Xiang Lab

  • Xiang Lab Research

    The Magnetoencephalography (MEG) Center at Cincinnati Children’s Hospital Medical Center conducts collaborative research aimed at tapping the full clinical potential for this advanced imaging technology. Many of our research projects focus on signal processing and presurgical functional mapping, which could lead to safer, less invasive neurosurgical procedures for patients with epilepsy.

    One of our areas of focus investigates high-frequency neuromagnetic signals (HFNS) associated with electric high-frequency oscillations (HFOs, ripple or fast ripple). Our preliminary data indicate that high-frequency brain signals are a new window for functional analysis of the brain activity. In addition, high-frequency neuromagnetic signals may provide unique information about brain maturation and development. Our research is some of the first to investigate these signals in children and adolescents.

    We also aim to develop new techniques to noninvasively localize seizure onset regions and ultimately avoid lengthy, costly and risky invasive intracranial recordings (or ECoG) to find the abnormal epileptic regions requiring surgical removal. From the clinical point of view, MEG can localize active areas of the brain targeted for surgical removal and provide more accurate spatial localization of functional areas of the brain that should be preserved. Our research can directly translate into safer, more reliable neurosurgery to treat children with severe epileptic seizures.

  • Lab Publications

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    2010

    Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, Degrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr. 5(1):113-22. 2010.

    Meng L, Xiang J, Kotecha R, Rose D, Zhao H, Zhao D, Yang J, Degrauw T. White matter abnormalities in children and adolescents with temporal lobe epilepsy. Magn Reson Imaging. Jul 23, 2010.

    Korostenskaja M, Pardos M, Fujiwara, H, Teija Kujala, Horn P, Rosea D, Byars A, Brown D, Seo JH, Wang YY, Vannest J, Xiang J, DeGrauw T, Näätänen R, Lee KH. Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy. Epilepsy Research. 2010.

    Huo X, Wang Y, Kotecha R, Kirtman EG, Fujiwara H, Hemasilpin N, Degrauw T, Rose DF, Xiang J. High gamma oscillations of sensorimotor cortex during unilateral movement in the developing brain: a MEG study. Brain Topogr. Jun 25, 2010.

    Wang X, Xiang J, Wang Y, Pardos M, Meng L, Huo X, Korostenskaja M, Powers SW, Kabbouche MA, Hershey AD. Identification of abnormal neuromagnetic signatures in the motor cortex of adolescent migraine. Headache. May 7, 2010.

    Chen Y, Xiang J, Kirtman EG, Wang Y, Kotecha R, Liu Y. Neuromagnetic biomarkers of visuocortical development in healthy children. Clin Neurophysiol. Apr 13, 2010.

    Korostenskaja M, Pardos M, Lee KH, Fujiwara H, Kujala T, Xiang J, Vannest J, Wang YY, Hemasilphin N, deGrauw T, Rose D. From Auditory Change Detection to Reading and Word Processing: Impairments in Children with Intractable Epilepsy. Advances in Biomagnetism – BIOMAG2010, IFMBE Proceedings. 28, pp. 378–380. 2010.

    Guo XY, Xiang J, Chen YM, Meng L, Wang XS, Wang YY. Quantification of the Time and Frequency Signatures of Visual Cortical Activation in the Developing Brain: A Study with MEG and Wave-Cross Spectrogram. Advances in Biomagnetism – BIOMAG2010, IFMBE Proceedings. 28, pp. 183–186. 2010.

    Meng L, Xiang J, Rose DF, Kotecha R, Vannest J, Byars A, deGrauw Ton. White Matter Abnormalities in Children with Epilepsy: A DTI and MEG Study. Advances in Biomagnetism – BIOMAG2010, IFMBE Proceedings. 28, pp. 397–400. 2010.

    Meng L, Xiang J, Rose DF, Kotecha R, Vannest J, Byars A, deGrauw Ton. Time Course and Neural Network for Comparing Written and Spoken Words: A MEG and DTI Study. Advances in Biomagnetism – BIOMAG2010, IFMBE Proceedings. 28, pp. 338–341. 2010.

    Wang YY, Xiang J, Rose DF, Holroyd T, Harris E, deGrauw TJ. The Frequency Profile of Somatosensory Evoked Magnetic Fields in the Developing Brain. Advances in Biomagnetism – BIOMAG2010, IFMBE Proceedings. 28, pp. 254–257. 2010.

    2009

    Huo X, Xiang J, Wang Y, Kirtman EG, Kotecha R, Fujiwara H, Hemasilpin N, Rose DF, Degrauw T. Gamma oscillations in the primary motor cortex studied with MEG. Brain Dev. 2009.

    Xiang J, Liu Y, Wang YY, Kirtman EG, Kotecha R, Chen YM, Huo XL, Fujiwara H, Hemasilpin N, Lee K, Mangano F, Leach J, Blaise J, deGrauw T, Rose D. Frequency and Spatial Characteristics of High-Frequency Neuromagnetic Signals in Childhood Epilepsy. Epileptic Disord. 11(2): 113-125. 2009.

