Section of Neonatology, Perinatal and Pulmonary Biology

  • Faculty Research

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    Section Chief

    A photo of Jeffrey Whitsett.

    Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute

    investigates the hierarchy of transcriptional controls and signaling cascades which determine commitment of progenitor cells that produce the differentiated epithelial cells lining the primordial and mature respiratory tract. The goal of his research is to provide insight into the pathogenesis of acute and chronic lung disorders. The role of surfactant in innate host defense and lung function is also an ongoing interest.
    Visit the Whitsett Lab.

    513-803-2790
    jeffrey.whitsett@cchmc.org

    Jeffrey A. Whitsett, MD

    Co-Director, Perinatal Institute

    Chief, Section of Neonatology, Perinatal and Pulmonary Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-803-2790

    Fax: 513-636-7868

    Email: jeffrey.whitsett@cchmc.org

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    Specialties

    Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy 

    Visit the Whitsett Lab.

    Biography

    Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.

    Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.

    Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.

    Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.

    Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.

    Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.

    Education and Training

    MD: Columbia University, New York, NY, 1973.

    Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

    Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

    Publications

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    Faculty

    A photo of Anne Akeson.

    Ann L. Akeson, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-3599

    Fax: 513-636-7868

    Email: ann.akeson@cchmc.org

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    Specialties

    Publications

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    A photo of Henry Akinbi.

    Henry T. Akinbi, MD Attending Neonatologist

    studies host defense proteins in innate defense of the lungs using gene-targeted mice. The role of lysozyme in: 1) lung infection; 2) inflammation and 3) anti-oxidant defense is a major focus of his research program.

    513-636-8915
    henry.akinbi@cchmc.org

    Henry T. Akinbi, MD

    Attending Neonatologist

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8915

    Fax: 513-636-7868

    Email: henry.akinbi@cchmc.org

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    Specialties

    Neonatal infections; blood transfusions; role of Lysozyme in airway host defense

    Education and Training

    MD: University of Ife, Ile-Ife, Nigera, Africa, 1980.

    Residency: Pediatrics, University of North Carolina at Chapel Hill, 1988-1991.

    Neonatology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 1991-1994.

    Certification: General Pediatrics, 1991. Recertification, 1998. Newborn Medicine, 1995, Recertification, 2002.

    Publications

    View PubMed Publications
    A photo of Cyndi Bachurski.

    Cindy J. Bachurski, PhD Director, Neonatology and Pulmonary Biology Elective Rotation, University of Cincinnati, School of Medicine

    studies transcriptional control of the establishment and maintenance of pulmonary type II cells. Her laboratory utilizes transgenic mouse technology and molecular and biochemical analysis methods to determine transcription factor interactions during lung development and in response to injury.

    513-636-8918
    cindy.bachurski@cchmc.org

    Cindy J. Bachurski, PhD

    Director, Neonatology and Pulmonary Biology Elective Rotation, University of Cincinnati, School of Medicine

    Director, High School Senior Summer Internship Program, Cincinnati Children's Hospital Medical Center

    Director, Excellence in Science Education and Learning (ExSEL) II Program, PATHWAYS to Health Careers, University of Cincinnati College of Medicine

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-8918

    Fax: 513-636-7868

    Email: cindy.bachurski@cchmc.org

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    Specialties



    Biography

    Cindy Bachurski, PhD, is an associate professor in the Division of Pulmonary Biology at Cincinnati Children's Research Foundation (CCRF) and the Department of Pediatrics at the University of Cincinnati.

    Dr. Bachurski's laboratory studies transcriptional control of the establishment and maintenance of the pulmonary Type II cell. She uses sophisticated transgenic mouse technology and molecular and biochemical analysis methods to ask mechanistic questions about transcription factor interactions during lung development, and in response to injury.

    Dr. Bachurski has a long-term interest in mentoring young scientists. She organized a Research Explorer Scout Troop for high school students (1997 to 2001). She is currently the director of the Summer Internship Program at Cincinnati Children's, for graduating high school students to work with clinician-mentors. She also co-chairs the Cincinnati Children's High School Science Symposium honoring outstanding, local high school students and their teachers.

    She is an active member of the Cincinnati Children's Women's Faculty Association where she has chaired several committees, organized workshops on Mentoring, and the Faculty Development page for the Cincinnati Children's web site.

    Starting in the summer of 2008, Dr. Bachurski also directs the ExSELII program in which the best students from the Howard Hughes Medical Institute funded ExSEL program are invited to work full time on a mentored research lab project for 9 weeks in the summer. Click here to access the HHMI summer programs.

    Education and Training

    PhD: Microbiology, University of Maryland, College Park, MD, 1990.

    Postdoctoral Fellowship: Biological Chemistry, Johns Hopkins University, Baltimore, MD, 1990 to 1992.

    Postdoctoral Fellowship: Pulmonary Biology, Children's Hospital Research Foundation, Cincinnati, OH, 1992 to 1994.

    Publications

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    Grants

    HHMI Precollege Outreach Initiative for Biomedical Research Institutions. Cincinnati Children's Liaison. Mentoring Community Outreach Grant. Sep 2007- Aug 2012.

    Cincinnati Center for Clinical and Translational Science and Training. Cincinnati Children's Liaison.
    National Institutes of Health. Aug 2009 - Mar 2014. #U54RR025216-01.
    A photo of Tanya Cahill.

    Tanya E. Cahill, MD Director, High-Risk Clinic

    is interested in high risk infant follow-up and neonatal abstinence syndrome.


    tanya.cahill@cchmc.org

    Tanya E. Cahill, MD

    Director, High-Risk Clinic

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Fax: 513-636-5454

    Email: tanya.cahill@cchmc.org

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    Specialties

    High risk infant follow up; neonatal abstinence syndrome

    Education and Training

    MD: University of Cincinnati, Cincinnati, OH 2000.

    Residency:
    Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2000-2003.

    Fellowship:
    Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2003-2006.

    Certification:
    Pediatrics, 2003; Neonatology, 2008.
    A photo of Michael Crossman.

    Michael W. Crossman, MD, PhD Attending Neonatologist

    focuses on intestinal function and host-microbial interactions, bioethics and neonatal palliative care.

    859-301-3850
    michael.crossman@cchmc.org

    Michael W. Crossman, MD, PhD

    Attending Neonatologist

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 859-301-3850

    Fax: 859-301-2066

    Email: michael.crossman@cchmc.org

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    Specialties

    Intestinal function and host-microbial interactions; bioethics and neonatal palliative care

    Education and Training

    PhD: Biochemistry, St. Louis University, St. Louis, MO, 1985.

