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Neutrophils and mechanisms of preterm laborThis study will define the role of neutrophils that infiltrate in the chorio-decidua during chorioamnionitis in initiating preterm labor. This grant will use intraamniotic injection of LPS to induce chorioamnionitis in non-human primates, in collaboration with Dr. Lisa Miller at the California National Primate Center, UC Davis.
Host-microbe cross-talk and pregnancy outcomesThis grant will study mechanisms and maternal/fetal immunology in the causation or initiation of preterm labor in a rhesus macaque model of chorioamnionitis induced by intraamniotic injection of live Ureaplasma Parvum. The project is in collaboration with Dr. Lisa Miller PhD at the California National Primate Center, U.C. Davis CA.
Initiation and Progression of Preterm Lung Injury with VentilationThis new grant will explore how the elements of mechanical ventilation (tidal volume, recruitment strategies, pressure) injure the fetal sheep lung. Ventilation induced injury will be characterized by the acute injury responses followed by their progression and resolution – with a focus on airway injury.
Patterned Experience for Preterm InfantsThe primary aim of this study is to test the effect of a PFE on neurobehavioral organization at three time points: the transition to oral feedings, NICU discharge, and 2 months corrected age (48 weeks PMA) in a randomized trial. The secondary aims are to the test the effect of a PFE on cognitive function at 6 months corrected age, neurobehavioral development; and clinical outcomes.
Mechanisms of fetal systemic inflammatory response syndrome induced by chorioamnionitisThis project will study the pathogenesis of fetal systemic inflammatory response syndrome (FIRS) in preterm fetuses exposed to endotoxin induced chorioamnionitis in sheep. The grant will also evaluate the fetal innate immune responses to chorioamnionitis and how endotoxin tolerance modulates FIRS.
Late Preterm Birth, Ureaplasma Species and Childhood Lung DiseaseThis project will study the pulmonary outcomes and immune modulation after exposure to Ureaplasma chorioamnionitis. The human component will evaluate late-preterm infants born between 32-37 week gestation and evaluate lung outcomes at 9 months and 2 years. The animal component will utilize a preterm sheep model and evaluate lung outcomes at 2 months.
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