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Francesco T. Mangano, DO, FACS, FAAP, FACOS Chief, Division of Pediatric Neurosurgery
Chief, Division of Pediatric Neurosurgery
Director, Pediatric Epilepsy Surgery Program
Professor, UC Department of Neurosurgery
Pediatric Epilepsy Program; Pediatric Epilepsy Surgery Program; imaging and monitoring of seizures; surgical intervention; vagal nerve stimulator implantation; brain resection; brain and spinal cord tumors; chiari malformations; tethered cord syndromes in patients with anorectal malformations.
Francesco Mangano joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an assistant professor of neurosurgery within the UC Department of Neurosurgery.
A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, MO.
Since joining the faculty of the Division of Pediatric Neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain.
His other clinical interests include tumors of the brain and spinal cord, chiari malformations, and tethered cord symptoms in patients with anorectal malformations.
In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the field.
Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons and the Congress of Neurological Surgeons. He was board certified in 2008 in neurological surgery by the American Osteopathic Board of Surgery and currently serves as the vice chair of the Residency Evaluation and Standards Committee and the Secretary Treasurer of the Neurological Surgery Discipline of the ACOS.
DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.
Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.
Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.
Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.
Yuan W, Holland SK, Shimony JS, Altaye M, Mangano FT, Limbrick DD, Jones BV, Nash T, Rajagopal A, Simpson S, Ragan D, McKinstry RC. Abnormal structural connectivity in the brain networks of children with hydrocephalus. Neuroimage Clin. 2015 Apr 29;8:483-92.
Kosnik-Infinger L, Carroll C, Greiner H, Leach J, Mangano FT. Management of cerebral cavernous malformations in the pediatric population: a literature review and case illustrations. J Neurosurg Sci. 2015 Sep;59(3):283-94.
Miles L, Greiner HM, Mangano FT, Horn PS, Leach JL, Miles MV. Cytochrome c oxidase deficit is associated with the seizure onset zone in young patients with focal cortical dysplasia Type II. Metab Brain Dis. 2015 Oct;30(5):1151-60.
Akbari SH, Limbrick DD Jr, McKinstry RC, Altaye M, Ragan DK, Yuan W, Mangano FT, Holland SK, Shimony JS. Periventricular hyperintensity in children with hydrocephalus. Pediatr Radiol. 2015 Jul;45(8):1189-97.
Ragan DK, Cerqua J, Nash T, McKinstry RC, Shimony JS, Jones BV, Mangano FT, Holland SK, Yuan W, Limbrick DD Jr. The accuracy of linear indices of ventricular volume in pediatric hydrocephalus: technical note. J Neurosurg Pediatr. 2015 Jun;15(6):547-51.
Arya R, Wilson JA, Vannest J, Byars AW, Greiner HM, Buroker J, Fujiwara H, Mangano FT, Holland KD, Horn PS, Crone NE, Rose DF. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: comparison with conventional electrical cortical stimulation. Epilepsy Res. 2015 Feb;110:78-87.
Arya R, Greiner HM, Horn PS, Turner M, Holland KD, Mangano FT. Corpus callosotomy for childhood-onset drug-resistant epilepsy unresponsive to vagus nerve stimulation. Pediatr Neurol. 2014 Dec;51(6):800-5.
Arya R, Tenney JR, Horn PS, Greiner HM, Holland KD, Leach JL, Gelfand MJ, Rozhkov L, Fujiwara H, Rose DF, Franz DN, Mangano FT. Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions. J Neurosurg Pediatr. 2015 Jan;15(1):26-33.
Leach JL, Miles L, Henkel DM, Greiner HM, Kukreja MK, Holland KD, Rose DF, Zhang B, Mangano FT. Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. J Neurosurg Pediatr. 2014 Jul;14(1):68-80.