    MD: St. Louis University, St. Louis, MO, 1986.

    Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.

    Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.

    Certification: Neonatal - Perinatal Medicine, 1995, 2003.

    Publications

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    A photo of Stephan W. Glasser.

    Stephan W. Glasser, PhD

    studies the function of surfactant protein C (SP-C) in lung innate defense and as a cause of familial interstitial lung disease (ILD) in neonates and children. SP-C deficient mice, generated in his laboratory, exhibit features of human ILD and are susceptible to inflammation/bacterial and viral pulmonary infection. Experiments are focused on determining mechanisms underlying the role of SP-C deficiency in lung injury.

    513-636-7850
    steve.glasser@cchmc.org

    Stephan W. Glasser, PhD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-7850

    Fax: 513-636-7868

    Email: steve.glasser@cchmc.org

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    Specialties

    Education and Training

    PhD: University of Cincinnati, Developmental Biology,1988.

    Publications

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    A photo of James M. Greenberg.

    James M. Greenberg, MD Co-Director, Perinatal Institute

    investigates the developmental biology of pulmonary vascular development, including how vascular endothelial growth factor (VEGF) mediates pulmonary vascular, lymphatic and airway development. He studies how VEGF mediates organization of pulmonary vasculature during late fetal life as well as how certain proteins implicated in axonal guidance during central nervous system development also direct developmental processes in the lung.

    513-636-3149
    james.greenberg@cchmc.org

    James M. Greenberg, MD

    Co-Director, Perinatal Institute

    Director, Division of Neonatology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-3149

    Fax: 513-803-0968

    Email: james.greenberg@cchmc.org

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    Specialties

    Neonatal chronic lung disease; late preterm infant

    Education and Training

    MD: University of Illinois College of Medicine, Chicago, Ill., 1977-1981.

    Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1984.

    Fellowship: Immunology / Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

    Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal / Perinatal Medicine, 1989.

    Publications

    View PubMed Publications
    A photo of Beth Haberman.

    Beth E. Haberman, MD Senior Medical Director, Neonatal Services

    has special interests in the care of infants with congenital diaphragmatic hernia and follow-up care of premature and term infants with complex medical needs.

    513-636-5465
    beth.haberman@cchmc.org

    Beth E. Haberman, MD

    Senior Medical Director, Neonatal Services

    Medical Director, Newborn Intensive Care Unit (NICU)

    Medical Director, Neonatal Transport Program

    Associate Director, High-Risk Infant Follow-Up Program

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-5465

    Fax: 513-636-5846

    Email: beth.haberman@cchmc.org

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    Specialties

    CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs

    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.

    MD: University of Louisville, Louisville, KY, 1993.

    Publications

    View PubMed Publications
    A photo of Steven B. Hoath.

    Steven B. Hoath, MD

    has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.

    513-803-0960
    steven.hoath@cchmc.org

    Steven B. Hoath, MD

    Academic Information

    Emeritus, UC Department of Pediatrics

    Phone: 513-803-0960

    Fax: 513-803-0969

    Email: steven.hoath@cchmc.org

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    Specialties

    Clinical Interests

    Clinical aspects of Dr Hoath’s work derive from an understanding of the basics of human skin development and the multiple roles of the skin in neonatal care. New perspectives on the skin as a sensory interface are central to this understanding as is the role of the skin as an accessible environmental interface which complements ‘internal’ medicine. This view of the skin provides a unique, pivotal, and powerful opportunity to effect evidence-based organizational change in healthcare delivery to newborns. This approach highlights the criticality of the interface between medicine and nursing and the importance of focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.

    Research Interests

    Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery.

    Biography

    Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.

    He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of 7 international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.

    He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on 5 patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.

    Education and Training

    Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.

    Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.

    Residency: University of California, Los Angeles, 1977-79.

    Internship: Harbor-UCLA Medical Center, 1976-1977.

    MD: University of California, Los Angeles, CA, 1976.

    Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.

    Baccalaureate: Stanford University, Biology & German Studies, 1972.

    Publications

    View PubMed Publications
    A photo of Machiko Ikegami.

    Machiko Ikegami, MD, PhD

    is working to find effective antenatal treatments to induce fetal lung maturation, better postnatal treatments for premature newborns using modified surfactant components, and improve understanding of the novel transcriptional pathways induced during ALI to mediate surfactant homeostasis during lung injury and repair.

    513-636-8661
    machiko.ikegami@cchmc.org

    Machiko Ikegami, MD, PhD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8661

    Fax: 513-636-8691

    Email: machiko.ikegami@cchmc.org

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    Specialties

    Transcriptional control of lung morphogenesis; molecular mechanisms of recovery from lung injury; surfactant biology

    Biography

    Dr. Ikegami contributed in development of surfactant treatment for immature newborns with respiratory distress syndrome. She is internationally renowned for her research in surfactant biology and pulmonary biology.

    Dr. Ikegami is the author of over 300 papers in the basic science.

    Education and Training

    MD: Tokyo Women's Medical University, Tokyo, Japan, 1971.

    PhD: Tokyo Women's Medical University, Tokyo, Japan, 1980.

    Residency, Fellowships: Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan, 1971-1975.

    Publications

    View PubMed Publications

    Grants

    Transcriptional programming of asthma related pathology in respiratory epithelial.  Co-Investigator. National Heart, Lung, and Blood Institute. Apr 2009 - Mar 2014.
    A photo of Alan Jobe.

    Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology

    has a special research focus on surfactant physiology. Dr. Jobe is also interested in lung maturation and lung injury in the fetus and newborn, the use of antenatal corticosteroids, and lung injury with ventilation of the preterm infant.

    513-636-8563
    alan.jobe@cchmc.org

    Alan H. Jobe, MD, PhD

    Director, Division of Perinatal Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8563

    Fax: 513-636-8691

    Email: alan.jobe@cchmc.org

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    Specialties

    Clinical Interests

    Clinical trials in neonatology; bronchopulmonary dysplasia

    Research Interests

    Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

    Education and Training

    MD: University of California, San Diego, 1973. 

    PhD: University of California, San Diego, CA, 1973. 

    Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

    Fellowship: University of California, San Diego, CA, 1975 to 1977.

    Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

    Publications

    View PubMed Publications
    A photo of Beth Ann Johnson.

    Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology

    has a research focus in perinatal cardiology, premature infants with congenital heart disease, fetal diagnosis, and simulation.

    513-636-3291
    beth_ann.johnson@cchmc.org

    Beth Ann Johnson, MD, MA

    Attending Neonatologist, Neonatology and Pulmonary Biology

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-3291

    Fax: 513-636-3952

    Email: beth_ann.johnson@cchmc.org

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    Specialties

    Cardiac intensive care; neonatology; premature infants with congenital heart disease; mechanical assist devices; fetal diagnosis; ethics

    Education and Training

    MD: University of Illinois.

    Residency:
    University of Texas Health Science Center at San Antonio.

    Fellowships: Neonatal / Perinatal, Children’s Hospital of Wisconsin; Pediatric Cardiology, Children’s Hospital of Wisconsin; Pediatric Critical Care, Children’s Hospital of Philadelphia.

    MA: Bioethics, Medical College of Wisconsin.

    Publications

    View PubMed Publications
    A photo of Tanya V. Kalin.

    Tanya V. Kalin, MD, PhD

    studies the transcriptional regulation of DNA replication and mitosis in tumor cells in vitro and in vivo. Mouse lung and prostate cancer models are used to gain insight into regulation of cell signaling pathways required for tumor initiation, progression, metastasis and tumor angiogenesis. The ultimate goal of the research program is to identify novel target genes for diagnostic, prevention and treatment of lung and prostate cancers.
    Visit the Kalin Lab.

    513-803-1201
    tatiana.kalin@cchmc.org

    Tanya V. Kalin, MD, PhD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-1201

    Fax: 513-636-2423

    Email: tatiana.kalin@cchmc.org

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    Specialties

    Transcriptional regulation of cancer initiation and progression, tumor microenvironment, tumor associated angiogenesis and metastasis. Chemotherapeutic drug development.

    Visit the Kalin Lab.

    Education and Training

    Postdoctoral research fellow: University of Chicago, Chicago, IL.

    PhD: Institute of Immunology, Moscow , Russia, 1997.

    MD: Moscow Medical University II, Moscow, Russia, 1992.

    Publications

    View PubMed Publications

    Grants

    1R01CA142724-01A1 (PI Kalin) NIH / NCI: Role of Foxm1 in Lung Cancer Microenvironment.

    Department of Defense #PC080478 (PI Kalin): Transcriptional regulation of Prostate Cancer Initiation and Progression.

    Concern Foundation (PI Kalin): Role of lung inflammation during lung carcinogenesis.

    A photo of Vladimir Kalinichenko.

    Vladimir V. Kalinichenko, MD, PhD

    is investigating the transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis. He studies the winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival, ultimately identifying novel mechanisms that cause human lung malformations and promote lung cancer formation.

    513-636-4822
    vladimir.kalinichenko@cchmc.org

    Vladimir V. Kalinichenko, MD, PhD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4822

    Fax: 513-636-2423

    Email: vladimir.kalinichenko@cchmc.org

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    Specialties

    Clinical Interests

    Lung development; cell proliferation; carcinogenesis; transcriptional regulation of gene expression.

    Research Interests

    Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation.

    Education and Training

    MD: Russian State Medical University, Moscow, Russia, 1993.

    PhD: Russian State Medical University, Moscow, Russia, 1995.

    Fellowship: From the European Soros Foundation, 1995.

    Postdoctoral: University of Illinois at Chicago, Center for Molecular Biology, IL, 2000.

    Postdoctoral: University of Illinois at Chicago, Department of Molecular Genetics, IL, 2002.

    Publications

    View PubMed Publications
    A photo of Suhas G. Kallapur.

    Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education

    is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Dr. Kallapur’s research focus is to understand the pathogenesis of lung injury and systemic inflammatory responses in fetuses and newborns. His lab uses a sheep model and has begun some work in humans.
    Visit the Kallapur Lab.

    513-636-3879
    suhas.kallapur@cchmc.org

    Suhas G. Kallapur, MD

    Director, Neonatology Continuing Medical Education

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-3879

    Fax: 513-636-7868

    Email: suhas.kallapur@cchmc.org

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    Specialties

    Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity

    Education and Training

    MBBS: University of Bombay, India, 1984. 

    DCH: College of Physicians and Surgeons, Bombay, 1986.

    MD, Pediatrics: University of Bombay, India, 1986.

    Residency: University of Bombay, India, 1984-87.

    Residency: Children's Hospital of Michigan, Detroit, Michigan, 1988-90. 

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1990-1993.

    Publications

    View PubMed Publications

    Grants

    Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. Principal Investigator. National Institute of Child Health and Human Development. Feb 2009-Jan 2014. #R01 HD57869.
    A photo of Beena Kamath-Rayne.

    Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology

    does clinical/translational research in preterm birth, fetal lung maturity and timing of delivery using biomarkers in amniotic fluid. She also has an interest in global health, and is on the Global Health Education Task Force. She is a master trainer for Helping Babies Breathe (HBB), a global curriculum in neonatal resuscitation, and is collaborating on several research studies of HBB around the world.

    513-803-1606
    beena.kamath-rayne@cchmc.org

    Beena D. Kamath-Rayne, MD, MPH

    Attending Neonatologist, Neonatology and Pulmonary Biology

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1606

    Fax: 513-636-0171

    Email: beena.kamath-rayne@cchmc.org

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    Specialties

    Perinatal epidemiology and public health; global health

    Biography

    Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal lung maturity, and biomarker discovery in amniotic fluid. She has received a BIRCWH K12 award to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.

    Dr. Kamath-Rayne was a reviewer for the Helping Babies Breathe (HBB) global neonatal resuscitation curriculum, and is currently a Master Trainer.  She is collaborating on several studies of HBB around the world. With Dr. Alan Jobe, she is also a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide.

    Education and Training

    MD: Georgetown University, Washington, D.C., 2000.

    Residency: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, Colorado, 2003.

    Fellowship: Children's Hospital Colorado/University of Colorado Health Sciences, Denver, Colorado, 2008.

    Publications

    View PubMed Publications

    Grants

    Novel amniotic fluid biomarkers to predict fetal lung maturity and clinical respiratory outcome. Principle Investigator. Jul 2011-Jun 2013.
    A photo of Heather C. Kaplan.

    Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology

    focuses on understanding variations in evidence-based care practices across hospitals and identifying strategies for increasing the implementation of evidence and other innovations into practice. She recently began a line of investigation aimed at building the evidence base for quality improvement so that QI can be used more effectively as a strategy for improving quality and patient outcomes.

