Ellis Arjmand, MD, PhD
Attending Otolaryngologist
Director of the Ear and Hearing Center
Director, Pediatric Cochlear Implant Program
Medical Director, Liberty Campus
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Clinical InterestsChildhood hearing impairment; cochlear implantation; newborn hearing screening; congenital inner ear anomalies; health policy and economics Research InterestsPediatric sensorineural hearing loss; congenital inner ear anomalies; genetic basis of sensorineural hearing loss; functional neuroimaging of the auditory system; integrated medical care of children with hearing impairment
Biography
Ellis Arjmand, MD, PhD, is a native of Chicago, Illinois, where he graduated from Northwestern University with his medical degree in 1986. He subsequently earned a PhD in auditory physiology at Northwestern University in the laboratory of Dr. Peter Dallas and a Master of Medical Management degree at Carnegie Mellon University. Dr. Arjmand completed his residency in otolaryngology at Washington University in St. Louis and his fellowship in pediatric otolaryngology at St. Louis at Children's Hospital. Upon completing his fellowship, he joined the faculty at Southern Illinois University of Medicine in 1994, where he practiced pediatric otolaryngology until 1999. He then joined the faculty at Pittsburgh School of Medicine, where he served as Director of the Hearing Center and the Pediatric Cochlear Implant Program at Children's Hospital of Pittsburgh. In July of 2004, Dr. Arjmand moved to Cincinnati to become Associate Professor at The University of Cincinnati and Director of The Ear and Hearing Center at Cincinnati Children's Hospital Medical Center. Dr. Arjmand is a fellow of the American College of Surgeons and The American Academy of Pediatrics and a member of the American Society for Pediatric Otolaryngology, the Society for Ear, Nose and Throat Advances in Children and the American Bronchoesophagological association. He is certified by the American Board of Otolaryngology and is a member of The American Academy of Otolaryngology-Head and Neck Surgery. Dr. Ellis Arjmand practices general pediatric otolaryngology with a special emphasis on pediatric otology. His research interests relate to the causes of childhood hearing impairment, congenital inner ear anomalies, newborn hearing screening and cochlear implants.
Education and Training
MD: Northwestern University, Chicago, IL, 1986. PhD: Northwestern University, Chicago, IL, 1996. MMM: Heinz School of Public Policy at Carnegie Mellon University, Pittsburgh, Pennsylvania, 2007. Residency: Washington University, St. Louis, MO, 1993. Fellowship: St. Louis Children's Hospital, 1994.
Publications
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Ksiazek J, Prager JD, Sun GH, Wood RE, Arjmand EM. Inhaled cidofovir as an adjuvant therapy for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg. 2011 Apr;144(4):639-41.
Propst EJ, Prager JD, Adams JM, Arjmand EM, Willging JP, Samy RN. A preliminary investigation of four-dimensional ultrasound for evaluation of middle ear ossicles: an in vitro study. Int J Pediatr Otorhinolaryngol. 2010 Sep;74(9):1028-33. Grisel J, Arjmand E. Comparing quality at an ambulatory surgery center and a hospital-based facility: preliminary findings. Otolaryngol Head Neck Surg. 2009 Dec;141(6):701-9.
Boston M, Halsted M, Meinzen-Derr J, Bean J, Vijayasekaran S, Arjmand E, Choo D, Benton C, Greinwald J. The large vestibular aqueduct: a new definition based on audiologic and computed tomography correlation. Otolaryngol Head Neck Surg. 2007 Jun;136(6):972-7.
Simons JP, Mandell DL, Arjmand EM. Computed tomography and magnetic resonance imaging in pediatric unilateral and asymmetric sensorineural hearing loss. Arch Otolaryngol Head Neck Surg. 2006 Feb;132(2):186-92.
Ruscetta MN, Arjmand EM, Pratt SR. Speech recognition abilities in noise for children with severe-to-profound unilateral hearing impairment. Int J Pediatr Otorhinolaryngol. 2005 Jun;69(6):771-9.
Mandell DL, Arjmand EM, Kay DJ, Casselbrant ML, Rosen CA. Intralesional cidofovir for pediatric recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg. 2004 Nov;130(11):1319-23.
Arjmand EM, Webber A. Audiometric findings in children with a large vestibular aqueduct. Arch Otolaryngol Head Neck Surg. 2004 Oct;130(10):1169-74.