Brahimaj B, Greiner HM, Leach JL, Horn PS, Stevenson CB, Miles L, Byars A, Holland K, Sutton M,Mangano FT. The surgical management of pediatric brain tumors causing epilepsy: consideration of the epileptogenic zone. Childs Nerv Syst. 2014 Aug;30(8):1383-91.
Karin Bierbrauer, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Associate Professor, UC Department of Pediatrics
Fetal malformations of the brain and spinal cord; spina bifida; tethered cord; head injury
MD: Medical University of South Carolina, Charleston, South Carolina, 1980-1984.
Residency: Neurosurgery, Emory University, Atlanta, Georgia, 1985-1989.
Fellowship: Pediatric Neurosurgery, The Children's Memorial Hospital, Chicago, Illinois.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010; 5 (4): 385-391.
Yuan W, Mangano, FT, Air EL, Holland SK, Jones BV, Altaye A, Bierbrauer K. Anisotropic Diffusion Properties in Infants with Hydrocephalus – a DTI Study. AJNR Am J Neuroradiol. 2009; 30(9):1792-8.
Hsieh PC, Ondra SL, Grande AW, O’Shaughnessy BA, Bierbrauer KS et al. Posterior Vertebral Column subtraction osteotomy: a novel surgical approach for the treatment of multiple recurrences of tethered cord syndrome. J Neurosurg Spine. 2009;10(4):278-286.
Kenneth J. Campbell, PhD
studies the molecular genetic control of mouse forebrain development with a particular focus on the generation of neuronal diversity in the ventral telencephalon.
Professor, UC Department of Pediatrics
Molecular genetic control of mammalian forebrain development
MS: University of Toronto, Toronto, Canada, 1990.
PhD: University of Lund, Lund, Sweden, 1994.
Postdoctoral Fellow: Skirball Institute, NYU Med Center, 1995-97.
Waclaw RR, Wang B, Pei Z, Ehrman LA, Campbell K. Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. Neuron. 2009;63:451-65.
Wang B, Waclaw RR, Allen ZJ II, Guillemot F, Campbell K. Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon. Neural Development. 2009;4:5.
Waclaw RR, Allen Z, Bell SM, Erdelyi F, Szabo G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. 2006;49:503-16.
Campbell K. Cortical neuron specification: it has its time and place. Neuron. 2005;46:373-6.
Waclaw RR, Wang B, Campbell K. The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalon. Development. 2004;131:4013-20.
Stenman J, Yu RT, Evans RM, Campbell K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the mouse telencephalon. Development. 2003;130:1113-22.
Stenman J, Toresson H, Campbell K. Identification of two distinct progenitor populations in the lateral ganglionic eminence: Implications for striatal and olfactory bulb neurogenesis. Journal of Neuroscience. 2003;23:167-74.
Steven A. Crone, PhD
Assistant Professor, UC Department of Pediatrics
Developmental biology; neurodegenerative disease; neural control of behavior; locomotion; respiration; motor circuits; amyotrophic lateral sclerosis (ALS; spinal muscular atrophy (SMA)
Visit the Crone Lab.
Steven Crone, PhD, is an assistant professor in the Division of Pediatric Neurosurgery within the UC Department of Surgery. He received his BS with honors from The Pennsylvania State University in 1995. He received his PhD from the University of California, San Diego while performing his thesis research at The Salk Institute for Biological Studies.
His thesis research demonstrated that the ErbB2 receptor tyrosine kinase is essential for maintenance of the enteric nervous system and prevention of dilated cardiomyopathy. His research has important implications for the treatment of Hirschsprung’s disease, heart disease and ErbB2/Her2 dependent breast cancer.
Dr. Crone performed his postdoctoral work at the University of Chicago where he used transgenic mouse models to label, ablate or alter gene expression in specific interneurons to establish that V2a neurons coordinate limb movement during locomotion and promote a normal breathing rhythm.
He joined Cincinnati Children’s Hospital Medical Center in September of 2012 where his laboratory will investigate how motor circuits are altered by injury or disease.
