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Ovarian cancer is the fourth leading cause of cancer death in American women after lung, breast and colorectal cancers. While the incidence of ovarian cancer has declined recently, the death rate has not, in part because it is difficult to diagnose the disease in the early stages. The underlying causes of epithelial ovarian cancers (EOC) are poorly understood and there are few treatment options for patients with advanced cases. Thus, it is an extremely important area for intense research.
We showed, for the first time, that Cox-1 plays roles in EOC carcinogenesis and that its selective inhibitor, SX-560, reduces EOC growth.
Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, DuBois RN, Dey SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res. 67:5285-5292. 2007.
Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65:3735-3744. 2005.
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