. Hall, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical informatics; process modeling; knowledge discovery in databases; data summarization
Biography
Eric S. Hall, PhD, participates in a number of interdisciplinary teams investigating prematurity and neonatal disease. Along with coordinating data collection and exchange efforts, his work involves the application of knowledge discovery techniques to clinical data sets as well as the development of software tools to assist in the summarization of clinical data and the modeling of clinical processes.
Education and Training
PhD: University of Utah, Salt Lake City, UT, 2008.
MS: Brigham Young University, Provo, UT, 2003.
BS: Brigham Young University, Provo, UT, 2001.
Publications
View PubMed Publications
Hall ES, Poynton MR, Narus SP, Jones SS, Evans RS, Varner MW, Thornton SN. Patient-level analysis of outcomes using structured labor and delivery data. J Biomed Inform. 2009 Aug;42(4):702-9. Hall ES, Thornton SN. Generating nurse profiles from computerized labor and delivery documentation. AMIA Annu Symp Proc. 2008 Nov 6:268-72. Hall ES, Thornton SN. Extracting nursing practice patterns from structured labor and delivery data sets. AMIA Annu Symp Proc. 2007 Oct 11:309-13. Hall ES, Poynton MR, Narus SP, Thornton SN. Modeling the distribution of Nursing Effort using structured Labor and Delivery documentation. J Biomed Inform. 2008 Dec;41(6):1001-8. Hall ES, Thornton SN. Aiding clinicians through summarization of perinatal data. AMIA Annu Symp Proc. 2005:975. Hall ES, Vawdrey DK, Knutson CD, Archibald JK. Enabling remote access to personal electronic medical records. IEEE Eng Med Biol Mag. 2003 May-Jun;22(3):133-9. Johnson KJ, Hall ES, Boekelheide K. Kinesin localizes to the trans-Golgi network regardless of microtubule organization. Eur J Cell Biol. 1996 Mar;69(3):276-87. Redenbach DM, Hall ES, Boekelheide K. Distribution of Sertoli cell microtubules, microtubule-dependent motors, and the Golgi apparatus before and after tight junction formation in developing rat testis. Microsc Res Tech. 1995 Dec 15;32(6):504-19. Stivelman JC, Soucie JM, Hall ES, Macon EJ. Dialysis survival in a large inner-city facility: a comparison to national rates. J Am Soc Nephrol. 1995 Oct;6(4):1256-61. Hall ES, Hall SJ, Boekelheide K. 2,5-Hexanedione exposure alters microtubule motor distribution in adult rat testis. Fundam Appl Toxicol. 1995 Feb;24(2):173-82.
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Steven B. Hoath, MD
Professor Emeritus
has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.
513-803-0960
steven.hoath@cchmc.org
Steven B. Hoath, MD
Professor Emeritus
Academic Information
Emeritus, UC Department of Pediatrics
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Specialties
Clinical InterestsClinical aspects of Dr Hoath’s work derive from an understanding of the basics of human skin development and the multiple roles of the skin in neonatal care. New perspectives on the skin as a sensory interface are central to this understanding as is the role of the skin as an accessible environmental interface which complements ‘internal’ medicine. This view of the skin provides a unique, pivotal, and powerful opportunity to effect evidence-based organizational change in healthcare delivery to newborns. This approach highlights the criticality of the interface between Medicine and Nursing and the importance of focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future. Research InterestsEpidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery
Biography
Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in Biology and German Studies. He received his MD from the University of California, Los Angeles and completed his Pediatric Residency and Fellowship in Neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984. He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of 7 international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body. He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on 5 patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.
Education and Training
Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983. Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.
Residency: University of California, Los Angeles, 1977-79.
Internship: Harbor-UCLA Medical Center, 1976-1977.
MD: University of California, Los Angeles, CA, 1976.
Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.
Baccalaureate: Stanford University, Biology & German Studies, 1972.
Publications
View PubMed Publications
Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16. Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32. Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15. Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6. Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81. Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33. Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78. Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94. Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.
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Alan H. Jobe, MD, PhD
Director, Division of Perinatal Biology
has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.
