Ronald E. Bokulic, DO
Academic Information
Associate Professor, UC Department of Pediatrics
Phone: 513-636-6771
Fax: 513-636-4615
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Specialties
Asthma; interstitial lung disease; exercise
Education and Training
DO: Philadelphia College of Osteopathic Medicine, 1983 Residency: Pediatrics, Children's Medical Center, Dallas, TX Fellowship: Pediatric Pulmonary Medicine, Tulane University Medical School, New Orleans, LA Certification: Pediatrics, 1989; Pediatric Pulmonology, 1994.
Publications
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Burrow TA, Cohen MB, Bokulic R, Deutsch G, Choudhary A, Falcone RA Jr, Grabowski GA. Gaucher disease: progressive mesenteric and mediastinal lymphadenopathy despite enzyme therapy. J Pediatr. 2007 Feb;150(2):202-6. Amin RS, Carroll JL, Jeffries JL, Grone C, Bean JA, Chini B, Bokulic R, Daniels SR. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med. 2004 Apr 15;169(8):950-6. Evans DA, Bokulic RE. Radiological case of the month. Posttraumatic pseudocysts. Arch Pediatr Adolesc Med. 1997 Aug;151(8):47-9.
Hardie W, Bokulic R, Garcia VF, Reising SF, Christie CD. Pneumococcal pleural empyemas in children. Clin Infect Dis. 1996 Jun;22(6):1057-63.
Bokulic RE, Hilman BC. Interstitial lung disease in children. Pediatr Clin North Am. 1994 Jun;41(3):543-67.
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Barbara Chini, MD
Director, Pulmonary Fellowship Program
Assistant Cystic Fibrosis Center Director, Division of Pulmonary Medicine
Academic Information
Associate Professor, UC Department of Pediatrics
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Education and Training
BS: University of Notre Dame Notre Dame, Indiana, 1986.
MD: Vanderbilt University Medical School, Nashville, TN, 1990.
Internship: Pediatrics, University of Rochester Medical Center Pediatrics, Rochester, New York, 1991.
Residency: Pediatrics, University of Rochester Medical Center, Rochester, New York, 1993.
Fellowships: University of Rochester Medical Center, Rochester, New York, 1994; Children’s Hospital Medical Center, Cincinnati, Ohio, 1997.
Publications
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Fricke BL, Donnelly LF, Shott SR, Kalra M, Poe SA, Chini BA, Amin RS. Comparison of lingual tonsil size as depicted on MR imaging between children with obstructive sleep apnea despite previous tonsillectomy and adenoidectomy and normal controls. Pediatr Radiol. 2006 Jun;36(6):518-23. Epub 2006 Apr 5. Shott SR, Amin R, Chini B, Heubi C, Hotze S, Akers R. Obstructive sleep apnea – Should all children with Down syndrome be tested? Arch Otolaryngol Head Neck Surg. 2006 Apr;132(4):432-436. Mannaa M, Chini B. A case in point. A boy with shortness of breath, cough, and myalgias. J Respiratory Diseases. 2006;27(8):356-8. Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin RS. Neuropsychological Effects of Pediatric Obstructive Sleep Apnea. JINS. 2004 Nov;10(7):962-975. Abbott MB, Donnelly LF, Dardzinski BJ, Poe SA, Chini BA, Amin RS. Obstructive Sleep Apnea: MR Imaging Volume Segmentation Analysis. Radiology. 2004 Sep;232(3):889-895. Amin RS, Carroll J, Bean J, Jeffries J, Chini B, Bokulic R, Daniels S. Twenty Four Hour Ambulatory Blood Pressure in Children with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2004 Apr;169(8):950-56. Donnelly LF, Shott SR, Connor RL, Chini BA, Amin RS. Causes of Persistent Obstructive Sleep Apnea Despite Previous Tonsillectomy and Adenoidectomy in Children with Down Syndrome as Depicted on Static and Dynamic Cine MRI. AJR. 2004 Jul;183(1):175-181.
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John P. Clancy, MD
Research Director, Division of Pulmonary Medicine
focuses primarily on airway epithelial biology, examining strategies to treat cystic fibrosis and to normalize protease dysregulation in lung inflammatory disorders. The goals of our research program are 1) to examine strategies to restore activity to mutant, disease-causing CFTR mutations, 2) to develop new biomarkers of CFTR activity, and 3) to investigate novel inflammatory pathways.
513-636-6771
john.clancy@cchmc.org
John P. Clancy, MD
Research Director, Division of Pulmonary Medicine
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Cystic fibrosis; airway cellular biology; CFTR regulation
Biography
John P. Clancy, MD, has served in several leadership roles at Univeristy of Alabama, Cincinnati Children's and within the international cystic fibrosis (CF) community. Some of his leadership roles include membership on the CFF Clinical Research Committee (2003 – present), the CFF-TDN Steering Committee (2002 – 2007), the CFF-TDN Translational Research Center Committee (2008 – present), DSMB membership for the Rare Lung Disease Consortium within the NIH Rare Disease Research Network (2005-2009, Chairman from 2010 – present)); organizing committee membership for the North American CF Conference (2003- present) and the European CF Society (2010), Co-chair of the CFFT Biomarkers Consortium (2010- present), member of the Promotion and Tenure Committee for the UAB Department of Pediatrics (2003 - 2010) and the UAB SOM (2007 – 2010, including committee Chair).
