(All fields required)
Please enter a valid email.
Please enter your name.
What is : (So we know you are human.)
Please supply the correct answer.
We are a developmental neuroscience laboratory that studies primary and motile ciliary signaling and its effects on neural and glial progenitor cell differentiation. We are currently studying cilia-related molecular and cellular events leading to and resulting from hydrocephalus, a common neurological condition occurring in 1 in 1,000 children and a condition that Dr. Vogel treats clinically for pediatric neurosurgery. Hydrocephalus results in dilated fluid spaces (ventricles) and has significant effects on the developing brain in children. To study the events underlying hydrocephalus, we have developed mouse models that closely resemble the hydrocephalic condition seen in children. Based on these studies, we have identified the importance of primary and motile cilia in neural stem cell migration from the subventricular zone (SVZ), in differentiation, in brain development, and ultimately in the genesis of hydrocephalus. Our lab, along with our collaborators at Cincinnati Children's: Kenneth Campbell and Masato Nakafuku, are actively pursuing the signaling pathways involved in hydrocephalus as it relates to ciliary signaling.
We are also interested in studying novel methods of imaging of cilia along with our collaborators at Massachusetts General Hospital at Harvard University. We have developed novel methods to capture images of cilia at subcellular resolution and are applying these techniques to various preclinical models for translation into human studies.
Finally, as a clinician, Dr. Vogel’s laboratory is uniquely positioned to study pediatric hydrocephalus and its effects on the developing central nervous system. In order to ground these studies in physiologically relevant models of human disease, we have ongoing institutional review board (IRB) approved studies to look at certain forms of human hydrocephalus during child development and the human molecular genetics associated with this disease. We are working closely with partners in the Newborn Intensive Care Unit (NICU) and other centers of excellence at Cincinnati Children’s on translational projects related to developing innovative therapeutics for hydrocephalus.
Zhang Q, Nishimura DY, Vogel T, Shao J, Swiderski R, Yin T, Searby C, Carter CC, Kim G, Bugge K, Stone EM, Sheffield VC. BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking. J Cell Sci. 2013 Jun 1;126(Pt 11):2372-80.
Carter CS*, Vogel TW*, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC. Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.Nature Medicine. 2012 Dec;18(12):1797-804. Cover Article. (*EQUAL AUTHOR CONTRIBUTION)
Vogel TW, Carter CS, Iyamah KA, Zhang Q, Robinson S. The role of primary cilia in the pathophysiology of neural tube defects. Neurosurgery Focus. 2012 Oct; 33(4):E2. Cover Article.
Vogel TW, Manjila S, Cohen AR. Novel neurodevelopmental disorder in a case of a giant occipitoparietal meningoencephalocele. J Neurosurg Pediatr. 2012 Jun 8. Cover Article.
Zhang Q, Nishimura DY, Seo S, Vogel T, Morgan DA, Searby C, Bugge K, Stone EM, Rahmouni K, Sheffield VC. A Bbs3 knockout mouse model reveals common BBS associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci USA. 2011 Dec 20;108(51):20678-83. Epub 2011 Dec 2.
Thompson S, Recober A, Vogel TW, Kuburas A, Sheffield VC, Russo AF, Stone EM. Light-aversion in mice originates with irradiance detection mechanisms that are independent of spatial-vision. Behav Neurosci. 2010 Dec; 124(6): 821-7.
Godzik J, Vogel TW, Gurnee E, Leonard, JR, Limbrick, DD. Variant Hajdu-Cheney Syndrome with complex chiari malformation: case report. (submitted, Childs Nerv Sys)
Manjila S, Vogel TW, Chen Y, Bahuleyan B, Rodgers MS, Cohen AR. Hypothalamic hamartoma simulating a supra sellar arachnoid cyst: resolution of precocious puberty following microsurgical resection. (Accepted Journal of Neurosurgery: Pediatrics)
Vogel TW, Woo A, Kane A, Patel K, Naidoo S, Smyth MD. A comparison of costs associated with endoscope-assisted craniectomy vs. open cranial vault repair for infants with sagittal synostosis. (accepted-Journal of Neurosurgery: Pediatrics)
Cohen AR, Vogel TW, Lidov HG. The Lost Art of Localization: Franc Ingraham's Legacy in Pediatric Neurosurgery. (Accepted- Journal of Neurosurgery: Pediatrics)
Vogel TW, Bahuleyan B, Robinson S, Cohen AR. The role of endoscopic third ventriculostomy in the treatment of hydrocephalus. J Neurosurg Pediatr. 2013 May 17. Cover article.
Bahuleyan B, Vogel TW,Robinson S, Cohen AR. Endoscopic total corpus callosotomy: Cadaveric demonstration of a new approach. Pediatr Neurosurg. 2012 Jul 7;47(6):455-460.
Dr. Timothy W. VogelPediatric Neurosurgery & Division of Developmental Biology, Cincinnati Children's Hospital Medical Center
Assistant ProfessorUniversity of Cincinnati
Mailing Address:3333 Burnet Ave, MLC 2016Cincinnati, OH 45229-3026
Phone: 513-636-7124Email: firstname.lastname@example.org
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900
New to Cincinnati Children’s or live outside of the Tristate area? 1-877-881-8479
© 1999-2016 Cincinnati Children's Hospital Medical Center. All rights reserved.