(All fields required)
Please enter a valid email.
Please enter your name.
Our research primarily focuses on genetic, epigenetic, and molecular mechanisms governing the aspects of uterine cell proliferation and differentiation in early pregnancy, as well as under the control of natural estrogen and xenoestrogens. We are currently interested on two major research areas. First, we primarily addresses at the genomic/epigenomic mechanisms for natural estrogen and xenoestrogen mediated actions in uterine cell biology. Another area of research specifically investigates mechanism of cell cycle regulation for the progression of uterine stromal cell differentiation for decidualization in implantation.
One branch of our research investigates the nongenomic actions of natural estrogen and xenoestrogens in the uterus, exclusive of known estrogen receptors.
We also examine aspects of uterine cell cycle regulation of decidualization in implantation.
Chung D, Gao F, Jegga AG and Das SK. Estrogen mediated epithelial cell proliferation in the uterus is directed by stroma-derived Fgf10 and Bmp8a. Molecular Cellular Endocrinology. 2014 Nov 7; 400C:48-60. doi: 10.1016/j.mce.2014.11.002. [Epub ahead of print] PMID: 25451979
Gao F and Das SK. Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.Biomolecular Concepts. 5: 95-107. 2014
Sroga JM, Gao F, Ma X and Das SK. Over-expression of cyclin D3 improves decidualization defects in Hoxa-10-/- mice. Endocrinology. 153:5575-5586. 2012.
Gao F, Ma X, Rusie A, Hemingway J, Ostmann AB, Chung D and Das SK. Epigenetic changes through DNA methylation contribute to uterine stromal cell decidualization.Endocrinology. 153:6078-6090. 2012
Chung D, Gao F, Ostmann A, Hou X and Das SK.Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα.Molecular Endocrinology. 26:385-398. 2012
Sroga JM, Ma X and Das SK. Developmental regulation of decidual cell polyploidy at the site of implantation.Frontiers in Bioscience (Schol Ed). 4:1475-1486. 2012
Das SK. The facilitative glucose transporter SLC2A8 regulates reproductive outcomes and growth phenotype in mice. Biology of Reproduction. 87:48, 1–2. 2012
Das SK. Contribution of Maternal NODAL to Term Pregnancy.Biology of Reproduction. 86:193, 1–2. 2012
Ma X, Gao F, Rusie A, Hemingway J, Ostmann AB, Sroga JM, Jegga AG and Das SK. Decidual cell polyploidization necessitates mitochondrial activity. PLoS ONE. 6(10): e26774. 2011.
Chung D, Das SK. Mouse primary uterine cell co-culture system revisited: ovarian hormones mimic the aspects of in vivo uterine cell proliferation. Endocrinology. 152:3246-3258. 2011
Gao F, Ma X, Ostmann AB, Das SK. GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERa) phosphorylation signals. Endocrinology. 152:1434-1447. 2011
Das SK. Regional development of uterine decidualization: molecular signaling by Hoxa-10. Mol Reprod Dev. 77:387-96. 2010.
Das SK, Dey SK. Embryo-uterine interactions during implantation: potential sites of interference by environmental toxins. In: Comprehensive Toxicology, Chapter 11.21; Reproductive and Endocrine Toxicology (Volume Eds: J Richburg and P Hoyer) 2nd Edition (Ed: CA McQueen), Academic Press, New York, pp 419-443. 2010.
Das SK. Cell cycle regulatory control for uterine stromal cell decidualization in implantation. Reproduction. 137:889-899. 2009.
Ray S, Xu F, Wang H, Das SK. Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Molecular Endocrinology. 22:1125-1140. 2008.
Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, Wang H. Inactivation of nuclear Wnt-b-catenin signaling limits blastocyst competency for implantation. Development. 135:717-727. 2008.
Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK. Stage-specific integration of maternal and embryonic Peroxisome Proliferator-activated Receptor d signaling is critical to pregnancy success. Journal of Biological Chemistry. 282:37770-37782. 2007.
Xie H, Wang H, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK, Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proceedings of the National Academy of Science, USA. 104:18315-18320. 2007.
