Molecular pathology; pediatric renal pathology

Molecular/Developmental Biology

MD: University of Cincinnati, Cincinnati, Ohio, 1979.

Residency: Pediatrics, Washington University, St. Louis, Mo., 1979-1980; Pathology, Washington University, St. Louis, Mo., 1980-1984.

Fellowship: Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1984-1986; Research Scholar, Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989.

Certification: Anatomic Pathology, American Board of Pathology, 1985; Pediatric Pathology, American Board of Pathology, 1991.

Research Interests

Dr. Bove's current research focus is on pathogenesis of biliary atresia and other cholestatic disorders of infancy. He has long term research interests in the early stages of childhood neoplasia and childhood diseases of skeletal muscle and heart.

Clinical Interests

Dr. Bove has been a career academic pediatric pathologist at Cincinnati Children's since 1968. He functions as a surgical pathologist, autopsy consultant and electron microscopist with diverse clinical interests. His collaborations with faculty and fellows in many divisions have resulted in more than 180 peer-reviewed and more than 120 publications.

MD: State University of New York, Buffalo, NY.

Residency: Rotating Intern, Cincinnati General Hospital, 1961-1962; Pathology, Cincinnati General Hospital, 1962-1966.

Certification: American Board of Pathology in Anatomic and Clinical Pathology, 1967 and 1968; Pediatric Pathology, 1990.

Research Interests

Dr. Boyd's current research interest is the pathogenesis of interstitial lung disease and developmental lung disorders of infancy. He also has an interest in graduate medical education.

Clinical Interests

Dr. Boyd has worked as an academic pediatric pathologist at Cincinnati Children's since 2008. He functions as a surgical and autopsy pathologist.

Clinical Interests

Dr. Collins is a pediatric pathologist specializing in pediatric gastrointestinal pathology, especially eosinophilic gastrointestinal diseases. She has provided biopsy analyses, including primary study endpoints, for several clinical trials testing novel therapies to treat eosinophilic esophagitis in children. She also performs clinical research in other disorders of bowel immunity, and bowel motility disorders.

BS: Fordham University, N.Y., 1972.

MD: Georgetown University, Washington, D.C., 1977.

Residency: Pathology, New York Hospital, N.Y., 1977-80; Pathology, Columbia-Presbyterian Medical Center, N.Y., 1980-83.

Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1985-87.

Certification: Pathology, 1981; Pediatric Pathology, 1991.

Nikolaidis NM, Kulkarni RM, Gray JK, Collins MH, Waltz SE. Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung. Innate Immun. 2010 Nov 18.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME.  Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP.Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME.Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME.Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.

Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010 Jan 21;29(3):368-79.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.

Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH. The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J Cell Physiol. 2009 Aug;220(2):319-31.

Research Interests

Dr. Gupta's current research focus is in liver tumors, cardiac transplants, vascular anomalies, and cilia abnormalities.

Clinical Interests

Dr. Gupta is a career academic pediatric pathologist at Cincinnati Children's since 2007 who functions as a surgical pathologist and electron microscopist.

Hammill AM, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan RG, Adams DM. Sirolimus for the treatment of complicated vascular anomalies in children.Pediatr Blood Cancer. 2011 Dec 1;57 (6):1018-24

Maugans T, Sheridan RM, Adams D, Gupta A. Cutaneous vascular anomalies associated with neural tube defects: nomenclature and pathology revisited. Neurosurgery. 2011 Jul;69(1):112-8

Gupta A, Kozakewich H. Histopathology of vascular anomalies. Clin Plast Surg. 2011 Jan;38(1):31-44.

Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.

Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.

DL Zynger, A. Gupta, C Luan , PM Chou, GY Yang, XJ Yang. Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases.Hum Pathol. 2008; 39 (2):224-30.

B. P. Adley, A. Gupta, F. Lin, C. Luan, B. T. Teh, X.J.Yang. Expression of Kidney- Specific Cadherin in Chromophobe Renal Cell Carcinoma.Am J Clin Pathol. 2006 Jul; 126(1): 79-85.

