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John Bissler, MD, focuses on proliferative renal diseases such as tuberous sclerosis complex, the polycystic kidney diseases, renal tumors, von Hippel-Lindau disease, and Birt–Hogg–Dubé syndrome. The research includes mechanisms of mutation, and the cell biology of disease. Dr. Bissler extends his bench research into clinical trials in order to find new and better treatments for his patients.
Bradley Dixon, MD, research focuses on the effects of hyperosmolar microenvironments such as the lower urinary tract on the DNA damage response and DNA repair mechanisms of cells in that microenvironment. Understanding these effects may help to explain the increased risk of cancer experienced by gastric or intestinal tissues in an augmented bladder.
Brian Siroky PhD, research focuses on understanding the mechanisms of renal cyst formation that occurs in the inherited disease Tuberous Sclerosis Complex (TSC). He is interested in the structural and functional relationship between renal epithelial primary cilia, which are specialized cellular organelles whose dysfunction is linked to cystogenesis, and mTOR signaling, the cell signaling pathway that is dysregulated in TSC.
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