513-636-8563
alan.jobe@cchmc.org
Alan H. Jobe, MD, PhD
Director, Division of Perinatal Biology
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsClinical trials in neonatology; bronchopulmonary dysplasia Research InterestsLung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm
Education and Training
MD: University of California, San Diego, 1973.
PhD: University of California, San Diego, CA, 1973.
Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.
Fellowship: University of California, San Diego, CA, 1975 to 1977.
Board Certified: Pediatrics and Neonatal-Perinatal Medicine.
Publications
View PubMed Publications
Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6. Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71. Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93. Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7. Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7. Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517. Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93. Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86. Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523. Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.
Grants
Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Co-Investigator. National Institute of Child Health and Human Development. Feb 2009 - Feb 2014.
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Beth Ann Johnson, MD, MA
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Cardiac intensive care; neonatology; premature infants with congenital heart disease; mechanical assist devices; fetal diagnosis; ethics
Education and Training
MD: University of Illinois.
Residency: University of Texas Health Science Center at San Antonio.
Fellowships: Neonatal / Perinatal, Children’s Hospital of Wisconsin; Pediatric Cardiology, Children’s Hospital of Wisconsin; Pediatric Critical Care, Children’s Hospital of Philadelphia.
MA: Bioethics, Medical College of Wisconsin.
Publications
View PubMed Publications
Johnson BA, Mussatto K, Uhing MR, Zimmerman H, Tweddell JS, Ghanayem N, Variability in the Preoperative Management of Infants with Hypoplastic Left Heart Syndrome. Pediatric Cardiology. 2008 29(3):515-520.
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Suhas G. Kallapur, MD
Director, Neonatology Continuing Medical Education
is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Dr. Kallapur’s research focus is to understand the pathogenesis of lung injury and systemic inflammatory responses in fetuses and newborns. His lab uses a sheep model and has begun some work in humans. Visit the Kallapur Lab.
513-636-3879
suhas.kallapur@cchmc.org
Suhas G. Kallapur, MD
Director, Neonatology Continuing Medical Education
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity Visit the Kallapur Lab.
Education and Training
MBBS: University of Bombay, India, 1984.
DCH: College of Physicians and Surgeons, Bombay, 1986.
MD, Pediatrics: University of Bombay, India, 1986.
Residency: University of Bombay, India, 1984-87.
Residency: Children's Hospital of Michigan, Detroit, Michigan, 1988-90.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1990-1993.
Publications
View PubMed Publications
Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18. Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51. Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151. Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010 Sep;68(3):210-5. Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis. Pediatr Res. 2010 May 28. Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5. Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124. Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5. Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7. Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.
Grants
Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Principal Investigator. National Institute of Child Health and Human Development. Feb 2009 - Jan 2014. #R01 HD57869.
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Beena D. Kamath-Rayne, MD, MPH
Assistant Professor, Department of Pediatrics
does clinical/translational research in preterm birth, fetal lung maturity and timing of delivery using biomarkers in amniotic fluid. She also has an interest in global health, and is on the Global Health Education Task Force. She is a master trainer for Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and is collaborating on several research studies of HBB around the world.
513-803-1606
beena.kamath-rayne@cchmc.org
Beena D. Kamath-Rayne, MD, MPH
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Perinatal epidemiology and public health; global health
Biography
Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal lung maturity, and biomarker discovery in amniotic fluid. She has received a BIRCWH K12 award to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010. Dr. Kamath-Rayne was a reviewer for the Helping Babies Breathe (HBB) global neonatal resuscitation curriculum, and is currently a Master Trainer. She is collaborating on several studies of HBB around the world. With Dr. Alan Jobe, she is also a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide.
Education and Training
MD: Georgetown University, Washington, D.C., 2000.
Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, Colorado, 2003.
Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, Colorado, 2008.
Publications
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Scientific JournalsKamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012; 119(5): 909-916. Kamath-Rayne BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Clinical algorithms for identification of sick newborns in community-based settings. Acta Paediatr. 2012; 101: 344-351. Kamath BD, Donovan EF, Christopher R, Brodbeck J, Slone C, Marcotte MP. Using improvement science to increase accuracy and reliability of gestational age documentation. Am J of Perinatol. 2012; 29(3): 217-223. Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8. Goldenberg RL, McClure EM, MacGuire ER, Kamath BD, Jobe AH. Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries. Int J Gynecol Obstet. 2011; 113(2):91-5. Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46. Kamath BD, Fashaw L, Kinsella JP. Adrenal insufficiency in newborns with congenital diaphragmatic hernia. J Pediatr. 2010; 156(3):495-497. Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010 Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360. Books and ChaptersJobe AH, Kamath-Rayne BD. Fetal lung development and surfactant. In: Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice. Greene MF, Creasy RK, Resnik R, Iams JD, Lockwood CJ, Moore T (Eds.). 2012.
