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Throughout her research career, Anne-Karina Perl, PhD, has been using complex conditional transgenic mice to learn about lung development and to study lung regeneration, and more recently, to study aberrant epithelial repair and lung fibrosis. Early on, she focused on the development and use of state-of-the-art transgenic mouse models to provide novel and innovative tools to address complex molecular pathways and lineage relationships in lung development and diseases. Over the last four years, the Perl lab focused its efforts to integrate the lessons learned from lung development with lung repair and successfully established new conditional mouse models to study re-alveolarization and bronchiolar repair after acute and chronic injury.
Our research projects are steered toward understanding the cellular and molecular mechanisms related to the cure of lung diseases like bronchopulmonary dysplasia (BPD), emphysema, chronic obstructive pulmonary disease (COPD) and bronchiolitis obliterans (BOS).
Read about our work to find out what cellular and molecular mechanisms are important to regrow lung.
We are working to better understand the pathogenesis of the loss of epithelial integrity and subsequent peribronchiolar fibrosis to help improve therapies for lung disorders.
Dr. Perl was seminal in establishing the conditional mouse technology to regulate gene activation and in activation in the lung epithelium using the tetracycline inducible gene regulation.
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