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Richard A. Lang, PhD Director, Visual Systems Group
Director, Visual Systems Group
Professor, UC Department of Pediatrics
UC Department of Ophthalmology
Wnt ligands in tumorigenesis; vascular regression and tissue regeneration; lens induction and morphogenesis.
Visit the Lang Lab.
BSc: Co-major in genetics and biochemistry, University of Melbourne, Australia, 1984 (with honors).
PhD: University of Melbourne, Australia, at the Ludwig Institute for Cancer Research under Drs. AR Dunn and TJ Gonda, 1988.
Postdoctoral Fellow: The G.W. Hooper Research Foundation, University of California, San Francisco under Dr. JM Bishop, 1989-92. Studied the role of the macrophage in developmentally programmed tissue remodeling.
Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA. Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8.
Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene. 2010 Jun 24;29(25):3715-22.
Plageman TF Jr, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA. Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development. 2010 Feb;137(3):405-15.
Smith AN, Radice G, Lang RA. Which FGF ligands are involved in lens induction? Dev Biol. 2010 Jan 15;337(2):195-8.
Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA. Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development. 2009 Nov;136(21):3657-67.
Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Development. 2009 Sep;136(17):2977-85. Erratum in: Development. 2009 Oct;136(19):3377.
Rao S, Lobov IB, Vallance JE, Tsujikawa K, Shiojima I, Akunuru S, Walsh K, Benjamin LE, Lang RA. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development. 2007 Dec;134(24):4449-58.
Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development. 2007 May;134(10):1873-85.
Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007 Apr 10;5:15.
Miller LA, Smith AN, Taketo MM, Lang RA. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol. 2006 Mar 15;6:14.
Fumika Hamada, PhD
Assistant Professor, UC Department of Pediatrics
Thermo- and pain sensation in Drosophila.
Visit the Hamada Lab.
Postdoctoral Fellow: Brandeis University, 2005-2009. Harvard Medical School, 2004-2005.
PhD: Tokyo University of Science, Japan, 2004.
BS: Tokyo University of Science, Japan, 1999.
Head L, Tang X, Hayley SE, Goda T, Umezaki Y, Chang EC, Leslie JR, Fujiwara M, Garrity PA, Hamada FN. The influence of light on temperature preference in Drosophila. Current Biology. 2015.
Goda T, Leslie J, Hamada FN. Design and analysis of temperature preference rhythm in Drosophila. J Vis Exp. 2014 Jan 13;(83).
Tang X, Platt MD, Lagnese CM, Leslie JR, Hamada FN. Temperature integration at the AC thermosensory neurons in Drosophila. J Neurosci. 2013 Jan 16;33(3):894-901.
Kaneko H, Head LM, Ling J, Liu Y, Hardin PE, Emery P, Hamada FN. Circadian rhythm of temperature preference and its neural control in Drosophila. Current Biology. 2012 Oct 9;22(19):1851-7.
Hamada FN, Rosenzweig M, Kang K, Pulver SR, Ghezzi A, Jegla TJ, Garrity PA. An internal thermal sensor controlling temperature preference in Drosophila. Nature. 2008 Jul 10;454(7201):217-20.
Hamada FN, Koshiyama A, Namekawa SH, Ishii S, Iwabata K, Sugawara H, Nara TY, Sakaguchi K, Sawado T. Proliferating cell nuclear antigen (PCNA) interacts with a meiosis-specific RecA homologues, Lim15/Dmc1, but does not stimulate its strand transfer activity. Biochem Biophys Res Commun. 2007 Jan 26;352(4):836-42.
Hamada FN, Park PJ, Gordadze PR, Kuroda MI. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Genes Dev. 2005 Oct 1;19(19):2289-94.
Virginia A. Miraldi Utz, MD
is a pediatric ophthalmologist who works closely with faculty within the Ophthalmology and Visual Science Research Department and Division of Human Genetics. Her research interests are in nosology of ophthalmic genetic disorders and syndromes including retinal dystrophies and mitochondrial disorders.
Assistant Professor, UC Department of Ophthalmology
Pediatric eye diseases such as amblyopia, cataracts and strabismus; diagnosis and management of genetic eye disorders and syndromes (retinal dystrophies such as retinitis pigmentosa, Stargardt disease, ocular malformations and mitochondrial disorders); pediatric uveitis and ocular inflammation.