Grants
Novel amniotic fluid biomarkers to predict fetal lung maturity and clinical respiratory outcome. Principle Investigator. Jul 2011-Jun 2013.
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Heather C. Kaplan, MD, MSCE
Assistant Professor, Department of Pediatrics
focuses on understanding variations in evidence-based care practices across hospitals and identifying strategies for increasing the implementation of evidence and other innovations into practice. She recently began a line of investigation aimed at building the evidence base for quality improvement so that QI can be used more effectively as a strategy for improving quality and patient outcomes.
513-803-0478
heather.kaplan@cchmc.org
Heather C. Kaplan, MD, MSCE
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Heather Kaplan conducts research focusing on understanding variations in evidence-based care practices across hospitals and examining strategies for increasing the implementation of evidence into practice in perinatal care. She uses a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.
Biography
Heather C. Kaplan, MD,MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and have formed collaborative relationships with obstetrical and neonatal care providers across the state.
Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.
Education and Training
BA: Washington University, St. Louis, Missouri.
MD: Northwestern University, Chicago, Illinois.
Residency: Children's National Medical Center, Washington, DC.
Fellowship: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
MSCE: University of Pennsylvania, Philadelphia, Pennsylvania.
Publications
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Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35. Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22. Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59. Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
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Alan P. Kenny, MD, PhD
Research Instructor, Department of Pediatrics, Affiliated
studies the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development, including the role of a pool of foregut progenitor cells in the ventral endoderm which are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme.
513-803-2224
alan.kenny@cchmc.org
Alan P. Kenny, MD, PhD
Research Instructor, Department of Pediatrics, Affiliated
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsNeonatal Care; neonatal lung disease; neonatal malformations and anomalies Research InterestsLung progenitor development; stem cell differentiation; fetal malformations
Biography
Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?
These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.
Education and Training
PhD: Biology.
MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.
Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.
Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.
Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.
Publications
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Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.
Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63. Kenny A. Vitamin A for prevention of bronchopulmonary dysplasia. Preemie Press. Local news brief for Good Samaritan Hospital. 2007. Angerer LM, Kenny AP, Newman LA, Angerer RC. Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Signal Transduction Wiley Interscience, New York. 2007 7(2), 174-178.
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Paul S. Kingma, MD, PhD
Neonatal Director, Fetal Care Center of Cincinnati
investigates the role of the innate immune system in neonatal infection. Specific projects currently focus on the role of surfactant protein D in neonatal sepsis and acute respiratory distress syndrome and on neutrophil function in cystic fibrosis patients.
513-636-2995
paul.kingma@cchmc.org
Paul S. Kingma, MD, PhD
Neonatal Director, Fetal Care Center of Cincinnati
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsNeonatology; congenital diaphragmatic hernia; neonatal infection Research InterestsInnate immune systems; surfactant protein D; neutrophil function in Cystic Fibrosis
Education and Training
Fellowship: Cincinnati Children's Hospital Medical Center, 2005.
Residency: Cincinnati Children's Hospital Medical Center, 2003.
PhD: Vanderbilt University, TN, 2000.
MD: Vanderbilt University, TN, 2000.
BS: Calvin College, MI, 1992.
Publications
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King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011 May 26. Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun;46(6):1165-71. King BA, Kingma PS. Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia. Am J Respir Cell Mol Biol. 2011 May;44(5):709-15. Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
White M, Kingma PS, Tecle T, Kacak N, Linders B, Heuser J, Crouch E, Hartshorn K. Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral or opsonic activities related to influenza A virus. J Immunol. 2008 Dec 1;181(11):7936-43. Kingma PS, Zhang L, Ikegami M, Hartshorn K, McCormack FX, Whitsett JA. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D. J Biol Chem. 2006 Aug 25;281(34):24496-505. Kingma PS, Whitsett JA. In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol. 2006 Jun;6(3):277-83.