    Xiang J, Liu Y, Wang YY, Kotecha R, Kirtman EG, Huo XL, Fujiwara H, Hemasilpin N, deGrauw T, Rose D. Neuromagnetic Correlates of Developmental Changes in Endogenous High-frequency Brain Oscillations in Children: A Wavelet-based Beamformer Study. Brain Research. 1274:28-39. 2009.

    Kotecha R, Pardos M, Wang Y, Wu T, Horn P, Brown D, Rose D, deGrauw T, Xiang J. Modeling the developmental patterns of auditory evoked magnetic fields in children. PLoS ONE. 4(3):e4811. 2009.

    Kotecha R, Xiang J, Wang Y, Huo X, Hemasilpin N, Fujiwara H, Rose D, Degrauw T. Time, frequency and volumetric differences of high-frequency neuromagnetic oscillation between left and right somatosensory cortices. Int J Psychophysiol. 72(2):102-110. 2009.

    Xiang J, Xiao Z. Spatiotemporal and frequency signatures of noun and verb processing: a wavelet-based beamformer study. Journal of Clinical and Experimental Neuropsychology. 31(6):648-657. 2009.

    2008

    Liu Y, Xiang J, Wang Y, Vannest JJ, Byars AW, Rose DF. Spatial and frequency differences of neuromagnetic activities in processing concrete and abstract words. Brain Topogr. 20(3):123-129. 2008.

    Ishii R, Canuet L, Ochi A, Xiang J, Imai K, Chan D, Iwase M, Takeda M, Snead OC 3rd, Otsubo H. Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia. Epilepsy Res. 81(2-3):228-232. 2008.

    Wang Y, Xiang J, Kotecha R, Vannest J, Liu Y, Rose D, Schapiro M, Degrauw T. Spatial and frequency differences of neuromagnetic activities between the perception of open- and closed-class words. Brain Topogr. 21(2):75-85. 2008.

    Other Significant Publications

    Xiang J, Wang YY, Xiao Zheng, Balioussis, Zhu HM, Holowka S, Sharma R, Hunjan A, Otsubo H, Chuang S. Volumetric localization of epileptic activity using wavelet-based synthetic aperture magnetometry. International Congress Series. 1300: 697-700. 2007.

    Xiang J, Xiao Z, Wang YY, Feng YG, Qiao H, Sun B, Holowka S, R, Hunjan A, Sharma R, Chuang S., Rose D. Detection of subtle structural abnormality in tuberous sclerosis using MEG guided post-image processing. International Congress Series. 1300: 693-696. 2007.

    Wu T, Liu HY, Rui Z, Xiang J. Localization of motor cortex using synthetic aperture magnetometry. Chinese Journal of Medical Imaging Technology. 11:1605-1612. 2007.

    Published Abstracts & Book Chapters

    Pardos M, Korostenskaja M, Fujiwara H, Wang Y, Xiang J, Horn P, Byars A, Vannest J, Hemasilphin N, Gummadavelli A, Rose DF. Neuromagnetic evidence of impaired receptive language function in children with intractable epilepsy. International conference on biomagnetism (BioMag). March 28 – April 1, 2010; Dubrovnik, Croatia.

    Korostenskaja M, Rose D, Pardos M, Kujala T, Horn P, Fujiwara H, Brown D, Alku P, Wang Y, Xiang J, Byars A, DeGrauw T,Näätänen R, Lee KH. Change detection mechanism differs between frontal and temporal intractable epilepsy patients.16th Annual Meeting of the Organization for Human Brain Mapping (HBM). June 6 –10, 2010; Barcelona, Spain. Abstract number 309 MT-AM.

    Thompson E, Holland S, Xiang J, Wang Y. MEG Source Localization Using a Frequency Beamformer. Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC). March 27-28, 2010; New York, NY, 1-2.

    Wang Y, Xiang J, Rose D, Holroyd T, Wang X, Huo X, Harris E, deGrauw T. Age and gender effects on finger somatosensory evoked magnetic fields. Biomag. Abstract. 2010.

    Harris E, Gilbert D, Xiang J, Wang Y, Meyer C, Fujiwara H, Rose D. Feasibility of magnetoencephalography in children with Tourette Syndrome. Soc. Neurosci. Abstract. 2009.

    Xiang J, Chen Y, Wang Y, Liu Y, Fujiwara H, Hemasilpin N, Lee K, Mangano F, Leach J, Franz D, Holland K, Rose D. Noninvasive Detection and Localization of Pathologic High-Frequency Oscillation in Tuberous Sclerosis Complex with Wavelet-Based Beamformer. Epilepsia. 2009, Suppl. 0. Abstract. 2.037.

    Meng L, Xiang J, Yuan W, Wang Y, Chen Y, Wang X, Fujiwara H, Hemasilpin N, Lee K, Mangano F, Leach J, Holland K, Rose D. Abnormalities of Diffusion Tensor Imaging In Epileptic Areas in Childhood Epilepsy. Epilepsia. 2009, Suppl. 0. Abstract. 2.052.

