Raymond Boissy, PhD
is interested in melanization, skin pigmentation and pigmentary diseases of the skin. He is analyzing cellular and molecular events governing the biosynthesis of pigment granules by the melanocyte and their subsequent transfer to and degradation by the keratinocyte. In addition, he is studying the cellular and molecular etiology of several hypopigmentary disorders including vitiligo, albinism and Hermansky-Pudlak syndrome.
Raymond Boissy, PhD
Academic Information
Associate Professor, University of Cincinnati College of Medicine
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Biography
Dr. Boissy is an expert in cell biology with interests in mechanisms regulating the generation of cell type specific gene products and the subsequent targeting of these glycoproteins to their site of function. He uses the melanocyte and skin pigmentation as a model system for these studies. As a pathophysiologist, he is interested in cellular mechanisms and consequences of diseases, specifically hypopigmentary disorders of the skin and hair. Dr. Boissy has elucidated the role of a novel and abundant melanocyte specific protein, tyrosinase related protein-1 (TRP-1) in melanin synthesis and its involvement in regulating brown/black pigment production. He defined the etiology of two severe hypopigmentary diseases, vitiligo and albinism, which can result in premature aging, cancer, and immunodysfunction of the skin. Dr. Boissy contributes significantly to the Skin Sciences Institute through his expertise in understanding and assessing the role of pigmentation and skin color on skin health, viability, and appearance.
Education and Training
PhD: University of Massachusetts, Amherst, MA
Grants
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Steven B. Hoath, MD
Director, Skin Sciences Institute
has varied research interests including epidermal barrier development (in utero and postnatal), fetal and neonatal skin adaptation (skin/environment interactions), tissue engineering of human skin (in vitro systems), innate immune function (biology of vernix and skin proteomics), development of non-invasive skin-based sensors for brain monitoring and the role of the skin as a critical interface for health care delivery.
513-803-0960
steven.hoath@cchmc.org
Steven B. Hoath, MD
Director, Skin Sciences Institute
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsClinical aspects of Dr Hoath’s work derive from an understanding of the basics of human skin development and the multiple roles of the skin in neonatal care. New perspectives on the skin as a sensory interface are central to this understanding as is the role of the skin as an accessible environmental interface which complements ‘internal’ medicine. This view of the skin provides a unique, pivotal, and powerful opportunity to effect evidence-based organizational change in healthcare delivery to newborns. This approach highlights the criticality of the interface between Medicine and Nursing and the importance of focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future. Research InterestsEpidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery
Biography
Dr Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in Biology and German Studies. He received his MD from the University of California, Los Angeles and completed his Pediatric Residency and Fellowship in Neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984. He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of 7 international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body. He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on 5 patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.
Education and Training
Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983. Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.
Residency: University of California, Los Angeles, 1977-79.
Internship: Harbor-UCLA Medical Center, 1976-1977.
MD: University of California, Los Angeles, CA, 1976.
Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.
Baccalaureate: Stanford University, Biology & German Studies, 1972.
Publications
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Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels.Arch Dermatol Res. 2010 Dec 16. Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32. Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation.Int J Cosmet Sci. 2010 Jul 15. Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants.Pediatr Res. 2010 Apr;67(4):382-6. Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions.Skin Res Technol. 2008 Nov;14(4):418-24. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity.J Pediatr. 2008 Jun;152(6):777-81. Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33. Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78. Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94. Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.
Grants
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Vivek Narendran, MD, MRCP, MBA
Medical Director, Neonatal Intensive Care Unit and Newborn Nursery, The University Hospital
is interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface.
513-803-0961
vivek.narendran@cchmc.org
Vivek Narendran, MD, MRCP, MBA
Medical Director, Neonatal Intensive Care Unit and Newborn Nursery, The University Hospital
Medical Director, Cincinnati Perinatal Outreach Project
Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsNon-Invasive Ventilation of the Preterm Infant, Business Case for Quality Improvements Research InterestsInterested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface
Biography
Education and Training
MBBS: Bangalore Medical College, Bangalore, India, 1985.
MD/DNB: JN Medical College, Belgaum, India, 1990.
Fellowship: Neonatology, Westmead Hospital, Sydney, Australia, 1992-94.
Residency: Pediatrics, Leicester Royal Infirmary, Leicester, United Kingdom, 1994-1996.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1997-1998.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 1996, 1998-2000.
Credentials: Pediatrics, 1998; Pediatrics, Royal College of Physicians (MRCP), United Kingdom, 1996; Neonatal-Perinatal Medicine 2001 & 2008.
Publications
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Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach.Pediatrics. 2011 Feb 14. Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants.Pediatr Res. 2010 Apr;67(4):382-6. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity.J Pediatr. 2008 Jun;152(6):777-81. Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant.J Perinatol. 2005 Sep;25(9):608-11. Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation.J Perinatol. 2005 Jul;25(7):440-6. Review. Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid.Am J Obstet Gynecol. 2004 Dec;191(6):2090-6. Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants.J Perinatol. 2003 Apr-May;23(3):195-9. Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review. Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.
Grants
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Marty Visscher, PhD
is focused on understanding the development, maturation and adaptation of neonatal skin at birth and in infancy. She is working to understand the ontogeny of skin development in premature infants. Research projects also include the application of objective, q uantitative skin imaging methods that assess multiple aspects of cutaneous response, i.e., erythema, perfusion, pigmentation, 3D shape, temperature and hydration, in the progression and treatment of skin conditions.
Marty Visscher, PhD
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Skin research; infant skin development; effects of environment and skin treatment products on the skin;
Biography
Education and Training
PhD: Indiana University, Bloomington, IN.
Grants
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