BS: The Pennsylvania State University, University Park, PA, 1995.
PhD: University of California, San Diego and The Salk Institute for Biological Studies, San Diego, CA, 2003.
Postdoctoral: University of Chicago, Chicago, IL, 2012.
Crone SA, Viemari J-C, Droho S, Ramirez J, Mrejeru A, Sharma K. Irregular breathing in mice following genetic ablation of V2a neurons. J Neuroscience. 2012;32(23):7895–7906.
Zhong G, Droho S, Crone SA, Dietz S, Kwan AC, Webb WW, Sharma K, Harris-Warrick R. Electrophysiological characterization of the V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord. J Neuroscience. 2010;30(1):170-182.
Crone SA, Zhong G, Harris-Warrick R, Sharma K. In mice lacking V2a interneurons, gait depends on speed of locomotion. J Neuroscience. 2009;29(21):7098-7109.
Crone SA, Quinlan KA, Zagoraiou L, Droho S, Restrepo CE, Lundfald L, Endo T, Setlak J, Jessell TM, Kiehn O, Sharma K. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron. 2008;60:70-83.
Joseph NM, Mukouyama Y, Mosher JT, Jaegle M, Crone SA, Dormand E, Lee K-F, Meijer D, Anderson DJ, Morrison SJ. Neural crest stem cells undergo multi-lineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development. 2004;131:5599-5612.
Crone SA, Negro A, Trumpp A, Giovannini M, Lee K-F. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron. 2003;37:29-40.
Crone SA, Zhao Y-Y, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J Jr, Chien KR, Lee K-F. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Medicine. 2002;8:459-465.
Crone SA, Lee K-F. Gene targeting reveals multiple essential functions of the neuregulin signaling system during development of the neuroendocrine and nervous systems. Annals of the New York Academy of Sciences. 2002;971:547-553.
Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee K-F, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences USA. 2002;99:2320-5.
Kerry R. Crone, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Professor, UC Department of Surgery
Minimal access surgery; including endoscopic surgery; chiari malformations; brain tumors; design and implementation of patient safety initiatives and clinical outcomes studies
Dr. Kerry Crone is a professor of neurosurgery and pediatrics at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine. He was director of the Division of Pediatric Neurosurgery at Cincinnati Children’s Hospital Medical Center beginning in July 1999.
Dr. Crone's specialty interests include minimal access surgery and its applications for children with brain tumors, hydrocephalus and complex cysts within the brain. He has lectured extensively and taught other neurosurgeons these techniques at national and international meetings and courses and written numerous scholarly articles about the use of endoscopy and other tools to allow for these minimally invasive operations and has even been instrumental in designing some of the tools used by neurosurgeons around the world in visualizing and navigating during these operations.
He also has developed a very large and well renowned practice specializing in pediatric patients from infancy to young adulthood with Chiari malformations, offering not only the latest in imaging and surgical approaches, but expertise based on extensive research in this field.
The design of our neurosurgical operative suite, which was the first of its kind in the world, and incorporates intraoperative MRI with specially designed pediatric operating beds and computer guided navigation instruments to allow for maximal safety during resection of brain tumors and other complex operations of the brain and spine, was guided by his experience and expertise.
MD: University of Cincinnati, Cincinnati, OH, 1978.
Residency: Neurosurgery, Bowman-Gray School of Medicine, Winston-Salem, NC.
Fellowship: Pediatric Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada, 1986.
Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16.
Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.
Air E, Ghomri YM, Tyagi R, Grande AW, Crone K, and Mangano FT. Management of Vagal Nerve Stimulator Infections. Do they need to be removed? J Neurosurg Pediatr. 2009; 3(1): 73-78.
Yuan W, Holland S, Jones BV, Crone K, and Mangano FT. Characterization of Abnormal Diffusion Properties of Supratentorial Brain Tumors: A Preliminary DTI Study. J Neurosurg Pediatr. 2009; 1(4): 263-269.
