Noah H. Hillman, MD
is a neonatologist who conducts translational research on lung injury during the initiation of ventilation at birth. Along with Dr. Alan Jobe and colleagues at the University of Western Australia, he has used a fetal sheep model of neonatal resuscitation to evaluate the effects of various maneuvers (tidal volume, PEEP) performed in the delivery room. His lab focuses on molecular pathways activated by mechanical ventilation.
513-803-0966
noah.hillman@cchmc.org
Noah H. Hillman, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
The effects of initiating ventilation in the preterm lamb; airway and parenchymal lung injury from ventilation; methods/interventions for decreasing injury
Biography
After completing a Procter Scholar Award, Dr. Hillman received a K08 from NHLBI (2009 -2014) to study the study the effects of initiating ventilation in the preterm lamb and means of modulating the inflammatory cascade. He has recently focused his research on both the injury and repair processes. Working with their colleagues in Western Australia, his lab has recently demonstrated benefits of PEEP in the delivery room and the progression of inflammation after injury. He continues to work with Dr. Alan Jobe (R01 NICHD- PI Jobe) on lung recruitment maneuvers and their effects on molecular markers on injury. He is a board-certified Neonatologist and a member of Society for Pediatric Research.
Education and Training
MD: University of Missouri, Columbia, MO, 2001.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001-2004.
Fellowship: University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2004-2007.
Ceritifications: Pediatrics, 2004; Neonatology, 2008.
Publications
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Hillman NH, Nitsos I, Berry C, Pillow JJ, Kallapur SG, Jobe AH. Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L712-20. Hillman NH, Polglase GR, Pilliow JJ, Saito M, Kallapur SG, Jobe AH. Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L232-41. Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151. Polglase GR, Hillman NH, Pillow JJ, Newham JP, Know CL, Kallapur SG, Jobe AH. Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs. Pediatr Res. 2010 Jun;67(6):630-5. Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SK, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124. Hillman NH, Kallapur SG, Pillow JJ, Moss TJM, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5. Polglase GR, Hillman NH, Pillow JJ, Cheah F, Kallapur SG, Ikegami M, Kramer BW, Moss TMJ, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008 Jun 25. Hillman NH, Moss TMJ, Nitsos I, Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptor and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008 Apr;63(4):388-93. Hillman NH, Moss TMJ, Kallapur SG, Bachurski C, Pillow JJ, Polglase GR, Nitsos I, Kramer BW, Jobe AH. Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep. Am J Res Crit Care Med. 2007 Sep 15;176(6):575-81. Pillow JJ, Hillman N, Moss TJ, Polglase G, Bold G, Beaumont C, Ikegami M, Jobe AH. Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs. Am J Respir Crit Care Med. 2007 Sep 15;176(6):575-81.
Grants
Lung Injury with Resuscitation of the Preterm. Principal Investigator. NIH-NHLBI. Aug 2009 - Jul 2014. K08-HL097085. Initiation and progression of Preterm Lung injury with Ventilation (PI-Jobe). Co-investigator. NIH-NICHD. Jul 2012–Jun 2017.
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Alan H. Jobe, MD, PhD
Director, Division of Perinatal Biology
has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.
513-636-8563
alan.jobe@cchmc.org
Alan H. Jobe, MD, PhD
Director, Division of Perinatal Biology
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsClinical trials in neonatology; bronchopulmonary bysplasia Research InterestsLung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm
Biography
Education and Training
MD: University of California, San Diego, 1973.
PhD: University of California, San Diego, CA, 1973.
Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.
Fellowship: University of California, San Diego, CA, 1975 to 1977.
Board Certified: Pediatrics and Neonatal-Perinatal Medicine.
Publications
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Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6. Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71. Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93. Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7. Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7. Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517. Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93. Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86. Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523. Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.
Grants
Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Co-Investigator. National Institute of Child Health and Human Development. Feb 2009 - Feb 2014.
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Suhas G. Kallapur, MD
Director, Neonatology Continuing Medical Education
is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Dr. Kallapur’s research focus is to understand the pathogenesis of lung injury and systemic inflammatory responses in fetuses and newborns. His lab uses a sheep model and has begun some work in humans. Visit the Kallapur Lab.
513-636-3879
suhas.kallapur@cchmc.org
Suhas G. Kallapur, MD
Director, Neonatology Continuing Medical Education
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity Visit the Kallapur Lab.
Biography
Education and Training
MBBS: University of Bombay, India, 1984.
DCH: College of Physicians and Surgeons, Bombay, 1986.
MD, Pediatrics: University of Bombay, India, 1986.
Residency: University of Bombay, India, 1984-87.
Residency: Children's Hospital of Michigan, Detroit, Michigan, 1988-90.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1990-1993.
Publications
View PubMed Publications
Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18. Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51. Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep.Respir Res. 2010 Oct 29;11:151. Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis.Pediatr Res. 2010 Sep;68(3):210-5. Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis.Pediatr Res. 2010 May 28. Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5. Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep.Respir Res. 2009 Dec 15;10:124. Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5. Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep.Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7. Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung.Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.
Grants
Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Principal Investigator. National Institute of Child Health and Human Development. Feb 2009 - Jan 2014. #R01 HD57869.
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