MJ Blecha, A.Gupta, JD Hoover, MB Madonna. Chronic abdominal pain secondary to a mucous cystadenoma of the appendix in a 10-year-old boy.J Pediatr Surg. 2005 Nov; 40(11): 1792-4.

G. Salanitri, E. Huo, F. Miller, A. Gupta, S. Pereles. MRI of Mycotic Sinus of Valsalva Pseudoaneurysm Secondary to Aspergillus Pericarditis.Amer J Roentgenology. 2005; 184: S25-S27

A.Gupta, J. Madallozo, T.Win Htin, A. Shah, P.M. Chou. Spindle cell rhabdomyosarcoma of the tongue in an infant.Pathol Research and Practice. 2004; 200: 537-543

Research Interests

Dr. McMasters has a research interest in childhood leukemia, lymphoma and bone marrow failure syndromes. His current focus is on applications of flow cytometry in the diagnosis and management of these disorders.

Clinical Interests

Dr. McMasters joined Cincinnati Children's in 2008. His main clinical interests are hematopathology and general surgical pathology. He is the laboratory director at Cincinnati Children's Liberty Campus.

Clinical Interests

Pediatric pathology; pediatric neuropathology; pediatric neuromuscular disease

Research Interests

Mitochondrial diseases; coenzyme Q10; pediatric brain tumors; classification and grading of cortical dysplasia; hepatic pathology in pediatric NASH patients and animal models

Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.

Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature.J Neurooncol. 2010 Oct 16.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.Hepatology. 2010 Sep;52(3):934-44.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm.Anesthesiology. 2009 Sep;111(3):533-46.

Kurth CD, McCann JC, Wu J, Miles L, Loepke AW. Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg. 2009 Apr;108(4):1268-77.

Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory.Anesth Analg. 2009 Jan;108(1):90-104.

Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review.Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets.Biomed Chromatogr. 2008 Dec;22(12):1403-8.

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.

Pediatric pharmacology; laboratory tests and biomarkers for monitoring mitochondrial function and oxidative stress; mitochondrial abnormalities associated with aging, obesity, sleep apnea, epilepsy and nutritional deficiencies; safety and efficacy of treatment with antioxidants, such as coenzyme Q and vitamin E.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.Hepatology. 2010 Sep;52(3):934-44.

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets.Biomed Chromatogr. 2008 Dec;22(12):1403-8.

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.

Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.Pediatr Neurol. 2007 Dec;37(6):398-403.

Miles MV. The uptake and distribution of coenzyme Q10. Mitochondrion. 2007 Jun;7 Suppl:S72-7.

Tang PH, Miles MV, Steele P, Davidson BS, Geraghty SR, Morrow AL. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography.Biomed Chromatogr. 2006 Dec;20(12):1336-43.

Miles MV, Patterson BJ, Schapiro MB, Hickey FJ, Chalfonte-Evans M, Horn PS, Hotze SL. Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial.Pediatr Neurol. 2006 Jul;35(1):30-7.

Miles L, Miles MV, Tang PH, Horn PS, Quinlan JG, Wong B, Wenisch A, Bove KE. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.Clin Chim Acta. 2005 Oct;360(1-2):87-96.

Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ, Bove KE. Muscle coenzyme Q: a potential test for mitochondrial activity and redox status.Pediatr Neurol. 2005 May;32(5):318-24.

Research Interests

Dr. Mo's research interests are childhood leukemia/lymphoma, hemophagocytic lymphohistiocytosis/macrophage activation syndrome, posttransplantation lymphoproliferative disorders and pediatric vascular lesions/tumors. 
 

Clinical Interests

Dr. Mo is a pediatric pathologist with a subspecialty in hematopathology at Cincinnati Children's. She has been actively involved in following clinical services: surgical pathology, gastrointestinal pathology and hematopathology including flow cytometric study/interpretation since 2004. Her collaborations with clinicians and researchers in many other divisions have resulted in more than 33 peer-reviewed publications. 
 