    513-803-0478
    heather.kaplan@cchmc.org

    Heather C. Kaplan, MD, MSCE

    Attending Neonatologist, Neonatology and Pulmonary Biology

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-0478

    Fax: 513-636-0171

    Email: heather.kaplan@cchmc.org

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    Specialties

    Heather Kaplan conducts research focusing on understanding variations in evidence-based care practices across hospitals and examining strategies for increasing the implementation of evidence into practice in perinatal care. She uses a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.

    Biography

    Heather C. Kaplan, MD, MSCE, is passionate about improving the quality and safety of perinatal care and has a solid foundation in epidemiology and research fundamentals. Through her role in the Ohio Perinatal Quality Collaborative, she gained practical experience in the use of quality improvement methods to reduce preterm births and improve outcomes of preterm newborns in Ohio and have formed collaborative relationships with obstetrical and neonatal care providers across the state.

    Additionally she has an understanding care delivery in a complex system requires taking a multidisciplinary, multilevel approach. Her career includes didactic coursework in multidisciplinary theories and methods.

    Education and Training

    BA: Washington University, St. Louis, Missouri.

    MD: Northwestern University, Chicago, Illinois.

    Residency: Children's National Medical Center, Washington, DC.

    Fellowship: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

    MSCE: University of Pennsylvania, Philadelphia, Pennsylvania.

    Publications

    View PubMed Publications
    A photo of Alan Kenny.

    Alan P. Kenny, MD, PhD

    studies the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development, including the role of a pool of foregut progenitor cells in the ventral endoderm which are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme.

    513-803-2224
    alan.kenny@cchmc.org

    Alan P. Kenny, MD, PhD

    Academic Information

    Instructor, UC Department of Pediatrics

    Phone: 513-803-2224

    Fax: 513-636-7868

    Email: alan.kenny@cchmc.org

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    Specialties

    Clinical Interests

    Neonatal care; neonatal lung disease; neonatal malformations and anomalies

    Research Interests

    Lung progenitor development; stem cell differentiation; fetal malformations

    Biography

    Alan P. Kenny, MD, PhD, focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates. Despite significant gains in our understanding of this process, fundamentally important questions remain unanswered. First, how are the common foregut organ progenitors specified? Second, how are FGF and BMP pathways spatiotemporally coordinated such that different organs are induced from the common foregut progenitor? A third and most intriguing question is - what are the endoderm genetic programs activated in response to induction from mesoderm that ultimately direct specific foregut organ development?

    These questions remain unanswered mostly due to experimental limitations inherent in mouse embryos, which are small and difficult to dissect at such an early stage. Dr. Kenny uses the experimental advantages of the large, externally developing, abundant Xenopus embryos to address these critical, unresolved issues. Specifically, Dr. Kenny is testing his hypothesis that cardiogenic FGF and BMP signaling of different durations induce different organs. Dr. Kenny’s microarray experiment to identify the endodermal genes induced very early in response to mesodermal signaling. Surprisingly, several negative regulators of BMP signaling were induced early by mesoderm signaling. My preliminary work suggests the hypothesis that BMP inhibitory feedback is a critical component induced during early foregut organ progenitor development. This work should ultimately increase our understanding of normal and abnormal early fetal organ development, lending further insight into foregut malformations such as tracheoesophageal fistula and congenital diaphragmatic hernia. Additionally, this work aims to offer better means to direct human embryonic stem cells toward more foregut organ-specific cell fates for therapeutic purposes.

    Education and Training

    PhD: Biology.

    MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 2002.

    Residency: Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY, 2002-2005.

    Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

    Certifications: In Pediatrics, 2007 American Board of Pediatrics; American Board of Pediatrics, Board Eligible in Neonatal-Perinatal Medicine, 2008.

    Publications

    View PubMed Publications
    A photo of Paul Kingma.

    Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center

    investigates the role of the innate immune system in neonatal infection. Specific projects currently focus on the role of surfactant protein D in neonatal sepsis and acute respiratory distress syndrome and on neutrophil function in cystic fibrosis patients.

    513-636-2995
    paul.kingma@cchmc.org

    Paul S. Kingma, MD, PhD

    Neonatal Director, Cincinnati Fetal Center

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-2995

    Fax: 513-636-7868

    Email: paul.kingma@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Neonatology; congenital diaphragmatic hernia; neonatal infection

    Research Interests

    Innate immune systems; surfactant protein D; neutrophil function in cystic fibrosis

    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

    Residency: Cincinnati Children's Hospital Medical Center, 2003.

    PhD: Vanderbilt University, TN, 2000.

    MD: Vanderbilt University, TN, 2000.

    BS: Calvin College, MI, 1992.

    Publications

    A photo of Thomas Korfhagen.

    Thomas R. Korfhagen, MD, PhD Attending Pediatrician, Neonatology and Pulmonary Biology

    studies the roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF receptor signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.

    513-636-7216
    thomas.korfhagen@cchmc.org

    Thomas R. Korfhagen, MD, PhD

    Attending Pediatrician, Neonatology and Pulmonary Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-7216

    Fax: 513-636-7868

    Email: thomas.korfhagen@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Care of high-risk infants; pediatric patients with complex, long term medical problems

    Research Interests

    Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.

    Education and Training

    BA: University of Cincinnati, Cincinnati, OH, 1972.

    PhD: University of Cincinnati, Cincinnati, OH, 1976.

    MD: University of Cincinnati, Cincinnati, OH, 1981.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984.

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director).

    Certifications: National Board of Medical Examiners, 7/1982;  American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987.

    Publications

    View PubMed Publications
    A photo of Timothy LeCras.

    Timothy D. LeCras, PhD Director of Admissions, Molecular & Developmental Biology Graduate Program

    studies the regulation of vascular and alveolar morphogenesis in the developing lung, as well as mechanisms to stimulate lung regeneration/growth in children and adults. A major focus is the causes and pathways mediating lung remodeling in premature newborns (BPD), pulmonary hypertension (PH), and asthma and to identify new therapeutic targets to treat and prevent these chronic lung diseases.

    Visit the LeCras Lab.

