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Francesco T. Mangano, DO, FACS, FACOS Chief, Division of Pediatric Neurosurgery
Chief, Division of Pediatric Neurosurgery
Director, Pediatric Epilepsy Surgery Program
Associate Professor, UC Department of Neurosurgery
Francesco Mangano joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an associate professor of neurosurgery.A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain. In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the fields of epilepsy, diffusion tensor imaging (MRI) of hydrocephalus, traumatic brain injury, and vascular and neoplastic brain lesions. He also has expertise in complex disorders of the spine and spinal cord, including spinal cord tumors, and craniocervical junction.
Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.
DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.
Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.
Kadar AA, Hearst MJ, Collins MH, Mangano FT, Samy RN. Ewing's Sarcoma of the Petrous Temporal Bone: Case Report and Literature Review. Skull Base. 2010 May;20(3):213-7.
Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Hertzler DA 2nd, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurg Focus. 2010 Jul;29(1):E1. Review.
Patel NN, Mangano FT, Klimo P Jr. Indirect revascularization techniques for treating moyamoya disease. Neurosurg Clin N Am. 2010 Jul;21(3):553-63. Review.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Desai R, Stevenson CB, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. J Spinal Disord Tech. 2010 Oct;23(7):474-9.
Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, DeGrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr. 2010 Jan;5(1):113-22.
Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.
Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones B, DeGrauw T, Rose D. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord. 2009 Jun;11(2):113-25.
Ellen L. Air, MD, PhD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Assistant Professor, UC Department of Neurosurgery
Ellen Air, MD, PhD, joined the Division of Pediatric Neurosurgery in September 2011. After earning her doctorate and medical degrees at the University of Cincinnati College of Medicine, she completed her residency in neurosurgery with the UC Department of Neurosurgery. Dr. Air continued her training with a fellowship in neurosurgical treatment of epilepsy, movement disorders, and pain at the University of California, San Francisco and San Francisco VA Medical Center. Dr. Air specializes in the use of deep brain stimulation for the treatment of dystonia, a disabling movement disorder which often presents in childhood. She brings particular expertise in the use of real-time magnetic resonance imaging to guide deep brain stimulator placement. This approach allows for highly accurate placement with improved patient comfort. In addition, Dr. Air treats a variety of chronic intractable pain syndromes using spinal cord stimulation which delivers electrical stimulation to the spinal cord, interrupting pain signals traveling to the brain.
In addition to seeing patients at Cincinnati Children's Hospital Medical Center, Dr. Air is in private practice with Mayfield Clinic. She also serves as assistant professor of neurosurgery and director of the Division of Epilepsy at UC, and is a member of the UC Epilepsy Center and the UC Neuroscience Institute.
Dr. Air's professional memberships include the American Association of Neurological Surgeons, Congress of Neurological Surgeons, American Society for Stereotactic and Functional Neurosurgery, World Society of Stereotactic and Functional Neurosurgery, Women in Neurosurgery, and the American Medical Association. She is board-eligible with the American Board of Neurological Surgeons (ABNS).
Air EL, Ostrem JL, Sanger TD, Starr PA. Deep brain stimulation in children: experience and technical pearls. J Neurosurg. 2011.
Air EL, Vagal AA, Kendler A, McPherson CM. Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient. Surg Neurol Int. 2010 Dec 13;1:81. Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91. Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8. Air EL, Leach JL, Warnick RE, McPherson CM. Comparing the risks of frameless stereotactic biopsy in eloquent and noneloquent regions of the brain: a retrospective review of 284 cases. J Neurosurg. 2009 Oct;111(4):820-4. Kissela B, Lindsell CJ, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Flaherty ML, Air E, Broderick J, Tsevat J. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke. 2009 Feb;40(2):530-6. Air EL, Ghomri YM, Tyagi R, Grande AW, Crone K, Mangano FT. Management of vagal nerve stimulator infections: do they need to be removed? J Neurosurg Pediatr. 2009 Jan;3(1):73-8.