Dr. Clancy has been the primary or co-mentor of more than 20 fellows, graduate students and junior faculty. He has been the initial recipient of two endowed chairs, including the Raymond K. Lyrene Chair in Pediatric Pulmonary Medicine at the University of Alabama (2005), and the Tom Boat Chair in Cystic Fibrosis Clinical and Translational Research at Cincinnati Children's (2011).
Education and Training
MD: University of Iowa College of Medicine, Iowa City, IA. Residency: University of Virginia, Charlottesville, VA. Fellowship: University of Alabama at Birmingham, Birmingham, AL.
Publications
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Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, Deboeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax. 2011 Aug 8. Epub ahead of print.
Hug MJ, Derichs N, Bronsveld I, Clancy JP. Measurement of ion transport function in rectal biopsies. Methods Mol Biol. 2011;741:87-107.
Rowe SM, Clancy JP, Wilschanski M. Nasal potential difference measurements to assess CFTR ion channel activity. Methods Mol Biol. 2011;741:69-86.
Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, Freedman SD, Rose LM, Mayer-Hamblett N, Dong Q, Zha J, Stone AJ, Olson ER, Ordoñez CL, Campbell PW, Ashlock MA, Ramsey BW. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18;363(21):1991-2003.
Clancy JP. Diagnosing cystic fibrosis in patients with non-diagnostic results: the case for intestinal current measurements. Thorax. 2010 Jul;65(7):575-6.
Rowe SM, Pyle LC, Jurkevante A, Varga K, Collawn J, Sloane PA, Woodworth B, Mazur M, Fulton J, Fan L, Li Y, Fortenberry J, Sorscher EJ, Clancy JP. DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers. Pulm Pharmacol Ther. 2010 Aug;23(4):268-78.
Com G, Clancy JP. Adenosine receptors, cystic fibrosis, and airway hydration. Handb Exp Pharmacol. 2009;(193):363-81.
Rowe SM, Clancy JP. Pharmaceuticals targeting nonsense mutations in genetic diseases: progress in development. BioDrugs. 2009;23(3):165-74.
Rowe SM, Accurso F, Clancy JP. Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials. Proc Am Thorac Soc. 2007 Aug 1;4(4):387-98.
Rowe SM, Varga K, Rab A, Bebok Z, Byram K, Li Y, Sorscher EJ, Clancy JP. Restoration of W1282X CFTR activity by enhanced expression. Am J Respir Cell Mol Biol. 2007 Sep;37(3):347-56.
Grants
Developing GI Outcome Measures for CFTR Modulator Trials in Young CF Patients. Principal Investigator. Feb 2010 - Jan 2012. An Open-Label, Rollover Study to Evaluate the Long-Term Safety and Efficacy of VX-770 in Subjects with Cystic Fibrosis. Site Principal Investigator. Vertex Pharmaceuticals Incorporated. Jun 2011 - Jun 2012. Randomized, Placebo-Controlled, Active-Controlled Multicenter Study to assess the Efficacy, Safety and Tolerability of Arikace® in Cystic Fibrosis with Chronic Infection Due to Pseudomonal aeruginosa. Principal Investigator. Insmed. Oct 2011 - May 2012. A Phase 3 Efficacy and Safety Study of PTC124 as an Oral Treatment for Nonsense-Mutation-Mediated Cystic Fibrosis. Principal Investigator. Apr 2009 - Apr 2012. Randomized, Active-Controlled Multicenter Study to assess the Efficacy, Safety and Tolerability of Repeated Cycles of Arikace® in Cystic Fibrosis with Chronic Infection Due to Pseudomonal aeruginosa. Principal Investigator. Oct 2011 - Mar 2012.
Cystic Fibrosis Translational Development Center. Principal Investigator. Cystic Fibrosis Foundation. Jan 2010 - Dec 2012.
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Daniel H. Grossoehme
Chaplain, Division of Pulmonary Medicine
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Research InterestsAdherence, spirituality and religion, chronic illness coping and HRQoL Visit the Grossoehme Lab.
Biography
Daniel H. Grossoehme, MDiv, BCC, is an ordained Episcopal priest who completed his clinical pastoral residency at the Cleveland Clinic Foundation Hospital with an emphasis in pediatrics and critical care in 1992-1993. He became the first Director of Chaplaincy Services at Children's Hospital Medical Center of Akron, where he served from 1993 to 2003, when he joined Cincinnati Children's Medical Center's College Hill Campus as Staff Chaplain.