Agabegi SS, Antekeier DP, Crawford AH, Crone KR. Postlaminectomy kyphosis in an achondroplastic adolescent treated for spinal stenosis. Orthopedics. 2008 Feb;31(2):168.
Neely JC 2nd, Jones BV, Crone KR. Spontaneous extracranial decompression of epidural hematoma. Pediatr Radiol. 2008; 38(3):316-8.
Levine NB, Miller MN, Crone KR. Endoscopic resection of colloid cysts: Indications, technique, and results during a 13-year period. Minim Invas Neurosurg. 2007; 50:313-317.
June Goto, PhD
is a neurobiologist who studies basic and pre-clinical models of brain malformation diseases. Her current studies focus on molecular and developmental basis of pediatric hydrocephalus using both genetic and sporadic rodent models of hydrocephalus.
Instructor, UC Department of Neurosurgery
Hydrocephalus; tuberous sclerosis complex; mouse genetic models
BS: Tokyo Gakugei University, 2000.
PhD: University of Tokyo, 2006.
Postdoctral training: University of Tokyo, 2007; Brigham and Women’s Hospital, Harvard Medical School, 2012.
Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet. 2013 Jan;43(1):51-9.
Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci USA. 2011 Nov 8;108(45):E1070-9.
Anderl S, Freeland M, Kwiatkowski DJ, Goto J. Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Hum Mol Genet. 2011 Dec 1;20(23):4597-604.
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA. 2011 Mar 8;108(10):4129-34.
Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Robert B, Kwiatkowski DJ, Finlay GA. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011 Apr 1;20(7):1290-305
Liang MC, Ma J, Chen L, Kozlowski P, Qin W, Li D, Goto J, Shimamura T, Hayes DN, Meyerson M, Kwiatkowski DJ, Wong KK. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Oncogene. 2010 Mar 18;29(11):1588-97.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009 Jul 1;18(13):2378-87.
Goto J, Tezuka T, Nakazawa T, Sagara H, Yamamoto T. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Mol Cell Neurosci. 2008 Jun;38(2):203-12.
Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 2006 Jun 21;25(12):2867-77.
Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T. Altered gene expression in the adult brain of fyn-deficient mice. Cell Mol Neurobiol. 2004 Feb;24(1):149-59.
Charles B. Stevenson, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Assistant Professor, UC Department of Neurosurgery
Brain tumors; spasticity; Chiari malformations; fetal surgery; neurovascular disorders; minimal access surgery
Charles Stevenson, MD, rejoined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center in July 2010, after having served for one year as staff neurosurgeon at Kosair Children’s Hospital in Louisville, Kentucky. Prior to completing his fellowship in pediatric neurosurgery at Cincinnati Children’s, he received his neurosurgical training at Vanderbilt University in Nashville, Tennessee. During that time, he also completed a two-year research fellowship in neurosurgical oncology. He graduated from medical school at Vanderbilt University in Nashville, Tennessee.
Dr. Stevenson’s interest, specialized training and research background in neuro-oncology make him uniquely qualified to lead our division in its collaborative efforts with the division of neuro-oncology in the Brain and Spinal Tumor Program to treat children with primary and recurrent brain tumors. He is assisted in these efforts by leading-edge technology such as the operating room BrainSUITE™, which creates precise three-dimensional maps of the brain and allows for intraoperative MRI imaging to more safely remove particularly complex and deep-seated tumors. Cincinnati Children’s was the first pediatric hospital in the world to offer this technology.
In addition, Dr. Stevenson brings expertise in selective dorsal rhizotomy as a treatment for spasticity, which, when added to implantation of baclofen pumps and medical therapy, allows for a wide range of treatment options for patients with spasticity from cerebral palsy or spinal cord injury. He is a member of a multidisciplinary team of specialists that includes neurosurgery, orthopedic surgery, physical medicine and rehabilitation as well as and physical and occupational therapies that offers comprehensive care for children with spasticity.
