Research Tools

Transgenics

The following transgenics are available from the lab of Jeffrey A. Whitsett, MD:

Null Mice

  • SP-A
  • SP-B
  • SP-C
  • SP-D
  • GM-CSF

tet-o Mice

  • VEGF
  • SHH
  • SP-D
  • SP-C
  • IL-~
  • IL-B
  • CFTR
  • ^508CFTR
  • TGF-~
  • GM-CSF
  • IL-10
  • FLK D/N
  • SRRY-4
  • FGF-R D/N
  • FGF-18
  • FGF-10
  • FGF-7
  • vas (mutant)
  • HGF
  • BMP-4
  • 3.7 hSP-C-rtTA/(otet)7-cre (mixed strain)
  • 2.2 rCCSP-rtTA/(otet)7-cre (mixed strain)
  • Lung Specific, TET-inducible SP-C mice and TET-inducible CC10 promoter mice
  • SP-C-TET-ON
  • CCSP-TET-ON

Other

  • FABP-CFTR-1
  • SP-C/FGF-R/Cre
  • FABP-CFTR (CF -/-) FABP^508CFTR
  • heterozygous 3.7 hSP-C-rtTA-FVB/N (pure strain)
  • homozygous 2.2 rCCSP-rtTA-FVB/N (pure strain)
  • Transgenic rat CCSP-RTTA mouse
  • SP-C rtTA activator mice

The following transgenics are available from the lab of Jeffrey Robbins, PhD:

  • Transgenic rabbits with expression targeted to the heart. These genetically modified animals may be generally useful as platforms for drug studies.

The following transgenics are available from the lab of Jeffery D. Molkentin, PhD:

  • MerCreMer transgenic mice
  • Transgene expressing a tamoxifen-regulated Cre recombinase fusion protein in the heart using the alpha-MHC promoter
  • Transgene expressing activated calcineurin (amino acids 1-398) in the heart using the alpha-MHC promoter.
  • Transgene expressing GATA4 (mouse cDNA) in the heart using the alpha-MHC promoter
  • Transgene expressing activated MEK1 (activates ERK) in the heart using the alpha-MHC promoter
  • Transgene expressing MKP-1 (inactivates MAPKs) in the heart using the alpha-MHC promoter
  • Transgene expressing ERK2 (wildtype) in the heart using the alpha-MHC promoter
  • Transgene expressing MKK7 (wildtype, activates JNK) in the heart using the alpha-MHC promoter
  • Transgene expressing dominant negative p38alpha in the heart using the alpha-MHC promoter
  • Transgene expressing dominant negative MKK3 in the heart using the alpha-MHC promoter
  • Transgene expressing dominant negative MKK6 in the heart using the alpha-MHC promoter
  • Transgene expressing dominant negative JNK1/2 proteins in the heart using the alpha-MHC promoter
  • Transgene expressing activated NFATc4 mutant in the heart using the alpha-MHC promoter
  • Transgene expressing dominant negative MEK1 mutant protein in the heart using the alpha-MHC promoter
  • Transgene expressing Cre in the heart using the alpha-MHC promoter
  • Transgene expressing Cre in the heart using the beta-MHC promoter
  • Transgene expressing MEF2C in the heart using the alpha-MHC promoter
  • Transgene expressing MEF2VP16 fusion protein in the heart using the alpha-MHC promoter
  • Transgene containing an NFAT-dependent luciferase reporter (expressed in all tissues of the mouse and is responsive to calcineurin signaling).
  • Calcineurin Abeta gene targeted mice (nulls are viable)
  • PKCalpha gene targeted mice (null are viable)
  • M3/6 phosphatase gene targeted mice
  • MKP-2 phosphatase gene targeted mice (nulls are viable)
  • NFATc4 gene targeted mice (nulls are viable)
  • (amino acids 1-398) in the heart using the alpha-MHC promoter

The following transgenics are available from the lab of David Repaske, PhD, MD:

  • PDE1B null C57BI/6 - I129 mice

The following transgenics are available from the lab of Susan E. Waltz, PhD:

  • Ron TK -/- mice (mice which lack the tyrosine kinase domain of the Ron receptor)

The following transgenics are available from the lab of Bruce Aronow, PhD:

  • apoJ/clusterine KO mice
  • C57/B6 Clusterin KO mice

The following transgenics are available from the lab of Jay L. Degen, PhD:

  • Fibrinogen-deficient mice