Education and Training
Doctor of Ministry: (Pastoral Counseling), Louisville Presbyterian Theological Seminary, 2006 MDiv: Protestant Episcopal Theological Seminary in Virginia, Alexandria, VA, 1992 BS: Astrophysics, Indiana University, 1985
Publications
Grossoehme, D.H., Opipari-Arrigan, L., VanDyke, R., Thurmond, S. & Seid, M. Relationship of adherence determinants and parental spirituality in cystic fibrosis. Pediatr Pulmonol. 2011 Dec 13. doi: 10.1002/ppul.21614. 2011. Grossoehme, D.H., Jacobson, C.J., Cotton, S., Ragsdale, J., VanDyke, R. & Seid, M. Written prayers and religious coping in a paediatric hospital setting. Mental Health, Religion & Culture. 14(5): 423-432. 2011. Grossoehme, D.H., Ragsdale, J.R., Snow, A., & Seid, M. We were chosen as a family: Parents’ evolving use of religion when their child has cystic fibrosis. Journal of Religion & Health. In press. DOI: 10.1007/s10943-011-9477-5. 2011. Cotton, S., Grossoehme, D.H., McGrady, M. Religious coping and use of prayer in sickle cell disease. Pediatric Blood and Cancer, in press. doi: 10.1002/pbc.23038. 2011. Grossoehme, D.H., VanDyke, R., Jacobson, C.J., Cotton, S., Ragsdale, J., & Seid, M. Written prayers in a pediatric hospital: linguistic analysis. Psychology of Religion & Spirituality, 2(4): 227-233. 2010. Grossoehme, D.H., Ragsdale, J.R., Wooldridge, J.L., Cotton, S., Grimes, L. & Seid, M. Parents’ use of religious coping in the first year after their child’s chronic illness diagnosis. Journal of Health Care Chaplaincy, 16(3): 109-122. 2010. Grossoehme, D.H., Ragsdale, J., Wooldridge, J.L., Cotton, S., & Seid, M. We can handle this: Parents’ use of religion in the first year following their child’s diagnosis with cystic fibrosis. Journal of Health Care Chaplaincy, 16(3): 95-108. 2010. Grossoehme, D.H., VanDyke, R., & Seid, M. Spirituality’s role in chronic disease self-management: Sanctification of the body in families dealing with cystic fibrosis. Journal of Health Care Chaplaincy, 15, 1-10. 2009. Cotton S, Grossoehme D, Rosenthal SL, McGrady ME, Roberts YH, Hines J, Yi, MS, & Tsevat J. Religious/spiritual coping in adolescents with sickle cell disease: A pilot study. Journal of Pediatric Hematology/Oncology. 31(5), 313-318. 2009. Grossoehme, D.H., Ragsdale, J., Dixon, C., Berz, K, & Zimmer, M. The changing face of medical education: the role of religion, integrative medicine and osteopathy. The Open Medical Education Journal . 2, 1-8. 2009.
Grants
NIH/NICHD K23HD062642 (PI: Grossoehme) Place Outcomes Award 2012-2014, James M. Anderson Center for Health System Excellence, Cincinnati Children’s Hospital Medical Center NIH/NICHD K23HD062642 (PI: Grossoehme) NIH/NICHD K23HD052639 (PI: Cotton).
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William D. Hardie, MD
Director, Pulmonary Function Laboratory
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Visit the Hardie Lab. Clinical InterestsPulmonary function tests; pneumonia; empyema Research InterestsGrowth factors in lung remodeling
Education and Training
MD: Vanderbilt University, Nashville, Tenn., 1990.
Residency: Children's Hospital Medical Center, Cincinnati, Ohio.
Fellowship: Children's Hospital Medical Center, Cincinnati, Ohio.
Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.
Publications
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Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86 Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. Hardie WD, Glasser SW, Hagood JS. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol. 2009 Jul;175(1):3-16. Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72. Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.
Hardie WD. 50 Years Ago in The Journal of Pediatrics Pediatric Empyema: A Second Look at its Incidence and Importance. Kiesewetter, WB, Rusnock JR, Girdany BR. J Pediatr 1959;54:81-6. J Pediatr. 2009 Jan 1;154(1):131. Loeb JS, Blower WC, Feldstein JF, Koch BA, Munlin AL, Hardie WD. Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria. Pediatr Pulmonol. 2008 Oct;43(10):1020-4. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54. McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child. Respiration. 2008;76(1):117-8.
Grants
Functional Genomics of Chemical-Induced Acute Lung Injury. Co-Investigator. National Institute of Environmental Health Sciences. Sep 2006 - May 2011. Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis. Principal Investigator. National Heart, Lung, and Blood Institute. Apr 2007 – Mar 2012.
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Patricia M. Joseph, MD
Adult Cystic Fibrosis Center Director, Division of Pulmonary Medicine
Academic Information
na
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Specialties
Transitional care of older adolescents to University of Cincinnati.
Education and Training
MD: University of Tennessee, Knoxville, TN, 1984. Residency: University of Tennessee, Knoxville, TN, 1988. Fellowship: Pulmonary and Critical Care Medicine, Massachusetts General Hospital, MA, 1992; Pediatric Pulmonology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1999-present. Certification: American Board of Pediatrics, 1989-1996; American Board of Internal Medicine, 1989; Pulmonary Medicine, 1992; Critical Care Medicine, 1993.
