Perinatal Biology

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    Section Chief

    A photo of Jeffrey Whitsett.

    Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute

    investigates the hierarchy of transcriptional controls and signaling cascades which determine commitment of progenitor cells that produce the differentiated epithelial cells lining the primordial and mature respiratory tract. The goal of his research is to provide insight into the pathogenesis of acute and chronic lung disorders. The role of surfactant in innate host defense and lung function is also an ongoing interest.
    Visit the Whitsett Lab.

    513-803-2790
    jeffrey.whitsett@cchmc.org

    Jeffrey A. Whitsett, MD

    Co-Director, Perinatal Institute

    Chief, Section of Neonatology, Perinatal and Pulmonary Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-803-2790

    Fax: 513-636-7868

    Email: jeffrey.whitsett@cchmc.org

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    Specialties

    Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy 

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    Biography

    Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.

    Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.

    Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.

    Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.

    Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.

    Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.

    Education and Training

    MD: Columbia University, New York, NY, 1973.

    Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

    Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

    Publications

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    Faculty

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    Hitesh Deshmukhj, MD, PhD

    and his laboratory focuses on the role of intestinal commensal bacteria in development of appropriate innate immune responses to pathogens in neonates. The ultimate goal of this research is to develop novel therapeutic approaches to decrease mortality in premature babies, one of the most vulnerable groups.

    513-803-7448
    hitesh.deshmukh@cchmc.org

    Hitesh Deshmukhj, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-7448

    Email: hitesh.deshmukh@cchmc.org

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    Education and Training

    MB; BS: University of Mumbai, Mumbai, India, 2001.

    PhD: University of Cincinnati, Cincinnati, OH, 2006.

    Residency: Pediatrics, State University of New York at Buffalo, Buffalo, NY, 2011.

    Fellowship: Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 2014.  

    Certification: American Board of Pediatrics, 2012.

    Publications

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    Grants

    Developmental Regulation of Host Resistance and Innate Immune Response by Intestinal MicrobesPrincipal Investigator. Children’s Hospital Research Foundation. July 2012 – June 2015.
    A photo of Alan Jobe.

    Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology

    has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.

    513-636-8563
    alan.jobe@cchmc.org

    Alan H. Jobe, MD, PhD

    Director, Division of Perinatal Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8563

    Fax: 513-636-8691

    Email: alan.jobe@cchmc.org

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    Specialties

    Clinical Interests

    Clinical trials in neonatology; bronchopulmonary dysplasia

    Research Interests

    Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

    Education and Training

    MD: University of California, San Diego, 1973. 

    PhD: University of California, San Diego, CA, 1973. 

    Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

    Fellowship: University of California, San Diego, CA, 1975 to 1977.

    Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

    Publications

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    A photo of Suhas G. Kallapur.

    Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education

    is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Dr. Kallapur’s research focus is to understand the pathogenesis of lung injury and systemic inflammatory responses in fetuses and newborns. His lab uses a sheep model and has begun some work in humans.
    Visit the Kallapur Lab.

    513-636-3879
    suhas.kallapur@cchmc.org

    Suhas G. Kallapur, MD

    Director, Neonatology Continuing Medical Education

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-3879

    Fax: 513-636-7868

    Email: suhas.kallapur@cchmc.org

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    Specialties

    Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity

    Education and Training

    MBBS: University of Bombay, India, 1984. 

    DCH: College of Physicians and Surgeons, Bombay, 1986.

    MD, Pediatrics: University of Bombay, India, 1986.

    Residency: University of Bombay, India, 1984-87.

    Residency: Children's Hospital of Michigan, Detroit, Michigan, 1988-90. 

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1990-1993.

    Publications

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    Grants

    Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Principal Investigator. National Institute of Child Health and Human Development. Feb 2009-Jan 2014. #R01 HD57869.