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LAMS, currently in its sixth year, is a collaborative, four-site study investigating long-term outcomes for children with low and high symptoms of mania. With funding support from the National Institute of Mental Health (NIMH), we are using epidemiological methods to follow a cohort of 6- to 12-year-old children with ESM, as well as a comparison group without ESM.
We have enrolled and completed baseline assessments on 180 subjects in Cincinnati with 600 subjects being enrolled in total. The study will follow these subjects for the next 20 years to determine their long-term outcomes.
This is an NIMH funded, five-year study (currently in its third year) testing the efficacy of family-focused treatment (FFT), a promising new intervention for adolescents with bipolar disorder. We are studying FFT as an adjunct to carefully controlled pharmacotherapy in a three-site randomized trial. Robert Kowatch, MD, is the principal investigator for this national study.
COLT is a large, multisite, controlled trial of lithium in children and adolescents with bipolar I disorder. The project is coordinated by Case Western Reserve University via a contract with the National Institute of Child Health and Human Development (NICHD). This study is not yet open to enrollment.
The aim of this project is to conduct a controlled trial of risperidone, valproate and placebo in 3- to 7-year-old children with bipolar disorder. Sixty subjects will be enrolled in this protocol. To date, 45 subjects are enrolled, and the study is closed to enrollment. This study is supported by the NAMI / Stanley Foundation Research Awards Program.
This project investigates the use of exomics to improve diagnosis and treatment for children with mood disorders.The advanced genomic and analytic services that the Genetic Variation and Gene Discovery Core of Cincinnati Children’s is providing advanced genomic and analytic services for this study, which is enrolling subjects from the LAMS study.
This study is ultimately intended to improve safety on the psychiatric inpatient unit by helping identify children and adolescents in the Emergency Department at high risk for violence when on the unit. We have collected data on nearly 900 patients while piloting the predictive scale, and data analysis is near completion. The project has been presented at two national conferences, and four manuscripts are expected to be published from this original data. The predictive scale created in this study is generating interest from sites from the US and other countries.
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