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Carolyn M. Kercsmar, MD
Co-Director, Pulmonary Medicine
Director, Asthma Center
Academic Information
Professor, UC Department of Pediatrics
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Education and Training
BS: Biology, Baldwin-Wallace College, Cleveland, Ohio, 1972.
MD: Case Western Reserve University, Cleveland, Ohio, 1978.
MS: Anatomy, Case Western Reserve University, Cleveland, Ohio, 1978.
Publications
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Kercsmar C. Exhaled nitric oxide in the diagnosis and management of childhood asthma. Ther Adv Respir Dis. 2010 Apr;4(2):71-82. Kattan M, Kumar R, Bloomberg GR, Mitchell HE, Calatroni A, Gergen PJ, Kercsmar CM, Visness CM, Matsui EJ, Steinbach SF, Szefler SJ, Sorkness CA, Morgan WJ, Teach SJ, Gan VJ. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol. 2010 125:584-92. Rohan J, Drotar D, McNally K, Schluchter M, Riekert K, Vavrek P, Schmidt A, Redline S, Kercsmar C. Adherence to pediatric asthma treatment in economically disadvantaged African-American children and adolescents: an application of growth curve analysis. J Pediatr Psychol. 2010 May;35(4):394-404. Ross KR, Hart MA, Storfer-Isser A, Kibler AM, Johnson NL, Rosen CL, Kercsmar CM, Redline S. Obesity and obesity related co-morbidities in a referral population of children with asthma. Pediatr Pulmonol. 2009 Sep;44(9):877-84. McNally KA, Rohan J, Schluchter M, Riekert KA, Vavrek P, Schmidt A, Redline S, Kercsmar C, Drotar D. Adherence to combined montelukast and fluticasone treatment in economically disadvantaged African American youth with asthma. J Asthma. 2009 Nov;46(9):921-7. Kercsmar CM, McDowell KM. Love it or Lev it: Levalbuterol for severe acute asthma; for now, leave it. J Pediatr. 2009 155:163-64. Short EJ, Kirchner HL, Asaad GR, Fulton S, Lewis B, Eisengart S, Baley J, Kercsmar C, Min MO, Singer LT. Long-term Sequelae of Postnatal Surfactant and Corticosteroid Therapies. BPD J Perinatol. 2008 Jul; 28(7):498-504. Szefler SL, Mirchell H, , Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SJ, , Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu, AH, Wildfire JJ, Busse WW. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008 372:1065-72. Kercsmar CM. Meeting the challenges of asthma: conference summary. Respir Care. 2008 Jun;53(6):787-95. Sobande PO, Kercsmar CM. Inhaled corticosteroids in asthma management. Respir Care. 2008 May;53(5):625-33; discussion 633-4. Review.
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Satish K. Madala, PhD
Research Instructor, Division of Pulmonary Medicine
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
Pulmonary fibrosis; cystic fibrosis; scleroderma
Biography
Dr. Satish K Madala joined the Division of Pulmonary Medicine in 2011, after postdoctoral training in fibrotic disease research in the laboratory of Dr. Thomas A. Wynn, NIAID, NIH. Dr. Madala’s major research interests are to identify cellular and molecular mechanisms of human fibrotic diseases in particular idiopathic pulmonary fibrosis, cystic fibrosis and scleroderma. We use transgenic and non-transgenic mouse models to determine the molecular pathways that dictate pulmonary inflammation and fibrosis.
Education and Training
Postdoctoral training: Immunopathogenesis Section, LPD, NIAD, NIH, Bethesda, USA. PhD: Osmania University, Hyderabad, India.
Publications
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Madala SK, Davidson CR, Schmidt SM, Ikegami M, Hardie WD. MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor activation. Am. J. Res. Cell Mol Biol. 2011 Oct:(in print). Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, Cheever AW, Ramalingam TR. Quantitative assessment of macrophage functions in repair and fibrosis. Curr Protoc Immunol. 2011 Apr; Chapter 14:Unit 14.22. Madala SK, Maxfield MD, Davidson CR, Schmidt SM, Garry D, Ikegami M, Hardie WD, Glasser SW. Rapamycin regulates bleomycin-induced lung damage in SP-C deficient mice. Pulm Med. 2011. Madala SK, Dolan M, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Thomas A. Wynn. Mapping mouse IL-13 binding regions using structure modeling, molecular docking and high-density peptide microarray analysis. Proteins. 2011 Jan;79(1):282-93. Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA. Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology. 2011 Jan;140(1):254-64. Németh K, Keane-Myers A, Brown J, Metcalfe D, Gorham J, Bundoc V,Madala SK, Hodges M, Karpati S, Mezey E . Bone marrow stromal cells use TGF-β to suppress allergic responses in a mouse model of ragweed-induced asthma. PNAS. 2010;107(12):5652-5657. Wilson MS, Madala SK, Ramalingam TR, Thompson RW Mentink-Kane MM, Cheever AW, Thomas A. Wynn. Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med. 2010 Mar;207(3):535-52. Madala SK, Pesce J, Ramalingam TR, Wilson MS, Thompson RW, Minnicozzi S, Mentink-Kane MM, Cheever AW, Thomas A. Wynn. Opposing roles for matrix metalloproteinases 12 and 13 in interleukin 13-dependent tissue remodeling during S. mansoni egg induced fibrosis. J Immunology. 2010;184(7):3955-3963. Ramalingam TR, Pesce JT, Mentink-Kane MM, Madala SK, Cheever AW, Comeau MR, Ziegler SF, Thomas A. Wynn. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunology. 2009;182(10):6452-6459.