Dr. Stevenson is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2013 in neurological surgery by the American Board of Neurological Surgeons.
MD: Vanderbilt University School of Medicine, Nashville, TN, 2001.
Residency: Neurosurgery, Vanderbilt University Medical Center, Nashville, TN.
Fellowship: Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008-09.
Board Certification: Neurological Surgery, American Board of Neurological Surgeons, 2013.
Hertzler II DA, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurgical Focus. 2010;29(1):E1.
Stevenson CB, Desai RR, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. Journal of Spinal Disorders and Techniques. 2010 Oct;23(7):474-9.
Reig AS, Stevenson CB, Tulipan NT. CT-based, fiducial-free frameless stereotaxy for difficult ventriculoperitoneal shunt insertion: experience in 26 consecutive patients. Stereotactic and Functional Neurosurgery. 2010;88(2):75-80.
Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari I malformation. J Neurosurg Ped. 2009; 4(6):557-63.
McMillan KM, Ehtesham M, Stevenson CB, Edgeworth ML, Thompson RC, Price RR. T2 detection of tumor invasion within segmented components of glioblastoma multiforme. J Mag Reson Imag. 2009; 29(2):251-7.
Ehtesham M, Mapara KY, Stevenson CB, Thompson RC.CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Letters. 2009;274(2):305-12.
Ehtesham M, Stevenson CB, Thompson RC. Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival. Neurosurgery. 2008; 63(4):E820.
Stevenson CB, Ehtesham M, McMillan KM, Valadez JG, Edgeworth ML, Price RR, Abel TW, Mapara KY, Thompson RC. CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peri-tumoral T2-weighted MRI signal abnormalities. Neurosurgery. 2008;63(3):560-9.
Johnson MD, Stevenson CB, Thompson RC, Atkinson J, Boyer P. 31-year-old woman with hemiparesis. Brain Pathology. 2007;17(2):255-7.
Stevenson CB, Crone KR. Head injury. In Operative Pediatric Surgery Ziegler MM, Azizkhan RG, Weber T, von Allmen D (eds.). 2nd Edition. Mcgraw-Hill: New York ,NY, 2012.
Sudhakar Vadivelu, DO Faculty Neurosurgeon, Division of Pediatric Neurosurgery
is interested in researching stem cells, neurogenesis, and modulation of cytokine activity.
Disorders of the brain and spine; brain and spine tumors; spinal deformity; chiari malformation; hydrocephalus; movement disorders; endovascular/ interventional neuroradiology; neuroendoscopy; neurostimulation
Sudhakar Vadivelu, DO, joined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center after completing his fellowship in pediatric neurosurgery at Texas Children’s Hospital and neurosurgical residency at Hofstra North Shore- LIJ School of Medicine. While at Hofstra North Shore-LIJ, he acquired additional training in open cerebrovascular surgery and endovascular surgery for specialized training in the care of vascular disorders of the brain and spine.
Dr. Vadivelu’s interest, specialized training and research background in the role of inflammation in neurogenesis and stem cells, make him uniquely qualified to lead our division in its collaborative efforts with the division of interventional neuroradiology for the treatment of children with vascular disorders of the brain and spine.
In addition, Dr. Vadivelu brings expertise in spinal diseases, brain and spinal cord tumors, neuroendoscopy and neurostimulation.
DO: Des Moines University, College of Osteopathic Medicine, Des Moines, IA.
Residency: Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Neurosurgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY.
Fellowship: Interventional Neuroradiology, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY; Cerebrovascular Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY; Pediatric Neurosurgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX.
Vadivelu S, Willsey M, Curry D, McDonald JW. Potential role of stem cells for neuropathic pain disorders. Neurosurg Focus. 2013 Sep;35(3):E11.
Desai S, Vadivelu S, Patel A, Jea A. Isolated Cervical Spinal Canal Stenosis in the Pediatric Population and in Williams Syndrome. J Neurosurg Spine. 2013 Jun; 18(6):558-63.
