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Our research primarily focuses on genetic, epigenetic, and molecular mechanisms governing the aspects of uterine cell proliferation and differentiation in early pregnancy, as well as under the control of natural estrogen and xenoestrogens. We are currently interested on two major research areas. First, we primarily addresses at the genomic/epigenomic mechanisms for natural estrogen and xenoestrogen mediated actions in uterine cell biology. Another area of research specifically investigates mechanism of cell cycle regulation for the progression of uterine stromal cell differentiation for decidualization in implantation.
One branch of our research investigates the nongenomic actions of natural estrogen and xenoestrogens in the uterus, exclusive of known estrogen receptors.
We also examine aspects of uterine cell cycle regulation of decidualization in implantation.
Chung D, Gao F, Jegga AG and Das SK. Estrogen mediated epithelial cell proliferation in the uterus is directed by stromal Fgf10 and Bmp8a. Molecular Cellular Endocrinology. 2015 Jan 15;400:48-60.
Gao F and Das SK. Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization. Biomolecular Concepts. 2014 May;5(2):95-107.
Sroga JM, Gao F, Ma X and Das SK. Over-expression of cyclin D3 improves decidualization defects in Hoxa-10-/- mice. Endocrinology. 2012 Nov;153(11):5575-86.
Gao F, Ma X, Rusie A, Hemingway J, Ostmann AB, Chung D and Das SK. Epigenetic changes through DNA methylation contribute to uterine stromal cell decidualization. Endocrinology. 2012 Dec;153(12):6078-90.
Chung D, Gao F, Ostmann A, Hou X and Das SK. Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα. Molecular Endocrinology. 2012 Mar;26(3):385-98.
Sroga JM, Ma X and Das SK. Developmental regulation of decidual cell polyploidy at the site of implantation. Frontiers in Bioscience (Schol Ed). 2012 Jun 1;4:1475-86.
Das SK. The facilitative glucose transporter SLC2A8 regulates reproductive outcomes and growth phenotype in mice. Biology of Reproduction. 2012 Aug 30;87(2):48.
Das SK. Contribution of Maternal NODAL to Term Pregnancy. Biology of Reproduction. 2012 Jun 28;86(6):193.
Ma X, Gao F, Rusie A, Hemingway J, Ostmann AB, Sroga JM, Jegga AG and Das SK. Decidual cell polyploidization necessitates mitochondrial activity. PLoS ONE. 2011;6(10):e26774.
Chung D, Das SK. Mouse primary uterine cell co-culture system revisited: ovarian hormones mimic the aspects of in vivo uterine cell proliferation. Endocrinology. 2011 Aug;152(8):3246-58.
Gao F, Ma X, Ostmann AB, Das SK. GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERa) phosphorylation signals. Endocrinology. 2011 Apr;152(4):1434-47.
Das SK. Regional development of uterine decidualization: molecular signaling by Hoxa-10.Mol Reprod Dev. 2010 May;77(5):387-96.
Das SK, Dey SK. Embryo-uterine interactions during implantation: potential sites of interference by environmental toxins. In: Comprehensive Toxicology, Chapter 11.21; Reproductive and Endocrine Toxicology (Volume Eds: J Richburg and P Hoyer) 2nd Edition (Ed: CA McQueen), Academic Press, New York, pp 419-443. 2010.
Das SK. Cell cycle regulatory control for uterine stromal cell decidualization in implantation. Reproduction. 2009 Jun;137(6):889-99.
Ray S, Xu F, Wang H, Das SK. Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Molecular Endocrinology. 2008 May;22(5):1125-40.
Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, Wang H. Inactivation of nuclear Wnt-b-catenin signaling limits blastocyst competency for implantation. Development. 2008 Feb;135(4):717-27.
Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK. Stage-specific integration of maternal and embryonic Peroxisome Proliferator-activated Receptor d signaling is critical to pregnancy success. Journal of Biological Chemistry. 2007 Dec 28;282(52):37770-82.
