Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure / Function
Co-PIs: Drs Hershey & Le Cras
The goals of this project are to determine whether diesel exhaust particle exposure during early life alters lung morphogenesis and immune patterning and predisposes for increased risk for asthma later in life.
Genetic Analysis of Murine Chronic-Hypoxia-Induced Pulmonary Hypertension
PI: Dr Nichols, Genetics Division; Co-I: Le Cras
The goals of this project are to identify specific regions of the mouse genome containing genes contributing to increased susceptibility to chronic hypoxia-induced right ventricular hypertrophy and right ventricular systolic pressure.
Pathogenesis of Neonatal Lung Disease
Also known as bronchopulmonary dysplasia; BPD
PI: Le Cras
The goals of this project are to determine the role of anti-angiogenic factors in pulmonary vascular development and disease, including vascular remodeling and right ventricular hypertrophy (failure) in the newborn.