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The goal of our research is to identify molecular mechanisms of temperature sensation using the fly brain as a model. We will elucidate how temperature stimuli are relayed and represented in the brain and will uncover the temperature-responsive neural circuits using genetic, behavioral and physiological approaches.
Tang X, Platt MD, Lagnese CM, Leslie JR, Hamada FN. Temperature integration at the AC thermosensory neurons in Drosophila. The Journal of Neuroscience. In press.
Kaneko H, Head LM, Ling J, Liu Y, Hardin PE, Emery P, Hamada FN. Circadian rhythm of temperature preference and its neural control in Drosophila. Current Biology. 22(19):1851-7. Oct 9, 2012.
Hamada FN, Rosenzweig M, Kang K, Pulver S, Ghezzi A, Jegla T, Garrity PA. An internal thermal sensor controlling temperature preference in Drosophila. Nature. 454(7201):217-20. 2008.
Ishii S, Koshiyama A, Hamada FN, Nara TY, Iwabata K, Sakaguchi K, Namekawa SH. Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1: a molecular link between recombination and chromatin assembly during meiosis. FEBS J. 275(9):2032-41. 2008.
Hamada FN, Namekawa SH, Ishii S, Iwabata K, Nara T, Koshiyama A, Yamaguchi T, Ishizaki T, Sakaguchi K, Sawado T. Proliferating cell nuclear antigen (PCNA) interacts with a meiosis-specific RecA homologues, Lim15/Dmc1, but does not stimulate its strand transfer activity. Biochem Biophys Res Commun. 352(4):836-42. 2007.
Koshiyama A, Hamada FN, Namekawa SH, Iwabata K, Sugawara H, Sakamoto A, Ishizaki T, Sakaguchi K. Sumoylation of a meiosis-specific RecA homolog, Lim15/Dmc1, via interaction with the small ubiquitin-related modifier (SUMO)-conjugating enzyme Ubc9. FEBS J. 273(17):4003-12. 2006.
Hamada FN, Park PJ, Gordadze PR, Kuroda MI. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Genes & Development.19(19):2289-94. 2005.
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