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Samantha A. Brugmann, PhD
is a developmental biologist who aims to understand craniofacial development and elucidate the molecular basis for diseases that affect the craniofacial complex. Furthermore, Dr. Brugmann attempts to understand the forces that help pattern the face during normal and abnormal development she utilizes various model systems with unique facial morphologies.
Visit the Brugmann Lab.
Assistant Professor, UC Department of Surgery
Samantha A. Brugmann, PhD, is an assistant professor of pediatrics in the Divisions of Plastic Surgery and Developmental Biology. She received her BS in cell and molecular biology in 1998 from Tulane University in New Orleans, LA. She then moved to Washington, DC to study cranial sensory placode development in Xenopus laevis at George Washington University. After receiving her PhD in genetics from George Washington University in 2004, she moved to Stanford, CA to do her postdoctoral research in craniofacial development at Stanford University. While at Stanford she received a Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32) in 2006, a Pediatric Research Fund-Child Health Research Program Grant in 2009 and a NIH Pathway to Independence Award (K99/R00) in 2010. She joined Cincinnati Children’s Hospital Medical Center in January 2011 to study craniofacial development and disease.
Zaghloul NA, Brugmann SA. The emerging face of primary cilia. Genesis. 2011 Apr;49(4):231-46.
Levi B, James AW, Nelson ER, Brugmann SA, Sorkin M, Manu A, Longaker MT. Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg. 2011 Mar;127(3):1182-90.
Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. A unique chromatin signature uncovers early developmental enhancers in humans. Nature. 2011 Feb 10;470(7333):279-83.
Cordero DR, Brugmann S, Chu Y, Bajpai R, Jame M, Helms JA. Cranial neural crest cells on the move: their roles in craniofacial development. Am J Med Genet A. 2011 Feb;155(2):270-9. Brugmann SA, Cordero DR, Helms JA. Craniofacial ciliopathies: A new classification for craniofacial disorders. Am J Med Genet A. 2010 Dec;152A(12):2995-3006. Brugmann SA, Allen NC, James AW, Mekonnen Z, Madan E, Helms JA. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet. 2010 Apr 15;19(8):1577-92. Brugmann SA, Powder KE, Young NM, Goodnough LH, Hahn SM, James AW, Helms JA, Lovett M. Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for human craniofacial disorders. Hum Mol Genet. 2010 Mar 1;19(5):920-30. Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA. Wnt signaling mediates regional specification in the vertebrate face. Development. 2007 Sep;134(18):3283-95. Brugmann SA, Kim J, Helms JA. Looking different: understanding diversity in facial form. Am J Med Genet A. 2006 Dec 1;140(23):2521-9. Brugmann SA, Tapadia MD, Helms JA. The molecular origins of species-specific facial pattern. Curr Top Dev Biol. 2006;73:1-42.
Rulang Jiang, PhD
is a developmental biologist directing research programs in craniofacial biology. His lab generates and uses mutant mouse models to investigate the genetic and developmental basis of craniofacial birth defects, including cleft lip, cleft palate, tooth defects, and other craniofacial deformities. His lab also studies development of joints, including long bone joints in the limb and the temporomandibular joint of the jaw.
Visit the Jiang Lab.
Professor, UC Department of Pediatrics
Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr;352(1):83-91.
Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb;350(2):520-531.
Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct;30(20):4797-4807.
Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-1396.
Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009;323(5918):1232-1234.
Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007;45(10):618-624.
Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006;235(5):1152-1166.
Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R. Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development. Dev Biol. 2005;288(2):582-594.
Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004;131(13):3207-3216.
Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in the Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Nat Acad Sci U S A. 2004;101(18):7022-7027.
Donna C. Jones, PhD
investigates questions regarding the determinants of bone development, function and shape. In particular, she focuses on the influences of ontogeny, function and evolution on craniofacial morphology. The goal of her research is to assist clinicians treating children with craniofacial abnormalities, either congenital or acquired, through translational and laboratory-based research endeavors.
Assistant Professor, UC Department of Pediatrics
Translational: Using shape analysis, we are characterizing quantifiable growth curves of craniofacial shape in children from three dimensional photographs. Results from this project are intended for use by clinicians during repair or reconstruction of facial features in future pediatric patients.