Air EL and Barbaro NM. Radiosurgery for the Treatment of Epilepsy. In Quinones A (Ed), Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results. 6th ed. Philadelphia, PA: Elsevier, 2011.Air EL, Abruzzo TA, Ringer AJ. Embolization of epistaxis. In Connolly ES, McKhann GM, Huang J, Choudhri TF, Komotar RJ, and Mocco J (Eds), Fundamentals of Operative Techniques in Neurosurgery. 2nd ed. New York, NY: Thieme, 2010.
Karin Bierbrauer, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Associate Professor, UC Department of Pediatrics
Fetal malformations of the brain and spinal cord; spina bifida; tethered cord; head injury
Head injury; biomedical informatics
MD: Medical University of South Carolina, Charleston, South Carolina, 1980-1984
Residency: Neurosurgery, Emory University, Atlanta, Georgia, 1985-1989
Fellowship: Pediatric Neurosurgery, The Children's Memorial Hospital, Chicago, Illinois
Kenneth J. Campbell, PhD
Professor, UC Department of Pediatrics
Molecular genetic control of mammalian forebrain development
MS: University of Toronto, Toronto, Canada, 1990.
PhD: University of Lund, Lund, Sweden, 1994.
Postdoctoral Fellow: Skirball Institute, NYU Med Center, 1995-97.
Steven A. Crone, PhD
Assistant Professor, UC Department of Pediatrics
Developmental biology; neurodegenerative disease; neural control of behavior; locomotion; respiration; motor circuits; amyotrophic lateral sclerosis (ALS; spinal muscular atrophy (SMA)
Visit the Crone Lab.
Steven Crone, PhD, is an assistant professor in the Division of Pediatric Neurosurgery. He received his BS with honors from The Pennsylvania State University in 1995. He received his PhD from the University of California, San Diego while performing his thesis research at The Salk Institute for Biological Studies.
His thesis research demonstrated that the ErbB2 receptor tyrosine kinase is essential for maintenance of the enteric nervous system and prevention of dilated cardiomyopathy. His research has important implications for the treatment of Hirschsprung’s disease, heart disease and ErbB2/Her2 dependent breast cancer.
Dr. Crone performed his postdoctoral work at the University of Chicago where he used transgenic mouse models to label, ablate or alter gene expression in specific interneurons to establish that V2a neurons coordinate limb movement during locomotion and promote a normal breathing rhythm.
He joined Cincinnati Children’s Hospital Medical Center in September of 2012 where his laboratory will investigate how motor circuits are altered by injury or disease.
BS: The Pennsylvania State University, University Park, PA, 1995.
PhD: University of California, San Diego and The Salk Institute for Biological Studies, San Diego, CA, 2003.
Postdoctoral: University of Chicago, Chicago, IL, 2012.
Crone SA, Viemari J-C, Droho S, Ramirez J, Mrejeru A, Sharma K. Irregular breathing in mice following genetic ablation of V2a neurons. J Neuroscience. 2012;32(23):7895–7906.
Zhong G, Droho S, Crone SA, Dietz S, Kwan AC, Webb WW, Sharma K, Harris-Warrick R. Electrophysiological characterization of the V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord. J Neuroscience. 2010;30(1):170-182.
Crone SA, Zhong G, Harris-Warrick R, Sharma K. In mice lacking V2a interneurons, gait depends on speed of locomotion. J Neuroscience. 2009;29(21):7098-7109.
Crone SA, Quinlan KA, Zagoraiou L, Droho S, Restrepo CE, Lundfald L, Endo T, Setlak J, Jessell TM, Kiehn O, Sharma K. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron. 2008;60:70-83.
Joseph NM, Mukouyama Y, Mosher JT, Jaegle M, Crone SA, Dormand E, Lee K-F, Meijer D, Anderson DJ, Morrison SJ. Neural crest stem cells undergo multi-lineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development. 2004;131:5599-5612.
Crone SA, Negro A, Trumpp A, Giovannini M, Lee K-F. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron. 2003;37:29-40.
Crone SA, Zhao Y-Y, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J Jr, Chien KR, Lee K-F. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Medicine. 2002;8:459-465.
Crone SA, Lee K-F. Gene targeting reveals multiple essential functions of the neuregulin signaling system during development of the neuroendocrine and nervous systems. Annals of the New York Academy of Sciences. 2002;971:547-553.
Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee K-F, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences USA. 2002;99:2320-5.
Kerry R. Crone, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Professor, UC Department of Surgery
Minimal access surgery; including endoscopic surgery; chiari malformations; brain tumors; design and implementation of patient safety initiatives and clinical outcomes studies
Chiari malformations; brain tumors; telemedicine
MD: University of Cincinnati, Cincinnati, OH, 1978.
Residency: Neurosurgery, Bowman-Gray School of Medicine, Winston-Salem, NC.
Fellowship: Pediatric Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada, 1986.
Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16. Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63. Air E, Ghomri YM, Tyagi R, Grande AW, Crone K, and Mangano FT. Management of Vagal Nerve Stimulator Infections. Do they need to be removed? J Neurosurg Pediatr. 2009; 3(1): 73-78.Yuan W, Holland S, Jones BV, Crone K, and Mangano FT. Characterization of Abnormal Diffusion Properties of Supratentorial Brain Tumors: A Preliminary DTI Study. J Neurosurg Pediatr. 2009; 1(4): 263-269.Agabegi SS, Antekeier DP, Crawford AH, Crone KR. Postlaminectomy kyphosis in an achondroplastic adolescent treated for spinal stenosis. Orthopedics. 2008 Feb;31(2):168. Neely JC 2nd, Jones BV, Crone KR. Spontaneous extracranial decompression of epidural hematoma. Pediatr Radiol. 2008; 38(3):316-8.
Levine NB, Miller MN, Crone KR. Endoscopic resection of colloid cysts: Indications, technique, and results during a 13-year period. Minim Invas Neurosurg. 2007; 50:313-317.
June Goto, PhD
is a neurobiologist who studies basic and pre-clinical models of brain malformation diseases. Her current studies focus on molecular and developmental basis of pediatric hydrocephalus using both genetic and sporadic rodent models of hydrocephalus.
Instructor, UC Department of Neurosurgery
Hydrocephalus; tuberous sclerosis complex; mouse genetic models
BS: Tokyo Gakugei University, 2000.
PhD: University of Tokyo, 2006.
Postdoctral training: University of Tokyo, 2007; Brigham and Women’s Hospital, Harvard Medical School, 2012.
Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet. 2013 Jan;43(1):51-9.
Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci USA. 2011 Nov 8;108(45):E1070-9.
Anderl S, Freeland M, Kwiatkowski DJ, Goto J. Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Hum Mol Genet. 2011 Dec 1;20(23):4597-604.
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA. 2011 Mar 8;108(10):4129-34.
Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Robert B, Kwiatkowski DJ, Finlay GA. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011 Apr 1;20(7):1290-305
Liang MC, Ma J, Chen L, Kozlowski P, Qin W, Li D, Goto J, Shimamura T, Hayes DN, Meyerson M, Kwiatkowski DJ, Wong KK. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Oncogene. 2010 Mar 18;29(11):1588-97.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009 Jul 1;18(13):2378-87.
Goto J, Tezuka T, Nakazawa T, Sagara H, Yamamoto T. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Mol Cell Neurosci. 2008 Jun;38(2):203-12.
Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 2006 Jun 21;25(12):2867-77.
Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T. Altered gene expression in the adult brain of fyn-deficient mice. Cell Mol Neurobiol. 2004 Feb;24(1):149-59.
