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The primary focus of Jennifer’s work is identifying novel therapeutics for Angelman syndrome (AS), a genetic disorder that causes severe developmental delay, epilepsy, and movement defects. She is also working to develop a better understanding of the underlying cellular mechanisms of learning and memory that are disrupted in cognitive disorders, such as AS.
Arnold studies the cognitive and behavioral impairments produced by exposure to psychostimulants. He is currently looking at the effects of binge doses of methamphetamine on short-term, working memory. Using behavioral methods such as the Morris Water Maze and Radial Arm Maze, he is studying how binge doses of methamphetamine affect trial-dependent spatial memory long after exposure to the drug. He is also involved in examining changes in neurotransmitter systems in creatine transporter deficiency models.
Jillian is focusing on a global Pde1b knockout by crossing our floxed Pde1b with Cre(CMV) mice and phenotyping for induced immobility, a model of depression. Later, Floxed mice will be crossed with Cre lines to create brain and cell (neuronal vs. glia) specific knockouts to provide insight into Pde1b’s role in depression as a new target for antidepressant activity. She is also working on an ADHD model; she is characterizing the genetic defect in these rats and how the phenotype mimics hyperactivity and impulsivity; core symptoms in ADHD.
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