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2011
Perl, A-K.T., Riethmacher, D. and Whitsett, J.A.: Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis. Am. J. Respir. Crit. Care Med. 183(4):511-521, February, 2011.
Bell, S.M., Zhang, L., Mendell, A., Xu, Y., Haitchi, H.M., Lessard, J.L. and Whitsett, J.A.: Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Dev. Biol. July 22, 2011 [Epub ahead of print].
Tompkins, D.H., Besnard, V., Lange, A.W., Keiser, A.R., Wert, S.E., Bruno, M.D. and Whitsett, J.A.: Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am. J. Respir. Cell Mol. Biol. 45(1):101-110, July, 2011.
Whitsett, J.A., Haitchi, H.M. and Maeda, Y.: Intersections between pulmonary development and disease. Am. J. Respir. Crit. Care Med. 184(4):401-406, August, 2011.
Plantier, L., Crestani, B., Wert, S.E., Dehoux, M., Zweytick, B., Guenther, A. and Whitsett, J.A.: Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. THORAX 66(8):651-657, August, 2011.
Maeda, Y., Chen, G., Xu, Y., Haitchi, H-M., Du, L., Keiser, A.R., Howarth, P.H., Davies, D.E., Holgate, S.T. and Whitsett, J.A.: Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am. J. Respir. Crit. Care Med. 184(4):421-429, August, 2011.
2010
Whitsett JA, Wert SE, Weaver TE. Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Ann Rev Med. 61:105-19. 2010.
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 184(11):6133-41. 2010.
Besnard, V., Matsuzaki, Y., Clark, J., Xu, Y., Wert, S.E., Ikegami, M., Stahlman, M.T., Weaver, T.E., Hunt, A.N., Postle, A.D. and Whitsett, J.A.: Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice. Am J. Physiol. 298(5):L646-L659, May, 2010.
Sato, A., Whitsett, J.A., Scheule, R.K. and Ikegami, M.: Surfactant protein-D inhibits lung inflammation caused by ventilation in premature newborn lambs. Am. J. Respir. Crit. Care Med. 181(10):1098-1105, May, 2010.
Xu, Y., Zhang, M., Wang, Y., Kadambi, P., Dave’, V., Lu, L.J. and Whitsett, J.A.: A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics 11:451, July, 2010.
Lin, S-C.J., Wani, M.A., Whitsett, J.A. and Wells, J.M.: Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development 137(23):3953-3963, December, 2010.
2009
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 119(10):2914-24. 2009.
Tompkins DH, Besnard V, Lange AW, Wert SE, Keiser AR, Smith AN, Lang R, Whitsett JA. Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS ONE. 4:e8248. 2009.
Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA. Sox17 promotes cell cycle progression and inhibits TGF-ß/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS One. 4:e5711. 2009.
Ikegami M, Grant S, Korfhagen T, Scheule RK, Whitsett JA. Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes. J Appl Physiol. 106:1545-52. 2009.
Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA. Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem. 284:4018-30. 2009.
Spence, J.R., Lange, A.W., Lin, S-C.J., Kaestner, K.H., Lowry, A.M., Kim, I., Whitsett, J.A. and Wells, J.M.: Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev. Cell 17(1):62-74, July, 2009.
2008
Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 135:1049-58. 2008.
Wan H, Luo F, Wert SE, Zhang L, Xu Y, Ikegami M, Maeda Y, Bell SM, Whitsett JA. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development. 135:2563-72. 2008.
Other Significant Publications
Maeda Y, Davé V, Whitsett JA. Transcriptional control of lung morphogenesis. Physiol Rev. 87:219-44. 2007.
Park K-S, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE, Hershey GKK, Chen G, Whitsett JA. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest. 117:978-88. 2007.
Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 280(14):13809-16. 2005.
Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang S-L, Whitsett JA. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci USA. 101:14449-54. 2004.
DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue specific gene expression. J Biol Chem. 278:35574-83. 2003.
Whitsett JA, Weaver TE. Hydrophobic surfactant proteins in lung function and disease. N Engl J Med. 347:2141-8. 2002.
