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research focuses on alveolar fibroblasts during septation and bronchiolar
fibrosis after epithelial injury. Our projects strive to understand the
cellular and molecular mechanisms related to the pathology of lung diseases,
like Bronchopulmonary Dysplasia (BPD), emphysema, chronic obstructive pulmonary
disease (COPD) and bronchiolitis obliterans (BOS). We use state of the art
transgenic mouse models to provide novel and innovative tools to enable studies
of complex molecular pathways and lineage relationships, in lung development
and diseases. Jenna Green established immunofluorescence staining protocols for
adult mouse lung that allow 3d high resolution confocal imaging.
Our histological approach is complemented by sophisticated flow cytometry to
identify subpopulations of pulmonary fibroblasts, which was established by Leiling
Chen, PhD. We have
two major focuses in the lab:
Figure : 3D reconstruction of
immunoflourescent confocal image of a 300 micron thick mouse lung. Distinct
cell compartments in the adult mouse lung alveolar epithelial cells (WHITE),
interstitial fibroblasts (GREEN) and vascular fibroblasts (RED).
Read about our work to find out what cellular and molecular mechanisms are important to regrow lung.
We are working to better understand the pathogenesis of the loss of epithelial integrity and subsequent peribronchiolar fibrosis to help improve therapies for lung disorders.
Dr. Perl was seminal in establishing the conditional mouse technology to regulate gene activation and in activation in the lung epithelium using the tetracycline inducible gene regulation.
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