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The objective of this project is to address two specific aims:
We will digitize MEG data at 6,000 Hz. We will determine abnormalities of cortical excitability in migraine by analyzing neuromagnetic spectral power in 0-3,000 Hz at source levels using a wavelet-based beamformer. Since MEG has mainly been used in the study of brain activities in low-frequency ranges (< 40 Hz) in adult migraines, the study of the motor cortex excitability in pediatric migraine with neuromagnetic signals in 0-3,000 Hz is novel. Likewise, our quantification of the cortical excitability with neuromagnetic spectral and frequency signatures is technically innovative.
Although this proposal focuses on the motor cortex, the same methodologies can be applied to evaluate other brain areas. If successful, it will provide a noninvasive assessment and localization option for abnormalities of cortical excitability. Effective methods for treating and preventing migraine attacks may be possible by normalizing cortical excitability with TMS, medication and other methods.
Given that HFBS are a new discovery and our MEG methodologies are novel, improved treatment and prevention solutions based on better understanding of the mechanisms of migraine may protect children with migraine from progressing into a chronic condition with significant disability.
Funded by a grant by NIH / NINDS R21-NS072817.
click to enlarge
MEG results combined with MR images (magnetic source imaging, MSI) showing the SAM imaging of movement-elicited neuromagnetic activation in 65-125 Hz. The red and yellow areas indicate regions of neuromagnetic activation (or synchronized neural firing). The neuromagnetic activation elicited by right finger movement is localized in the contralateral motor cortex in the healthy control. The neuromagnetic activation elicited by right finger movement is localized in the contralateral motor cortex as well as in the supplementary motor area in migraine. The color bar indicates the color coding of strength of activation.
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