    513-636-8151
    tim.lecras@cchmc.org

    Timothy D. LeCras, PhD

    Director of Admissions, Molecular & Developmental Biology Graduate Program

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8151

    Fax: 513-636-7868

    Email: tim.lecras@cchmc.org

    Show All

    Specialties

    Lung development; bronchopulmonary dysplasia; pulmonary hypertension; asthma; pulmonary fibrosis

    Biography

    Timothy LeCras, PhD, investigates the causes of chronic lung diseases, including pulmonary hypertension, bronchopulmonary dysplasia, pulmonary fibrosis, and asthma. The goal of his laboratory is to use this knowledge to identify therapeutic targets and preventative measures. Our efforts are aided by very productive collaborations with other groups at Cincinnati Children’s as well as other groups in the U.S.

    Education and Training

    Postdoctoral fellow: University of Virginia, Charlottesville, VA, 1993-1996.

    PhD: University of Cambridge, UK, 1988-1992.

    BSc: Biochemistry, Brunel University, London, UK, 1983-1987.

    Publications

    View PubMed Publications
    A photo of Kristin Melton, MD.

    Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship

    is interested in early craniofacial development and focuses on the tissue interactions that direct the formation, migration and differentiation of neural crest cells. The Melton lab focuses on understanding the influence of the endothelium and the cranial mesoderm on neural crest development.

    513-803-0022

    Kristin R. Melton, MD

    Associate Program Director, Neonatal-Perinatal Medicine Fellowship

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-0022

    Fax: 513-636-7868

    Show All

    Specialties

    Clinical Interests

    Congenital malformations

    Research Interests

    Craniofacial malformations; somitogenesis

    Biography

    Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.

    Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.

    Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.

    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001.

    Residency: Children's Mercy Hospital, Kansas City, Missouri, 1998.

    MD: University of Nebraska, Omaha, Nebraska, 1995.

    BA: Washington University, St. Louis, Missouri, 1991.

    Publications

    View PubMed Publications
    A photo of Stephanie Merhar.

    Stephanie L. Merhar, MD, MS Attending Neonatologist

    is interested in optimizing neuroimaging in preterm and term infants at risk for brain injury, neonatal seizure treatment and neurodevelopmental outcomes of infants in the NICU.

    513-803-5180
    stephanie.merhar@cchmc.org

    Stephanie L. Merhar, MD, MS

    Attending Neonatologist

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-5180

    Email: stephanie.merhar@cchmc.org

    Show All

    Education and Training

    MD: University of Pennsylvania, Philadelphia, PA ,2005.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2005-2008.

    Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, 2008-2011.

    Certification: Pediatrics, 2008.

    Publications

    View PubMed Publications
    A photo of Laurel Moyer.

    Laurel B. Moyer, MD Medical Director, TriHealth Nurseries

    has research interests that include quality improvement, late preterm infants, and international health.

    513-803-1607
    laurel.moyer@cchmc.org

    Laurel B. Moyer, MD

    Medical Director, TriHealth Nurseries

    Chair, Neonatal Pediatrics

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1607

    Fax: 513-803-0968

    Email: laurel.moyer@cchmc.org

    Show All

    Specialties

    Quality improvement; global health

    Education and Training

    MD: University of Vermont College of Medicine, Burlington, VT, 1999-2003.

    Residency: University of Massachusetts, Department of Pediatrics, Worcester, MA, 2003-2006.

    Fellowship: University of North Carolina, Division of Neonatal-Perinatal Medicine, Chapel Hill, NC, 2006-2009.

    Certification: American Board of Pediatrics, 2006.
    A photo of Vivek Narendran, MD.

    Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU

    is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.

    513-803-0961
    vivek.narendran@cchmc.org

    Vivek Narendran, MD, MRCP, MBA

    Medical Director, University of Cincinnati Medical Center NICU

    Medical Director, Cincinnati Perinatal Outreach Project

    Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-0961

    Fax: 513-803-0969

    Email: vivek.narendran@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Non-Invasive Ventilation of the Preterm Infant, Business Case for Quality Improvements

    Research Interests

    Interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface

    Education and Training

    MBBS: Bangalore Medical College, Bangalore, India, 1985.

    MD/DNB: JN Medical College, Belgaum, India, 1990.

    Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94. 

    Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996. 

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1997-1998. 

    Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1996, 1998-2000. 

    Credentials: Pediatrics, 1998; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.

    Publications

    View PubMed Publications
    A photo of Amy Nathan, MD.

    Amy T. Nathan, MD Medical Director, Neonatology

    focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

    513-803-0909
    amy.nathan@cchmc.org

    Amy T. Nathan, MD

    Medical Director, Neonatology

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-0909

    Email: amy.nathan@cchmc.org

    Show All

    Specialties

    Clinical Interests

    necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care

    Research Interests

    Immune modulation of lung injury and inflammation 

    Biography

    Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.

    Education and Training

    MD: Yale University School of Medicine, New Haven, CT, 1998.

    Residency: University of North Carolina, Chapel Hill, NC 1998-2002.

    Fellowship: University of North Carolina, Chapel Hill, NC 2002-2005.

    Certification: Pediatrics 2001; Neonatology, 2008 

    Publications

    View PubMed Publications
    A photo of Laurie Nommsen-Rivers.

    Laurie Nommsen-Rivers, PhD, RD, IBCLC

    has research interests that include human milk and lactation, clinical management of the breastfeeding dyad and perinatal epidemiology. 

    513-636-7208
    laurie.nommsen-rivers@cchmc.org

    Laurie Nommsen-Rivers, PhD, RD, IBCLC

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-7208

    Fax: 513-803-0968

    Email: laurie.nommsen-rivers@cchmc.org

    Show All

    Specialties

    Broad research objective is to provide evidence-based strategies for supporting the mother-baby dyad in successfully establishing breastfeeding; current area of research examines the causes and consequences of early breastfeeding difficulties, with particular emphasis on delayed onset of lactogenesis

    Biography

    Laurie Nommsen-Rivers, PhD, RD, IBCLC, worked with hundreds of breastfeeding dyads as a staff researcher in the field of human lactation before returning to school in 2004 to pursue a PhD in Epidemiology.  She has co-authored over 50 publications related to maternal child health.  In addition, Laurie Nommsen-Rivers served as the Associate Editor of the Journal of Human Lactation from 1997 to 2006.

    Education and Training

    PhD: University of California, Davis; December 2007.

    MS: University of California, Davis, September 1989.

    BS: University of California, Davis, 1985.

    Registered Dietitian: Registration # 706227, continuously since 1991.

    International Board Certified Lactation Consultant: Continuously since 1993 

    Publications

    View PubMed Publications
    A photo of Anne-Karina Perl.