Hummel T, Anyane-Yeboa A, Mo J, Towbin A, Weiss B. Response of NF1-related plexiform neurofibroma to high-dose carboplatin.Pediatr Blood Cancer. 2011 Mar;56(3):488-90. doi: 10.1002/pbc.22827.

Mehta PA, Harris RE, Davies SM, Kim MO, Mueller R, Lampkin B, Mo J, Myers K, Smolarek TA. Numerical chromosomal changes and risk of development of myelodysplastic syndrome--acute myeloid leukemia in patients with Fanconi anemia. Cancer Genet Cytogenet. 2010 Dec;203(2):180-6.

Towbin AJ, Luo GG, Yin H, Mo JQ. Focal nodular hyperplasia in children, adolescents, and young adults. Pediatr Radiol. 2011 Mar;41(3):341-9.

Hinze CH, Fall N, Thornton S, Mo JQ, Aronow BJ, Layh-Schmitt G, Griffin TA, Thompson SD, Colbert RA, Glass DN, Barnes MG, Grom AA. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis.Arthritis Res Ther. 2010;12(3):R123.

Lo MM, Mo JQ, Dixon BP, Czech KA. Disseminated histoplasmosis associated with hemophagocytic lymphohistiocytosis in kidney transplant recipients.Am J Transplant. 2010 Mar;10(3):687-91.

Liu Y, Mo JQ, Hu Q, Boivin G, Levin L, Lu S, Yang D, Dong Z, Lu S. Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer.Cancer Res. 2008 Aug 1;68(15):6396-406.

Lee K, Liu Y, Mo JQ, Zhang J, Dong Z, Lu S. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.BMC Cancer. 2008 Jun 2;8:158.

Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood. 2007 Dec 1;110(12):3853-61.

Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5091-6.

Stapp J, Wilkerson S, Stewart D, Coventry S, Mo JQ, Bove KE. Fulminant neonatal liver failure in siblings: probable congenital hemophagocytic lymphohistiocytosis. Pediatr Dev Pathol. 2006 May-Jun;9(3):239-44.

Research Interests

Dr. Mortensen's current research focus is antimicrobial susceptibility testing of fastidious pediatric pathogens.

Clinical Interests

Dr. Mortensen is a career academic clinical microbiologist in the Department of Pathology and Laboratory Medicine at Cincinnati Children's since 1991. Beyond providing consultation to the medical staff in Clinical Microbiology, his clinical interests include the application of rapid testing methods into the clinical microbiology laboratory and outpatient settings and LEAN manufacturing processes applied to Clinical Microbiology. His collaborations with faculty and fellows have resulted in more than 100 peer-reviewed publications, case studies and text chapters.

Motley WW, Melson AT, Mortensen JE. Pediatric Metarrhizium anisopliae keratitis. J AAPOS. 2011 Feb 10.

Major TA, Panmanee W, Mortensen JE, Gray LD, Hoglen N, Hassett DJ. Sodium nitrite-mediated killing of the major cystic fibrosis pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under anaerobic planktonic and biofilm conditions. Antimicrob Agents Chemother. 2010 Nov;54(11):4671-7.

Chhabra MS, Motley WW 3rd, Mortensen JE. Eikenella corrodens as a causative agent for neonatal conjunctivitis. J AAPOS. 2008 Oct;12(5):524-5.

Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Hobbs MM. Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women.Sex Transm Dis. 2008 Mar;35(3):250-4.

Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Miller WC, Hobbs MM. Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women.Clin Infect Dis. 2007 Jul 15;45(2):194-8.

Huppert JS, Biro F, Lan D, Mortensen JE, Reed J, Slap GB. Urinary symptoms in adolescent females: STI or UTI?J Adolesc Health. 2007 May;40(5):418-24.

Iyer SB, Gerber MA, Pomerantz WJ, Mortensen JE, Ruddy RM. Effect of point-of-care influenza testing on management of febrile children.Acad Emerg Med. 2006 Dec;13(12):1259-68.