Grants
Surfactant protein D in Systemic Infection and Inflammation. Principal Investigator. National Heart, Lung, and Blood Institute. Jul 2008 - Jun 2013.
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Thomas R. Korfhagen, MD, PhD
Professor, Department of Pediatrics
studies the roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF receptor signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
513-636-8920
thomas.korfhagen@cchmc.org
Thomas R. Korfhagen, MD, PhD
Professor, Department of Pediatrics
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical Interests Care of High Risk infants; pediatric patients with complex, long term medical problems Research Interests Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Education and Training
BA: University of Cincinnati, Cincinnati, OH, 1972.
PhD: University of Cincinnati, Cincinnati, OH, 1976.
MD: University of Cincinnati, Cincinnati, OH, 1981.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director).
Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.
Publications
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Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review. Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86. Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24. Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72. Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25. Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.
Grants
Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis. Co-Investigator. National Heart, Lung, and Blood Institute. Apr 1007 - Aug 2012.
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial. Co-Investigator. Apr 2009 - Mar 2013.
Role Of Surfactant Protein-C and Innate Lung Defense in Familial Interstitial Lung Disease. Co-Investigator. National Heart, Lung, and Blood Institute. Apr 2009 - Mar 2013.
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Kristin R. Melton, MD
Associate Professor, Department of Pediatrics
is interested in early craniofacial development and focuses on the tissue interactions that direct the formation, migration and differentiation of neural crest cells. The Melton lab focuses on understanding the influence of the endothelium and the cranial mesoderm on neural crest development. Visit the Melton Lab.
513-803-0022
Kristin R. Melton, MD
Associate Professor, Department of Pediatrics
Academic Information
Associate Professor, UC Department of Pediatrics
Phone: 513-803-0022
Fax: 513-636-7868
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Specialties
Clinical InterestsCongenital malformations Research InterestsCraniofacial malformations; somitogenesis Visit the Melton Lab.
Biography
Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest. Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development. Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.
Education and Training
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001.
Residency: Children's Mercy Hospital, Kansas City, Missouri, 1998.
MD: University of Nebraska, Omaha, Nebraska, 1995.
BA: Washington University, St. Louis, Missouri, 1991.
Publications
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Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31. Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61. Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9. Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.
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Stephanie L. Merhar, MD, MS
Assistant Professor, Department of Pediatrics
is interested in optimizing neuroimaging in preterm and term infants at risk for brain injury, neonatal seizure treatment and neurodevelopmental outcomes of infants in the NICU.
513-803-5180
stephanie.merhar@cchmc.org
Stephanie L. Merhar, MD, MS
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Education and Training
MD: University of Pennsylvania, Philadelphia, PA ,2005.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2005-2008.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, 2008-2011.
Certification: Pediatrics, 2008.
Publications
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Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7. Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154.
Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6.
Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30.
Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.
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Nagendra K. Monangi, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Maternal / infant nutrition; vitamin D
Education and Training
MBBS: Andhra Medical College, Visakhapatnam, India, 2001. Post Graduate Diploma: Pediatrics, Osmania Medical College, Hyderabad, India, 2005. Residency: Pediatrics, University of South Alabama, Mobile, AL, 2009. Fellwoship: Neonatal-Perinatal Medicine, Cincinnati Children’s Hospital Medical Center / University of Cincinnati, Cincinnati, OH, 2012. Certification: Pediatrics, 2009; Neonatology, Board Eligible.