Dr. Virginia Miraldi Utz, MD, FAAP, is an assistant professor of pediatric ophthalmology at the Abrahamson Eye Institute of Cincinnati Children’s Hospital Medical Center within the UC Department of Pediatrics. She completed her undergraduate degree in biochemistry and religious studies at The College of Wooster (Wooster, Ohio) and Kanda University (Chiba, Japan). She received her Doctor of Medicine from Case Western Reserve University School of Medicine in Cleveland, Ohio, where she was served as co-president of the Alpha Omega Alpha Society chapter. During her residency at University Hospitals Case Medical Center, she was awarded the Ocular Immunology and Uveitis Foundation Travel Grant for her basic science research in ocular microbiology and immunology and the Humanism in Ophthalmology Award. She completed her fellowship training in pediatric ophthalmology and adult strabismus at the Cleveland Clinic Cole Eye Institute. She recently completed additional clinical training in the field of ocular inflammation and uveitis preceptorship to serve patients with juvenile idiopathic arthritis and related disorders.
Dr. Miraldi Utz specializes in the management of pediatric eye disorders such as amblyopia, strabismus, and pediatric cataracts. She has special clinical and research interests in ocular inflammatory disease and ophthalmic genetic disorders, including ocular malformations and retinal dystrophies. Dr. Miraldi Utz has published multiple research articles in peer-reviewed journals, as well as having contributed abstracts and presentations at a number of professional association meetings. She is a peer reviewer for several journals, including Ophthalmic Genetics, Molecular Vision, and British Journal of Ophthalmology. She is a member of American Association for Pediatric Ophthalmology and Strabismus, American Academy of Ophthalmology, American Uveitis Society, Ophthalmic Genetic Study Club, International Society for Genetic Eye Diseases and Retinoblastoma, and Fellow of the American Academy of Pediatrics.
Medical School: Case Western Reserve University School of Medicine, Cleveland, OH.
Residency: Ophthalmology, University Hospitals Eye Institute Case Medical Center, Case Affiliated Hospitals Residency Program, Cleveland, Ohio.
Fellowship: Pediatric Ophthalmology and Adult Strabismus, Cole Eye Institute, Cleveland Clinic; Cleveland, Ohio.
Preceptorship: Pediatric Uveitis, The Retina Group, Columbus, OH; Cincinnati Eye Institute, Cincinnati, OH.
Board Certification: American Board of Ophthalmology, 2013.
Utz VM, Coussa RG, Marino MJ, Chappelow AV, Pauer GJ, Hagstrom SA, Traboulsi EI. Predictors of Visual Acuity and Genotype-Phenotype Correlates in a Cohort of Patients with Stargardt Disease. Br J Ophthalmol. 2014 Apr:98(4):513-8.
Utz VM, Chappelow AV, Marino MJ, Beight CD, Sturgill-Short GM, Pauer GJ, Crowe S, Hagstrom SA, Traboulsi EI. Identification of Three ABCA4 Sequence Variations Exclusive to African-American Patients in a Cohort of Patients with Stargardt Disease. Am J Ophthalmol. 2013 Dec;156(6):1220-1227.
Utz VM, Beight CD, Marino MJ, Hagstrom SA, Traboulsi EI. Autosomal Dominant Retinitis Pigmentosa Secondary to Pre-mRNA Splicing Factor Gene PRPF31: Review of Disease Mechanism and Report of Family with a Novel 3-Base Insertion. Ophthalmic Gen. 2013 Dec;34(4):183-8.
Utz VM, Tang J. Ocular Manifestations of Antiphospholipid Syndrome. Br J Ophthalmol. 2011 Apr;95(4):454-9.
Mucci JJ, Utz VM, Galor A, Jeng BH. Recurrence Rates of Herpes Simplex Virus Keratitis in Contact Lens Wearers: Eye Contact Lens. Eye Contact Lens. 2009 Jul;35(4):185-7.
Utz VM, Krueger RR. Management of Irregular Astigmatism Following Rotationally Disoriented Free Cap After LASIK. J Refract Surg. 2008 Apr;24(4):383-91.
