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This project uses magnetoencephalography (MEG) to characterize the normal neuromagnetic profile in children of intrinsic neuromagnetic activities and sensorimotor, auditory, visual and language elicited magnetic fields in 0-2,000 Hz. Since MEG can detect neuromagnetic signals with high spatial and temporal resolution, many brain properties can be studied. Currently, we are focusing on three areas:
This approach may lead to a new way to study the brain functions in normal children and in children with various brain disorders.
Funded by a trustee grant.
This project has three aims:
Visual identification of spikes (14-70 Hz) in invasive EEG recordings is the widely used method for estimating ictogenic zones. This work is innovative because it examines the relationship between HFBS and ictogenic zones noninvasively (using MEG). This is a novel use of MEG, and we will use new data analysis techniques to accomplish this work.
If successful, MEG localization of HFBS could replace risky intracranial recordings and improve the outcome of epilepsy surgery. After causality analysis of MEG HFBS, a single ictogenic focus may be identified in patients thought to have multiple epileptic areas based on current methodologies. As a result, additional patients may have successful surgery.
Funded by a trustee grant, NIH / NINDS R01-NS072341 (pending).
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