Huppert JS, Gerber MA, Deitch HR, Mortensen JE, Staat MA, Adams Hillard PJ. Vulvar ulcers in young females: a manifestation of aphthosis.J Pediatr Adolesc Gynecol. 2006 Jun;19(3):195-204.

Mortensen JE, Gerrety MJ, Gray LD. Surveillance of antimicrobial resistance in Neisseria meningitidis from patients in the Cincinnati tristate region (Ohio, Kentucky, and Indiana). J Clin Microbiol. 2006 Apr;44(4):1592-3.

Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. J Clin Invest. 2006 Feb;116(2):436-46.

MD: College of Medicine, Jagiellonian University, Kraków, Poland, 1968.

PhD: College of Medicine, Jagiellonian University, Kraków, Poland, 1974
Residencies:  University Hospital of Obstetrics and Gynecology, Jagiellonian University, Kraków, Poland, 1970-1976; Georgetown University Medical Center, Washington, DC, and Rush Presbyterian-St.Luke's Medical Center, Chicago, IL, 1990-1994.

Fellowship: Reproductive Endocrinology, University Hospital of Obstetrics and Gynecology, Kraków, Poland; 1976-1977.

Certifications: Obstetrics and Gynecology, Polish Board of Obstetrics and Gynecology, 1976; Endocrinology, Postgraduate Medical Center, Poland, 1977; Anatomic and Clinical Pathology, American Board of Pathology, 1994; Pediatric Pathology, American Board of Pathology, 1999.

Garrett KM, Kim HK, Stanek J, Emery KH. MR findings of primary bone lymphoma in a 15-year-old girl: emphasis on diffusion-weighted imaging. Pediatr Radiol. 2011 May;41(5):658-62.

Stanek J, Sheridan RM, Le LD, Crombleholme TM. Placental fetal thrombotic vasculopathy in severe congenital anomalies prompting EXIT procedure. Placenta. 2011 Mar 22.

Stanek J. Placental membrane and placental disc microscopic chorionic cysts share similar clinicopathologic associations. Pediatr Dev Pathol. 2011 Jan-Feb;14(1):1-9.

Oestreich AE, Stanek JW. Preautopsy imaging in cerebro-costo-mandibular syndrome. Pediatr Radiol. 2010 Dec;40 Suppl 1:S50.

Copeland JW, Stanek J. Dizygotic twin pregnancy with a normal fetus and a nodular embryo associated with a partial hydatidiform mole. Pediatr Dev Pathol. 2010 Nov-Dec;13(6):476-80.

Stanek J. Diagnosing Placental Membrane Hypoxic Lesions Increases the Sensitivity of Placental Examination. Arch Pathol Lab Med. 2010 Jul;134: 989-995.

Stanek J. Membrane microscopic chorionic pseudocysts are associated with increased amount of placental extravillous trophoblasts. Pathology. 2010 Feb;42(2):125-130.

Stanek J. Placental haemosiderosis. Pathology.2010;42(5):499-501. 

Stanek J. Acute and chronic placental membrane hypoxic lesions. Virchows Arch. 2009 Oct;455(4):315-322.

Kessler CA, Bachurski CJ, Schroeder J, Stanek J, Handwerger S. TEAD1 Inhibits Prolactin Gene Expression in Cultured Human Uterine Decidual Cells. Mol Cell Endocrinol. 2008 Nov;295(1-2):32-38.

BSc: University of British Columbia, Vancouver, British Columbia, Canada.

MSc: University of Toronto, Toronto, Ontario, Canada.

MD: University of Calgary, Calgary, Alberta, Canada, 1995.

DABP: Anatomic and Pediatric Pathology.

 Xu YH, Jia L, Quinn B, Zamzow M, Stringer K, Aronow B, Sun Y, Zhang W, Setchell KD, Grabowski GA. Global gene expression profile progression in Gaucher disease mouse models. BMC Genomics. 2011 Jan 11;12:20.

Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6.

Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer. 2010 Nov 15;127(10):2334-50.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.