    Anne Karina T. Perl, MS, PhD

    studies molecular mechanisms underlying normal lung formation and lung repair processes in the preterm and postnatal lung. Data from our laboratory supports the hypothesis of the existence of distinct subsets of endodermaly derived progenitor cells during lung development. Our long-term goal is to understand the characteristics and the fate of these lung progenitors for prevention and therapy of lung disease.
    Visit the Perl Lab.

    513-636-6084
    anne.perl@cchmc.org

    Anne Karina T. Perl, MS, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-6084

    Fax: 513-636-7868

    Email: anne.perl@cchmc.org

    Show All

    Specialties

    Lung development and lung regeneration

    Visit the Perl Lab.

    Education and Training

    PhD: University of Vienna, Austria, 1998.

    Publications

    View PubMed Publications

    Grants

    FGF and PDGF regulate myofibroblast differentiation in alveolar regeneration
    R01 HL104003 (PI: Perl)
    07/01/10 – 06/30/14
    NIH/NHLBI

    Airway Progenitor Cell Proliferation and Differentiation During Lung Repair
    U01 HL110964 (Co investigator: Perl
    12/01/11 – 11/30/16
    NIH/NHLBI

    A photo of John Reuter.

    John H. Reuter, MD, PhD Attending Neonatologist

    is active in the administration of a 4000 delivery/year community level II service. His academic interests include breast milk and nutrition in the preterm infant.

    513-862-2748
    john.reuter@cchmc.org

    John H. Reuter, MD, PhD

    Attending Neonatologist

    Chair, Department of Pediatrics at Bethesda North Hospital Nurseries

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-862-2748

    Fax: 513-862-4979

    Email: john.reuter@cchmc.org

    Show All

    Education and Training

    MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1976.

    PhD:
    Physiology, University of Cincinnati College of Medicine, 1973.

    Residency: Pediatrics, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, Ohio, 1978.

    Fellowship: Moffitt Hospital, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, Calif., 1980.

    Certifications: Pediatrics, 1982 Neonatal; Perinatal Medicine, 1983.

    photo of Ward Rice, MD, PhD.

    Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center

    studies the molecular and cellular mechanisms that regulate processing of Surfactant Protein C, a protein that is critical for lung function.

    513-636-3149
    ward.rice@cchmc.org

    Ward R. Rice, MD, PhD

    Medical Director, Newborn Services, St. Elizabeth Medical Center

    Director, Neonatology Fellowship Training Program

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-3149

    Fax: 513-636-7868

    Email: ward.rice@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Hypotension in ELBW infants; EMR

    Research Interests

    Processing of Surfactant Protein C

    Biography

    Ward R. Rice, MD, PhD, is the Director of the Neonatology Fellowship Training Program and Director of Newborn Services, St. Elizabeth Medical Center.

    Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the Director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.

    His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of Surfactant Protein C.

    Education and Training

    PhD: 1972-76 University of Chicago, Chicago, Illinois.

    PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane"

    MD: 1972-78 University of Chicago, Chicago, Illinois.

    Internship: 1978-79 Duke University Medical Center, Durham, North Carolina.

    Residency: 1979-81 Duke University Medical Center, Durham, North Carolina.

    Fellowship Neonatology: 1981-83 University of Cincinnati College of Medicine, Children's Hospital Medical Center.

    Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.

    Publications

    View PubMed Publications
    A photo of Kurt Schibler.

    Kurt R. Schibler, MD Director, Neonatology Clinical Research Program

    is the principal investigator for the NICHD Neonatal Research Network at Cincinnati Children’s and is also involved in thematic collaborative research investigating the immune mechanisms underlying morbidity and mortality associated with preterm birth. He aims to identify infants at high risk for developing necrotizing enterocolitis and late onset infection and to devise strategies to prevent and to treat these complications.

    513-636-3972
    kurt.schibler@cchmc.org

    Kurt R. Schibler, MD

    Director, Neonatology Clinical Research Program

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-3972

    Fax: 513-636-7868

    Email: kurt.schibler@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Clinical trials; neonatal immune development

    Research Interests

    Immune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity

    Education and Training

    MD: University of Cincinnati, Cincinnati, Ohio, 1984.

    Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.

    Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.

    Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.

    Publications

    View PubMed Publications

    Grants

    The natural history of CMV-related hearing loss and the feasibility of CMV screening as adjunct to hearing in the newborn. Co-investigator. National Institutes of Health. Jan 2006 - Dec 2012. #HHS-N-260200500008C.

    Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants. Co-Principal Investigator. National Institutes of Health. Mar 2009 - Feb 2014. #R01-HD059140.

    A photo of John Shannon.

    John M. Shannon, PhD

    studies the elucidation of molecular mechanisms that regulate morphogenesis and differentiation of the lung epithelium and mesenchyme. A major focus of the lab is the role of fibroblast growth factors and epithelial-mesenchymal signaling pathways in the regulation of branching morphogenesis in the developing lung.

    513-636-2938
    john.shannon@cchmc.org

    John M. Shannon, PhD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-2938

    Fax: 513-636-7868

    Email: john.shannon@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Lung morphogenesis and differentiation; isolation and characterization of genes differentially expressed in the developing lung; maintenance of alveolar lung cell differentiation; pulmonary vascular development; congenital diaphragmatic hernia

    Research Interests

    Elucidation of the molecular mechanisms that regulate morphogenesis; differentiation of the lung epithelium

    Education and Training

    AB: Biology, University of California, Santa Cruz, 1972.

    PhD: University of California, Berkeley, 1979.

    Publications

    View PubMed Publications

    Grants

    Role of HIF-1α in fetal lung epithelial differentiation. Principal Investigator. National Institutes of Health. Feb 2007 - Jan 2012.
    A photo of Bruce Trapnell.

    Bruce C. Trapnell, MS, MD Assistant Director, Adult Cystic Fibrosis Center

    seeks to define mechanisms regulating innate immunity and inflammation in the lungs. His major focus is alveolar macrophage function in health and disease and the regulation alveolar homeostasis and host defense by GM-CSF in health and disease.

