Brunner

Patricia Vega-Fernandez, Eyal Muscal, Natasha M.Ruth, Frank Zelko, Andrea Vincent, Erin C. Thomas, Marisa S. Klein-Gitelman, Debra Canter, Alison Tian, Lisa Ravindra, HaiMei Liu, Jessica Hummel, Deborah M. Levy, Hermine Brunner and Tresa Roebuck-Spencer. Pediatric automated Neuropsychological Assessment Metrics As a Screening Tool for Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus. #280; Arthritis & Rheumatism, Vol 64 (Suppl): S121. 2012.

Patricia Vega-Fernandez, Marisa S. Klein-Gitelman, Jessica Hummel, Erin C. Thomas, Jennifer L. Huggins, Frank Zelko, Tresa Roebuck-Spencer, Jun Ying and Hermine Brunner. #281; The Pediatric Automated Neuropsychological Assessment Metrics -Reproducibility and Responsive to Change in Cognition in Childhood-Onset Lupus. Arthritis & Rheumatism, Vol 64 (Suppl): S122. 2012.

Alexandria J. Greenler, Laura E. Schanberg, Michael P. Flannery, Shannen Nelson, Janet Wootton, Esi M. Morgan DeWitt and Hermine I. Brunner. Validation of Promis Modules for Use in Childhood-Onset Lupus. # 288; Arthritis & Rheumatism, Vol 64 (Suppl): S126. 2012.

Rina Mina, Marisa S. Klein-Gitelman,Shannen Nelson, Lori B. Tucker, B. Anne Eberhard, Nora G. Singer,Deborah M. Levy, Kathleen A. Haines, Karen Onel, Marilynn G. Punaro,Kathleen M. O’Neil, Michael Henrickson, Jun Ying and HermineI. Brunner. Effects of Obesity On Health-Related Quality of Life in Childhood-Onset Systemic Lupus Erythematosus. #294; Arthritis & Rheumatism, Vol 64 (Suppl): S129. 2012.

Ravi Nunna ,Rina Mina, Michael Bennett  Shannen Nelson, Jessica Hummel, Prasad Devarajan, David Witte and Hermine I. Brunner. Clinicopathologic Correlates for Activity and Damage of Lupus Nephritis in Childhood-Onset Systemic Lupus Erythematosus. # 305; Arthritis & Rheumatism, Vol 64 (Suppl): S134. 2012.

Hermine I. Brunner ,Jessica Hummel, Shannen Nelson, Erin C. Thomas, Jennifer L. Huggins, Megan L. Curran, Jun Ying and Marisa S. Klein-Gitelman. Blood-Based Biomarkers of Neurocognitive Dysfunction in Childhood-Onset Systemic Lupus Erythematosus. # 312;  Arthritis & Rheumatism, Vol 64 (Suppl):  S137. 2012.

Hermine I. Brunner, Nicolino Ruperto, Pierre Quartier, Tama’s Constantin, Nico Wulffraat, Gerd Horneff, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Yackov Berkun, Inmaculada Calvo, Muferet Erguven, Laurence Goffin, Michael Hofer, Tilmann Kallinich, Karine Lheritier, Ken Abrams, Andrea Stancati, D. J. Lovell and Alberto Martini. Efficacy and Safety of Canakinumab in Patients with Active Systemic Juvenile Idiopathic Arthritis and Fever: Results From Two Pivotal Phase 3 Trials. # 759; Arthritis & Rheumatism, Vol 64 (Suppl): S326

Nico Wulffraat, Hermine I. Brunner, Nicolino Ruperto, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan,Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Hila’rio, Kristin Houghton, Rik Joos, Daniel Kingsbury, Arndt Brachat, Stephan Bek, Martin Schumacher, Marie-Anne Valentin, N.R Nirmala, Hermann Gram, Ken Abrams, Alberto Martini and D. J. Lovell. Analysis of Biomarkers in Systemic Juvenile Idiopathic Arthritis Patients On Canakinumab Therapy. # 761; Arthritis & Rheumatism, Vol 64 (Suppl):  S328. 2012.

