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2012
2011
Kramer EL, Hardie WD, Mushaben E, Acciani T, Pastura P, Korfhagen T, Hershey G, Whitsett J, Le Cras T. Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease. J. Appl. Physiol. Dec;111(6):1760-7. 2011.
Madala SK, Maxfield MD, Davidson CR, Schmidt SM, Garry D, Ikegami M, Hardie WD, Glasser SW. Rapamycin regulates bleomycin-induced lung damage in SP-C deficient mice. Pulm Med. 2011:653524. 2011.
T.D. Le Cras, T.H. Acciani, E.M. Mushaben, E.L. Kramer, P. A. Pastura, W.D. Hardie, T.R. Korfhagen, U. Sivaprasad, M. Ericksen, A. Gibson, M. J. Holtzman, J. A. Whitsett, G. K. Khurana Hershey. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic allergic asthma. Am J Physiol Lung Cell Mol Physiol. 300L414-L421 2011.
2010
Hardie, WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 9(14): 2769-76. 2010.
Glasser SW, Hardie WD, Hagood JS. Pathogenesis of Interstitial Lung Disease in Children and Adults. Pediatric Allergy, Immunology and Pulmonology. 23: 9-14. 2010.
LeCras TD, Korfhagen TR, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-{alpha}-Induced Pulmonary Fibrosis. Am J Pathol, 176(2): 679-86. 2010.
2009
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di P, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase (MMP) 14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 180: 834-45. 2009.
Korfhagen TR, LeCras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 41(5), 562-72, 2009.
Hardie WD, Glasser SW, Hagood JS. Emerging Concepts in the Pathogenesis of Lung Fibrosis. Am J Pathol. 175(1), 3-16. 2009.
Kramer EL, Mushaben E, Pastura P, Acciani T, Hake A, Deutsch GH, Hershey GK, Whitsett JA, Korfhagen TR, Hardie WD, Le Cras TD. Egr-1 suppresses EGFR-mediated airway hyperresponsiveness and lung remodeling in mice. Am. J. Respir Cell Mol. Biol. 41: 415-25. 2009.
Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel V, Medvedovic M, Sartor M, Henning LN, Venditto C, BorchersMT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 41(2): 226-36. 2009.
Past Seminal Publications
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-{alpha}-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 294(6):L1217-25, 2008.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Crit Care Med 38(4): 446-54, 2008.
Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. Perinatal Increases in TGF-{alpha} Disrupt the Saccular Phase of Lung Morphogenesis & Cause Remodeling: Microarray Analysis. Am J Physiol Lung Cell Mol Physiol. 293: L314-327, 2007.