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Ardythe L. Morrow, PhD
Director, Center for Interdisciplinary Research in Human Milk & Lactation
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Human milk; child health and nutrition
Biography
Dr. Morrow received her MSc in nutrition from the University of the West Indies, Kingston, Jamaica (1980) and PhD in epidemiology from the University of Texas at Houston (1991). Since 1987 she has worked with colleagues in Mexico, Boston, and Houston on an NIH-funded program project on human milk immune protection against infectious disease. She is currently Professor of Pediatrics at the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, where she founded and directs the Center for Epidemiology and Biostatistics that has 35 faculty and staff and a multi-disciplinary Human Milk Research Program that includes clinical and basic science investigators in eight divisions. She has published extensively on breastfeeding promotion and human milk protection against infectious diseases. Her primary focus is on protection by human milk glycans and protection against infectious disease, but she has expanded her research to understanding the relationship between breastfeeding and chronic diseases. She has been an ad hoc reviewer for NIH on breastfeeding research and a technical advisor for international breastfeeding policy and programs for Gates Foundation, UNICEF, and WHO, is on the editorial board of the Journal of Human Lactation and the journal of the Academy of Breastfeeding Medicine. She is an elected member of the American Pediatric Society. She has over 100 publications, and is the primary author of the WHO monograph, Community-based Strategies for Breastfeeding Promotion and Support in Developing Countries (2004). She has served as Chair of the Milk Club of the (American) Society for Pediatric Research for the past 4 years. In 1997, she received a Young Investigator award from ISRHML for her randomized trial of breastfeeding support (Lancet, 1999). She was co-organizer of the 2002 ISRHML international meeting in Mexico and is co-editor of the book Protecting Infants through Human Milk: Advancing the Scientific Evidence.
Education and Training
BA: Rice University, Houston, Texas.
MSc: University of the West Indies, Kingston, Jamaica.
PhD: The University of Texas School of Public Health, Houston, Texas 1991.
Publications
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South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10. Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51. Farkas T, Cross RW, Hargitt E 3rd, Lerche NW, Morrow AL, Sestak K. Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses. J Virol. 2010 Sep;84(17):8617-25. Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9. Huang P, Morrow AL, Jiang X. The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognition. Glycoconj J. 2009 Nov;26(8):1085-96. Meinzen-Derr J, Morrow AL, Hornung RW, Donovan EF, Dietrich KN, Succop PA. Epidemiology of necrotizing enterocolitis temporal clustering in two neonatology practices. J Pediatr. 2009 May;154(5):656-61. Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. Reporting individual test results of environmental chemicals in breast milk: potential for premature weaning. Breastfeed Med. 2008 Dec;3(4):207-13. Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91. Meinzen-Derr J, Poindexter B, Wrage L, Morrow AL, Stoll B, Donovan EF. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J Perinatol. 2009 Jan;29(1):57-62. Woo JG, Dolan LM, Morrow AL, Geraghty SR, Goodman E. Breastfeeding helps explain racial and socioeconomic status disparities in adolescent adiposity. Pediatrics. 2008 Mar;121(3):e458-65.
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Vivek Narendran, MD, MRCP, MBA
Medical Director, Neonatal Intensive Care Unit and Newborn Nursery, The University Hospital
is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.
513-803-0961
vivek.narendran@cchmc.org
Vivek Narendran, MD, MRCP, MBA
Medical Director, Neonatal Intensive Care Unit and Newborn Nursery, The University Hospital
Medical Director, Cincinnati Perinatal Outreach Project
Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsNon-Invasive Ventilation of the Preterm Infant, Business Case for Quality Improvements Research InterestsInterested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface
Education and Training
MBBS: Bangalore Medical College, Bangalore, India, 1985.
MD/DNB: JN Medical College, Belgaum, India, 1990.
Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.
Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1997-1998.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1996, 1998-2000.
Credentials: Pediatrics, 1998; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.
Publications
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Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Feb 14. Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81. Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep;25(9):608-11. Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol. 2005 Jul;25(7):440-6. Review. Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec;191(6):2090-6. Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9. Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review. Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.
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Amy T. Nathan, MD
Medical Director, Good Samaritan Hospital, Neonatal Intensive Care Unit
focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
513-803-0909
amy.nathan@cchmc.org
Amy T. Nathan, MD
Medical Director, Good Samaritan Hospital, Neonatal Intensive Care Unit
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical Interestsnecrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care Research InterestsImmune modulation of lung injury and inflammation
Biography
Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
Education and Training
MD: Yale University School of Medicine, New Haven, CT, 1998.
Residency: University of North Carolina, Chapel Hill, NC 1998-2002.
Fellowship: University of North Carolina, Chapel Hill, NC 2002-2005.
Certification: Pediatrics 2001; Neonatology, 2008
Publications
View PubMed Publications
Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10. Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8. Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010. Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2. Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8.
Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.
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Laurie Nommsen-Rivers, PhD, RD, IBCLC
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Broad research objective is to provide evidence-based strategies for supporting the mother-baby dyad in successfully establishing breastfeeding; current area of research examines the causes and consequences of early breastfeeding difficulties, with particular emphasis on delayed onset of lactogenesis
Biography
Laurie Nommsen-Rivers, PhD, RD, IBCLC, worked with hundreds of breastfeeding dyads as a staff researcher in the field of human lactation before returning to school in 2004 to pursue a PhD in Epidemiology. She has co-authored over 50 publications related to maternal child health. In addition, Laurie Nommsen-Rivers served as the Associate Editor of the Journal of Human Lactation from 1997 to 2006.
Education and Training
PhD: University of California, Davis; December 2007.
MS: University of California, Davis, September 1989.
BS: University of California, Davis, 1985.
Registered Dietitian: Registration # 706227, continuously since 1991.
International Board Certified Lactation Consultant: Continuously since 1993
Publications
View PubMed Publications
Onyango AW, Nommsen-Rivers L, Siyam A, Borghi E, de Onis M, Garza C, Lartey A, Baerug A, Bhandari N, Dewey KG, Araújo CL, Mohamed AJ, Van den Broeck J; for the WHO Multicentre Growth Reference Study Group. Post-partum weight change patterns in the WHO Multicentre Growth Reference Study. Matern Child Nutr. 2011 Feb 22. doi: 10.1111/j.1740-8709.2010.00295.x. Nommsen-Rivers LA, Cohen RJ, Chantry CJ, Dewey KG. The Infant Feeding Intentions scale demonstrates construct validity and comparability in quantifying maternal breastfeeding intentions across multiple ethnic groups. Matern Child Nutr. 2010 Jul 1;6(3):220-7. Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr. 2010 Sep;92(3):574-84. Nommsen-Rivers LA, Chantry CJ, Cohen RJ, Dewey KG. Comfort with the idea of formula feeding helps explain ethnic disparity in breastfeeding intentions among expectant first-time mothers. Breastfeed Med. 2010 Feb;5(1):25-33. Marshall AM, Nommsen-Rivers LA, Hernandez LL, Dewey KG, Chantry CJ, Gregerson KA, Horseman ND. Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution. J Clin Endocrinol Metab. 2010 Feb;95(2):837-46. Nommsen-Rivers LA, Dewey KG. Growth of breastfed infants. Breastfeed Med. 2009 Oct;4 Suppl 1:S45-9. Nommsen-Rivers LA, Mastergeorge AM, Hansen RL, Cullum AS, Dewey KG. Doula care, early breastfeeding outcomes, and breastfeeding status at 6 weeks postpartum among low-income primiparae. J Obstet Gynecol Neonatal Nurs. 2009 Mar-Apr;38(2):157-73. Nommsen-Rivers LA, Dewey KG. Development and validation of the Infant Feeding Intentions Scale. Matern Child Health J. 2009;13(3):334-42. Nommsen-Rivers LA, Heinig MJ, Cohen RJ, Dewey KG. Newborn wet and soiled diaper counts and timing of onset of lactation as indicators of breastfeeding inadequacy. J Hum Lact. 2008;24(1):27-33.
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John H. Reuter, MD, PhD
is active in the administration of a 4000 delivery/year community level II service. His academic interests include breast milk and nutrition in the preterm infant.
513-862-2748
john.reuter@cchmc.org
John H. Reuter, MD, PhD
Neonatologist
Chair, Department of Pediatrics at Bethesda North Hospital Nurseries
Academic Information
Associate Professor, UC Department of Pediatrics
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Education and Training
MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1976.
PhD: Physiology, University of Cincinnati College of Medicine, 1973. Residency: Pediatrics, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, Ohio, 1978. Fellowship: Moffitt Hospital, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, Calif., 1980. Certifications: Pediatrics, 1982 Neonatal; Perinatal Medicine, 1983.
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Ward R. Rice, MD, PhD
Director, Neonatology Fellowship Training Program
studies the molecular and cellular mechanisms that regulate processing of Surfactant Protein C, a protein that is critical for lung function.
