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Energy sensing and metabolic pathways in neural cells, neural stem cells, brain cancer stem cells. Mouse models of high grade human brain tumor (glioma) and mechanisms of resistance of brain cancer cells.
Molecular hubs of nutrient sensing, oxygen sensing, oncogene and tumor suppressor signaling in glioma.
Molecular mechanisms of energy-dependent and independent functions of the cellular energy sensor AMP Kinase in mammalian brain development, cell fate chose and differentiation, cell survival, metabolic stress, cell division and mobility.
Identification of new druggable targets in brain cancer.
I did my graduate studies in signaling and molecular biology of cancer at National Centre for Cell Science (Pune, India) and my first postdoctoral training at The Roswell Park Cancer Institute (Buffalo, NY, USA), In the Dasgupta lab, I am interested in deciphering the role of metabolic regulator kinase AMPK in the development and treatment of brain cancers, particularly the role played by the different AMPK subunits in glioblastoma. Using knockout mouse models of human brain cancer and primary cancer cells derived from patients, we are assembling pieces of puzzle to reveal the functions of AMPK subunits in brain cancer pathophysiology and metabolism. Our ultimate goal is to develop novel AMPK complex specific modulators that have the potential to inhibit tumor growth.
I obtained my PhD in Anatomy, Histology and Embryology from Shanghai Medical College Fudan University, China, 2002. I study the mechanism of AMPK regulation of mitochondrial function and tumor metabolism in glioblastoma. Qiang.Fan@cchmc.org
I obtained my PhD in Stem cell biology and Cancer Genetics in 2014 from the University of Nottingham, UK. My PhD was focused on exploring the mechanism for tumor initiation and maintenance of the stem cell. My current research is focused on understanding the role of AMPK in neural development.
I obtained my Bachelor of Science in Molecular and Cellular Biology and Bachelor of Arts in German Studies from University of Arizona. Currently I’m working toward a PhD in the Cancer and Cell Biology Graduate Program at University of Cincinnati. My research interests include examining metabolic vulnerabilities in adult and pediatric high grade gliomas.
I am a research assistant in the Dasgupta lab. I have expertise in molecular cloning and I am in charge of maintenance of our transgenic mouse colony. I assist all researchers in various ways including cloning genes, targeted mutagenesis, generating CRISPR/Cas9 knockout lines, cell culture, genotyping transgenic mice, designing primers and sequencing clones. I am also in charge of ordering reagents and lab organization.
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