Charles B. Stevenson, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Brain tumors; spasticity; Chiari malformations; fetal surgery; neurovascular disorders; minimal access surgery
Neuro-oncology; epilepsy; spasticity
Charles Stevenson, MD, rejoined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center in July 2010, after having served for one year as staff neurosurgeon at Kosair Children’s Hospital in Louisville, Kentucky. Prior to completing his fellowship in pediatric neurosurgery at Cincinnati Children’s, he received his neurosurgical training at Vanderbilt University in Nashville, Tennessee. During that time, he also completed a two-year research fellowship in neurosurgical oncology. He graduated from medical school at Vanderbilt University in Nashville, Tennesee. Dr. Stevenson’s interest, specialized training and research background in neuro-oncology make him uniquely qualified to lead our division in its collaborative efforts with the division of neuro-oncology in the Brain and Spinal Tumor program to treat children with primary and recurrent brain tumors. He is assisted in these efforts by leading-edge technology such as the operating room BrainSUITE™, which creates precise three-dimensional maps of the brain and allows for intraoperative MRI imaging to more safely remove particularly complex and deep-seated tumors. Cincinnati Children’s was the first pediatric hospital in the world to offer this technology. In addition, Dr. Stevenson brings expertise in selective dorsal rhizotomy as a treatment for spasticity, which, when added to implantation of baclofen pumps and medical therapy, allows for a wide range of treatment options for patients with spasticity from cerebral palsy or spinal cord injury. He is a member of a multidisciplinary team of specialists that includes neurosurgery, orthopedic surgery, physical medicine and rehabilitation as well as and physical and occupational therapies that offers comprehensive care for children with spasticity.
Dr. Stevenson is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2013 in neurological surgery by the American Board of Neurological Surgeons.
MD: Vanderbilt University School of Medicine, Nashville, Tennessee, 2001 Residency: Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee Fellowship: Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 2008-09.
Board Certification: Neurological Surgery, American Board of Neurological Surgeons, 2013.
Hertzler II DA, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurgical Focus. 2010;29(1):E1. Stevenson CB, Desai RR, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. Journal of Spinal Disorders and Techniques. 2010 Oct;23(7):474-9. Reig AS, Stevenson CB, Tulipan NT. CT-based, fiducial-free frameless stereotaxy for difficult ventriculoperitoneal shunt insertion: experience in 26 consecutive patients. Stereotactic and Functional Neurosurgery. 2010; 88(2):75-80. Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari I malformation. J Neurosurg Ped. 2009; 4(6):557-63. McMillan KM, Ehtesham M, Stevenson CB, Edgeworth ML, Thompson RC, Price RR. T2 detection of tumor invasion within segmented components of glioblastoma multiforme. J Mag Reson Imag. 2009; 29(2):251-7. Ehtesham M, Mapara KY, Stevenson CB, Thompson RC. CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Letters. 2009; 274(2):305-12. Ehtesham M, Stevenson CB, Thompson RC. Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival. Neurosurgery. 2008; 63(4):E820. Stevenson CB, Ehtesham M, McMillan KM, Valadez JG, Edgeworth ML, Price RR, Abel TW, Mapara KY, Thompson RC. CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peri-tumoral T2-weighted MRI signal abnormalities. Neurosurgery. 2008;63(3):560-9. Johnson MD, Stevenson CB, Thompson RC, Atkinson J, Boyer P. 31-year-old woman with hemiparesis . Brain Pathology. 2007;17(2):255-7.
Stevenson CB, Crone KR. Head injury. In Operative Pediatric Surgery Ziegler MM, Azizkhan RG, Weber T, von Allmen D (eds.). 2nd Edition. Mcgraw-Hill: New York ,NY, 2012. (In press).
Sudhakar Vadivelu, DO Faculty Neurosurgeon, Division of Pediatric Neurosurgery
is interested in researching stem cells, neurogenesis, and modulation of cytokine activity.
Disorders of the brain and spine; brain and spine tumors; spinal deformity; chiari malformation; hydrocephalus; movement disorders; endovascular/ interventional neuroradiology; neuroendoscopy; neurostimulation
Stem cells; neurogenesis; modulation of cytokine activity
Sudhakar Vadivelu, DO, joined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center after completing his fellowship in pediatric neurosurgery at Texas Children’s Hospital and neurosurgical residency at Hofstra North Shore- LIJ School of Medicine. While at Hofstra North Shore-LIJ, he acquired additional training in open cerebrovascular surgery and endovascular surgery for specialized training in the care of vascular disorders of the brain and spine.
Dr. Vadivelu’s interest, specialized training and research background in the role of inflammation in neurogenesis and stem cells, make him uniquely qualified to lead our division in its collaborative efforts with the division of interventional neuroradiology for the treatment of children with vascular disorders of the brain and spine.
In addition, Dr. Vadivelu brings expertise in spinal diseases, brain and spinal cord tumors, neuroendoscopy and neurostimulation.