513-636-3149
ward.rice@cchmc.org
Ward R. Rice, MD, PhD
Director, Neonatology Fellowship Training Program
Director, Newborn Services, St. Elizabeth Medical Center
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsHypotension in ELBW infants; EMR Research InterestsProcessing of Surfactant Protein C
Biography
Ward R. Rice, MD, PhD, is the Director of the Neonatology Fellowship Training Program and Director of Newborn Services, St. Elizabeth Medical Center. Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the Director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world. His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of Surfactant Protein C.
Education and Training
PhD: 1972-76 University of Chicago, Chicago, Illinois. PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane" MD: 1972-78 University of Chicago, Chicago, Illinois. Internship: 1978-79 Duke University Medical Center, Durham, North Carolina. Residency: 1979-81 Duke University Medical Center, Durham, North Carolina. Fellowship Neonatology: 1981-83 University of Cincinnati College of Medicine, Children's Hospital Medical Center. Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.
Publications
View PubMed Publications
Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9. Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61. Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64. Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25. Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32. Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7. Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83. Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review. Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32. Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.
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Kurt R. Schibler, MD
Director, Neonatology Clinical Research Program
is the principal investigator for the NICHD Neonatal Research Network at Cincinnati Children’s and is also involved in thematic collaborative research investigating the immune mechanisms underlying morbidity and mortality associated with preterm birth. He aims to identify infants at high risk for developing necrotizing enterocolitis and late onset infection and to devise strategies to prevent and to treat these complications.
513-636-3972
kurt.schibler@cchmc.org
Kurt R. Schibler, MD
Director, Neonatology Clinical Research Program
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsClinical trials; neonatal immune development Research InterestsImmune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity
Education and Training
MD: University of Cincinnati, Cincinnati, Ohio, 1984. Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990. Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993. Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.
Publications
View PubMed Publications
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 Jan 20.
Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.
Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91.
Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8. Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16. Book ChaptersSchibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.
Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.
Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.
Grants
The natural history of CMV-related hearing loss and the feasibility of CMV screening as adjunct to hearing in the newborn. Co-investigator. National Institutes of Health. Jan 2006 - Dec 2012. #HHS-N-260200500008C. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants. Co-Principal Investigator. National Institutes of Health. Mar 2009 - Feb 2014. #R01-HD059140.
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Debora I. Sinner, PhD
is interested in understanding the molecular mechanisms underlying foregut formation. Specifically, her lab focuses on the molecular mechanism underlying lung and upper airway development and the paracrine interactions between epithelium and mesenchyme. Ultimately, her goal is to use the embryo as a paradigm to understand diseases affecting upper airway and lung. To this end her lab utilizes knockout mouse models and the frog embryo combined with molecular and cellular approaches using in vitro systems.
513-803-1353
debora.sinner@cchmc.org
Debora I. Sinner, PhD
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
Developmental biology; pulmonary biology
Biography
Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease. After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.
Education and Training
MS: University of Buenos Aires, Argentina, 1999.
PhD: University of Buenos Aires, Argentina, 2003.
Post doctoral training: Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2009.
Publications
View PubMed Publications
Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010 Jan;239(1):56-68.
Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Sinner D, Kordich JJ, Opoka R Rankin SA,. Lin S-J, Jonatan D, Zorn AM, Wells JM. Beta-catenin/Tcf activity is repressed by Sox17 and enhanced by Sox4 in colon carcinoma cells. Mol Cell Biol. 2007;27:7802-7815.
Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development. 2006 May;133(10):1955-66.
Sinner D, Rankin S, Lee M, Zorn AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development. 2004 Jul;131(13):3069-80.
Sinner D, Caviglia JM, Jawerbaum A, Igal RA, Gonzalez E. Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2. Reprod Fertil Dev. 2003;15(1-2):75-80.
Grants
"Molecular mechanisms underlying lung growth and hypoplasia: Role of Wntless" Basil O' Connor Starter Scholar Research Award. March of Dimes. 2/1/2012-1/30/2014 "Molecular mechanisms underlying upper airway patterning and tracheomalacia" K01 NIH-NHLBI 8/1/2012-7/31/2017
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Andrew Patrick South, MD, MPH
Assistant Professor, Department of Pediatrics
has research interests that include epidemiology and prevention of late-preterm birth and the long-term outcome of infants born with gastroschisis.