Patel A, Vadivelu S, Desai S, Jea A. Congenital Hypoplasia or Aplasia of the Lumbosacral Pedicle as an Unusual Cause for Spondylolisthesis in the Pediatric Age Group. J Neurosurg Pediatr. 2013 Jun; 11(6):717-21.
Vadivelu S, Effendi S, Starke J, Luerssen T, Jea A. Neurological management in tuberculous meningitis. Clin Pediatr (Phila). 2013 Jul 10.
Vadivelu S, Kelley RI, Edelman M, Schneider S, Mittler M. Choroid plexus papilloma and Pierpont syndrome. J Neurosurg Pediatr. 2013 Feb; 11(2):115-8.
Vadivelu S, Xin X, Loven T, Restrepo G, Chalif DJ, and Setton A. Iatrogenic dural AVF and aneurysmal subarachnoid hemorrhage. Neurosurg Focus. 2012 May;32(5):E1.
Vadivelu S, Bolognese P, Milhorat T, Mogilner AY. Occipital nerve stimulation for refractory headache in the chiari malformation population. Neurosurgery. 2012 70(6):1430-7.
Vadivelu S, Bell RS, Crandall B, DeGraba T, Armonda RA. (2010) Delayed detection of carotid-cavernous fistulas associated with wartime blast-induced craniofacial trauma. Neurosurg Focus. 28(5), E6.
Vadivelu S, Tomlinson K, Valles J, Hundert M, Bagdonas R, Eisenberg M. Acute anti-emetic withdrawal associated with a hemorrhagic cerebellar arteriovenous malformation. J Clin Neurosci. 2010 17(8), 1061-3.
Vadivelu S, Sharer L, Schulder M. Regression of Multiple Intracranial Meningioma after Cessation of long term progesterone agonist therapy. J Neurosurg. 2010 May;112(5):920-4.
Timothy W. Vogel, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Tim Vogel, MD, joined the Division of Pediatric Neurosurgery at Cincinnati Children’s in 2013 as an assistant professor of neurosurgery and developmental biology within the University of Cincinnati College of Medicine. Dr. Vogel is a graduate of Princeton University and Columbia University’s College of Physicians and Surgeons. Dr. Vogel completed his residency at the University of Iowa Hospitals and Clinics in 2011. He then completed a minimally invasive fellowship at Boston Children’s Hospital at Harvard University, followed by a pediatric neurosurgery fellowship at St. Louis Children’s Hospital at Washington University in St. Louis.
Dr. Vogel specializes in craniofacial surgery and the use of endoscopy in the minimally invasive treatment of children. He also utilizes endoscopy and his expertise with minimally invasive surgery to treat hydrocephalus and certain tumors of the brain.
In addition to his clinical activities, Dr. Vogel is a principal investigator in the Division of Developmental Biology focused on human and molecular genetics of hydrocephalus and other neurodevelopmental disorders. Dr. Vogel has completed postdoctoral fellowships for the Howard Hughes Medical Institute at the University of Iowa and at Massachusetts General Hospital. Dr. Vogel is focused on cilia (hair like structures in the brain) and their contribution to hydrocephalus during development. He utilizes basic and translational applications to study cellular signaling in hydrocephalus with the goal of developing innovative treatment strategies for this disease.
Dr. Vogel is a member of the American Association for the Advancement of Science, the American Association of Neurological Surgeons, the American Society of Craniofacial Surgery, the American Society of Human Genetics, the Ciliopathy Alliance, and the Congress of Neurological Society and the Society of Neuroscience.
MD: Columbia University College of Physicians and Surgeons, New York, NY, 2005.
Residency: University of Iowa Hospitals and Clinics, Iowa City, IA, 2011.
Research Fellowship: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2013.
