• Current Projects & Grants

    Asthma

    Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure / Function

    Co-PIs: Drs Hershey & Le Cras
    The goals of this project are to determine whether diesel exhaust particle exposure during early life alters lung morphogenesis and immune patterning and predisposes for increased risk for asthma later in life.


    Pulmonary Hypertension

    Genetic Analysis of Murine Chronic-Hypoxia-Induced Pulmonary Hypertension

    PI: Dr Nichols, Genetics Division; Co-I: Le Cras
    The goals of this project are to identify specific regions of the mouse genome containing genes contributing to increased susceptibility to chronic hypoxia-induced right ventricular hypertrophy and right ventricular systolic pressure.


    Pathogenesis of Neonatal Lung Disease

    Also known as bronchopulmonary dysplasia; BPD

    PI: Le Cras
    The goals of this project are to determine the role of anti-angiogenic factors in pulmonary vascular development and disease, including vascular remodeling and right ventricular hypertrophy (failure) in the newborn.

  • Diesel exhaust particles in macrophage.

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  • Diesel exhaust particles in macrophage.

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  • Arterial remodeling.

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  • Arteriograms of the lungs.

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