    Xiang J, Wang YY, Chen YM, Liu Y, Huo XL, Fujiwara H, Hemasilpin N, Lee KH; Mangano F, Leach J, Blaise J, deGrauw T, Rose DF. Volumetrically Mapping Ictal Activity in Childhood Epilepsy with Neuromagnetic Signals in Multiple-frequency Bands. Human Brain Mapping, 2009, p127.

    Chen YM, Wang YY, Liu Y, Fujiwara H, Hemasilpin N, deGrauw T, Lee KH, Rose D, Xiang J. Spatial and Frequency Characteristics of Epileptic High-Frequency Neuromagnetic Activation in Patients with Tuberous Sclerosis Complex. Human Brain Mapping. 2009, p213.

    Wang YY, Xiang J, Vannest J, Huo XL, Chen YM, Wu T, Liu YH, Holland S, deGrauw T, Rose DF. Neuromagnetic measures of word processing in Bilinguals and Monolinguals. Human Brain Mapping. 2009, p248.

    Xiang J, Kotecha R, Wang YY, Pardos M, Horn P, Zhang FW , Rose DF, deGrauw T. Modeling Maturational Pattern of Auditory Function in Healthy Children with Magnetoencephalography. Human Brain Mapping. 2009, p552.

    Huo X, Xiang J, Wang Y, Kirtman E, Kotecha R, Liu Y, Fujiwara H, Hemasilpin N, Rose D, Degrauw T. Movement-Related Ipsilateral Desynchronization and Contralateral Synchronization of Gamma Oscillations Studied with MEG. Human Brain Mapping. 2009, p479.

    Wang X, Xiang J, Wang Y, Powers S, Kabbouche M, Hershey A. Neuromagnetic Signatures of Abnormal Brian Activation Elicited by Finger Movement in Adolescent Migraine. International Headache Congress (IHC). 2009, Philadelphia, USA.

    Korostenskaja M, Pardos M, Alku P, Brown D, Horn P, Fujiwara H, Xiang J, DeGrauwT, Rose D, Näätänen R, Kujala T. Effective assessment of discriminating multiple speech and sound features with MEG in healthy subjects. 15th Annual Meeting of the Organization for Human Brain Mapping. June 18-23, 2009, San Francisco, California, USA. Citation: NeuroImage, 47(1): S129.

    Korostenskaja M, Pardos M, Wang Y, Alku P, Brown D, Horn P, Fujiwara H, Xiang J, Rose D, DeGrauw T,Näätänen R, Kujala T. Effective assessment of discriminating multiple speech and sound features with MEG in healthy children. 15th International Congress on ERPs of the brain (EPICXV). April 22-25, 2009 Indiana University, Bloomington, Indiana, USA. Citation: Abstract book, 8.49679, p. 84.

    Korostenskaja M, Pardos M, Wang Y, Xiang J, Kujala T, Kabbouche M, Powers S, Hershey A. Abnormal Auditory Information Processing in Adolescent Migraine: preliminary magnetoencephalography study. International Headache Congress (IHC). 2009, Philadelphia, USA.

    Korostenskaja M, Pardos M, Kujala T, Horn P, Fujiwara H, Braown D, Alku P, Wang Y, Rose D, Xiang J, Byars T, Degrauw T, Naatanen R, Lee K. Evidence of Impaired Auditory Information Processing in Children with Intractable Epilepsy: MEG Study. Epilepsia. 2009, Suppl. 0. Abstract. 2.052.

    Korostenskaja M, Pardos M, Kujala T, Näätänen R, Horn P, Fujiwara H, Brown D, Alku P, Wang Y, Rose D, Xiang J, DeGrauwT, Lee KH. Exploring impaired auditory information processing in intractable epilepsy. International Society for the Advancement of Clinical Magnetoencephalography (ISACM). September 3rd - 5th 2009, Athens, Greece.

    Harris E, Gilbert D, Xiang J, Wang Y, Meyer C, Hastie E, Fujiwara H, Rose D. Magnetoencephalography (MEG) and electroencephalography (EEG) of children with Tourette Syndrome reveals a slow wave prior to tic onset and oscillating frontal activity. Tourette Syndrome Assoc. Abstract. 2009.


 
  • 275 MEG channels and 128 EEG electrodes. Sampling rate is up to 12 kHz per channel. Supersensitive (superconducting) magnetic detectors record the brain's spontaneous neuromagnetic signals.

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    275 MEG channels and 128 EEG electrodes. Sampling rate is up to 12 kHz per channel. Supersensitive (superconducting) magnetic detectors record the brain's spontaneous neuromagnetic signals.
  • Contact Us

    Jing Xiang, MD, PhD
    MEG Center, Department of Neurology
    3333 Burnet Ave.
    MLC 2015
    Cincinnati, OH 45229

    Phone: 513-636-6303
    Fax: 513-636-1888
    Email: jing.xiang@cchmc.org