Takiko Daikoku, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Endometrial cancer and ovarian cancer initiation; molecular and genetic clues to embryo-uterine interactions during implantation Visit the Daikoku Lab.
Education and Training
PhD: The University of Tokushima/Japan, 2000.
MS: The University of Tokushima/Japan, 1997.
BS: The University of Tokushima/Japan, 1995 .
Publications
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Daikoku T, Jackson L, Besnard V, Whitsett J, Ellenson LH, Dey SK. Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes. Gynecol Oncol. 2011 May 12. Hirota Y, Acar N, Tranguch S, Burnum KE, Xie H, Kodama A, Osuga Y, Ustunel I, Friedman DB, Caprioli RM, Daikoku T, Dey SK. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci USA. 2010 Aug 31;107(35):15577-82. Hirota Y, Daikoku T, Tranguch S, Xie H, Bradshaw HB, Dey SK. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest. 2010 Mar 1;120(3):803-15. Sun X, Jackson L, Dey SK, Daikoku T. In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. Endocrinology. 2009 Nov;150(11):5065-73. Zhuge Y, Lagman JA, Ansenberger K, Mahon CH, Daikoku T, Dey SK, Bahr JM, Hales DB. CYP1B1 expression in ovarian cancer in the laying hen Gallus domesticus. Gynecol Oncol. 2009;112:171-178. Brown AJ, Alicknavitch M, D’Souza SS, Daikoku T, Kim-Safran CB, Marchetti D, Carson DD, Farach-Carson MC. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008;43:689-699. Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008;68:9331-9337. Daikoku T, Dey SK. Two faces of PTEN. Nat Med. 2008:11:1192-1193. Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK. Deficiency of immunophilin FKBP52 promotes endometriosis. Am J Pathology. 2008;173:1747-1757. Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008;68(14): 5619-5627.
Grants
Endocannabinoid Signaling During Early Pregnancy. Co-Investigator. National Institute on Drug Abuse. Feb 1997 - Nov 2012. #R37DA006668.
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Sanjoy K. Das, PhD
focuses on two independent areas: 1) Characterization of non-genomic actions of natural estrogen and xenoestrogens in the uterus without involving the nuclear ERα and ERβ, and 2) Aspects of uterine cell cycle regulation for decidualization in implantation. Visit the Das Lab.
513-803-1159
sanjoy.das@cchmc.org
Sanjoy K. Das, PhD
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Characterization of non-genomic actions of natural estrogen and xenoestrogens in the uterus without involving the nuclear ERa and ERb; aspects of uterine cell cycle regulation for decidualization in implantation Visit the Das Lab.
Education and Training
PhD: Biochemistry, University of Calcutta, Calcutta, India. MSc: Biochemistry, University of Calcutta, Calcutta, India. BSc: Chemistry (Honors), University of Calcutta, Calcutta, India.
Publications
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Gao F, Ma X, Ostmann AB, Das SK. GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals. Endocrinology. 2011 Apr;152(4):1434-47.
Das SK. Regional development of uterine decidualization: molecular signaling by Hoxa-10. Mol Reprod Dev. 2010 May;77(5):387-96. Review. Das SK. Cell cycle regulatory control for uterine stromal cell decidualization in implantation. Reproduction. 2009 Jun;137(6):889-99. Davies SM, Borowitz MJ, Rosner GL, Ritz K, Devidas M, Winick N, Martin PL, Bowman P, Elliott J, Willman C, Das S, Cook EH, Relling MV. Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008 Mar 15;111(6):2984-90. Ray S, Xu F, Wang H, Das SK. Cooperative Control via Lymphoid Enhancer Factor 1/T Cell Factor 3 and Estrogen Receptor-a for Uterine Gene Regulation by Estrogen. Molecular Endocrinology. 2008;22:1125-40. Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, Wang H. Inactivation of nuclear Wnt-b-catenin signaling limits blastocyst competency for implantation. Development. 2008;135:717-27. Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK. Stage-specific integration of maternal and embryonic Peroxisome Proliferator-activated Receptor d signaling is critical to pregnancy success. Journal of Biological Chemistry. 2007;282:37770-82. Xie H, Wang H, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK, Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proceedings of the National Academy of Science USA. 2007;104:18315-20. Ray S, Xu F, Li P, Sanchez NS, Wang H, Das SK. Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus. Endocrinology. 2007;148:4774-85.