Belmont MJ, Arjmand EM. Recurrent acute otitis media associated meningitis in a patient with a contralateral cochlear implant and bilateral cochleovestibular dysplasia. Int J Pediatr Otorhinolaryngol. 2004 Aug;68(8):1091-3.
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Robin T. Cotton, MD, FACS, FRCS(C)
Director, Aerodigestive and Sleep Center
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology - Head and Neck Surgery
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Specialties
Pediatric airway reconstruction; congenital and acquired anomalies of the airway; cleft lip repair; cleft palate repair; dysphagia; laryngitis; laryngomalacia; otitis media; tonsillitis
Biography
Originally from England, Robin T. Cotton, MD, has built the world's premiere center for the diagnosis and treatment of airway abnormalities. He was instrumental in developing the Airway Management Unit, which has evolved into the Aerodigestive Sleep Center. The Aerodigestive Sleep Center is now the forefront of the multidisciplinary approach management for children with complex airway disorders. Dr. Cotton was the director of the Department of Pediatric Otolaryngology -- Head and Neck Surgery at Cincinnati Children's Hospital Medical Center from1973 to 2012. The Department of Pediatric Otolaryngology has become the busiest surgical subspecialties at Cincinnati Children's, with more than 36,000 visits and 15,000 surgeries each year. The Pediatric Otolaryngology -- Head and Neck Surgery Division was the first to utilize Cincinnati Children's outpatient facilities. Dr. Cotton has been an invited speaker to many national and international functions each year. Because of his reputation, 70 percent of his patients requiring airway surgery are from outside the Ohio, Indiana and Kentucky area. Together, Dr. Cotton and his colleagues have developed a world-renowned program to treat primary and specialized ear, nose and throat problems, including swallowing disorders, speech disorders and cochlear implants. Named one of the "Best Doctors in the United States" in 1998, Dr. Cotton and his staff have built an international reputation for the treatment of hearing and aerodigestive conditions in children.
Education and Training
MD: University of Cambridge, Cambridge, England, 1966 Residency: General Surgery, United Birmingham Hospital, Birmingham, England, 1968; Otolaryngology Residency, University of Toronto, Toronto, Canada, 1971 Fellowship: Otolaryngology Fellowship, University of Toronto, Toronto, Canada, 1972; Head and Neck Fellowship, University of Cincinnati, Cincinnati, OH, 1973 Certification: American Board of Otolaryngology, 1972
Publications
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Prager JD, Hopkins BS, Propst EJ, Shott SR, Cotton RT. Oropharyngeal stenosis: a complication of multilevel, single-stage upper airway surgery in children. Arch Otolaryngol Head Neck Surg. 2010 Nov;136(11):1111-5. Cotton RT, Cohen AP. Eco-conservation and healthcare ethics: a call to action. Laryngoscope. 2010 Jan;120(1):4-8. Burrow TA, Saal HM, de Alarcon A, Martin LJ, Cotton RT, Hopkin RJ. Characterization of congenital anomalies in individuals with choanal atresia. Arch Otolaryngol Head Neck Surg. 2009 Jun;135(6):543-7. Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7. Hart CK, Richter GT, Cotton RT, Rutter MJ. Arytenoid prolapse: a source of obstruction following laryngotracheoplasty. Otolaryngol Head Neck Surg. 2009 May;140(5):752-6. Wootten CT, Goudy SL, Rutter MJ, Willging JP, Cotton RT. Airway injury complicating excision of thyroglossal duct cysts. Int J Pediatr Otorhinolaryngol. 2009 Jun;73(6):797-801. Fricke BL, Abbott MB, Donnelly LF, Dardzinski BJ, Poe SA, Kalra M, Amin RS, Cotton RT. Upper airway volume segmentation analysis using cine MRI findings in children with tracheostomy tubes. Korean J Radiol. 2007 Nov-Dec;8(6):506-11. Schraff SA, Zur KB, Jacobs I, Darrow DH, Cotton RT, Rutter MJ. The clinical relevance of the submucosal cricoid cleft. Int J Pediatr Otorhinolaryngol. 2007 Jul;71(7):1099-104. Johnson LB, Cotton RT, Rutter MJ. Management of symptomatic tracheal pouches. Int J Pediatr Otorhinolaryngol. 2007 Apr;71(4):527-31. Azizkhan RG, Rutter MJ, Cotton RT, Lim LH, Cohen AP, Mason JL. Lymphatic malformations of the tongue base. J Pediatr Surg. 2006 Jul;41(7):1279-84.