DO: Des Moines University, College of Osteopathic Medicine, Des Moines, IA.
Residency: Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Neurosurgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY.
Fellowship: Interventional Neuroradiology, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY; Cerebrovascular Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY; Pediatric Neurosurgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX.
Vadivelu S, Willsey M, Curry D, McDonald JW. Stem cells for neuropathic pain. Neurosurgical Focus. Accepted.
Desai S, Vadivelu S, Patel A, Jea A. Isolated Cervical Spinal Canal Stenosis in the Pediatric Population and in Williams Syndrome. J Neurosurg Spine. 2013 Jun; 18(6):558-63
Patel A, Vadivelu S, Desai S, Jea A. Congenital Hypoplasia or Aplasia of the Lumbosacral Pedicle as an Unusual Cause for Spondylolisthesis in the Pediatric Age Group. J Neurosurg Pediatr. 2013 Jun; 11(6):717-21
Vadivelu S, Effendi S, Starke J, Luerssen T, Jea A. (2012) Neurological management in tuberculous meningitis. Clin Pediatr (Phila). 2013 Jul 10
Vadivelu S, Kelley RI, Edelman M, Schneider S, Mittler M (2012). Choroid plexus papilloma and Pierpont syndrome. Journal of Neurosurgery Pediatrics. 2013 Feb; 11(2):115-8
Vadivelu S, Xin X, Loven T, Restrepo G, Chalif DJ, and Setton A (2012) Iatrogenic dural AVF and aneurysmal subarachnoid hemorrhage. Neurosurgical Focus. 32(5):E1
Vadivelu S, Bolognese P, Milhorat T, Mogilner AY (2011) Occipital nerve stimulation for refractory headache in the chiari malformation population. Neurosurgery. 70(6):1430-7.
Vadivelu S, Bell RS, Crandall B, DeGraba T, Armonda RA. (2010) Delayed detection of carotid-cavernous fistulas associated with wartime blast-induced craniofacial trauma. Neurosurg Focus. 28(5), E6.
Vadivelu S, Tomlinson K, Valles J, Hundert M, Bagdonas R, Eisenberg M. (2010) Acute anti-emetic withdrawal associated with a hemorrhagic cerebellar arteriovenous malformation. J Clin Neurosci. 17(8), 1061-3.
Vadivelu S, Sharer L, Schulder M. (2010) Regression of Multiple Intracranial Meningioma after Cessation of long term progesterone agonist therapy. Journal of Neurosurgery. 112(5), 920-4.
Timothy W. Vogel, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Tim Vogel, MD, joined the Division of Pediatric Neurosurgery at Cincinnati Children’s in 2013 as an assistant professor of neurosurgery and developmental biology. Dr. Vogel is a graduate of Princeton University and Columbia University’s College of Physicians and Surgeons. Dr. Vogel completed his residency at the University of Iowa Hospitals and Clinics in 2011. He then completed a minimally invasive fellowship at Boston Children’s Hospital at Harvard University, followed by a pediatric neurosurgery fellowship at St Louis Children’s Hospital at Washington University in St. Louis.
Dr. Vogel specializes in craniofacial surgery and the use of endoscopy in the minimally invasive treatment of children. He also utilizes endoscopy and his expertise with minimally invasive surgery to treat hydrocephalus and certain tumors of the brain.
In addition to his clinical activities, Dr. Vogel is a principal investigator in the Division of Developmental Biology focused on human and molecular genetics of hydrocephalus and other neurodevelopmental disorders. Dr. Vogel has completed postdoctoral fellowships for the Howard Hughes Medical Institute at the University of Iowa and at Massachusetts General Hospital. Dr. Vogel is focused on cilia (hair like structures in the brain) and their contribution to hydrocephalus during development. He utilizes basic and translational applications to study cellular signaling in hydrocephalus with the goal of developing innovative treatment strategies for this disease.
Dr. Vogel is a member of the American Association for the Advancement of Science, the American Association of Neurological Surgeons, the American Society of Craniofacial Surgery, the American Society of Human Genetics, the Ciliopathy Alliance, and the Congress of Neurological Society and the Society of Neuroscience.