Grants
Environmental Toxins and Uterine Gene Expression. National Institute of Environmental Health Sciences. May 1997- May 2013.
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Tony J. De Falco, PhD
has basic research programs in gonad differentiation and homeostasis. His lab investigates how the initially undifferentiated gonad primordium transforms into a testis or ovary, as well as how the adult testis maintains sperm production over a long reproductive lifespan. His specific interests are in the novel and diverse roles of myeloid immune cells in reproductive biology. Visit the De Falco Lab.
513-803-3988
tony.defalco@cchmc.org
Tony J. De Falco, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Differentiation of the fetal gonad into a sexually dimorphic and structurally specialized organ; spermatogonial differentiation; roles of myeloid cells in tissue remodeling, organ vascularization and spermatogonial development. Visit the De Falco Lab.
Education and Training
BA: University of Virginia, Charlottesville, VA. PhD: Johns Hopkins University, Baltimore, MD. Postdoc: Duke University Medical Center, Durham, NC. Postdoc: National Institute of Genetics, Mishima, Japan.
Publications
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Cool J, DeFalco T, Capel B. Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. WIREs Dev Biol. 2012. Jameson S, Natarajan A, Cool J, DeFalco T, Maatouk D, Mork L, Munger SC, Capel B. Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. PLoS Genet. 2012;8(3).
DeFalco T, Takahashi S, Capel B. Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol. 2011;352:14-26.
Cool J, DeFalco TJ, Capel B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proc Natl Acad Sci USA. 2011;108:167-172.
DeFalco T, Capel B. Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annu Rev Cell Dev Biol. 2009;25:457-482.
Nanda S, DeFalco TJ, Loh SH, Phochanukul N, Camara N, Van Doren M, Russell S. Sox100B, a Drosophila group E Sox-domain gene, is required for somatic testis differentiation. Sex Dev. 2009;3:26-37.
DeFalco T, Camara N, Le Bras S, Van Doren M. Nonautonomous sex determination controls sexually dimorphic development of the Drosophila gonad. Dev Cell. 2008;14:275-286.
DeFalco T, Le Bras S, Van Doren M. Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad. Mech Dev. 2004;121(11):1323-1333.
DeFalco TJ, Verney G, Jenkins AB, McCaffery JM, Russell S, Van Doren M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell. 2003;5:205-216.
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Satoshi H. Namekawa, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
The long-term goal of my research is to understand the mechanisms and evolution of epigenetic events during mammalian reproduction. One of our focus areas is epigenetic regulation of sex chromosomes in germ cell development. Recently, my laboratory demonstrated that DNA damage response pathways trigger epigenetic programming on the sex chromosomes in germ cells. An on-going direction of my laboratory is to pursue a general link between DNA damage response pathways and epigenetic programming. Another goal of my laboratory is to identify novel factors and related pathways that control epigenetic programming during mouse reproduction, especially focusing on the events occurring on sex chromosomes during spermatogenesis as well as the regulatory mechanisms in germline stem cells. Visit the Namekawa Lab
Biography
Dr. Namekawa received his PhD from Tokyo University of Science in 2005. He completed postdoctoral training in the laboratory of Dr. Jeannie T. Lee at Massachusetts General Hospital and Harvard Medical School in 2009, followed by his faculty appointment at Cincinnati Children's in 2009. He is funded by NIH R01 Award and the Basil O’Connor Award from March of Dimes Foundation.
Education and Training
PhD: Tokyo University of Science, Japan, 2005.