Qi X, Chu Z, Mahller YY, Stringer KF, Witte DP, Cripe TP. Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein. Clin Cancer Res. 2009 Sep 15;15(18):5840-51.

Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008 Nov 15;181(10):7390-9.

Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008 Jul;1(4):289-96.

Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9.

Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.

Clinical Interests

In vitro diagnositcs; disease monitoring procedures

Research Interests

Mitochondrial dysfunction; metabolic disorders; neurodegenerative diseases; hemoglobin disorders; neurogenesis; and therapeutic drug monitoring

PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.

MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.

BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.

Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats. Int J Dev Neurosci. 2011 Feb;29(1):45-55.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44. 

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8. 

 Tang PH. Drug monitoring and toxicology: a simple procedure for the monitoring of felbamate by HPLC-UV detection. J Anal Toxicol. 2008 Jun;32(5):373-8. 

Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 2008 May 30;9:49. 

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80. 

Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol. 2007 Dec;37(6):398-403. 

Tang PH, Miles MV, Steele P, Davidson BS, Geraghty SR, Morrow AL. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography. Biomed Chromatogr. 2006 Dec;20(12):1336-43.

Tang PH. Determination of coenzyme Q10 in over-the-counter dietary supplements by high-performance liquid chromatography with coulometric detection. J AOAC Int. 2006 Jan-Feb;89(1):35-9. 

Pulmonary pathology; pediatric and adult lung diseases

BS: Mathematics/Natural Science, Secondary Education Minor, University of Mary, Bismarck, ND, 1988.

PhD: Developmental Biology, Developmental Biology and Medical Science Scholars Programs, University of Cincinnati, Cincinnati, OH, 1994.

MD: Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1996.

Residency: Anatomic Pathology, Department of Pathology and Immunology, Washington University-Barnes/Jewish Hospital, St. Louis, MO, 1996-2002.

Clinical Training/Postdoctoral Research: Department of Pathology and Immunology, Washington University, St. Louis, MO, 1999-2002.

Licensure: State of Ohio, 2003.

Certification: Anatomic Pathology, The American Board of Pathology, 1999.

Fuller KK, Richie DL, Feng X, Krishnan K, Stephens TJ, Wikenheiser-Brokamp KA, Askew DS, Rhodes JC. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus. Mol Microbiol. 2010 Dec 17.

Hagaman JT, Panos RJ, McCormack FX, Thakar CV, Wikenheiser-Brokamp KA, Shipley RT, Kinder BW. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. Chest. 2010 Aug 5.

Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res. 2009 Nov 15;69(22):8733-41.

Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33.

Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. Cancer Res. 2009 Mar 1;69(5):1792-9.

Hoskins EE, Morris TA, Higginbotham JM, Spardy N, Cha E, Kelly P, Williams DA, Wikenheiser-Brokamp KA, Duensing S, Wells SI. Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene. 2009 Feb 5;28(5):674-85. 

 Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI. DEK proto-oncogene expression interferes with the normal epithelial differentiation program. Am J Pathol. 2009 Jan;174(1):71-81.

Mason-Richie NA, Mistry MJ, Gettler CA, Elayyadi A, Wikenheiser-Brokamp KA. Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res. 2008 Jun 1;68(11):4068-76.

Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, Srinivasan SV, Liu X, Wikenheiser-Brokamp K, Boivin GP, Lee JS, Aronow BJ, Thorgeirsson SS, Knudsen ES. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology. 2007 Sep;133(3):976-84.

Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, Koenig RJ, Nikiforov YE. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.Endocr Relat Cancer. 2007 Jun;14(2):445-52.

Research Interests

Dr. Yin's current research focus is pathogenesis of Proliferative renal diseases, polycystic kidney disease, tuberous sclerosis complex, Von Hippel-Lindau diseasel, Birt-Hogg-Dube syndrome, renal tumors, solid organ and bone tumors.

Clinical Interests

Dr. Yin is a career academic pediatric pathologist at Cincinnati Children's who functions as a surgical pathologist and renal pathologist.