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Alessandro de Alarcon, MD, MPH
Director, Center for Pediatric Voice Disorders at Cincinnati Children’s
Academic Information
Assistant Professor, UC Department of Pediatrics
Assistant Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Airway reconstruction; pediatric voice disorders; pediatric sinonasal conditions; eosinophilic esophagitis; health outcomes research; quality improvement in health care
Education and Training
MD: VCU School of Medicine.
Residency: University of Virginia Health Systems.
Fellowship: Cincinnati Children's Hospital Medical Center.
Certification: American Board of Otolaryngology, 2007.
Publications
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Cortina S, McGraw K, Dealarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care. 2010 Oct;39(4):266-278. Kelchner LN, Brehm SB, Weinrich B, Middendorf J, deAlarcon A, Levin L, Elluru R. Perceptual evaluation of severe pediatric voice disorders: rater reliability using the consensus auditory perceptual evaluation of voice. J Voice. 2010 Jul;24(4):441-9.
Richter GT, Rutter MJ, deAlarcon A, Orvidas LJ, Thompson DM. Late-onset laryngomalacia: a variant of disease. Arch Otolaryngol Head Neck Surg. 2008 Jan;134(1):75-80.
de Alarcón A, Kesser BW, Jahrsdoerfer RA. Congenital Absence of the Oval Window: Diagnosis, Surgery, and Audiometric Outcomes. Otology & Neurotology. 2008;29(1):23-8.
Becker SS, de Alarcón A, Bomeli SR, Han JK, Gross CW. Risk Factors for Recurrent Sinus Surgery in Cystic Fibrosis: Review of a Decade of Experience. American Journal of Rhinology. 2007;21(4):478-82.
de Alarcón A, Choo DI. Controversies in Aural Atresia Repair. Current Opinion in Otolaryngology & Head and Neck Surgery. 2007;15(5):310-314.
de Alarcón A, Steinke JW, Caughey R, Barekzi E, Hise K, Gross CW, Han JK, Borish L. Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. American Journal of Rhinology. 2006;20(5): 545-549.
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Ravindhra G. Elluru, MD, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
Associate Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Clinical InterestsGeneral pediatric otolaryngology; airway reconstruction; head and neck tumors; hearing loss and otologic disease; plastic surgery; vascular malformations Research InterestsMolecular genetics of upper respiratory tract anomalies
Biography
Dr. Ravi Elluru obtained his MD and PhD degrees from the University of Texas Southwestern Medical Center in Dallas, Texas and completed a residency in otolaryngology at Washington University School of Medicine in St. Louis, Missouri. After residency, Dr. Elluru completed an accredited fellowship in pediatric otolaryngology with an emphasis on treating children with disorders of the upper aerodigestive tract. Dr. Elluru enjoys treating a broad variety of ear, nose, and throat conditions in children. In addition to his clinical interests, one of Dr. Elluru's long-term research goals is to gain a better understanding of upper respiratory tract lesions and develop more efficacious treatment options.
Education and Training
MD - PhD: University of Texas Southwestern Medical Center, Dallas, Texas, 1996.
Residency: Washington University School of Medicine, St. Louis, Missouri, 2001.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003.
Certification: Otolaryngology, 2002.
Publications
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Sun GH, Elluru RG. Radiology quiz case 2. Allergic fungal rhinosinusitis (AFRS). Arch Otolaryngol Head Neck Surg. 2010 Mar;136(3):307, 308-9.
Morris LM, Lim FY, Elluru RG, Hopkin RJ, Jaekle RK, Polzin WJ, Crombleholme TM. Severe micrognathia: indications for EXIT-to-Airway. Fetal Diagn Ther. 2009;26(3):162-6.
Hom DB, Sun GH, Elluru RG. A contemporary review of wound healing in otolaryngology: current state and future promise. Laryngoscope. 2009 Nov;119(11):2099-110. Review.
Brehm SB, Weinrich B, Zieser M, Kelchner L, Middendorf J, Elluru R, de Alarcon A. Aerodynamic and acoustic assessment in children following airway reconstruction: an assessment of feasibility. Int J Pediatr Otorhinolaryngol. 2009 Jul;73(7):1019-23.
Elluru RG, Thompson F, Reece A. Fibroblast growth factor 18 gives growth and directional cues to airway cartilage. Laryngoscope. 2009 Jun;119(6):1153-65.
