Publications: Representative Samples
These publications are representative of the research being done in the Le Cras lab. The linked text will take you to the journal's abstract of the article.
Mushaben E.M., Kramer E.L., Brandt E.B., Khurana Hershey G.K.,Le Cras T.D. (2011) Rapamycin Attenuates Airway Hyperreactivity, Goblet Cells, and IgE in Experimental Allergic Asthma.J Immunol. [Epub ahead of print]
Kramer E.L., Hardie W.D., Mushaben E.M., Acciani T.H., Pastura P.A., Korfhagen T.R., Hershey G.K., Whitsett J.A., Le Cras T.D. (2011) Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease.J Appl Physiol. [Epub ahead of print]
T. D. Le Cras, T.H. Acciani, E.M. Mushaben, E.L. Kramer, P. A. Pastura, W.D. Hardie, T.R. Korfhagen, U. Sivaprasad, M. Ericksen, A. Gibson, M. J. Holtzman, J. A. Whitsett, G. K. Khurana Hershey. (2011)Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic allergic asthma.Am. J. Physiol. (Lung Cell. Mol. Physiol.) 300: L414-L421
Ryan M.A., Nattamai K.J., Xing E., Schleimer D., Daria D., Sengupta A., Köhler A., Liu W., Gunzer M., Jansen M., Ratner N., Le Cras T.D., Waterstrat A., Van Zant G., Cancelas J.A., Zheng Y, Geiger H. (2010) Pharmacological Inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nat Med. 2010 Oct;16(10):1141-1146
T.D. Le Cras, T.R. Korfhagen, C. Davidson, S. Schmidt, M. Fenchel, M. Ikegami, J.A. Whitsett, William D. Hardie. (2010)Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha induced pulmonary fibrosis.Am. J. Path. 176(2):1-8
E.L. Kramer, E.M. Mushaben, P.A. Pastura, T.H. Acciani, G.H. Deutsch, G. Khurana Hershey, T.R. Korfhagen, W.D. Hardie, J.A. Whitsett, T.D. Le Cras. (2009) Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.Am. J. of Respir. Cell and Mol. Biol.;41(4):415-25. PMC2746988.
E. L. Kramer, G. H. Deutsch, M. Sartor, M. Ikegami, W. D. Hardie, T. R. Korfhagen, and T. D. Le Cras. (2007) Perinatal induction of TGF-a disrupts the saccular phase of lung morphogenesis and causes remodeling: Microarray analysis. Am. J. Physiol. (Lung Cell Mol. Physiol.). 293:L314-L327
T.D. Le Cras, L.G. Fernandez, and V.E. Laubach. (2005) Vascular growth and remodeling in compensatory lung growth following right pneumonectomy.J. Appl. Physiol. 98:1140-1148
T. D. Le Cras, W. D. Hardie, J. A. Whitsett, and T. R. Korfhagen. (2004) Transient induction of TGF-a disrupts lung morphogenesis, causing pulmonary disease in adulthood. Am. J. Physiol. (Lung Cell Mol. Physiol.) 287: L718-L729
*Publication above was published along with an editorial: D. Massaro and G. DeCarlo Massaro. (2004) Critical period for alveologenesis and early determinants of adult pulmonary disease.Am J Physiol (Lung Cell Mol Physiol) 287: L715-L717
T. D. Le Cras, R.E. Spitzmiller, J.M. Greenberg, J. A. Whitsett, and L. Akeson. (2004) VEGF causes pulmonary hemorrhage, hemosiderosis, and airspace enlargement in neonatal mice.Am. J. Physiol. (Lung Cell Mol. Physiol.) 287: L134-142
T. D. Le Cras, W. D. Hardie, K. Fagan, J. A. Whitsett, and T. R. Korfhagen. (2003) Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing Transforming growth factor-α.Am. J. Physiol. (Lung Cell Mol. Physiol.) 285 (5): L1046-L1054
T. D. Le Cras, N. Markham, R. Tuder, N. F. Voelkel, and S. H. Abman. (2002) Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.Am. J. Physiol. (Lung Cell Mol. Physiol.) 283: L555-L562
Contact information
Tim D. Le Cras PhD
Associate Professor of Pediatrics
Division of Pulmonary Biology
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave.
Cincinnati, Ohio 45229-3039
Phone: 513-636-8151
Fax: 513-636-7868
Email: tim.lecras@cchmc.org