Grants
Role of TGFα-induced fibrocytes in pulmonary fibrosis and pulmonary hypertension. Principal Investigator. AHA NCRP Scientist Development Grant. Jan 2012- Dec 2015 Role of IL-31 in immunopathology of Systemic sclerosis (SSc). Principal Investigator. Bristol-Myers Squibb preclinical contract. 2011- 2013 Molecular Interventions for Pulmonary Fibrosis. Co-Principal Investigator. P50HL107159 (PI: Hardie). May 2011- April 2013.
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Karen M. McDowell, MD
Director, Infant Pulmonary Function Lab
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsAsthma; flexible bronchoscopy; general pediatric pulmonology; quality improvement methodologies; infant pulmonary function test Research InterestsClinical asthma research; quality improvement methodologies; infant pulmonary function test
Education and Training
Residency: Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Fellowship: Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Certification: Pediatric Pulmonology, 1996.
MD: Temple University School of Medicine, Philadelphia, Pennsylvania, 1990.
MS: University of Connecticut, Storrs, Connecticut, 1986.
BS: College of William and Mary, Williamsburg, Virginia, 1983.
Publications
View PubMed Publications
McDowell KM, Craven DI. Pulmonary complications of Down syndrome during childhood. J Pediatr. 2011 Feb;158(2):319-25. Kercsmar CM, McDowell KM. Love It or Lev It: The Role of Levalbuterol in Acute Severe Asthma—For now, Leave it. J Pediatr. 2009 155(2):162-164. Richards MM, Banez, GA, McDowell KM. Pediatric Puzzler. Pediatric Perspectives. April 2006. Ogunmola N, Wyllie R, McDowell K, Kay M, Mahajan L. Endoscopic closure of esophagobronchial fistula with fibrin glue. J Pediatr Gastroenterol Nutr. 2004 38(5): 539-541.
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Gary Lewis McPhail, MD
Cystic Fibrosis Center Director, Division of Pulmonary Medicine
Associate Director, Fellowship Training Program
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsMedical Education; outcomes research; quality improvement; sleep medicine; thoracic insufficiency syndrome Research InterestsMedical Education; Pulmonary Vascular Disease; Thoracic Insufficiency Syndrome
Education and Training
MD: University of Texas Southwestern Medical Center, Dallas TX, 2001.
Residency: Children's Medical Center, University of Texas Southwestern, Dallas TX, 2004.
Fellowship: Cincinnati Children's Hospital Medical Center, 2007.
Certification: Pediatrics, 2004; Pediatric Pulmonary, 2008.
Publications
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McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60. McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35 Ednick M, Cohen AP, McPhail GL, Beebe D, Simakajornboon N, Amin RS. A review of the effects of sleep during the first year of life on cognitive, psychomotor, and temperament development. Sleep. 2009 Nov 1;32(11):1449-58. Review. McPhail GL, Acton JD, Fenchel MC, Amin RS, Seid M. Improvements in lung function outcomes in children with cystic fibrosis are associated with better nutrition, fewer chronic pseudomonas aeruginosa infections, and dornase alfa use. J Pediatr. 2008 Dec;153(6):752-7. McPhail GL. Coagulation disorder as a presentation of cystic fibrosis. J Emerg Med. 2010 Apr;38(3):320-2. Amin R, Somers VK, McConnell K, Willging P, Myer C, Sherman M, McPhail G, Morgenthal A, Fenchel M, Bean J, Kimball T, Daniels S. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008 Jan;51(1):84-91. McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child. Respiration. 2008;76(1):117-8.
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Michael Seid, PhD
Director, Health Outcomes and Quality Care Research, Pulmonary Medicine and James M. Anderson Center for Health Systems Excellence
The basic science behind whatto do to improve health include genetics, biology, and chemistry, and physiology; the basic science behind how to do it right is behavioral and social science. Dr. Seid's Lab applies behavioral and social science to answer the question ‘What does it take to make sure the right treatment gets to the right child in the right way at the right time, every time?’ In the lab, we take a noncategorical approach to answering this question, as there are many more similarities than differences across diseases in what it takes to get things right. We also recognize that answering this question requires expertise from many areas: patients and families; clinicians; social scientists like psychologists, sociologists, economists, and anthropologists; designers; story-tellers and artists; systems engineers; organizers; technologists; health informaticians; and epidemiologists and other statisticians. Visit the Seid Lab.
