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Co-PIs: Drs Hershey & Le CrasThe goals of this project are to determine whether diesel exhaust particle exposure during early life alters lung morphogenesis and immune patterning and predisposes for increased risk for asthma later in life.
PI: Dr Nichols, Genetics Division; Co-I: Le CrasThe goals of this project are to identify specific regions of the mouse genome containing genes contributing to increased susceptibility to chronic hypoxia-induced right ventricular hypertrophy and right ventricular systolic pressure.
PI: Le CrasThe goals of this project are to determine the role of anti-angiogenic factors in pulmonary vascular development and disease, including vascular remodeling and right ventricular hypertrophy (failure) in the newborn.
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