MD: Columbia University College of Physicians and Surgeons, New York, NY, 2005.
Residency: University of Iowa Hospitals and Clinics, Iowa City, IA, 2011.
Research Fellowship: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2013.
Pediatric Neurosurgery Fellowship: St. Louis Children’s Hospital, Washington University in St. Louis, Division of Pediatric Neurosurgery, St. Louis, MO, 2013.
Minimally Invasive Fellowship: Boston Children’s Hospital, Harvard University, Department of Neurosurgery, Boston, MA, 2012.
Postdoctoral Research Fellowship: Harvard Medical School, Harvard University, Boston, MA, 2012.
Postdoctoral Research Fellowship: Howard Hughes Medical Institute, University of Iowa, Iowa City, IA, 2010.
Zhang Q, Nishimura DY, Vogel T, Shao J, Swiderski R, Yin T, Searby C, Carter CC, Kim G, Bugge K, Stone EM, Sheffield VC. BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking. J Cell Sci. 2013 Jun 1;126(Pt 11):3272-80.
Carter CS*, Vogel TW*, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC. Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat Med. 2012 Nov 18 Epub. Cover Article. (*EQUAL AUTHOR CONTRIBUTION)
Vogel TW, Carter CS, Abode-Iyamah K, Zhang Q, Robinson S. The role of primary cilia in the pathophysiology of neural tube defects. Neurosurgery Focus. 2012 Oct; 33(4):E2. Cover Article.
Vogel TW, Manjila S, Cohen AR. Novel neurodevelopmental disorder in a case of a giant occipitoparietal meningoencephalocele. J Neurosurg Pediatr. 2012 Jun 8. Cover Article.
Zhang Q, Nishimura DY, Seo S, Vogel T, Morgan DA, Searby C, Bugge K, Stone EM, Rahmouni K, Sheffield VC. Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci USA. 2011 Dec 20;108(51):20678-83.
Thompson S, Recober A, Vogel TW, Kuburas A, Sheffield VC, Russo AF, Stone EM. Light aversion in mice depends on nonimage-forming irradiance detection. Behav Neurosci. 2010 Dec; 124(6): 821-7.
Vogel TW, Vortmeyer AO, Lubensky IA, Lee YS, Furuta M, Ikejiri B, Kim HJ, Lonser RR, Oldfield EH, Zhuang Z. Coexpression of erythropoietin and its receptor in endolymphatic sac tumors. J Neurosurg. 2005 Aug;103(2):284-8.
Vogel TW, Zhuang Z, Li J, Okamoto H, Furuta M, Lee YS, Zeng W, Oldfield EH, Vortmeyer AO, Weil RJ. Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme. Clin Cancer Res. 2005 May 15;11(10):3624-32.
Vogel TW, Brouwers FM, Lubensky IA, Vortmeyer AO, Weil RJ, Walther MM, Oldfield EH, Linehan WM, Pacak K, Zhuang Z. Differential expression of erythropoietin and its receptor in von Hippel-Lindau-associated and MEN type 2-associated pheochromocytomas. J Clin Endocrinol Metab. 2005 June;90(6):3747-51.
Lee YS, Vortmeyer AO, Lubensky IA, Vogel TW, Ikejiri B, Ferlicot S, Benoit G, Giraud S, Oldfield EH, Linehan WM, Teh BT, Richard S, Zhuang Z. Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma. Clin Cancer Res. 2005 Feb 1;11(3):1059-64.
Primary cilia signaling in CNS progenitors and their role in neonatal hydrocephalus. Principal Investigator. K12 Neurosurgeon Research Career Development Program (NRCDP); National Institute of Neurological Disorders and Stroke (NINDS); National Institutes of Health (NIH); and Massachusetts General Hospital, Harvard Medical School. Jan 2014 – Jan 2017.
Role of neural progenitor cells in the development of neonatal hydrocephalus. Principal Investigator. Hydrocephalus Association’s CSF Production, Flow and Regulation, Therapeutics and Diagnostics Award. Sep 2013-Sep 2016.
Role of progenitor cells in the development of congenital hydrocephalus. Collaborator. National Institutes of Health. Sep 2013-Sep 2016.
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