    513-636-6361
    bruce.trapnell@cchmc.org

    Bruce C. Trapnell, MS, MD

    Assistant Director, Adult Cystic Fibrosis Center

    Attending Physician

    Pulmonologist - Research, Adult Clinical, Division of Pulmonary Medicine

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-6361

    Fax: 513-636-3723

    Email: bruce.trapnell@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Pulmonary alveolar proteinosis; cystic fibrosis; alpha-1 antitrypsin deficiency; other rare lung disorders

    Research Interests

    Alveolar macrophage function; molecular techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation

    Biography

    Bruce Trapnell, MS, MD received his medical degree from the University of Maryland in 1985, and completed a medical residency at The Ohio State University Hospitals and a fellowship in pulmonary medicine at the Clinical Center of the National Institutes of health, where he then served as Senior Attending Physician. Subsequently, he established the Division of Pulmonary and Virology Studies at Genetic Therapy, Inc., a subsidiary of Novartis, Pharma, serving as Vice President before joining Cincinnati Children’s Hospital Medical Center, where he is now Full Professor.

    Dr. Trapnell has conducted lung disease research since his training and has been continuously funded by the NIH since 2001, shortly after his arrival in Cincinnati. He has published over 90 original articles and has trained more than 16 post-doctoral fellows. Dr. Trapnell’s research interests are focused to the pathogenesis and therapy of rare lung diseases and mechanisms by which GM-CSF regulates innate immunity and lung host defense.

    Dr. Trapnell is Director of Cincinnati’s Cystic Fibrosis Therapeutics Development Network Center, Assistant Director of the Adult Cystic Fibrosis Care Center, Director of the Rare Lung Diseases Clinical Research Consortium, Scientific Director of the Pulmonary Alveolar Proteinosis Foundation. Dr. Trapnell is the past Scientific Director of the Alpha-1 Foundation, for which he organized and directed the grant program for eight years.

    Education and Training

    MS: Genetics, The George Washington University, Washington, DC, 1981.

    MD:
    University of Maryland School of Medicine, Baltimore, MD, 1984.

    Residency: Internal Medicine, The Ohio State University Hospitals, Columbus, OH, 1987.

    Fellowship: Pulmonary Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, 1989.

    Certification: Diplomate in Internal Medicine, American Board of Internal Medicine, 1987; Diplomate, National Board of Medical Examiners, 1987; Diplomate in Pulmonary Medicine, American Board of Internal Medicine, 2000 .

    Publications

    View PubMed Publications

    Grants

    Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity. Principal Investigator. National Institutes of Health. Apr 2007 - Mar 2012. #R01 HL085453-01A1. 
    A photo of Laura Ward.

    Laura Placke Ward, MD

    focuses on strategies to prevent significant hyperbilirubinemia in term and late preterm infants.

    513-803-0963
    laura.ward@cchmc.org

    Laura Placke Ward, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-0963

    Fax: 513-803-0969

    Email: laura.ward@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Multidisciplinary quality improvement; family centered care; evidence-based practice

    Research Interests

    Strategies to prevent significant hyperbilirubinemia in infants

    Biography

    Dr. Ward has been a neonatologist in the division since 2002, and attends at The University Hospital.

    Education and Training

    MD: St. Louis University School of Medicine, St. Louis, Missouri, 1994.

    Residency: Children’s National Medical Center, Washington DC, 1994-1997.

    Fellowship: Children’s National Medical Center, Washington DC, 1997-2000.

    Certifications: Pediatrics, 1997; Neonatology, 2003.
    A photo of Timothy Weaver.

    Timothy E. Weaver, MS, PhD Co-Director, Division of Pulmonary Biology

    focuses on the identification of cytoprotective pathways that mediate adaptation to genetic and environmental stresses in the pulmonary epithelium. These molecular pathways play a critical role in preventing or slowing the progression of chronic lung disease and may provide novel targets for therapeutic intervention.
    Visit the Weaver Lab.

    513-636-7223
    tim.weaver@cchmc.org

    Timothy E. Weaver, MS, PhD

    Co-Director, Division of Pulmonary Biology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-7223

    Fax: 513-636-7868

    Email: tim.weaver@cchmc.org

    Show All

    Specialties

    Research

    Lung development; chaperone biology and diseases of protein misfolding; pulmonary fibrosis; asthma; respiratory distress syndrome; acute and chronic lung disease

    Visit the Weaver Lab Site.

    Biography

    Dr. Weaver has a long-standing interest in lung development and disease. His early work with Dr. Whitsett uncovered the function of surfactant proteins SP-B and SP-C, a discovery that has profoundly influenced the treatment of respiratory distress syndrome and survival of pre-term infants worldwide. His current research is focused to the molecular pathways (ER stress and autophagy) that link mutations in the SFTPC gene (encoding surfactant protein C) to development of interstitial lung disease (ILD) in both children and adults. His work has been continuously funded by the National Institutes of Health since 1986, including a MERIT (R37) award from the National Heart, Lung and Blood Institute (2001-2011).

    Dr. Weaver has trained 14 graduate students in the past 15 years and is the past director of the Molecular and Developmental Biology Graduate Program. During the same period of time he has trained 11 postdoctoral fellows, eight of whom are current faculty members at institutions in the US, Germany, France, Japan and UK.

    Education and Training

    BS: Biology, Bob Jones University, Greenville, South Carolina, 1975.

    MS: Embryology, Hahnemann Medical College, Philadelphia, Pennsylvania, 1979.

    PhD:
    Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 1983.

    Postdoc: Molecular Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 1986.

    Publications

    View PubMed Publications

    Grants

    Role of Autophagy in Pathogenesis of Interstitial Lung Disease. Principal Investigator. National Institutes of Health. Jul 2011 - Jun 2015. R01-HL103923.

    Stard7, A Novel Inhibitor Of Allergic Lung Disease. Principal Investigator. National Institutes of Health. Dec 2013 - Nov 2017. R01-HL122130.

    A photo of Kathy Wedig.

    Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital

    focuses on neonatal follow-up, including the follow-up of graduates from the NICU and drug exposed neonates with neonatal abstinence syndrome. Her future research plans involve neuroimaging and therapy based on the neurological findings.

    513-872-2748
    kathy.wedig@cchmc.org

    Kathy E. Wedig-Stevie, MD

    Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital

    Neonatologist, Good Samaritan Hospital

    Medical Director, Mercy Hospital Fairfield Nurseries

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-872-2748

    Fax: 513-872-4979

    Email: kathy.wedig@cchmc.org

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    Specialties

    Neonatal high risk infant follow-up and developmental follow-up

    Education and Training

    MD: University of Cincinnati Medical School, Cincinnati, Ohio, 1978.

    Residency:
    Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, 1978-1981.

    Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, 1983.

    Certifications: Pediatrics, 1983; Neonatology, 1983.