Pediatric Neurosurgery Fellowship: St. Louis Children’s Hospital, Washington University in St. Louis, Division of Pediatric Neurosurgery, St. Louis, MO, 2013.
Minimally Invasive Fellowship: Boston Children’s Hospital, Harvard University, Department of Neurosurgery, Boston, MA, 2012.
Postdoctoral Research Fellowship: Harvard Medical School, Harvard University, Boston, MA, 2012.
Postdoctoral Research Fellowship: Howard Hughes Medical Institute, University of Iowa, Iowa City, IA, 2010.
Zhang Q, Nishimura DY, Vogel T, Shao J, Swiderski R, Yin T, Searby C, Carter CC, Kim G, Bugge K, Stone EM, Sheffield VC. BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking. J Cell Sci. 2013 Jun 1;126(Pt 11):3272-80.
Carter CS*, Vogel TW*, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC. Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat Med. 2012 Dec;18(12):1797-804. Cover Article. (*EQUAL AUTHOR CONTRIBUTION)
Vogel TW, Carter CS, Abode-Iyamah K, Zhang Q, Robinson S. The role of primary cilia in the pathophysiology of neural tube defects. Neurosurgery Focus. 2012 Oct; 33(4):E2. Cover Article.
Vogel TW, Manjila S, Cohen AR. Novel neurodevelopmental disorder in a case of a giant occipitoparietal meningoencephalocele. J Neurosurg Pediatr. 2012 Jun 8. Cover Article.
Zhang Q, Nishimura DY, Seo S, Vogel T, Morgan DA, Searby C, Bugge K, Stone EM, Rahmouni K, Sheffield VC. Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci USA. 2011 Dec 20;108(51):20678-83.
Thompson S, Recober A, Vogel TW, Kuburas A, Sheffield VC, Russo AF, Stone EM. Light aversion in mice depends on nonimage-forming irradiance detection. Behav Neurosci. 2010 Dec; 124(6): 821-7.
Vogel TW, Vortmeyer AO, Lubensky IA, Lee YS, Furuta M, Ikejiri B, Kim HJ, Lonser RR, Oldfield EH, Zhuang Z. Coexpression of erythropoietin and its receptor in endolymphatic sac tumors. J Neurosurg. 2005 Aug;103(2):284-8.
Vogel TW, Zhuang Z, Li J, Okamoto H, Furuta M, Lee YS, Zeng W, Oldfield EH, Vortmeyer AO, Weil RJ. Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme. Clin Cancer Res. 2005 May 15;11(10):3624-32.
Vogel TW, Brouwers FM, Lubensky IA, Vortmeyer AO, Weil RJ, Walther MM, Oldfield EH, Linehan WM, Pacak K, Zhuang Z. Differential expression of erythropoietin and its receptor in von Hippel-Lindau-associated and MEN type 2-associated pheochromocytomas. J Clin Endocrinol Metab. 2005 June;90(6):3747-51.
Lee YS, Vortmeyer AO, Lubensky IA, Vogel TW, Ikejiri B, Ferlicot S, Benoit G, Giraud S, Oldfield EH, Linehan WM, Teh BT, Richard S, Zhuang Z. Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma. Clin Cancer Res. 2005 Feb 1;11(3):1059-64.
Primary cilia signaling in CNS progenitors and their role in neonatal hydrocephalus. Principal Investigator. K12 Neurosurgeon Research Career Development Program (NRCDP); National Institute of Neurological Disorders and Stroke (NINDS); National Institutes of Health (NIH); and Massachusetts General Hospital, Harvard Medical School. Jan 2014 – Jan 2017.
Role of neural progenitor cells in the development of neonatal hydrocephalus. Principal Investigator. Hydrocephalus Association’s CSF Production, Flow and Regulation, Therapeutics and Diagnostics Award. Sep 2013-Sep 2016.
Role of progenitor cells in the development of congenital hydrocephalus. Collaborator. National Institutes of Health. Sep 2013-Sep 2016.
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