Michael B. Yang, MD Director, Pediatric Ophthalmology
investigates prognostic risk factors for the development of severe retinopathy of prematurity (ROP). These risk factors may generate hypotheses about underlying mechanisms that contribute to the pathogenesis of ROP. The role of light exposure to the fetus during early gestation is an ongoing interest.
Director, Pediatric Ophthalmology
Associate Professor, UC Department of Ophthalmology
Cataract; glaucoma; pediatric and adult strabismus; surgery for
nystagmus patients with abnormal head posture; periocular capillary
hemangiomas; retinopathy of prematurity
BS: Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 1988.
MD: Harvard Medical School-Massachusetts Institute of Technology, Joint Program in Health Sciences and Technology, Boston, MA, 1993.
Internship: Internal Medicine, St. Elizabeth Hospital, Boston, MA, 1993-1994.
Residency: Ophthalmology, Estelle Doheny Eye Institute, University of Southern California/LosAngeles County Hospital, Los Angeles, CA, 1994-1997.
Fellowship: Pediatric Ophthalmology, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 1998-1999.
Board Certification: American Board of Ophthalmology, 2000. Recertified 2011.
Liu H, Yang MB, Li SK, Hao J. Effects of dosing protocol on distribution of propranolol in periocular tissues after topical ocular instillation. Current Eye Research. 2015 May;40(6):638-45.
Yang MB, Rao S, Copenhagen DR, Lang RA. Length of Day during Early Gestation as an Independent Predictor of Risk for Severe Retinopathy of Prematurity. Ophthalmology. 2013 Dec;120(12):2706-13.
Yang MB, Melia M, Lambert SR, Chiang MF, Simpson JL, Buffenn AN. Fibrin Glue for Closure of Conjunctiva in Strabismus Surgery: a Report by the American Academy of Ophthalmology. Ophthalmology. 2013 Sep;120(9):1935-41.
Lambert SR, Melia M, Buffenn AN, Chiang MF, Simpson JL, Yang MB. Rebound Tonometry: a Report by the American Academy of Ophthalmology. Published Online. Ophthalmology. 2013 Apr;120(4):e21-7.
Rao S, Chun C, Fan J, Kofron M, Yang MB, Hegde R, Ferrara N, Copenhagen DR, Lang RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013 Feb 14;494(7436):243-6.
Chiang MF, Melia M, Buffenn AN, Lambert SR, Recchia FM, Simpson JL, Yang MB. Detection of Clinically Significant Retinopathy of Prematurity Using Wide-Angle Digital Retinal Photography: a Report by the American Academy of Ophthalmology. Ophthalmology. 2012 Jun;119(6):1272-80.
Simpson JL, Melia M, Yang MB, Buffenn AN, Chiang MF, Lambert SR. Current Role of Cryotherapy in Retinopathy of Prematurity: a Report by the American Academy of Ophthalmology. Ophthalmology. 2012 Apr;119(4):873-7.
Hao J, Yang MB, Liu H, Li SK. Distribution of Propranolol in Periocular Tissues: A Comparison of Topical and Systemic Administration. J Ocul Pharmacol Ther 27:453-9, 2011.
Yang MB, Donovan EF. Risk Analysis and Alternative Protocols for Reduction of Screening for Retinopathy of Prematurity. J AAPOS. 2009;13(6)-539-45.
Yang MB, Donovan EF, Wagge JR. Race, Gender, and Clinical Risk Index for Babies (CRIB) Score as Predictors of Severe Retinopathy of Prematurity. J AAPOS. 2006;10:253-61.
G-ROP: Growth in Retinopathy of Prematurity Model Development. Site Principal Investigator. National Eye Institute: Subaward from Children's Hospital of Philadelphia. Aug 2012-Jul 2017.
INS-3: A Phase 3, Randomized, Double-Masked, Placebo Controlled Study of the Efficacy and Safety of myo-Inositol 5% Injection to Increase Survival without Severe Retinopathy of Prematurity (Reduce-ROP) in Extremely Premature Infants. Site Co-Investigator. National Institutes of Health: Subaward from University of Rochester. 2014–2019.
Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity. Site Principal Investigator. National Eye Institute: Subaward from Pediatric Eye Disease Investigators Group. 2015-2016.
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