Richter GT, Mehta D, Albert D, Elluru RG. A novel murine model for the examination of experimental subglottic stenosis. Arch Otolaryngol Head Neck Surg. 2009 Jan;135(1):45-52.
Kelchner LN, Brehm SB, Weinrich B, Middendorf J, deAlarcon A, Levin L, Elluru R. Perceptual evaluation of severe pediatric voice disorders: rater reliability using the consensus auditory perceptual evaluation of voice. J Voice. 2010 Jul;24(4):441-9.
Mihaescu M, Gutmark E, Murugappan S, Elluru R, Cohen A, Willging JP. Modeling flow in a compromised pediatric airway breathing air and heliox. Laryngoscope. 2009 Jan;119(1):145-51.
Mihaescu M, Gutmark E, Murugappan S, Elluru R, Cohen A, Willging JP. Modeling flow in a compromised pediatric airway breathing air and heliox. Laryngoscope. 2008 Dec;118(12):2205-11.
Dasgupta R, Adams D, Elluru R, Wentzel MS, Azizkhan RG. Noninterventional treatment of selected head and neck lymphatic malformations. J Pediatr Surg. 2008 May;43(5):869-73.
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John H. Greinwald Jr., MD, FAAP
Professor, Genetics and Division of Otolaryngology
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Biography
Education and Training
BS: Wofford College, Spartanburg, SC, 1983.
MD: Medical University of South Carolina, Charleston, SC, 1987.
Internship: Naval Medical Center, Portsmouth, VA, 1988.
Residency: Naval Medical Center, Portsmouth, VA, 1995.
Fellowship: Pediatric Otolaryngology, University of Iowa, Iowa City, IA, 1998.
Publications
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Sun GH, Harmych BM, Dickson JM, Gonzalez Del Rey JA, Myer CM 3rd, Greinwald JH Jr. Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding. Arch Otolaryngol Head Neck Surg. 2011 Jan;137(1):65-8. Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7. Hopkins BS, Johnson KE, Ksiazek JM, Sun G, Greinwald JH, Rutter M. H1N1 influenza A presenting as bacterial tracheitis. Otolaryngol Head Neck Surg. 2010 Apr;142(4):612-4. Kothiyal P, Cox S, Ebert J, Husami A, Kenna MA, Greinwald JH, Aronow BJ, Rehm HL. High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays. BMC Biotechnol. 2010 Feb 10;10:10. Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6. Kothiyal P, Cox S, Ebert J, Aronow BJ, Greinwald JH, Rehm HL. An overview of custom array sequencing. Curr Protoc Hum Genet. 2009 Apr;Chapter 7:Unit 7.17. Lee KH, Larson DA, Shott G, Rasmussen B, Cohen AP, Benton C, Halsted M, Choo D, Meinzen-Derr J, Greinwald JH Jr. Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations. Laryngoscope. 2009 Mar;119(3):554-8. Greinwald J Jr, Cohen AP, Hemanackah S, Azizkhan RG. Massive lymphatic malformations of the head, neck, and chest. J Otolaryngol Head Neck Surg. 2008 Apr;37(2):169-73. Schraff SA, Schleiss MR, Brown DK, Meinzen-Derr J, Choi KY, Greinwald JH, Choo DI. Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngol Head Neck Surg. 2007 Oct;137(4):612-8. Vijayasekaran S, Halsted MJ, Boston M, Meinzen-Derr J, Bardo DM, Greinwald J, Benton C. When is the vestibular aqueduct enlarged? A statistical analysis of the normative distribution of vestibular aqueduct size. AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1133-8.
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David R. Moore, PhD
is a neuroscientist with basic and translational research programs in the development and plasticity of hearing. He studies how hearing develops in children and declines in older age, and how that development is affected by hearing loss, learning difficulties and auditory rehabilitation. A new interest is integrating hearing into large scale and biobank studies in collaboration with specialists outside hearing research.
513-803-4170
david.moore2@cchmc.org
David R. Moore, PhD
Academic Information
Professor, Division of Pediatric Surgery
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Specialties
Hearing; development; neuroscience; brain plasticity; biobank
Biography
David Moore, PhD, is a professor of Otolaryngology and associate director of the Communication Sciences Research Center at Cincinnati Children’s Hospital. Educated (PhD Monash University) in Australia, he spent 22 years at Oxford University on projects including auditory spatial hearing, biology of deafness and the consequences of otitis media. He became professor of Auditory Neuroscience in 2000. As director of the Medical Research Council Institute of Hearing Research, Nottingham (2002-12), he focused on auditory development and learning in humans. In 2008, he also co-founded the National Biomedical Research Unit in Hearing (NBRUH), refunded in 2011. He has been a visiting scientist at the University of California, Irvine, the University of Washington, Seattle, New York University, and Northwestern University, Chicago. He was the founder of MindWeavers PLC, creating digital learning experiences based on world-leading brain science. In 2010 he was awarded the George Davey Howells prize of the Royal Society of Medicine for editing the “Oxford Handbook of Auditory Science."