Ray S, Xu F, Li P, Sanchez NS, Wang H, Das SK. Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus. Endocrinology. 148:4774-4785. 2007.
Desmarais JA, Lopes FL, Zhang H, Das SK, Murphy BD. The peroxisome proliferator-activated receptor-gamma regulates trophoblast cell differentiation in mink (Mustela vison). Biology of Reproduction. 77:829-839. 2007.
Ray S, Hou X, Zhou HE, Wang H, Das SK. Bip is a molecular link between the phase-I and phase-II estrogenic responses in uterus. Molecular Endocrinology. 20:1825-1837. 2006.
Ray S, Das SK. Chromatin immunoprecipitation assay detects ERa recruitment to gene specific promoters in uterus. Biological Procedures Online. 8:69-76. 2006.
Rahman MA, Li M, Li P, Wang H, Dey SK, Das SK. Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization. Developmental Biology. 290:105-117. 2006.
Hou X, Tan Y, Li M, Dey SK, Das SK. Canonical Wnt Signaling Is Critical to Estrogen Mediated Uterine Growth. Molecular Endocrinology. 18:3035-3049. 2004.
Tan Y, Li M, Cox S, Davis MK, Tawfik O, Paria BC, Das SK.HB-EGF directs stromal cell polyploidy and decidualization via Cyclin D3 during implantation. Developmental Biology. 265:181-195. 2004.
Tan J, Raja S, Davis MK, Tawfik O, Dey SK, Das SK. Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation. Mechanisms of Development. 111:99-113. 2002.
Das SK, Tan J, Raja S, Halder J, Paria BC, Dey SK. Estrogen targets genes involved in protein processing, calcium homeostasis and Wnt signaling in the mouse uterus independent of estrogen receptor -alpha and -beta.Journal of Biological Chemistry. 275:28834-28842. 2000.
Paria BC, Tan J, Lubahn DB, Dey SK, Das SK. Uterine decidual response occurs in estrogen receptor-alpha-deficient mice. Endocrinology. 140:2704-2710. 1999.
Tan J, Paria BC, Dey SK, Das SK. Differential uterine expression of estrogen and progesterone receptors correlates with uterine preparation for implantation and decidualization in the mouse. Endocrinology. 140: 5310-5321. 1999.
Das SK, Taylor JA, Korach KS, Paria BC, Dey SK, Lubahn DB. Estrogenic responses in estrogen receptor‑deficient mice reveal a novel estrogen signaling pathway. Proceedings of the National Academy of Science, USA.94:12786-12791. 1997.
Das SK, Yano S, Wang J, Edwards DR, Nagase H, Dey SK. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the periimplantation period.Developmental Genetics. 21:44-54. 1997.
Das SK, Chakraborty I, Paria BC, Wang X‑N, Plowman G, Dey SK. Amphiregulin is an implantation‑specific and progesterone‑regulated gene in the mouse uterus.Molecular Endocrinology. 9:691‑705. 1995.
Das SK, Paria BC, Chakraborty I, Dey SK. Cannabinoid ligand‑receptor signaling in the mouse uterus.Proceedings of the National Academy Science, USA. 92:4332‑4336. 1995.
Das SK, Tsukamura H, Paria BC, Andrews GK, Dey SK. Differential expression of epidermal growth factor receptor (EGF‑R) gene and regulation of EGF‑R bioactivity by progesterone and estrogen in the adult mouse uterus. Endocrinology. 134:971‑981. 1994.
Das SK, Wang X‑N, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK, Dey SK. Heparin‑binding EGF‑like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: A possible ligand for interaction with blastocyst EGF‑receptor in implantation. Development.120:1071‑1083. 1994.
Sanjoy K. Das, PhDProfessor
Division of Reproductive Sciences3333 Burnet Ave.MLC 7045Cincinnati, OH 45229 Phone: 513-803-1159Fax: 513-803-1160Email: firstname.lastname@example.org
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY: 1-513-636-4900
New to Cincinnati Children’s or live outside of the Tristate area? 1-877-881-8479
© 1999-2014 Cincinnati Children's Hospital Medical Center