BS: Tokyo University of Science, Japan, 2000.
Publications
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Sin, H. S., Barski, A., Zhang, F., Kartashov, A. V., Nussenzweig, A.,Chen,J., Andreassen,P. R.,and Namekawa, S. H.*RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in postmeiotic spermatids. Genes Dev, Dec 15:26(24)2737-2748. 2012. *Corresponding author Ichijima, Y., Sin,H. S., and Namekawa, S. H. Sex chromosome inactivation in germ cells: Emerging roles of DNA damage response pathways. Cell. Mol. Life. Sci, Aug;69(15):2559-72.2012. Sin, H. S., Ichijima, Y., Koh, E.,Namiki, M., and Namekawa, S. H. Human post meiotic sex chromatin and its impact on sex chromosome evolution.Genome Res, May;22(5):827-36.2012. Anguera, M. C., Ma, W., Clift, D., Namekawa, S. H., Kelleher III, R. J, and Lee, J. T. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PloS Genet,. Sep;7(9):e1002248. Epub 2011 Sep 1. 2011. Payer, B., Lee, J. T., and Namekawa, S. H. X-inactivation and X-reactivation: Epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet, Aug;130(2):265-80. Epub 2011 Jun 12. 2011. Ichijima, Y., Ichijima,M., Lou, Z., Nussenzweig, A.,Camerini-Otero,R. D., Chen,J., Andreassen,P. R., and Namekawa, S. H. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev, May 1;25(9):959-71. 2011. Namekawa, S. H. and Lee, J. T. Detection of nascent RNA, single-copy DNA, and protein localization by immunoFISH in murine germ cells and pre-implantation embryos.Nature Protocols. Feb;6(3):270-84. Epub 2011 Feb 10. 2011. Namekawa, S. H., Payer, B., Huynh K. D., Jaenisch, R., and Lee, J. T Two-step imprinted X-inactivation: Repeat vs genic silencing in the mice. Mol Cell Biol Jul;30(13):3187-205. Epub 2010 Apr 19. 2010. Namekawa, S. H. and Lee, J. T. XY and ZW: is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. May;5(5):e1000493. Epub 2009 May 22. 2009. Namekawa, S. H., VandeBerg, J. L., McCarrey, J. R., and Lee, J. T. Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A,104, 9730-9735. 2007. Kim, S., Namekawa, S. H., Niswander, L. M., Ward, J. O., Lee, J. T., Bardwell, V. J., and Zarkower, D.A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet,3, e62. 2007. Namekawa, S. H., Park, P. J., Zhang, L. F., Shima, J. E., McCarrey, J. R., Griswold, M. D., and Lee, J. T. Postmeiotic sex chromatin in the male germline of mice. Curr Biol, 16, 660-667. 2006.
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Yuya Ogawa, PhD
is interested in how non-coding RNAs impact gene regulation and development in animals using X-chromosome inactivation as a model system
513-803-1949
yuya.ogawa@cchmc.org
Yuya Ogawa, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
In mammalian females, one of the two X-chromosomes is silenced to correct the imbalance of X-linked gene dosage between males (Xy) and females (XX). This chromosome-wide gene silencing is induced by a long noncoding RNA, Xist RNA.
Our laboratory is interested in the mechanisms of: (1) how the chromosome-wide silencing is induced by Xist RNA and (2) how the long-range silencing is maintained and organized. Our long-term goal is to understand how noncoding RNAs impact gene regulation and development in animals.
Education and Training
PhD: Biology, Osaka University, Japan, 1998.
MS: Molecular Biology, Nagoya University, Japan, 1994.
BS: Molecular Biology, Nagoya University, Japan, 1992.
Publications
Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT. Telomeric RNAs mark sex chromosomes in stem cells. Genetics. 2009 182,685-98. Ogawa Y, Sun BK, Lee JT. Intersection of the RNA interference and X-inactivation pathways. Science. 2008 320,1336-41.
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