Education and Training
BSc (Hons): Physiology and Psychology, Monash University, Melbourne, Australia, 1974.
PhD: Psychology, Monash University, Melbourne, Australia, 1978.
NIH Fogarty Fellow: Anatomy and Neurobiology, University of California, Irvine, 1983-1984.
Publications
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Zhang YX, Barry J, Moore DR, Amitay S. The Test of Attention in Listening (TAIL) predicts basic auditory skills. PLoS ONE. 2012. Moore DR. Listening difficulties in children: Bottom-up and top-down contributions. J Comm Dis. 2012;45:411-418. Ramirez-Inscoe J, Moore DR. Processes that influence communicative impairments in deaf children using cochlear implants. Ear Hear. 2011;32:690-698. Moore DR, Cowan JC, Riley A, Edmondson-Jones AM, Ferguson MA. Development of auditory processing in 6-11 year old children. Ear Hear. 2011;32:269-285. Moore DR, Ferguson MA, Edmondson-Jones AM, Ratib S, Riley A. The nature of auditory processing disorder in children. Pediatrics. 2010;126:e382-e390. Bajo VM, Nodal FR, Moore DR, King AJ. The descending corticocollicular pathway mediates learning-induced auditory plasticity. Nature Neurosci. 2010;13:253–260. Moore DR, Shannon RV. Beyond cochlear implants – Awakening the deafened brain. Nature Neurosci. 2009;12:686-691. Moore DR, Halliday LF, Amitay S. Use of auditory learning to manage listening problems in children. Phil Trans R Soc B. 2009;364:409-420. Amitay S, Irwin A, Moore DR. Discrimination learning induced by training with identical stimuli. Nature Neurosci. 2006;9:1446-1448. Hawkey DJC, Amitay S, Moore DR. Early and rapid perceptual learning. Nature Neurosci. 2004;7:1055-6.
Grants
Deafness and Hearing Problems. Co-Principal Investigator. National Institute of Health Research UK. Apr 2012-Mar 2017. Novel genetic variants influencing hearing. Co-Principal Investigator. Action on Hearing Loss UK. Sep 2009-Aug 2013. The Auditory Brain. Co-Principal Investigator. Medical Research Council UK. Apr 2009-Mar 2015.
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Charles Monroe Myer III, MD
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Medical education; general pediatric otolaryngology (ear, nose and throat); head and neck tumors; airway problems; congenital abnormalities; sinus disease
Biography
Education and Training
BA: Vanderbilt University, Nashville, TN, 1975.
MD: University of Alabama, Birmingham, AL, 1978.
Residency: Good Samaritan Hospital, Cincinnati, OH; University of Cincinnati, Cincinnati, OH, 1980 to 1984.
Fellowship: Children's Hospital of Pittsburgh, PA, 1984 to 1985.
Certification: Diplomate, American Board of Otolaryngology, 1984.
Publications
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Sun GH, Harmych BM, Dickson JM, Gonzalez del Rey JA, Myer CM 3rd, Greinwald JH Jr. Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding. Arch Otolaryngol Head Neck Surg. 2011 Jan;137(1):65-8. Prager JD, Myer CM 4th, Hayes KM, Myer CM 3rd, Pensak ML. Improving methods of resident selection. Laryngoscope. 2010 Dec;120(12):2391-8. Statham MM, Myer CM 3rd. Complications of adenotonsillectomy. Curr Opin Otolaryngol Head Neck Surg. 2010 Dec;18(6):539-43. Prager JD, Myer CM 3rd, Pensak ML. Improving the letter of recommendation. Otolaryngol Head Neck Surg. 2010 Sep;143(3):327-30. Burkart CM, Richter GT, Rutter MJ, Myer CM 3rd. Update on endoscopic management of lingual thyroglossal duct cysts. Laryngoscope. 2009 Oct;119(10):2055-60. Wootten CT, Bromwich MA, Myer CM 3rd. Trends in blunt laryngotracheal trauma in children. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1071-5. Sun GH, Myer CM 3rd. Otolaryngologic manifestations of Maffucci's syndrome. Int J Pediatr Otorhinolaryngol. 2009 Jul;73(7):1015-8. Boston M, Rutter M, Myer CM 3rd, Cotton RT. Airway reconstruction in children with recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol. 2006 Jun;70(6):1097-101. White DR, Preciado DA, Stamper B, Willging JP, Myer CM 3rd, Cotton RT, Rutter MJ. Airway reconstruction in pediatric burn patients. Otolaryngol Head Neck Surg. 2005 Sep;133(3):362-5. Salamone FN, Myer CM 3rd. Van der Woude syndrome: the most common cleft syndrome. Otolaryngol Head Neck Surg. 2004 Jul;131(1):141.
