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Samantha A. Brugmann, PhD
is a developmental biologist who aims to understand craniofacial development and elucidate the molecular basis for diseases that affect the craniofacial complex. Furthermore, Dr. Brugmann attempts to understand the forces that help pattern the face during normal and abnormal development she utilizes various model systems with unique facial morphologies.
Visit the Brugmann Lab.
Assistant Professor, UC Department of Surgery
Samantha A. Brugmann, PhD, is an assistant professor of pediatrics in the Divisions of Plastic Surgery and Developmental Biology. She received her BS in cell and molecular biology in 1998 from Tulane University in New Orleans, LA. She then moved to Washington, DC to study cranial sensory placode development in Xenopus laevis at George Washington University. After receiving her PhD in genetics from George Washington University in 2004, she moved to Stanford, CA to do her postdoctoral research in craniofacial development at Stanford University. While at Stanford she received a Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32) in 2006, a Pediatric Research Fund-Child Health Research Program Grant in 2009 and a NIH Pathway to Independence Award (K99/R00) in 2010. She joined Cincinnati Children’s Hospital Medical Center in January 2011 to study craniofacial development and disease.
Chang CF, Schock EN, Attia A, Stottmann RW, Brugmann SA. The ciliary baton: orchestrating neural crest development. Current Topics in Developmental Biology. In press.
Brugmann SA, Wells JM. Building additional complexity to in vitro-derived intestinal tissues. Stem Cell Res Ther. 2013;4 Suppl 1:S1.
Liu H, Lan Y, Xu , Chang CF, Brugmann SA, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18555-60.
Chang CF, Schock EN, O’Hare EA, Dodgson J, Cheng HH, Muir WM, Edelmann RE, Delany ME, Brugmann SA. The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant, talpid2. Development. 2014 Aug;141(15):3003-12.
Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell. 2012 Nov 2;11(5):633-48.
Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT. Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96.
Powder KE, Ku YC, Brugmann SA, Veile RA, Renaud NA, Helms JA, Lovett M. A cross-species analysis of microRNAs in the developing avian face. PLoS One. 2012;7(4):e35111.
Haithem M. Elhadi Babiker, MD, DMD
works in the upper airway center to develop protocols for management of pediatric sleep apnea syndrome. His other interests include reconstruction of critical mandibular defects using stem cells and cadaveric bone.
Pediatric obstructive sleep apnea syndrome; complex upper airway problems
Dr. Elhadi Babiker, MD, DMD, holds a double degree in medicine and dentistry. In addition, he is trained in both plastic surgery and in oral and maxillofacial surgery. He has completed fellowship training in craniofacial surgery. This training places him among an elite group of surgeons in the USA and around the world.
MD: Kasturba Medical College, Manipal, India.
Residency: University of Cincinnati Plastic Surgery, General Surgery and Oral Maxillofacial Surgery, Cincinnati, OH.
Fellowship: Pediatric and Craniofacial Plastic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Pan BS, Elhadi H, Billmire DA. Maxillofacial Trauma. In Wheeler DS, Wong HR, Shanley TP, Editors: Pediatric Critical Medicine. Basic science and clinical evidence. 2nd Edition. Accepted.
Vu A, Elhadi H, Patel P, Schwentker A, Yakuboff K. Pediatric Thoracic Outlet Syndrome: A case series and literature review. J Hand Surg. 2014 Accepted.
Patel P, Elhadi H, Kitzmiller J, Billmire D, Yakuboff K. Complications of Tissue Expanders in the Pediatric Burn Patients: A 10 year follow up review. Ann Plast Surg. 2014. Accepted.
Elhadi H, Reddy LV. Nasal Fractures. In Fonseca, Marciani and Turvey Editors: Oral And Maxillofacial Surgery. Saunders. 2009. 2nd Edition.
Reddy LV, Elhadi H. Maxillary Advancement by Distraction Osteogenesis. Atlas Oral Maxillofac Surg Clin North Am. 2008 Sep;16(2):237-47.
McIntosh JE, Campbell JH, Aguirre A, Reddy LV, Elhadi H. Expansile Mass of the Maxilla. J Oral Maxillofac Surg. 2008 June 6; 66:1253-58.
Elhadi H, Reddy LV. Maxillofacial Trauma. In Wheeler DS, Wong HR, Shanley TP, Editors: Pediatric Critical Care Medicine. Basic science and clinical evidence. Springer-Verlag. 2007. 1st Edition.
Rulang Jiang, PhD
is a developmental biologist directing research programs in craniofacial biology. His lab generates and uses mutant mouse models to investigate the genetic and developmental basis of craniofacial birth defects, including cleft lip, cleft palate, tooth defects, and other craniofacial deformities. His lab also studies development of joints, including long bone joints in the limb and the temporomandibular joint of the jaw.
Visit the Jiang Lab.
Professor, UC Department of Pediatrics
Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr;352(1):83-91.
Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb;350(2):520-531.
Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct;30(20):4797-4807.
Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-1396.
Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009;323(5918):1232-1234.
Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007;45(10):618-624.
Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006;235(5):1152-1166.
Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R. Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development. Dev Biol. 2005;288(2):582-594.
Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004;131(13):3207-3216.
Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in the Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Nat Acad Sci U S A. 2004;101(18):7022-7027.
Donna C. Jones, PhD
investigates questions regarding the determinants of bone development, function and shape. In particular, she focuses on the influences of ontogeny, function and evolution on craniofacial morphology. The goal of her research is to assist clinicians treating children with craniofacial abnormalities, either congenital or acquired, through translational and laboratory-based research endeavors.
Assistant Professor, UC Department of Pediatrics
UC Department of Surgery
Translational: Using shape analysis, we are characterizing quantifiable growth curves of craniofacial shape in children from three dimensional photographs. Results from this project are intended for use by clinicians during repair or reconstruction of facial features in future pediatric patients.
Bench research: Working with in vitro cells and in vivo mouse models, the lab is examining how the interaction of muscle force influences the developing shape of bone, particularly in the mandible. Using a variety of cell markers, tension sensors, and morphological investigations, this research aims to improve our understanding of the cause of developmental abnormalities of the lower jaw, to hopefully reduce the need for surgeries and long hospital stays in children affected with these disorders.
BS: State University of New York, College at Fredonia, Fredonia, NY, 1995.
MS: University of Rochester, Rochester, NY, 1998.
PhD: University of Cincinnati, Cincinnati, OH, 2004.
PostDoc: Johns Hopkins, Baltimore, MD, 2007.
Bastidas N, Runyan CM, Jones DC, Taylor JA. Anatomic study of full facial and scalp allografts without cutaneous facial scars. J Plast Surg Hand Surg. 2013 May 6. Epub ahead of print.
Jones DC, German RZ. Variation in Protein and Calorie Consumption Following Protein Malnutrition in Rattus norvegicus. Animals. 2013; 3(1), 33-44.
Rapp SJ, Jones DC, Billmire D, Taylor JA. Dissection in the subgaleal and subperiosteal plane: Implications on scalp wound healing. J Plast Surg Hand Surg. 2013 Jun;47(3):168-8.
Visscher M, Burkes S, Wickett R, Hammill A, Dasgupta R, Chute C, Elluru R, Patel M, Jones DC, Azizkhan R, Adams D. Use of Multimodal Quantitative Imaging to Determine Stage and Treatment Response of Infantile Hemangiomas. ISSVA Sweden. 2012:235X-F7C6P8G9B4.
Rapp SJ, Jones DC, Gerety P, Taylor JA. Repairing Critical-Sized Rat Calavarial Defects with Progenitor Cell-Seeded Acellular Periosteum: A Novel Biomimetic Scaffold. Surgery. 2012 Oct;152(4):595-604.
Jones DC, German RZ. Catch-up and targeted growth following variable duration protein restriction: effects on bone and body mass. J Morphol. 2011 April; 272(4):485-96.
Runyan CM, Jones DC, Bove K, Simpson D, Maercks RA, Taylor JA. Porcine Allograft Mandible Revitalization Using Autologous Adipose-Derived Stem Cells, Bone Morphogenetic protein-2, and Periosteum. Plast Reconstr Surg. 2010 May;125(5):1372-82.
Jones DC, Zelditch ML, Peake PL, German RZ. The effects of muscular dystrophy on the craniofacial shape of Mus musculus. J Anat. 2007 Jun;210(6):723-30.
Yu Lan, PhD
Associate Professor, UC Department of Surgery
UC Department of Pediatrics
Yu Lan, PhD, is interested in understanding the genetic basis and developmental mechanisms of structural birth defects. Specifically, Dr. Lan investigates the molecular pathways governing normal palate development in laboratory mice. Her ongoing investigations focus on delineating the molecular pathways involving these factors in palate development using a combination of genetic, embryological, and biochemical approaches.
PhD: University of Maine, Orono, ME.
Post-doc training: Wesleyan University, Middletown, CT; The Jackson Laboratory, Bar Harbor, ME.
Lan Y, Jia S, Jiang R. Molecular patterning of the mammalian dentition. Semin Cell Dev Biol. 2014 Jan-Feb;25-26: 61-70.
Liu H, Lan Y, Xu J, Chang CF, Brugmann SA, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18555-60.
Xu J, Liu H, Park JS, Lan Y, Jiang R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52.
Zhou H, Zou S, Lan Y, Fei W, Jiang R, Hu J. Smad7 modulates TGFbeta signaling during cranial suture development to maintain suture patency. J Bone Miner Res. 2014 Mar;29(3):716-24.
Zhou J, Gao Y, Lan Y, Jia S, Jiang R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18.