D. J. Lovell, Nicolino Ruperto, Katerina Jarosova, Dana Nemcova, Veronika Vargova, Hartmut Michels, Elizabeth Chalom, Norman Ilowite, Carine Wouters, Hermine Brunner, Karolyn Kracht, Hartmut Kupper, Edward Giannini, Alberto Martini and Neelufar Mozaffarian. The Impact of Adalimumab On Growth in Patients with Juvenile Idiopathic Arthritis. # 764; Arthritis & Rheumatism, Vol 64 (Suppl): S329. 2012.

Rachel E. Sobel, D. J. Lovell, Hermine I. Brunner, Jennifer E. Weiss, Paula W. Morris, Beth S. Gottlieb, Elizabeth C. Chalom, Lawrence K. Jung, Karen Onel, Lisa Petinoit, Donald P. Goldsmith, Staci Abramsky-Risman, James P., Young and Edward H. Giannini.  Safety of Celecoxib and Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Juvenile Idiopathic Arthritis. #1141; Arthritis & Rheumatism, Vol 64 (Suppl): S489. 2012.

Alberto Spindler, D. J. Lovell, Alberto Martini and Fabrizio De Benedetti. Efficacy and Safety of Tocilizumab in Patients with Polyarticular Juvenile Idiopathic Arthritis: Data From a Phase 3 Trial. #1597; Arthritis & Rheumatism, Vol 64 (Suppl): S682. 2012.

Meredith P. Riebschleger, Eyal Muscal, Matthew M. Davis, Hermine Brunner, B.Anne Eberhard, C.J. Inman, Marisa S. Klein-Gitelman, Lakshmi N. Moorthy, Marc D. Natter, Sampath Prahalad, Rayfel Schneider and Peter A. Nigrovic. The Current State of Mentoring Among Pediatric Rheumatology Fellows and Junior Faculty in the United States and Canada. # 1890; Arthritis & Rheumatism, Vol 64 (Suppl): S802. 2012.

Bin Huang, Jennifer Farrell, Adam Carle, Stacey Niehaus, Hermine Brunner, Alexei A. Grom, Michael Henrickson, Jennifer L. Huggins, D. J. Lovell, Tracy V. Ting and Esi M. Morgan DeWitt. ACR Criteria, Providers’ Global Rating of Change and Role of Patient Self-Report in Evaluating Change in Disease Over Time: A Patient Reported Outcomes Measurement Information System Study. # 2011; Arthritis & Rheumatism, Vol 64 (Suppl): S853. 2012.

Matthew C. Hollander. Jessica M. Sage, Alexandria J. Greenler, Tadej Avcin, Michael W. Beresford, Graciela Espada, Marisa S. Klein-Gitelman, Michael Henrickson, Tsz-Leung Lee, Joshua D. Pendl, Marilynn G. Punaro, Jennifer L. Huggins, Anne M. Stevens and Hermine Brunner. Provisions of Quality Driven Care in Childhood-Onset Systemic Lupus Erythematosus. # 2040; Arthritis & Rheumatism, Vol 64 (Suppl):  S864. 2012.

Rina Mina, Michael Bennett, Lining Qi, Shannen Nelson, Jessica Hummel, Pavel Shiyanov, John Schlager, Prasad Devarajan and Hermine I. Brunner. Urine Biomarkers Distinguish Between Proliferative and Membranous Lupus Nephritis in Childhood Onset Systemic Lupus Erythematosus # 2474; Arthritis & Rheumatism, Vol 64 (Suppl): S1043. 2012.

Sasha Bernatsky, Ann E. Clarke, Jeremy Labrecque, Emily von Scheven, Laura E. Schanberg,Earl D. Silverman, Hermine I. Brunner, Kathleen A. Haines, Randy Q. Cron, Kathleen M. O’Neil, Kiem Oen, Alan M. Rosenberg, Ciaran M. Duffy, Jennifer LF Lee, Mruganka Kale, Elizabeth M. Turnbull and Rosalind Ramsey-Goldman. Cancer in Pediatric-onset Systemic Lupus: What is the Role of Disease Duration and Other Factors of Risk ?;  # 2475; Arthritis & Rheumatism, Vol 64 (Suppl): S1043. 2012.