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Saima Riazuddin, PhD
is focused on molecular and genetic basis of hearing impairment. For these studies, we utilize large human pedigrees and mutant mouse models. Through genetic screening disease causing mutations are identified in human families. To further understand the underlying cause of deafness in human pedigrees, we generate orthologue mouse models. These mouse models are evaluated for structural, physiological and developmental defects of the inner ear.
513-803-2888
saima.riazuddin@cchmc.org
Saima Riazuddin, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
Assistant Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Investigating molecular and genetic basis of hearing loss, utilizing human and mouse genetics to identify novel genes and pathways that underlie inherited human hearing impairment.
Biography
Saima Riazuddin, PhD is head of the Laboratory of Molecular Genetics and Assistant Professor in the Division of Pediatric Otolaryngology, Head and Neck Surgery at the Cincinnati Children’s Research Foundation. She holds secondary appointments in the Division of Opthalmology at the Cincinnati Children’s Research Foundation and the Departments of Otolaryngology and Ophthalmology at the University of Cincinnati. Dr. Riazuddin is interested in the molecular and genetic basis of Hearing impairment. She utilizes human and mouse genetics to identify novel genes and pathways that underlie inherited human hearing impairment.
Education and Training
BS: University of the Punjab, Lahore, Pakistan, 1995. MS: Quaid-i-Azam University, Islamabad, Pakistan, 1998. PhD: University of the Punjab, Lahore, Pakistan, 2001.
Publications
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Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome. BMC Med Genet. 2011 Feb 9;12:21. Borck G, Ur Rehman A, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nürnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nürnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Müller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C. Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42. Am J Hum Genet. 2011 Feb 11;88(2):127-37. Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet. 2011 Jan 7;88(1):19-29. Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, Hinshaw JE, Sellers J, Bartles JR, Hammer JA 3rd, Richardson GP, Griffith AJ, Frolenkov GI, Friedman TB. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28;141(5):786-98. Hertzano R, Puligilla C, Chan SL, Timothy C, Depireux DA, Ahmed Z, Wolf J, Eisenman DJ, Friedman TB, Riazuddin S, Kelley MW, Strome SE. CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. J Assoc Res Otolaryngol. 2010 Sep;11(3):407-18. Rehman AU, Morell RJ, Belyantseva IA, Khan SY, Boger ET, Shahzad M, Ahmed ZM, Riazuddin S, Khan SN, Riazuddin S, Friedman TB. Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Am J Hum Genet. 2010 Mar 12;86(3):378-88. Odeh H, Hunker KL, Belyantseva IA, Azaiez H, Avenarius MR, Zheng L, Peters LM, Gagnon LH, Hagiwara N, Skynner MJ, Brilliant MH, Allen ND, Riazuddin S, Johnson KR, Raphael Y, Najmabadi H, Friedman TB, Bartles JR, Smith RJ, Kohrman DC. Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. Am J Hum Genet. 2010 Feb 12;86(2):148-60. Waryah AM, Rehman A, Ahmed ZM, Bashir ZH, Khan SY, Zafar AU, Riazuddin S, Friedman TB, Riazuddin S. DFNB74, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 12q14.2-q15. Clin Genet. 2009 Sep;76(3):270-5. Riazuddin S, Anwar S, Fischer M, Ahmed ZM, Khan SY, Janssen AG, Zafar AU, Scholl U, Husnain T, Belyantseva IA, Friedman PL, Riazuddin S, Friedman TB, Fahlke C. Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome. Am J Hum Genet. 2009 Aug;85(2):273-80. Khan SY, Riazuddin S, Shahzad M, Ahmed N, Zafar AU, Rehman AU, Morell RJ, Griffith AJ, Ahmed ZM, Riazuddin S, Friedman TB. DFNB79: reincarnation of a nonsyndromic deafness locus on chromosome 9q34.3. Eur J Hum Genet. 2010 Jan;18(1):125-9.
