Le Cras Lab

  • Current Projects & Grants

    Asthma

    Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure / Function

    Co-PIs: Drs Hershey & Le Cras
    The goals of this project are to determine whether diesel exhaust particle exposure during early life alters lung morphogenesis and immune patterning and predisposes for increased risk for asthma later in life.


    Pulmonary Hypertension

    Genetic Analysis of Murine Chronic-Hypoxia-Induced Pulmonary Hypertension

    PI: Dr Nichols, Genetics Division; Co-I: Le Cras
    The goals of this project are to identify specific regions of the mouse genome containing genes contributing to increased susceptibility to chronic hypoxia-induced right ventricular hypertrophy and right ventricular systolic pressure.


    Pathogenesis of Neonatal Lung Disease

    Also known as bronchopulmonary dysplasia; BPD

    PI: Le Cras
    The goals of this project are to determine the role of anti-angiogenic factors in pulmonary vascular development and disease, including vascular remodeling and right ventricular hypertrophy (failure) in the newborn.

 
  • Diesel exhaust particles in macrophage.

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    Diesel exhaust particles in macrophage.

    Picture shows diesel exhaust particles (DEP) in a lung macrophages from a DEP exposed mouse.

  • Diesel exhaust particles in macrophage.

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    Diesel exhaust particles in macrophage.

    Picture shows diesel exhaust particles (DEP) in macrophages of an exposed mouse and CLCA3 positive mucus-producing goblet cells in the airways of the lungs.

  • Arterial remodeling.

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    Arterial remodeling.

    Picture shows arterial remodeling in transgenic mouse model which develops severe pulmonary hypertension.

  • Arteriograms of the lungs.

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    Arteriograms of the lungs.

    Picture shows arteriograms of the lungs from a normal wild type mouse (left) and a transgenic mouse (right) which overexpresses transforming growth factor-alpha (TGF-α) in its airway epithelial cells. The arteriograms show extensive arterial branching in the lungs of the wild type mouse, but very reduced arterial structure in the transgenic mouse. See publications by Le Cras lab (4, 5)  for more information. High TGF-α levels have been reported in a number of chronic lung diseases, including in tissue from human infants who have died from BPD.