Restoring Lung Architecture in Neonatal and Adult Lung Injury
Bronchopulmonary dysplasia (BPD) remains a major complication in premature infants, despite advances in neonatal care such as prenatal corticosteroids, surfactant therapy, and noninvasive ventilation.
While these interventions have reduced the incidence of the classical fibrotic form of BPD, a newer phenotype has emerged. This modern form is characterized by an arrest in alveolar development, rather than by overt fibrosis or emphysema. Understanding and reversing this alveolar simplification is a central challenge in neonatal lung disease.