513-803-0083
michael.seid@cchmc.org
Michael Seid, PhD
Director, Health Outcomes and Quality Care Research, Pulmonary Medicine and James M. Anderson Center for Health Systems Excellence
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Health care quality / outcomes Visit the Seid Lab.
Biography
Michael Seid, PhD, is director of Health Outcomes and Quality of Care Research in the Division of Pulmonary Medicine and a core faculty in the James M Anderson Center for Health Systems Excellence at Cincinnati Children's Hospital Medical Center. Dr. Seid applies behavioral and social science to the question ‘What does it take to make sure the right treatment gets to the right child in the right way at the right time, every time?’ Dr. Seid has worked at the Center for Child Health Outcomes at Children's Hospital, San Diego and was a behavioral / research scientist at the RAND Corporation. He has been principal and co-principal investigator of several large multidisciplinary research studies, collaborates with investigators at CCHMC and beyond, and publishes widely in such journals as Medical Care, HSR: Health Services Research, Archives of Pediatrics and Adolescent Medicine, Pediatrics, American Journal of Medical Quality, the Journal of Ambulatory Pediatrics, and Milbank Quarterly. Dr. Seid has served as the chair of Children's Hospital San Diego's Institutional Review Board, as a member of the Health Care Quality and Effectiveness Research (HCQER) Study Section at the Agency for Healthcare Quality and Research, and on several national and local expert panels. He is on the Review Board of the Journal of Clinical Outcomes Management and an ad hoc reviewer for Health Services Research, Pediatrics and the Journal of Ambulatory Pediatrics.
Education and Training
PhD: Psychology, University of Illinois, Urbana-Champaign, 1995.
Publications
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Grossoehme DH, Ragsdale JR, Snow A, Seid M. We were Chosen as a Family: Parents' Evolving Use of Religion when Their Child has Cystic Fibrosis. J Relig Health. 2011 Mar 16. McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60.
Muething SE, Conway PH, Kloppenborg E, Lesko A, Schoettker PJ, Seid M, Kotagal U. Identifying causes of adverse events detected by an automated trigger tool through in-depth analysis. Qual Saf Health Care. 2010 Oct;19(5):435-9. Grossoehme DH, Ragsdale J, Cotton S, Wooldridge JL, Grimes L, Seid M. Parents' religious coping styles in the first year after their child's cystic fibrosis diagnosis. J Health Care Chaplain. 2010 Jul;16(3-4):109-22. Grossoehme DH, Ragsdale J, Wooldridge JL, Cotton S, Seid M. We can handle this: parents' use of religion in the first year following their child's diagnosis with cystic fibrosis. J Health Care Chaplain. 2010 Jul;16(3-4):95-108. Stevens GD, Seid M, Pickering TA, Tsai KY. National disparities in the quality of a medical home for children. Matern Child Health J. 2010 Jul;14(4):580-9. Ernst MM, Wooldridge JL, Conway E, Dressman K, Weiland J, Tucker K, Seid M. Using Quality Improvement Science to Implement a Multidisciplinary Behavioral Intervention Targeting Pediatric Inpatient Airway Clearance. J Pediatr Psychol. 2010 Jan-Feb; 35(1):1. Seid M, Limbers CA, Driscoll KA, Opipari-Arrigan LA, Gelhard LR, & Varni JW. Reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory™ (PedsQL™) Generic Core Scales and Asthma Symptoms Scale in vulnerable children with asthma. Journal of Asthma. 2010;47:170-177. Wirtschafter DD, Pettit J, Kurtin P, Dalsey M, Chance K, Morrow HW, Seid M, Byczkowski TL, Huber TP, Milstein JM, Bowles SM, Fichera S, Kloman S. A statewide quality improvement collaborative to reduce neonatal central line-associated blood stream infections. J Perinatol. 2010 Mar;30(3):170-81. Epub 2009 Nov 26. Fairbrother G, Cassedy A, Ortega-Sanchez IR, Szilagyi PG, Edwards KM, Molinari NA, Donauer S, Henderson D, Ambrose S, Kent D, Poehling K, Weinberg GA, Griffin MR, Hall CB, Finelli L, Bridges C, Staat MA; New Vaccine Surveillance Network (NVSN). High costs of influenza: Direct medical costs of influenza disease in young children. Vaccine. 2010 Jul 12;28(31):4913-9.
Grants
DM Health: Feasibility of a cell-phone adherence trial for underserved youth with T1DM. Co-Principal Investigator. 2009-2011. Pediatric Center for Education and Research on Therapeutics (CERT). Project Principal Investigator / Research Center Director. Agency for Healthcare Research and Quality. 2007 - 2012.
Determinants of Health-Related Quality of Life in JIA. Principal Investigator. National Institutes of Health. 2008 - 2013.
Enhancing PROMIS in Pediatric Pain, Rheumatology, and Rehabilitation Research. Co-Investigator. National Institutes of Health. 2009 - 2013. #U-01AR057940.
Phase II Study of Rapamycin for Complicated Vascular Anomalies. Co-Investigator. National Institutes of Health. 2009 - 2013. #R01FD003712.