Jessica M. Sage, Arshia Ali, Jennifer Farrell, Jennifer L. Huggins, Kara Covert, Diane Eskra, Rina Mina, Shweta Srivastava, Janalee Taylor, Tracy V. Ting, Esi M. Morgan DeWitt, and Hermine I. Brunner. Moving Into the Electronic Age: Validation of Rheumatology Self- Assessment Questionnaires On Tablet Computers # 2603; Arthritis & Rheumatism, Vol 64 (Suppl):  S1102. 2012.

Sherwin CMT, Sagcal-Gironella AC, Fukuda T, Cox S, Nelson S, Dina B, Klein-Gitelman MS, Brunner HI, Vinks AA. Pharmacokinetics of prednisolone in childhood-onset systemic lupus erythematosus (cSLE). Clinical Therapeutics. In press, 2011.

Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E, Evans GW, Mieszkalski KL, Ilowite NT, Eberhard A, Imundo L, Kimura Y, von Scheven E, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman MS, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Soep JB, Reed A. Provenzale, for the APPLE investigators. Use of Atorvastatin in Systemic Lupus Erythematosus (SLE) in Children and Adolescents. Arthritis & Rheum. In press, 2011.

Sherwin MT, Fukuda T, Brunner HI, Vinks AA. Development of a Population Pharmacokinetic Model with Enterohepatic Circulation for Mycophenolic Acid in Patients with Childhood-onset Systemic Lupus Erythematosus. British Journal of Clinical Pharmacology. Submitted.

Brunner HI, Mina R, Pilkington C, Beresford MW, Reiff A, Levy DM, Tucker LB, Eberhard BA, Ravelli A, Schanberg L, Saad-Magalhaes C, Higgins GC, Onel K, Singer NG, von Scheven E, Itert L, Klein-Gitelman MS, Punaro M, Ying J, Giannini EH. Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus. Arthritis Care & Research. In press, 2011.

Antonchak MA, Saoudian M, Khan AR, Brunner HI, Luggen ME. Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus: A Controlled Study. J Rheumatol. 2011.

Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011.

Sagcal-Gironella AC, Fukuda T, Wiers K, Cox S, Nelson S, Dina B, Sherwin CM, Klein-Gitelman MS, Vinks AA, Brunner HI. Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus. Semin Arthritis Rheum. Feb 2011.

Brunner HI, Mina R, Pilkington C, Beresford MW, Reiff A, Levy DM, Tucker LB, Eberhard BA, Ravelli A, Schanberg L, Saad-Magalhaes C, Higgins GC, Onel K, Singer NG, von Scheven E, Itert L, Klein-Gitelman MS, Punaro M, Ying J, Giannini EH. Preliminary Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. Arthritis Care & Research. May, 2011.

Wu YL, Lundström E, Liu CC, Yang Y, Tsao BP, Chung EK, Zhou B, Jones KN, Nagaraja HN, Higgins GC, Spencer CH, Brunner HI, Gunnarsson I, Svenungsson E, Birmingham DJ, Rovin BH, Ahearn JM, Hebert LA, Padyukov L, Yung Yu C. Finding the Missing Heritability of a Common Disease: Copy-Number Variation (CNV) of Complement C4A and the Presence of HLA-DRB1 alleles DR3 and DR2 Are Common, Medium-to-High, and Additive Risk Factors for Human Systemic Lupus Erythematosus (SLE) of European Ancestry. PLOS Genetics. 2010, submitted.

Ardoin SP, Schanberg LE, Sandborg C, Yow E, Barnhart HX, Mieszkalski KL, Ilowite NT, von Scheven E, Eberhard A, Levy DM, Kimura Y, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Imundo L,  Soep JB, Reed AM. APPLE Investigators. Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort. Lupus. 19. 2010, in press.

Brunner HI, Higgins GC, Wiers K, Lapidus SK, Olson JC, Onel K, Punaro M, Ying J, Klein-Gitelman MS, Giannini EH. Minimal clinically important differences of disease activity indices in childhood-onset systemic lupus erythematosus. Arthritis Care Res. 62: 950-959. 2010.

Ruperto N, Giannini EH, Pistorio A, Brunner HI, Martini A, Lovell DJ. Is it time to move to active comparator trials in juvenile idiopathic arthritis? a review of current study designs. Arthritis Rheum. 62(11):3131-9. 2010.