513-803-0998
andrew.south@cchmc.org
Andrew Patrick South, MD, MPH
Assistant Professor, Department of Pediatrics
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Epidemiology and prevention of late-preterm birth; long term outcome of infants born with gastroschisis
Education and Training
MD: Case Western Reserve University, Cleveland, OH, 2000. Residency: Pediatrics, University of North Carolina Children’s Hospital, Chapel Hill, NC. Fellowship: Neonatology, University of North Carolina Children’s Hospital, Chapel Hill, NC. Certification: Pediatrics, 2004; Neonatology, 2008.
Publications
View PubMed Publications
Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011 Feb 10. South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10. South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3. Winik BC, Asial RA, McGrath JA, South AP, Boente MC. Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder. Br J Dermatol. 2009 Apr;160(4):868-74. South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol. 2008 Oct;28(10):702-6. South MMT, Strauss RA, South AP, Boggess JF, Thorp JM. The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: A randomized controlled trial. Am J of Obstet and Gynec 2005;193:537-43.
Grischkan J, Storfer-Isser A, Rosen CL, Larkin EK, Kirchner HL, South A, Wilson-Costello DC, Martin RJ, Redline S. Variation in childhood asthma among former preterm infants. J Pediatr 2004;144:321-6.
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Jean J. Steichen, MD
Professor Emeritus, High Risk Clinic
has special interests in high-risk infant follow-up.
513-803-0962
Jean J. Steichen, MD
Professor Emeritus, High Risk Clinic
Academic Information
Emeritus, UC Department of Pediatrics
Phone: 513-803-0962
Fax: 513-803-0969
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Specialties
High-risk infant follow-up
Education and Training
MD: University of Paris Medical School, Paris, France, 1969. Residency: Pediatrics, University Hospital and St. Joseph Hospital, Paris, France, 1969-1970; Franklin Square Hospital/John's Hopkins Hospital, Baltimore, Md., 1979; Children's Hospital Medical Center, Cincinnati, Ohio, 1970-1972. Fellowship: Cincinnati General Hospital and Children's Hospital Medical Center, Cincinnati, Ohio, 1974.
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Laura Placke Ward, MD
Assistant Professor, Department of Pediatrics
Director, Mercy Hospital Anderson Nurseries
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsMultidisciplinary quality improvement; family centered care; evidence-based practice Research InterestsStrategies to prevent significant hyperbilirubinemia in infants
Biography
Dr. Ward has been a neonatologist in the Division since 2002, and attends at The University Hospital.
Education and Training
MD: St. Louis University School of Medicine, St. Louis, Missouri, 1994.
Residency: Children’s National Medical Center, Washington DC, 1994-1997.
Fellowship: Children’s National Medical Center, Washington DC, 1997-2000.
Certifications: Pediatrics, 1997; Neonatology, 2003.
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Kathy E. Wedig-Stevie, MD
Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
focuses on neonatal follow-up, including the follow-up of graduates from the NICU and drug exposed neonates with neonatal abstinence syndrome. Her future research plans involve neuroimaging and therapy based on the neurological findings.
513-872-2748
kathy.wedig@cchmc.org
Kathy E. Wedig-Stevie, MD
Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
Neonatologist, Good Samaritan Hospital
Medical Director, Mercy Hospital Fairfield Nurseries
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Neonatal high risk infant follow-up and developmental follow-up
Education and Training
MD: University of Cincinnati Medical School, Cincinnati, Ohio, 1978.
Residency: Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, 1978-1981. Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, 1983.
Certifications: Pediatrics, 1983; Neonatology, 1983.
Publications
View PubMed Publications
Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008 Jan;152(1):140, 140.e1.
Wedig KE, Kogan J, Schorry EK, Whitsett JA. Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4.
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Scott L. Wexelblatt, MD
Medical Director, Regional Newborn Services
Academic Information
Assistant Professor, UC Department of Pediatrics
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Education and Training
MD: University of Vermont, Burlington, VT. 1996.
Residency: Cincinnati Children’s Hospital Medical Center.
Certification: Pediatrics, 1999.
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