• Research Faculty

  • A photo of Jeffrey Whitsett.

    Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute

    investigates the hierarchy of transcriptional controls and signaling cascades which determine commitment of progenitor cells that produce the differentiated epithelial cells lining the primordial and mature respiratory tract. The goal of his research is to provide insight into the pathogenesis of acute and chronic lung disorders. The role of surfactant in innate host defense and lung function is also an ongoing interest.
    Visit the Whitsett Lab.

    513-803-2790

    A photo of Timothy Weaver.

    Timothy E. Weaver, MS, PhD Co-Director, Division of Pulmonary Biology

    focuses on the identification of cytoprotective pathways that mediate adaptation to genetic and environmental stresses in the pulmonary epithelium. These molecular pathways play a critical role in preventing or slowing the progression of chronic lung disease and may provide novel targets for therapeutic intervention.
    Visit the Weaver Lab.

    513-636-7223

    A photo of Henry Akinbi.

    Henry T. Akinbi, MD Attending Neonatologist

    studies host defense proteins in innate defense of the lungs using gene-targeted mice. The role of lysozyme in: 1) lung infection; 2) inflammation and 3) anti-oxidant defense is a major focus of his research program.

    513-636-8915

    A photo of Sandip Bhattacharyya.

    Sandip Bhattacharyya, MSc, PhD

    is an immunologist, who has basic science research programs in inflammation biology and signal transduction. The major research interest of Dr. Bhattacharyya’s laboratory is to understand the molecular mechanisms of glucocorticoid action in innate immunity and define context-specific immunomodulatory functions. 

    513-803-8039

    A photo of James Bridges.
    A photo of Hitesh Deshmukh.

    Hitesh Deshmukh, MD, PhD

    and his laboratory focuses on the role of intestinal commensal bacteria in development of appropriate innate immune responses to pathogens in neonates. The ultimate goal of this research is to develop novel therapeutic approaches to decrease mortality in premature babies, one of the most vulnerable groups.

    513-803-7448

    A photo of Stephan W. Glasser.

    Stephan W. Glasser, PhD

    studies the function of surfactant protein C (SP-C) in lung innate defense and as a cause of familial interstitial lung disease (ILD) in neonates and children. SP-C deficient mice, generated in his laboratory, exhibit features of human ILD and are susceptible to inflammation/bacterial and viral pulmonary infection. Experiments are focused on determining mechanisms underlying the role of SP-C deficiency in lung injury.

    513-636-7850

    A photo of James M. Greenberg.

    James M. Greenberg, MD Co-Director, Perinatal Institute

    investigates the developmental biology of pulmonary vascular development, including how vascular endothelial growth factor (VEGF) mediates pulmonary vascular, lymphatic and airway development. He studies how VEGF mediates organization of pulmonary vasculature during late fetal life as well as how certain proteins implicated in axonal guidance during central nervous system development also direct developmental processes in the lung.

    513-636-3149

    A photo of Beth Haberman.

    Beth E. Haberman, MD Senior Medical Director, Neonatal Services

    has special interests in the care of infants with congenital diaphragmatic hernia and follow-up care of premature and term infants with complex medical needs.

    513-636-5465

    A photo of Eric Hall.

    Eric S. Hall, PhD

    participates in a number of interdisciplinary teams investigating prematurity and neonatal disease. Along with coordinating data collection and exchange efforts, his work involves the application of knowledge discovery techniques to clinical data sets, as well as the development of software tools to assist in the summarization of clinical data and the modeling of clinical processes.

    513-803-2083

    A photo of Steven B. Hoath.

    Steven B. Hoath, MD

    has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.

    513-803-0960

    A photo of Machiko Ikegami.

    Machiko Ikegami, MD, PhD

    is working to find effective antenatal treatments to induce fetal lung maturation, better postnatal treatments for premature newborns using modified surfactant components, and improve understanding of the novel transcriptional pathways induced during ALI to mediate surfactant homeostasis during lung injury and repair.

    513-636-8661

    A photo of Alan Jobe.

    Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology

    has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.

    513-636-8563

    A photo of Tanya V. Kalin.

    Tanya V. Kalin, MD, PhD

    studies the transcriptional regulation of DNA replication and mitosis in tumor cells in vitro and in vivo. Mouse lung and prostate cancer models are used to gain insight into regulation of cell signaling pathways required for tumor initiation, progression, metastasis and tumor angiogenesis. The ultimate goal of the research program is to identify novel target genes for diagnostic, prevention and treatment of lung and prostate cancers.
    Visit the Kalin Lab.

    513-803-1201

    A photo of Vladimir Kalinichenko.

    Vladimir V. Kalinichenko, MD, PhD

    is investigating the transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis. He studies the winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival, ultimately identifying novel mechanisms that cause human lung malformations and promote lung cancer formation.

    513-636-4822

    A photo of Suhas G. Kallapur.

    Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education

    is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Dr. Kallapur’s research focus is to understand the pathogenesis of lung injury and systemic inflammatory responses in fetuses and newborns. His lab uses a sheep model and has begun some work in humans.
    Visit the Kallapur Lab.

    513-636-3879

    A photo of Beena Kamath-Rayne.

    Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology

    does clinical/translational research in preterm birth, fetal lung maturity and timing of delivery using biomarkers in amniotic fluid. She also has an interest in global health, and is on the Global Health Education Task Force. She is a master trainer for Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and is collaborating on several research studies of HBB around the world.

    513-803-1606

    A photo of Heather C. Kaplan.

    Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology

    focuses on understanding variations in evidence-based care practices across hospitals and identifying strategies for increasing the implementation of evidence and other innovations into practice. She recently began a line of investigation aimed at building the evidence base for quality improvement so that QI can be used more effectively as a strategy for improving quality and patient outcomes.

    513-803-0478

    A photo of Alan Kenny.

    Alan P. Kenny, MD, PhD

    studies the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development, including the role of a pool of foregut progenitor cells in the ventral endoderm which are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme.

    513-803-2224

    A photo of Paul Kingma.

    Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center

    investigates the role of the innate immune system in neonatal infection. Specific projects currently focus on the role of surfactant protein D in neonatal sepsis and acute respiratory distress syndrome and on neutrophil function in cystic fibrosis patients.

    513-636-2995

    A photo of Thomas Korfhagen.

    Thomas R. Korfhagen, MD, PhD Attending Pediatrician, Neonatology and Pulmonary Biology

    studies the roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF receptor signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.

    513-636-7216

    A photo of Timothy LeCras.

    Timothy D. LeCras, PhD Associate Director of Admissions, Medical Scientist Training Program

    studies the regulation of vascular and alveolar morphogenesis in the developing lung, as well as mechanisms to stimulate lung regeneration/growth in children and adults. A major focus is the causes and pathways mediating lung remodeling in premature newborns (BPD), pulmonary hypertension (PH), and asthma and to identify new therapeutic targets to treat and prevent these chronic lung diseases.

    Visit the LeCras Lab.

    513-636-8151

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    Yutaka Maeda, DVM, PhD

    is interested in understanding the mechanisms of transcriptional regulation in lung diseases, including lung cancer and asthma.

    513-636-3322

    A photo of Kristin Melton, MD.

    Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship

    is interested in early craniofacial development and focuses on the tissue interactions that direct the formation, migration and differentiation of neural crest cells. The Melton lab focuses on understanding the influence of the endothelium and the cranial mesoderm on neural crest development.

    513-803-0022

    A photo of Laurel Moyer.

    Laurel B. Moyer, MD Medical Director, TriHealth Nurseries

    has research interests that include quality improvement, late preterm infants, and international health.

    513-803-1607

    A photo of Vivek Narendran, MD.

    Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU

    is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.

    513-803-0961

    A photo of Amy Nathan, MD.

    Amy T. Nathan, MD Medical Director, Neonatology

    focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

    513-803-0909

    A photo of Anne-Karina Perl.

    Anne Karina T. Perl, MS, PhD

    studies molecular mechanisms underlying normal lung formation and lung repair processes in the preterm and postnatal lung. Data from our laboratory supports the hypothesis of the existence of distinct subsets of endodermaly derived progenitor cells during lung development. Our long-term goal is to understand the characteristics and the fate of these lung progenitors for prevention and therapy of lung disease.
    Visit the Perl Lab.

    513-636-6084

    A photo of John Reuter.

    John H. Reuter, MD, PhD Attending Neonatologist

    is active in the administration of a 4000 delivery/year community level II service. His academic interests include breast milk and nutrition in the preterm infant.

    513-862-2748

    photo of Ward Rice, MD, PhD.

    Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center

    studies the molecular and cellular mechanisms that regulate processing of Surfactant Protein C, a protein that is critical for lung function.

    513-636-3149

    A photo of Kurt Schibler.

    Kurt R. Schibler, MD Director, Neonatology Clinical Research Program

    is the principal investigator for the NICHD Neonatal Research Network at Cincinnati Children’s and is also involved in thematic collaborative research investigating the immune mechanisms underlying morbidity and mortality associated with preterm birth. He aims to identify infants at high risk for developing necrotizing enterocolitis and late onset infection and to devise strategies to prevent and to treat these complications.

    513-636-3972

    A photo of John Shannon.

    John M. Shannon, PhD

    studies the elucidation of molecular mechanisms that regulate morphogenesis and differentiation of the lung epithelium and mesenchyme. A major focus of the lab is the role of fibroblast growth factors and epithelial-mesenchymal signaling pathways in the regulation of branching morphogenesis in the developing lung.

    513-636-2938

    A photo of Deborah Sinner.

    Debora I. Sinner, PhD

    is interested in understanding the molecular mechanisms underlying foregut formation. Specifically, her lab focuses on the molecular mechanism underlying lung and upper airway development and the paracrine interactions between epithelium and mesenchyme. Ultimately, her goal is to use the embryo as a paradigm to understand diseases affecting upper airway and lung. To this end her lab utilizes knockout mouse models and the frog embryo combined with molecular and cellular approaches using in vitro systems.

    513-803-1353

    A photo of Bruce Trapnell.

    Bruce C. Trapnell, MS, MD Assistant Director, Adult Cystic Fibrosis Center

    seeks to define mechanisms regulating innate immunity and inflammation in the lungs. His major focus is alveolar macrophage function in health and disease and the regulation alveolar homeostasis and host defense by GM-CSF in health and disease.

    513-636-6361

    A photo of Susan Wert.

    Susan E. Wert, PhD Associate Professor, Division of Pulmonary Biology, Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute

    studies lung development, injury, and repair as it pertains to molecular morphology (gene and protein expression in situ), ultrastructure, and histopathology of the developing and adult lung. In addition, she studies the histopathology of the human lung as it relates to interstitial lung disease, especially to genetic disorders of surfactant dysfunction in the neonatal and pediatric population.

    513-636-4297