Ross GS, Zelko F, Klein-Gitelman M, Levy DM, Muscal E, Schanberg LE, Anthony K, Brunner HI; for the  Childhood Arthritis & Rheumatology Research Alliance (CARRA) Ad-Hoc Neurocognitive Lupus Committee. A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. Arthritis Care Res. 62: 1029-33. 2010.

Brunner HI, Klein-Gitelman MS, Higgins GC, Lapidus SK, Levy D, Eberhard A, Singer N, Olson JC, Onel K,  Punaro M, Schanberg L, Von Scheven E, Ying J, Giannini EH. Toward the development of criteria for global flares in juvenile systemic lupus erythematosus. Arthritis Care Res. 62: 811–820. 2010.

Brunner HI, Higgins GC, Wiers K, Lapidus SK, Olson JC, Onel K, Punaro M, Ying J, Klein-Gitelman MS, Giannini EH. Prospective validation of the provisional criteria for the evaluation of response to therapy in childhood-onset systemic lupus erythematosus (cSLE). Arthritis Care Res. 62 (3): 335-344. 2010.

Ford KR, Myer GD, Melson PG, Darnell SC, Brunner HI, Hewett TE. Land-Jump Performance in Patients with Juvenile Idiopathic Arthritis (JIA): A Comparison to Matched Controls. International Journal of Rheumatology. 478526. 2009.

Kocharla L, Taylor J, Weiler T, Ting TV, Luggen M, Brunner HI. Monitoring methotrexate toxicity in juvenile idiopathic arthritis. J Rheumatology. 36(12):2813-2818. 2009.

Hinze CH, Suzuki M, Klein-Gitelman M, Passo MH, Olson J, Singer NG, Tucker L, Ying J, Devarajan P, Brunner HI. Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. Arthritis Rheum. 60:2772-2781. 2009.

Brunner HI, Higgins GC, Wiers K, Lapidus SK, Olson JC, Onel K, Punaro M, Ying J, Klein-Gitelman MS, Seid M. Health-related quality of life and its relationship to patient disease course in childhood-onset systemic lupus erythematosus. J Rheumatology. 36:1536-45. 2009.

Schanberg LE, Sandborg C, Barnhart HX, Brunner HI, Jung L, Soep JB, Reed A. Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors of increased carotid intima-medial thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. Arthritis Rheum. 60; 1496-1507. 2009.

S. Collins, D.P. Schauer, A. Gupta, H.I. Brunner, A.B. Storrow, M.H. Eckman. Cost-Effectiveness Analysis of Emergency Department Decision Making in Non-High Risk Heart Failure Patients. Amer J Emerg Medicine. 27:293-302. 2009.

Brunner HI, Klein-Gitelman MS, Ying J, Tucker LB, Silverman ED. Corticosteroid use in childhood-onset systemic lupus erythematosus – practice patterns at four pediatric rheumatology centers. Clin Exp Rheumatol. 27: 155-162. 2009.

Suzuki M, Wiers K, Brooks EB, Greis KD, Haines K, Klein-Gitelman MS, Olson J, Onel K, O'Neil KM, Silverman ED, Tucker L, Ying J, Devarajan P, Brunner HI. Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis. Ped Research. 65(5):530-6. 2009.

Koneru S, Kochrala L, Higgins GC, Ware A, Passo MH, Farhey YD, Mongey AB, Graham TB, Houk JL, Brunner HI. Adherence to medications in systemic lupus erythematosus. J Clin Rheumatol. 14(4):195-201. 2008.

Brunner HI, Gladman DD, Ibañez D, Urowitz MD, Silverman ED. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum. 58: 556–562. 2008.

Suzuki M, Wiers KM, Klein-Gitelman MS, Haines KA, Ying J, Devarajan P, Brunner HI. Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol. 23(3):403-12. 2008.

DiFrancesco MW, Holland SK, Ris MD, Adler CM, DeBello MP, Altaye M, Brunner HI. Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus:  a pilot study. Arthritis Rheum. 56:4151-63. 2007.

Suzuki M, Wiers K, Nelson S, Rutherford C, Devarjan P, Brunner HI. Identification of a urinary proteomic signature for lupus nephritis in children. Pediatr Nephrol. 22:2047-2057. 2007.

Brunner HI, Ruth NM, German A, Nelson S, Passo MH, Roebuck-Spencer T, Ying J, Ris D. Initial validation of the pediatric automated neuropsychological assessment metrics for childhood-onset systemic lupus erythematosus. Arthritis Rheum. 57: 1174-1182. 2007.