Open Source Science: Transforming Chronic Illness Care. Co-Principal Investigator. National Institutes of Health. 2009 - 2014. #1R01DK085719-01.
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Robert E. Wood, PhD, MD
Director, Pulmonary Bronchoscopy Department
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Bronchology and pulmonary alveolar proteinosis
Biography
Dr. Robert Wood, PhD, MD, is a pediatric pulmonary specialist, with particular interest in bronchoscopy. He has played a major role in the development of instrumentation and techniques for flexible bronchoscopy in pediatric patients. He is recognized as a teacher of endoscopic techniques, and has published many papers and book chapters on the subject. Additionally, he has extensive experience with clinical problems in pediatric pulmonary medicine, especially children with complex airway problems and cystic fibrosis. Before coming to Cincinnati Children's Hospital Medical Center, Dr. Wood was on the faculty of Case Western Reserve University in Cleveland, Ohio (1976 to 1983), and the University of North Carolina at Chapel Hill (1983 to 1999).
Education and Training
PhD: Medical Physiology, Vanderbilt University, Nashville, TN, 1968.
MD: Vanderbilt University, Nashville, TN, 1970.
Residency: Pediatrics, Duke University Medical Center, Durham, NC, 1970 to 1972.
Fellowship: Pediatric Metabolism, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD, 1972 to 1974; Pediatric Pulmonology, Case Western Reserve University, Cleveland, OH; Rainbow Babies and Children's Hospital, Cleveland, OH, 1974 to 1976.
Certification: Pediatrics, 1976; Pediatric Pulmonology, 1986, 1997.
Publications
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Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G; NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan;44(1):2-13. Muenzer J, Beck M, Eng CM, Escolar ML, Giugliani R, Guffon NH, Harmatz P, Kamin W, Kampmann C, Kosepglu ST, Link B, Martin RA, Molter DW, MuAoz Rojas MV, Ogilvie JW, Parini R, Ramaswami U, Scarpa M, Schwartz IV, Wood RE, Wraith E. Multidisciplinary Management of Hunter Syndrome. Pediatrics. 2009; 124:e1228-39. Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, Grabowski G, Carey BC, Stevens C, van der Loo JC, Trapnell BC. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008 Nov 24;205(12):2703-10.
Wood RE. Evaluation of the upper airway in children. Curr Opin Pediatr. 2008 Jun;20(3):266-71. Review.
Boesch RP, Daines C, Willging JP, Kaul A, Cohen AP, Wood RE, Amin RS. Advances in the diagnosis and management of chronic pulmonary aspiration in children. Eur Respir J. 2006 Oct;28(4):847-61. Review.
Zur KB, Wood RE, Elluru RG. Pediatric postcricoid vascular malformation: a diagnostic and treatment challenge. Int J Pediatr Otorhinolaryngol. 2005 Dec;69(12):1697-701.
Lim LH, Cotton RT, Azizkhan RG, Wood RE, Cohen AP, Rutter MJ. Complications of metallic stents in the pediatric airway. Otolaryngol Head Neck Surg. 2004 Oct;131(4):355-61. Wood RE. The emerging role of flexible bronchoscopy in pediatrics. Clin Chest Med. 2001 Jun;22(2):311-7, viii. Review.
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Jason C. Woods, PhD
Director, Pulmonary Imaging Research Center
is an imaging scientist who focuses on basic and translational pulmonary MRI and CT. His lab studies new methods for in-vivo assessment of regional pulmonary function, microstructure and physiology using hyperpolarized gases (3He and 129Xe) and 1H MRI, in addition to multi-volume CT. As new therapeutics for pulmonary diseases are developed, these new methods will be used for efficacy assessment and potential image guidance.
513-803-4463
jason.woods@cchmc.org
Jason C. Woods, PhD
Director, Pulmonary Imaging Research Center
Academic Information
Professor, Division of Pediatric Radiology
Professor, UC Department of Pediatrics
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Specialties
Pulmonary MRI translational studies; image-guided pulmonary interventions
Biography
Dr. Woods is one of the world’s leading experts on hyperpolarized-gas MRI and the use of such gas MRI to measure regional lung function, microstructure and physiology. He began his career at Washington University, where he helped lead multiple team projects related to lung imaging, biology and physiology. Interests in both world-class science and higher education led him to pursue simultaneous roles as a professor and academic dean, when he became program director for Washington University’s MARC (T34) training program. Currently Dr. Woods directs the Pulmonary Imaging Research Center at Cincinnati Children’s Hospital Medical Center—a multidisciplinary research and training program between Pulmonary Medicine and Radiology.
Education and Training
PhD: Washington University, St. Louis, MO, 2002. Postdoctoral: Washington University, St. Louis, MO, 2004.