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Michael J. Rutter, MD
Pediatric Otolaryngologist and Director of Clinical Research
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Tracheal reconstruction and complex airway surgery
Education and Training
Fellowship: Cincinnati Children's Hospital Medical Center, 1997 to 2000; Health Research Council of New Zealand Training, 1995 to 1996; Fellowship in Clinical Research, New Zealand, 1996. FRACS: Part II, Sydney, 1996. Primary FRCS: Glasgow, 1989. BHB: Auckland School of Medicine, 1983. MBChB: Auckland School of Medicine, 1986. Residency: Various RMO posts, New Zealand Otolaryngology Training Scheme; Health Research Council of New Zealand Training Fellowship in Clinical Research. Certification: USMLE II, Sydney, June 1995; USMLE I, Sydney, June 1996; USMLE III, Cincinnati, July 2000; Board Certification, American Board of Otolaryngology, 1999; Ohio State Medical Board, 2001.
Publications
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Manning PB, Rutter MJ, Lisec A, Gupta R, Marino BS. One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children. J Thorac Cardiovasc Surg. 2011 Jan;141(1):155-61. Burkart CM, Richter GT, Rutter MJ, Myer CM 3rd. Update on endoscopic management of lingual thyroglossal duct cysts. Laryngoscope. 2009 Oct;119(10):2055-60. Richter GT, Wootten CT, Rutter MJ, Thompson DM. Impact of supraglottoplasty on aspiration in severe laryngomalacia. Ann Otol Rhinol Laryngol. 2009 Apr;118(4):259-66. Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7. Hart CK, Richter GT, Cotton RT, Rutter MJ. Arytenoid prolapse: a source of obstruction following laryngotracheoplasty. Otolaryngol Head Neck Surg. 2009 May;140(5):752-6. Wootten CT, Goudy SL, Rutter MJ, Willging JP, Cotton RT. Airway injury complicating excision of thyroglossal duct cysts. Int J Pediatr Otorhinolaryngol. 2009 Jun;73(6):797-801. Wootten CT, Rutter MJ, Dickson JM, Samuels PJ. Anesthetic management of patients with tracheal T-tubes. Paediatr Anaesth. 2009 Apr;19(4):349-57. Review. Dickson JM, Richter GT, Meinzen-Derr J, Rutter MJ, Thompson DM. Secondary airway lesions in infants with laryngomalacia. Ann Otol Rhinol Laryngol. 2009 Jan;118(1):37-43. Statham MM, Vohra A, Mehta DK, Baker T, Sarlay R, Rutter MJ. Serratia marcescens causing cervical necrotizing oropharyngitis. Int J Pediatr Otorhinolaryngol. 2009 Mar;73(3):467-73. Rutter MJ, Cohen AP, de Alarcon A. Endoscopic airway management in children. Curr Opin Otolaryngol Head Neck Surg. 2008 Dec;16(6):525-9.
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Sally R. Shott, MD
Pediatric Otolaryngologist
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Specific ear, nose and throat (ENT) problems relating to down syndrome patients
Biography
Sally R. Shott, MD, is a member of the American Board of Otolaryngology and specializes in treating children. Dr. Shott is affiliated with a private practice, in addition to her duties as an associate professor at Cincinnati Children's Hospital Medical Center and the University of Cincinnati Medical Center. Dr. Shott treats children with otologic disease, sinus disease and provides airway management. She has a special interest in children with Down syndrome and the specific medical issues they face. In addition to ongoing research, Dr. Shott performs surgery and sees patients at numerous locations, making patient care more convenient for families. In 2006 Shott was elected the President of the Society of Ear, Nose, and Throat Advances in Children - also known as SENTAC.
Education and Training
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1982.
Residency: University of Cincinnati Medical Center, Cincinnati, OH, General Surgery, 1982 to 1983; University of Cincinnati Medical Center, Cincinnati, OH, Otolaryngology, 1983 to 1987.
Fellowship: Children's Hospital Medical Center, Cincinnati, OH, Pediatric Otolaryngology, 1987.
Certification: American Board of Otolaryngology, 1988.