Mikdashi J* (cochair), Esdaile JM(cochair), Alarcón GS(cochair), Crofford L, Fessler BJ, Schanberg L, Brunner HI, Gall V, Kalden JR, Lockshin MD, Liang MH, Roberts Jr. N, Schneider M; for the  Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee. Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus. 16, 418-425. 2007.

Silva CA, Brunner HI. Gonadal functioning and preservation of reproductive fitness with juvenile systemic lupus erythematosus. Lupus. 16:593-99. 2007.

Koneru S, Shishov M, Ware A, Farhey Y, Mongey AB, Houk JL, Brunner HI. Effectively measuring adherence to medications for systemic lupus erythematosus in a clinical setting. Arthritis Rheum. 57: 1000-1006. 2007.

Nabors L, Jobst E, Weisman J, Precht B, Chiu P, Brunner HI. School support and Functioning for Children with Juvenile Rheumatic Diseases. J. Dev Phys Disabil. 19:81-89. 2007.

Bleesing J, Prada E, Siegel DM, Villanueva J, Olson J, Ilowite N, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Filipovich A, Grom AA. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum. 56(3):965-71. 2007.

Sommers E, Brunner HI, Nabors L. Pain, Fatigue, Family Functioning, and Attitude Toward Illness in Children with Juvenile Rheumatic Diseases. J. Dev Phys Disabil. 18: 64- 71. 2007.

Brunner HI, Klein-Gitelman M. Lupus in the Child’s Mind. The Rheumatologist. March 2009.

Brunner HI, Das L, Passo MH, Koneru S. Reply letter for Adherence to medications in systemic lupus erythematosus. Arthritis Rheum. 57: 1000-1006. 2007.

Brunner HI, Huggins J, Klein-Gitelman M. Pediatric SLE--towards a comprehensive management plan. Nature Review Rheumatology. 7(4):225-33. Apr 2011.

Sherwin CMT, Fukuda T, Brunner HI, Goebel J, Vinks AA. The Evolution of Population Pharmacokinetic Models to Describe the Enterohepatic Recycling of Mycophenolic Acid in Solid Organ Transplantation and Autoimmune Disease. British Journal of Clinical Pharmacology. 2011, in press.

Ruperto N, Giannini EH, Pistorio A, Brunner HI, Martini A, Lovell DJ. Is it time to move to active comparator trials in juvenile idiopathic arthritis? a review of current study designs. Arthritis & Rheumatism. 2010.

Sherwin C, Fukuda Y, Goebel J, Cox S, Brunner HI, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clinical Pharmacokinetics. 2011.

Mina R, Brunner HI. Pediatric lupus—are there differences in presentation, genetics, response to therapy, and damage accrual compared with adult lupus?Rheum Dis Clin N Am. 36: 53-80. 2010.

Ravelli A, Brunner HI. Development outcome measures in pediatric rheumatic diseases. Best Practice and Research Clinical Rheumatology. Issue 23:6. 2009.

Das L, Brunner HI. Biomarkers for Renal Disease in Childhood. Current Rheumatology Reports. 11: 218-225. 2009.

Klein-Gitelman MS, Brunner HI. The impact and implications of neuropsychiatric systemic lupus erythematosus in adolescents. Current Rheumatology Reports. 11: 212-217. 2009.

Brunner HI. More may not be better--but is less enough?Rheumatol. January 36:7-8. 2009.

Hinze C, Brunner HI. Pediatric rheumatology--its own specialty. Nature in Clinical Rheumatology. 4:279. 2008.

Silva CA, Brunner HI. Gonadal functioning and preservation of reproductive fitness with juvenile systemic lupus erythematosus. Lupus. 16:593-99. 2007.

Brunner HI, Giannini ED. Design, Measurement and Clinical Investigations. Pediatric Rheumatology Cassidy Textbook; Editors: R. Petty, R. Laxer; 2010.

Mina R, Brunner HI. Differences of adult and childhood-onset systemic lupus erythematosus. Clinical Manifestations of Childhood-onset SLE.  Pediatric Rheumatology; Chapter, Lupus Dubois Textbook; Editors: R. Lahita and B. Hahn. 2010.