Publications
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DA Yablonskiy, AL Sukstanskii, JD Quirk, JC Woods, MS Conradi. Probing Lung Microstructure in Health and Disease with Hyperpolarized Noble Gases Diffusion MRI: Theoretical Models and Experimental Results. Magn Reson Med. Epub ahead of print. 2013 Apr. M Castro, JC Woods. Insights into pediatric asthma with hyperpolarized MRI of the Lung. J Allergy Clin Immunol. 2013;131:377-378. AJ Hajari, DA Yablonskiy, AL Sukstanskii, JD Quirk, MS Conradi, JC Woods. Morphometric changes in the human pulmonary acinus during inflation. J Appl Physiol. 2012;112:937-43. A Aliverti, F Pennati, C Salito, JC Woods. Regional lung function and heterogeneity of specific gas volume in health and emphysema. Eur Resp J2012. 2012 Aug 9. W Wang, NM Nguyen, E Agapov, DA Yablonskiy, MJ Holtzman, JC Woods. Monitoring in-vivo changes in lung microstructure with 3He MRI in Sendai-virus infected mice. J Appl Physiol. 2012;112:1593-1599. W Wang, NM Nguyen, DA Yablonskiy, AL Sukstanskii, E Osmanagic, JJ Atkinson, MS Conradi, JC Woods. Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI. Mag Reson Med. 2011;65:620-626. JD Quirk, BA Lutey, DS Gierada, JC Woods, RM Senior, SS Lefrak, AL Sukstanskii, MS Conradi, DA Yablonskiy. Detection of Acinar Microstructural Changes in Early Emphysema by in vivo Lung Morphometry with Hyperpolarized 3He MRI. Radiology. 2011;260:866-874. JE McDonough, R Yuan, M Suzuki, N Seyednejad, WM Elliott, PG Sanchez, AC Wright, WB Gefter, L Litzky, HO Coxson, PD Paré, DD Sin, RA Pierce, JC Woods, JD Cooper, JC Hogg. The relationship between small airway obstruction and emphysematous destruction in chronic obstructive pulmonary disease. New Engl J Med. 2011;365:1567-1575. C Salito, JC Woods, A Aliverti. 3-D airway tree reconstruction in healthy subjects and emphysema patients. Lung. 2011;189:287-293. AH Hajari, DA Yablonskiy, JD Quirk, AL Sukstanskii, RA Pierce, G Deslée, MS Conradi, JC Woods. Alveolar-duct geometry during expiration via 3He lung morphometry. J Appl Physiol. 2011;110:1448-54.
Grants
Single-session bronchial thermoplasty for severe asthmatics guided by HXe MRI. Co-Principal Investigator. NHLBI. Sep 2012 – Aug 2015. Regulatory Advancement of HXe as a Diagnostic MRI Contrast Agent. Co-Principal Investigator. NHLBI. Sep 2011 – Aug 2014. Severe Asthma Research Program (SARP). Investigator. NHLBI. Aug 2011 – Jul 2017. Evaluation of Endobronchial Interventions for COPD via CT and 3He MRI. Principal Investigator. NHLBI. Aug 2008 – Jul 2013.
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Jamie L. Wooldridge, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Cystic fibrosis; cystic fibrosis related diabetes
Education and Training
MD: Indiana University, Indianapolis, IN 1995
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Residency: Pediatrics, Indiana University, Indianapolis, IN, 1998.
Fellowship: Pediatric Pulmonology, University of Colorado Health Sciences Center, 2001.
Certification: Pediatrics, 1998; Pediatric Pulmonology, 2002.
Publications
View PubMed Publications
Grossoehme DH, Ragsdale J, Cotton S, Wooldridge JL, Grimes L, Seid M. Parents' religious coping styles in the first year after their child's cystic fibrosis diagnosis. J Health Care Chaplain. 2010 Jul;16(3-4):109-22.
Grossoehme DH, Ragsdale J, Wooldridge JL, Cotton S, Seid M. We can handle this: parents' use of religion in the first year following their child's diagnosis with cystic fibrosis. J Health Care Chaplain. 2010 Jul;16(3-4):95-108.
Modi AC, Lim CS, Driscoll KA, Piazza-Waggoner C, Quittner AL, Wooldridge J. Changes in pediatric health-related quality of life in cystic fibrosis after IV antibiotic treatment for pulmonary exacerbations. J Clin Psychol Med Settings. 2010 Mar;17(1):49-55.
Wooldridge JL, Heubi JE, Amaro-Galvez R, Boas SR, Blake KV, Nasr SZ, Chatfield B, McColley SA, Woo MS, Hardy KA, Kravitz RM, Straforini C, Anelli M, Lee C. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009 Dec;8(6):405-17. Ernst MM, Wooldridge JL, Conway E, Dressman K, Weiland J, Tucker K, Seid M. Using quality improvement science to implement a multidisciplinary behavioral intervention targeting pediatric inpatient airway clearance. J Pediatr Psychol. 2010 Jan-Feb;35(1):14-24.
Elder DA, Wooldridge JL, Dolan LM, D’Alessio DA. Glucose Tolerance, Insulin Secretion and Insulin Sensitivity in Children and Adolescents with Cystic Fibrosis and No Prior History of Diabetes. J Pediatr 2007;151(6):653-8. Xu Y, Clark JC, Aronow BJ, Dey CR, Liu C, Wooldridge JL, Whitsett JA. Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency. J Biol Chem. 2003 Feb 28;278(9):7674-82.
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