    Publications

    View PubMed Publications
    A photo of Susan Wert.

    Susan E. Wert, PhD Associate Professor, Division of Pulmonary Biology, Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute

    studies lung development, injury, and repair as it pertains to molecular morphology (gene and protein expression in situ), ultrastructure, and histopathology of the developing and adult lung. In addition, she studies the histopathology of the human lung as it relates to interstitial lung disease, especially to genetic disorders of surfactant dysfunction in the neonatal and pediatric population.

    513-636-4297
    susan.wert@cchmc.org

    Susan E. Wert, PhD

    Associate Professor, Division of Pulmonary Biology, Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4297

    Fax: 513-636-7868

    Email: susan.wert@cchmc.org

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    Specialties

    Clinical Interests

    Structural morphology of the lung; tissue responses to acute and chronic lung injury; morphogenesis of the lung and the origin of pulmonary malformations; use of transgenic mouse models to study mechanisms of lung development, cytodifferentiation, injury and repair in the lung; development of molecular markers for the study of respiratory epithelial cell differentiation and for cell lineage studies; image analysis and morphometry

    Research Interests

    Lung development, injury and repair as it pertains to molecular morphology (gene and protein expression in situ); ultrastructure, and histopathology of the developing and adult lung; the histopathology of the human lung as it relates to interstitial lung disease, especially to genetic disorders of surfactant dysfunction in the neonatal and pediatric population

    Education and Training

    PhD: Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 1988.

    Postdoctoral Fellowship: Perinatology, Division of Neonatology, Department of Pediatrics, University of Cincinnati College of Medicine, 1988-1991.

    Publications

    View PubMed Publications

    Grants

    Transcriptional Control of Respiratory Epithelial Progenitor Cells. Co-Investigator. National Heart, Lung and Blood Institute.  Sep 2007 - Sep 2011. #5R01HL090156-02.
    A photo of Scott Wexelblatt.

    Scott L. Wexelblatt, MD Medical Director, Regional Newborn Services

    has interests in the late preterm infant and regional newborn care.

    513-803-2681
    scott.wexelblatt@cchmc.org

    Scott L. Wexelblatt, MD

    Medical Director, Regional Newborn Services

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-2681

    Fax: 513-803-2633

    Email: scott.wexelblatt@cchmc.org

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    Education and Training

    MD: University of Vermont, Burlington, VT. 1996.

    Residency: Cincinnati Children’s Hospital Medical Center.

    Certification: Pediatrics, 1999.
    A photo of Kathryn Wikenheiser-Brokamp.

    Kathryn A. Wikenheiser-Brokamp, MD, PhD Director, Residency Research Program

    investigates pediatric and adult lung diseases, including cancer, which are characterized by aberrant epithelial cell growth and differentiation. A major focus is the molecular mechanisms underlying Rb/p16, p53, and Dicer1 pathway function in lung development and the pathogenesis of lung disease. The ultimate goal is to identify new diagnostic, prognostic and therapeutic targets for common pulmonary disorders.

    513-803-0239
    kathryn.wikenheiser-brokamp@cchmc.org

    Kathryn A. Wikenheiser-Brokamp, MD, PhD

    Director, Residency Research Program

    Associate Director, Medical Scientist Training Program

    Academic Information

    Associate Professor, UC Department of Pathology & Laboratory Medicine

    Phone: 513-803-0239

    Fax: 513-636-7868

    Email: kathryn.wikenheiser-brokamp@cchmc.org

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    Specialties

    Clinical

    Pathology; pulmonary pathology

    Education and Training

    BS: Mathematics/Natural Science, Secondary Education Minor, University of Mary, Bismarck, ND, 1988.

    PhD: Developmental Biology, Developmental Biology and Medical Science Scholars Programs, University of Cincinnati, Cincinnati, OH, 1994.

    MD: Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1996.

    Residency: Anatomic Pathology, Department of Pathology and Immunology, Washington University-Barnes/Jewish Hospital, St. Louis, MO, 1996-2002.

    Clinical Training/Postdoctoral Research: Department of Pathology and Immunology, Washington University, St. Louis, MO, 1999-2002.

    Licensure: State of Ohio, 2003.

    Certification: Anatomic Pathology, The American Board of Pathology, 1999.

    Publications

    View PubMed Publications
    A photo of Yan Xu.

    Yan Xu, PhD Director, Bioinformatics Microarray Core

    focuses on bioinformatics applications and systems biology. Her research interests are the identification of gene signatures, regulatory networks and biological pathways controlling 1) surfactant homeostasis, 2) lung maturation, 3) lung cell type specific signaling and 4) asthma associated pathology. The goal is to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.

    513-636-8921
    yan.xu@cchmc.org

    Yan Xu, PhD

    Director, Bioinformatics Microarray Core

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-8921

    Fax: 513-636-7868

    Email: yan.xu@cchmc.org

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    Specialties

    Bioinformatics; systems biology application in pulmonary research; lung cell type specific signaling; asthma associated pathology

    Biography

    Yan Xu, PhD, is an associate professor in the Department of Pediatrics, Divisions of Pulmonary Biology and Biomedical Informatics. Her main research interests are bioinformatics applications and systems biology.  She is currently focusing on the identification of gene signatures, regulatory networks and biological pathways controlling 1) surfactant homeostasis, 2) lung maturation and 3) lung cell type specific signaling. Her research goal is to integrate the data and information from new computational methods and experimental approaches in a synergistic way to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.

    Education and Training

    BS: Pharmacology, Shanghai Medical University, China, 1986.

    MS: Pathology, Shanghai Medical University, China, 1989.

    PhD: Molecular and Cellular Pharmacology, University of South Alabama, Mobile, Alabama, 1997.

    Publications

    View PubMed Publications

    Grants

    Transcriptional Control of Respiratory Epithelial Progenitor Cells. Co-investigator. National Heart, Lung and  Blood Institute. Sep 2007 - Sep 2011. #5R01HL090156-02.

    Role of SFTPC in Pathogenesis of Interstitial Lung Disease. Co-investigator. National Institutes of Health. Dec 2008 - Nov 2013. #1R01HL086492-01A2.

    Role of C/EBPa in Cytoprotection and Recovery from Lung Injury. Co-investigator. National Heart, Lung and  Blood Institute. Apr 2009 - Mar 2014. #1R01HL095464-01.

    Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial. Co-investigator. National Heart, Lung and  Blood Institute. Apr 2009 - Mar 2014. #1R01HL095589-01.