Lan Y, Liu H, Ovitt CE, Jiang R. Generation of Osr1 conditional mutant mice. Genesis. 2011 May;49(5):419-22.
Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr 1;352(1):83-91.
Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31.
Chen J, Lan Y, Baek JA, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 Oct 1;334(1):174–85.
Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96.
Thomas J. Sitzman, MD
Thomas Sitzman, MD, is a pediatric plastic surgeon with interests in clinical outcomes research and health sciences research. His work includes the development of quality outcomes measures and decision instruments for surgical patients. He works within the Surgery Department and Anderson Center and Cincinnati Children’s Hospital Medical Center.
Pediatric plastic surgery; quality improvement; outcomes research
Thomas Sitzman, MD, graduated summa cum laude from the University of Virginia in 2001. He obtained his medical degree from Duke University, where he conducted research on the genetics of craniofacial anomalies. Dr. Sitzman completed an integrated residency in Plastic and Reconstructive Surgery at the University of Wisconsin. While in residency he received a grant from the Plastic Surgery Education Foundation to support his work in detection of tissue ischemia.
Dr. Sitzman completed a fellowship in pediatric plastic surgery at the prestigious Hospital for Sick Children in Toronto, Ontario. During his fellowship he obtained advanced training in management of cleft lip and palate, facial reanimation, traumatic and congenital deformities of the upper and lower extremity, sarcoma reconstruction, and brachial plexus reconstruction.
Joining Cincinnati Children’s Hospital in 2012, Dr. Sitzman is a key member of the quality improvement efforts within the Department of Surgery. He has an active practice in plastic surgery at Cincinnati Children’s.
MD: Duke University, Durham, NC, 2006.
Residency: Plastic & Reconstructive Surgery, University of Wisconsin Hospital and Clinics, Madison, WI, 2011.
Fellowship: Pediatric Plastic Surgery, The Hospital for Sick Children, Toronto, ON, 2012.
Sitzman TJ, Hanson SE, King TW, Gutowski KA. Detection of Flap Venous and Arterial Occlusion Using Interstitial Glucose Monitoring in a Rodent Model. Plastic and Reconstructive Surgery. 2012;126:71.
Sitzman TJ, Hanson SE, Alsheik NH, Gentry LR, Doyle JF, Gutowski KA. Clinical Criteria for Obtaining Maxillofacial CT in Trauma Patients. Plastic and Reconstructive Surgery. 2011;127:1270.
Sitzman TJ, Girotto J, Marcus JM. Current Surgical Practices in Cleft Care: Unilateral Cleft Lip Repair. Plastic and Reconstructive Surgery. 2008 May;121:261e-270e.
Marty O. Visscher, PhD
studies the development and adaptation of the skin barrier in premature and full term infants, the biology of vernix caseosa, skin barrier repair, the effect of topical emollient therapy to reduce infant mortality, and irritant contact dermatitis in health care. She uses color, three dimensional thermal skin imaging and skin biomarker analysis to quantify treatment response in infantile hemangiomas, wounds and scars.
Skin research; infant skin development; effects of environment and skin treatment products on the skin;
Visscher M, Narendran V. The ontogeny of skin. Adv Wound Care (New Rochelle). 2014 Apr 1;3(4):291-303.
Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A quality-improvement collaborative project to reduce pressure ulcers in PICUs. Pediatric. 2013 Jun;131(6)e:1950-60.
Visscher MO, Wickett RR. Hand hygiene compliance and irritant dermatitis: A juxtaposition of health care issues. Int J Cosmet Sci. 2012 Oct;34(5):402-15.
Bailey JK, Burkes SA, Visscher MO, Whitestone J, Kagan RJ, Yakuboff KP, Warner P, Randall Wickett R. Multimodal quantitative analysis of early pulsed-dye laser treatment of scars at a pediatric burn hospital. Dermatol Surg. 2012 Sep;38(9):1490-6.
Visscher MO, Taylor T, Narendran V. Neonatal intensive care practices and the influence on skin condition. J Eur Acad Dermatol Venereol. 2013 Apr;27(4):486-93.
Visscher MO, Barai N, LaRuffa AA, Pickens WL, Narendran V, Hoath SB. Epidermal barrier treatments based on vernix caseosa. Skin Pharmacol Physiol. 2011;24(6):322-9.
Visscher MO, Utturkar R, Pickens WL, LaRuffa AA, Robinson M, Wickett RR, Narendran V, Hoath SB. Neonatal skin maturation – Vernix caseosa and free amino acids. Pediatr Dermatol. 2011 Mar-Apr; 28(2):122-32.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-a polymorphism -308 and atopy on irritant contact dermatitis in health care workers. Contact Dermatitis. 2010 Dec;63(6):320-32.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2011 Apr;33(2):105-12.
Visscher M, Robinson M, Wickett R. Stratum corneum free amino acids following barrier perturbation and repair. Int J Cosmet Sci. 2011 Feb;33(1):80-9.
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