Publications
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Prager JD, Hopkins BS, Propst EJ, Shott SR, Cotton RT. Oropharyngeal stenosis: a complication of multilevel, single-stage upper airway surgery in children. Arch Otolaryngol Head Neck Surg. 2010 Nov;136(11):1111-5.
Wootten CT, Shott SR. Evolving therapies to treat retroglossal and base-of-tongue obstruction in pediatric obstructive sleep apnea. Arch Otolaryngol Head Neck Surg. 2010 Oct;136(10):983-7. Rubin LG, Papsin B; Committee on Infectious Diseases and Section on Otolaryngology-Head and Neck Surgery. Cochlear implants in children: surgical site infections and prevention and treatment of acute otitis media and meningitis. Pediatrics. 2010 Aug;126(2):381-91. Schaaf WE Jr, Wootten CT, Donnelly LF, Ying J, Shott SR. Findings on MR sleep studies as biomarkers to predict outcome of genioglossus advancement in the treatment of obstructive sleep apnea in children and young adults. AJR Am J Roentgenol. 2010 May;194(5):1204-9.
Skotko BG, Kishnani PS, Capone GT; Down Syndrome Diagnosis Study Group. Prenatal diagnosis of Down syndrome: how best to deliver the news. Am J Med Genet A. 2009 Nov;149A(11):2361-7.
Skotko BG, Capone GT, Kishnani PS; Down Syndrome Diagnosis Study Group. Postnatal diagnosis of Down syndrome: synthesis of the evidence on how best to deliver the news. Pediatrics. 2009 Oct;124(4):e751-8. Guimaraes CV, Donnelly LF, Shott SR, Amin RS, Kalra M. Relative rather than absolute macroglossia in patients with Down syndrome: implications for treatment of obstructive sleep apnea. Pediatr Radiol. 2008 Oct;38(10):1062-7.
Guimaraes CV, Kalra M, Donnelly LF, Shott SR, Fitz K, Singla S, Amin RS. The frequency of lingual tonsil enlargement in obese children. AJR Am J Roentgenol. 2008 Apr;190(4):973-5.
Merrell JA, Shott SR. OSAS in Down syndrome: T&A versus T&A plus lateral pharyngoplasty. Int J Pediatr Otorhinolaryngol. 2007 Aug;71(8):1197-203.
Shott SR. Down syndrome: common otolaryngologic manifestations. Am J Med Genet C Semin Med Genet. 2006 Aug 15;142C(3):131-40.
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J. Paul Willging, MD
Director, Interdisciplinary Feeding Team, FEES Clinic and the Velopharyngeal Insufficiency Clinic
Academic Information
Professor, UC Department of Pediatrics
Professor, Otolaryngology – Head and Neck Surgery
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Specialties
Clinical InterestsCongenital atresia of the ear; pediatric trauma Research InterestsHearing loss issues; cleft lip and palate patients, ear, nose and throat; ENT anomalies
Biography
Jay P. Willging, MD, is certified to practice in Ohio and Kentucky. He is a member of the American Board of Otolaryngology. Dr. Willging enjoys all areas of Otolaryngology and has a special interest in congenital atresia of the ear and pediatric trauma. A member of several multi-disciplinary teams, the Cincinnati Children's Hospital Medical Center Craniofacial Team, the Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic and the Functional Endoscopic Evaluation of Swallow Clinic, he is highly respected for his expertise. The Craniofacial Team brings together Pediatric Otolaryngology -- Head and Neck Surgery, Plastic Surgery, Oral Surgery, Pediatric Dentistry and Orthodontics, Child Psychology, Human Genetics, Speech Pathology and Nutrition to extensively evaluate and manage children with cleft lip and cleft palate issues, as well as other children with craniofacial anomalies. The Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic brings together Otolaryngology, Speech Pathology and Human Genetics to evaluate children with complex speech difficulties. The Fiberoptic Endoscopic Evaluation of Swallow Clinic (FEES) brings together Otolaryngology and Speech Pathology to evaluate children with swallowing disorders. In addition to ongoing research, Dr. Willging performs surgery and sees children at numerous locations, making treatment more convenient and accessible for his patients.
Education and Training
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1985.
Residency: Department of General Surgery, University of Cincinnati Medical Center, Cincinnati, OH, 1985 to 1987; Otolaryngology Residency, Department of Otolaryngology and Maxillofacial Surgery, University of Cincinnati Medical Center, Cincinnati, OH, 1987 to 1991.
Fellowship: Department of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1991 to 1992.
Certification: American Board of Otolaryngology, 1992.
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