Bench research: Working with in vitro cells and in vivo mouse models, the lab is examining how the interaction of muscle force influences the developing shape of bone, particularly in the mandible. Using a variety of cell markers, tension sensors, and morphological investigations, this research aims to improve our understanding of the cause of developmental abnormalities of the lower jaw, to hopefully reduce the need for surgeries and long hospital stays in children affected with these disorders.
BS: State University of New York, College at Fredonia, Fredonia, NY, 1995.
MS: University of Rochester, Rochester, NY, 1998.
PhD: University of Cincinnati, Cincinnati, OH, 2004.
PostDoc: Johns Hopkins, Baltimore, MD, 2007.
Bastidas N, Runyan CM, Jones DC, Taylor JA. Anatomic study of full facial and scalp allografts without cutaneous facial scars. J Plast Surg Hand Surg. 2013 May 6. Epub ahead of print.
Jones DC, German RZ. Variation in Protein and Calorie Consumption Following Protein Malnutrition in Rattus norvegicus. Animals. 2013; 3(1), 33-44.
Rapp SJ, Jones DC, Billmire D, Taylor JA. Dissection in the subgaleal and subperiosteal plane: Implications on scalp wound healing. J Plast Surg Hand Surg. 2013 Jun;47(3):168-8.
Visscher M, Burkes S, Wickett R, Hammill A, Dasgupta R, Chute C, Elluru R, Patel M, Jones DC, Azizkhan R, Adams D. Use of Multimodal Quantitative Imaging to Determine Stage and Treatment Response of Infantile Hemangiomas. ISSVA Sweden. 2012:235X-F7C6P8G9B4.
Rapp SJ, Jones DC, Gerety P, Taylor JA. Repairing Critical-Sized Rat Calavarial Defects with Progenitor Cell-Seeded Acellular Periosteum: A Novel Biomimetic Scaffold. Surgery. 2012 Oct;152(4):595-604.
Jones DC, German RZ. Catch-up and targeted growth following variable duration protein restriction: effects on bone and body mass. J Morphol. 2011 April; 272(4):485-96.
Runyan CM, Jones DC, Bove K, Simpson D, Maercks RA, Taylor JA. Porcine Allograft Mandible Revitalization Using Autologous Adipose-Derived Stem Cells, Bone Morphogenetic protein-2, and Periosteum. Plast Reconstr Surg. 2010 May;125(5):1372-82.
Jones DC, Zelditch ML, Peake PL, German RZ. The effects of muscular dystrophy on the craniofacial shape of Mus musculus. J Anat. 2007 Jun;210(6):723-30.
Yu Lan, PhD
Associate Professor, UC Department of Surgery
Associate Professor, UC Department of Pediatrics
Yu Lan, PhD, is a developmental geneticist interested in understanding the genetic basis and developmental mechanisms of structural birth defects. Cleft palate is one of the most common birth defects in humans. To understand the molecular and cellular mechanisms of cleft palate pathogenesis, we have been investigating the molecular pathways governing normal palate development in the laboratory mice.
Through gene expression screening, we have identified several putative transcription factor genes with distinct and dynamic expression patterns in the developing mouse palate. Using the gene targeting technology, we have generated mice carrying null or conditional null mutations in some of these transcription factor genes. Analyses of the mutant mice revealed that several of these transcription factors, such as Osr1 and Osr2, play essential roles in palate development. Ongoing investigations focus on delineating the molecular pathways involving these factors in palate development using a combination of genetic, embryological, and biochemical approaches.
PhD: University of Maine, Orono, ME.
Post-doc training: Wesleyan University, Middletown, CT; The Jackson Laboratory, Bar Harbor, ME.
Genetic Basis of Cleft Lip and Palate. Co-Investigator. National Institutes of Health. Apr 2003 - Jan 2013. #R01 DE015207.
Molecular Genetic Analysis of Craniofacial Development. Co-Investigator. National Institutes of Health. Apr 2000 - Jun 2015. #R01 DE013681.
Marty Visscher, PhD
Professor, UC Department of Surgery
Skin research; infant skin development; effects of environment and skin treatment products on the skin;
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