Xie H, Wang H, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK, Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proceedings of the National Academy of Science, USA. 2007 Nov 13;104(46):18315-20.
Ray S, Xu F, Li P, Sanchez NS, Wang H, Das SK. Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus. Endocrinology. 2007 Oct;148(10):4774-85.
Desmarais JA, Lopes FL, Zhang H, Das SK, Murphy BD. The peroxisome proliferator-activated receptor-gamma regulates trophoblast cell differentiation in mink (Mustela vison). Biology of Reproduction. 2007 Nov;77(5):829-39.
Ray S, Hou X, Zhou HE, Wang H, Das SK. Bip is a molecular link between the phase-I and phase-II estrogenic responses in uterus. Molecular Endocrinology. 2006 Aug;20(8):1825-37.
Ray S, Das SK. Chromatin immunoprecipitation assay detects ERa recruitment to gene specific promoters in uterus. Biological Procedures Online. 2006;8:69-76.
Rahman MA, Li M, Li P, Wang H, Dey SK, Das SK. Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization. Developmental Biology. 2006 Feb 1;290(1):105-17.
Hou X, Tan Y, Li M, Dey SK, Das SK. Canonical Wnt Signaling Is Critical to Estrogen Mediated Uterine Growth. Molecular Endocrinology. 2004 Dec;18(12):3035-49.
Tan Y, Li M, Cox S, Davis MK, Tawfik O, Paria BC, Das SK. HB-EGF directs stromal cell polyploidy and decidualization via Cyclin D3 during implantation. Developmental Biology. 2004 Jan 1;265(1):181-95.
Tan J, Raja S, Davis MK, Tawfik O, Dey SK, Das SK. Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation. Mechanisms of Development. 2002 Feb;111(1-2):99-113.
Das SK, Tan J, Raja S, Halder J, Paria BC, Dey SK. Estrogen targets genes involved in protein processing, calcium homeostasis and Wnt signaling in the mouse uterus independent of estrogen receptor -alpha and -beta. Journal of Biological Chemistry. 2000 Sep 15;275(37):28834-42.
Paria BC, Tan J, Lubahn DB, Dey SK, Das SK. Uterine decidual response occurs in estrogen receptor-alpha-deficient mice. Endocrinology. 1999 Jun;140(6):2704-10.
Tan J, Paria BC, Dey SK, Das SK. Differential uterine expression of estrogen and progesterone receptors correlates with uterine preparation for implantation and decidualization in the mouse. Endocrinology. 1999 Nov;140(11):5310-21.
Das SK, Taylor JA, Korach KS, Paria BC, Dey SK, Lubahn DB. Estrogenic responses in estrogen receptor‑deficient mice reveal a novel estrogen signaling pathway. Proceedings of the National Academy of Science, USA. 1997 Nov 25;94(24):12786-91.
Das SK, Yano S, Wang J, Edwards DR, Nagase H, Dey SK. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the periimplantation period. Developmental Genetics. 1997;21(1):44-54.
Das SK, Chakraborty I, Paria BC, Wang X‑N, Plowman G, Dey SK. Amphiregulin is an implantation‑specific and progesterone‑regulated gene in the mouse uterus. Molecular Endocrinology. 1995 Jun;9(6):691-705.
Das SK, Paria BC, Chakraborty I, Dey SK. Cannabinoid ligand‑receptor signaling in the mouse uterus. Proceedings of the National Academy Science, USA. 1995 May 9;92(10):4332-6.
Das SK, Tsukamura H, Paria BC, Andrews GK, Dey SK. Differential expression of epidermal growth factor receptor (EGF‑R) gene and regulation of EGF‑R bioactivity by progesterone and estrogen in the adult mouse uterus. Endocrinology. 1994 Feb;134(2):971-81.
Das SK, Wang X‑N, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK, Dey SK. Heparin‑binding EGF‑like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: A possible ligand for interaction with blastocyst EGF‑receptor in implantation. Development. 1994 May;120(5):1071-83.
Sanjoy K. Das, PhDProfessorUC Department of Pediatrics
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